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All Journal CERATA Jurnal Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Urecol Journal. Part D: Applied Sciences Borobudur Pharmacy Review CERATA
Aristhasari Putri
STIKES Muhammadiyah Klaten
Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Antipyretic effect of Cymbopogon citratus ethanol extract on yeast-induced fever in mice Septyasari, Avanilla Fany; Putri, Aristhasari; Sholihatun, Anik
Borobudur Pharmacy Review Vol. 5 No. 2 (2025): August-Dec
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/bphr.v5i2.15115

Abstract

Lemongrass (Cymbopogon citratus) contains several secondary metabolites, one of which is flavonoids that have the ability to inhibit the activity of cyclooxygenase enzymes. Aims of this study is to determine the efficacy of lemongrass stem ethanol extract (Cymbopogon citratus) as an antipyretic and to determine the minimum effective dose for reducing fever in mice (Mus musculus) induced by yeast. The type of study is an experimental laboratory study, divided into 5 treatment groups, 0.5% CMC Na, paracetamol, lemongrass stem extract at doses of 4 mg/20 g, 6 mg/20 g, and 8 mg/20 g. Fever in mice was induced by subcutaneous injection of a 1.5% yeast solution. Rectal temperature measurements were taken at regular intervals at 30, 60, 90, 120, 150, and 180 minutes. The test results showed that the ethanol extract of lemongrass stem at a dose of 4 mg/20 g was able to reduce the fever-induced temperature of mice by 0.78°C from the fever temperature, while the 8 mg/20 g dose of lemongrass extract exhibited antipyretic effects similar to paracetamol.
Co-Authors Agustina Styawan, Anita Avanilla Fany Septyasari Choiril Hana Mustofa Hardhani, Salsabila Nur Hastikanuari, Anis Anggiara Maherawati Noni Muchson Arrosyid Nurul Hidayati Ocha Ardela Fitria Kresnaya Rahmi Nurhaini, Rahmi Refida Ramadhani Nur Cholifa Rheni Haryanti Ridhwan, Adib Muhammad Septyasari, Avanilla Fany Shefia Nur Rohmah Sholihatun, Anik