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Annisa Mulia Anasis
Program Studi Farmasi Universitas Tulang Bawang
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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AKTIVITAS ANTIFUNGI MINYAK ATSIRI DAUN KEMANGI (Ocimum x africamum Lour.) TERHADAPTrichophyton rubrum dan Trichophyton mentagrophytes Annisa Mulia Anasis; Mashuri Yusuf; Sigit Prayoga
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.704

Abstract

Abstract Traditional medicine using natural because it has small side effects and more economical than the synthetic drugs. One of the medicinal plants that for traditional medicine is basil (Ocimum x africamum Lour.).Basil plants contain active compounds such as alkaloids, saponins, flavonoids, triterpenoids, steroids, tannins, eugenol, phenols and essential oils that act as antifungals. Sweet basil essential oil can damage fungal cell membranes so that fungal cell molecules lyse which results in fungal cell death. The purpose of this study was to prove the antifungal activity of sweet basil essential oil as antifungal against T. rubrum and T. mentagrophytes. The essential oil from sweet basil leaves was obtained as much as 18 ml using the steam distillation method. Testing for antifungal activity was carried out using the agar dilution method/well method. The concentrations used in this study were 10%, 20%, 30%, 40%, 100%, positive control using ketoconazole and negative control using aquades with media Potato Dextrose Agar (PDA).Based on the results of research that has been carrier out, basil leaves essential oil has antifungal activity against with the largest inhibition greatest at 100% concentration with an inhibition zone diameter of 15,05 mm for T. rubrum and 19,11 mm for T. mentagrophytes Key words : antifungal, essential oil of sweet basil leaves, Trichophyton rubrum, Trichophyton mentagrophytes
AKTIVITAS ANTIPIRETIK KOMBINASI EKSTRAK ETANOLMENIRAN (Phyllanthus niruriL) DAN DAUN BELIMBING WULUH (Avverhoabillimbi) PADA TIKUS PUTIH JANTAN YANG DIINDUKSI VAKSIN DPT-Hb Yuli Wahyu Tri Mulyani; Annisa Mulia Anasis; Vatiyah Hari Utami
JFL : Jurnal Farmasi Lampung Vol. 11 No. 1 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i1.705

Abstract

Abstract Fever is defined as a change in the body's temperature regulation mechanism which results in an increase in body temperature above normal above 32.7ºC. Antipyretics are drugs used to reduce fever, one of which is paracetamol, but the use of paracetamol in large doses and for a long time has the potential to cause damage to the kidneys, brain, liver (hepatotoxic), disorders of the digestive system, respiratory system and hematological effects. These unwanted effects can be minimized using the active ingredients of meniran (Phylantus niruri L) and wuluh (Avverhoa bilimbi) plants. The purpose of this study was to prove the antipyretic activity of the combination of meniran leaf extract (Phylantus niruri L) and wuluh starfruit leaf (Avverhoa bilimbi) in male white rats (Rattus norvegicus L) induced by the DPT-Hb vaccine. The principle of this research is laboratory experimental research. This study included a combination of samples of meniran leaves and starfruit leaves, making thick extracts of meniran leaves and starfruit leaves, and testing the effect of antipyretics on the test animals. This study used the DPT–Hb (fever) vaccine induction method and the SPSS analysis method. The results showed that ethanol extract of meniran leaves 200mg/200grBB, ethanol extract of belimbing wuluh leaves 7.2mg/200grBB and a combination of ethanolic extract of meniran leaves with starfruit at doses of 200mg/200grBB and 7.2mg/200grBB, 100mg/200grBB and 3.6mg/ 200grBW, 200mg/200grBW and 3.6mg/200grBW, 100mg/200grBW, and 7.2mg/200grBW had antipyretic effects on male white rats. Keywords: antipyretic, starfruit, meniran
KOMBINASI EKSTRAK DAUN BIDARADENGAN DAUN KEMANGI SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus DAN Escherichia coli. Muhammad Richja As seffi; Yuli Wahyu Tri Mulyani; Annisa Mulia Anasis
JFL : Jurnal Farmasi Lampung Vol. 11 No. 2 (2022): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v11i2.807

Abstract

Infectious diseases are still at the top of the list of causes of illness and death in developing countries including Indonesia, Staphylococcus aureus and Escherichia coli are commonly found around the human environment, therefore prevention is needed to reduce infection by utilizing plants that have antibacterial effects such as bidara leaves with basil leaves. This study aims to determine the antibacterial activity of the combination of bidara leaf extract and basil leaves, and to determine the best combination concentration in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria compared to single extracts and positive controls. Using the diffusion method, the combination of dau bidara extract with basil leaves is K1 (0% + 100 %), K2 (20 + 80%), K3 (40% + 60%), K4 (50% + 50%), K5 (60 %+40%), K6 (80% + 20%), K7 (100% + 0%), K(-) Aquadest and K(+) Ampicillin. In the bacterial test (well diffusion method). The variable measured in this study was the diameter of the inhibition zone formed by the combination of extracts. Data analysis was tested using One Way Anova. The sig value for Staphylococcus aureus was 0.000≤0.05, while for Escherichia coli was 0.000≤0.05, it indicated that there was a significant difference between the test groups. The results of this study obtained the largest inhibition zone on bacteria, S. aureus, namely at K7 14.46 mm had a strong inhibitory response, while in bacteria E. Coli was found in K7 with the largest average value of 17.95 mm having a strong inhibitory response. This study can be concluded that the combination of bidara leaves and basil leaves has greater antibacterial power against Staphylococcus aureus and Escherichia coli bacteria than single extracts and positive control. Keywords: Ampicillin, antibacterial, Bidara leaves, basil leaves, diffuse
FRAKSI ETANOL RIMPANG KENCUR (Kaempferia Galanga L.) SEBAGAI ANTIBAKTERI TERHADAP Bacillus Subtilis dan Escherichia coli Yuli Wahyu Tri Mulyani; Annisa Mulia Anasis; Ari Yanto
JFL : Jurnal Farmasi Lampung Vol. 12 No. 1 (2023): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v12i1.995

Abstract

Abstract People were accustomed to use natural ingredients as traditional medicine because it was more economical and has little bit side effects compared with synthetic drugs. One of the herbs that has been widely known in the community as traditional medicine was the kencur rhizome. The kencur rhizome contains flavonoid and saponins which were antibacterial. The purpose of this study was to prove that there was the inhibition in ethanol fraction of kencur rhizome towards the growth of bacillus subtilis and Escherichia coli. The extraction process of kencur rhizome was carried out by maceration method used 70% ethanol solvent and continued with fractionation by using ethanol, n-hexane and chloroform solvents. Then, antibacterial test used diffusion method with concentrations of 25%, 50%, 75%, 100%, positive control of ciprofloxacin and negative control of aquadest. The test was continued by looking at the formation of inhibition zones around the diffusion and measured by using a calipers. The highest diameter of inhibition zone antibacterial activity of kencur rhizome at concentration 100% with a diameter of 22.00 mm in E. Coli and 20.00 mm for B. Subtilis, whereas positive control diameter inhibition zone of ciproflocaxin was 40.00 mm in E. Coli and 40.0 in B. Subtilis. The conclusion of this study was the ethanol fraction of kencur rhizome 100% concentration is the best concentration in the inhibition zone. Keywords: Antibacterial, Bacillus Subtilis, Escherichia coli, Kencur.
Co-Authors Ari Yanto Mashuri Yusuf Muhammad Richja As seffi Sigit Prayoga Vatiyah Hari Utami Yuli Wahyu Tri Mulyani