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PENGARUH KONSENTRASI PELARUT TERHADAP AKTIVITAS ANTIOKSIDAN DAN KANDUNGAN TOTAL FLAVONOID EKSTRAK ETANOL KULIT BAWANG MERAH (Allium cepa L.) Nadiya Eka Wahyuni; Mashuri Yusuf; Tutik Tutik
Jurnal Farmasi Malahayati Vol 4, No 2 (2021)
Publisher : Jurnal Farmasi Malahayati (JFM)

Kulit bawang merah (Allium cepa L.) yang masih kurang dimanfaatkan mengandung senyawa flavonoid yang sangat berpotensi sebagai antioksidan. Tujuan penelitian ini untuk mengetahui pengaruh konsentrasi pelarut terhadap aktivitas antioksidan dan mengukur kadar flavonoid dalam ekstrak etanol kulit bawang merah. Metode penelitian ini mengekstraksi kulit bawang merah dengan metode maserasi menggunakan pelarut etanol dengan variasi konsentrasi. Hasil ekstraksi diukur aktivitas antioksidan dengan metode DPPH dan kadar flavonoidnya. Hasil ekstraksi diperoleh % rendemen terbaik dari proses ekstraksi di dapatkan pada ekstrak yang menggunakan pelarut etanol 96% yaitu sebesar 28,88%. Hasil uji aktivitas antioksidan diperoleh nilai IC50 terbaik didapatkan pada ekstrak dengan pelarut etanol 96% yaitu sebesar 34,74 ppm. Hasil pengukuran kadar flavonoid terbesar juga didapatkan oleh ekstrak dengan pelarut etanol 96% yaitu sebesar 948,33 mg QE/g. Konsentrasi dari pelarut mempengaruhi aktivitas antioksidan dan kadar flavonoid ekstrak etanol kulit bawang merah.

Formulation Of Ointment From Extract Combination Of Lemongrass (Cymbopogon nardus L. Rendle), Green Betel Leaf (Piper betle L.) And Natural Zeolite As An Antibacterial Agent Laila Susanti; Subur Widodo; Mashuri Yusuf; Retno Fardila Sari
Biota Vol 6 No 2 (2020): Jurnal Biota 2020
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/10.19109/Biota.v6i2.6363

Lemongrass (Cymbopogon nardus L. Rendle) and green betel (Piper betle L.) plants are native to Indonesia. Empirically betel leaf can be used as a wound healer, lemongrass leaves are widely used as medicine for insect bites. On the basis of information obtained from various literatures, in this research has been done formulation of ointment from extract combination of lemongrass, green betel leaf and natural zeolite as antibacterial of Staphylococcus aureus. The use of zeolites based on features has a three-dimensional framework structure that is interconnected so that it has a large surface. Based on these reasons, it is believed that zeolites can increase the activity of active substances in ointments. The formulation of ointment extracts of lemongrass leaves-green betel leaves and zeolites with various dosages are KZ (zeolite control), KE (20% -5%), F1 (10% -6% + zeolite), F2 (20% - 5% + zeolite), F3 (30% -4% + zeolite), F4 (20% -0% + zeolite), F5 (0% -5% + zeolite) with a fixed amount of zeolite (2 gr). Evaluation of ointment preparations including organoleptic test, pH, homogeneity, spreading test and adhesion test showed results that met the requirements. The sample was tested for antibacterial activity with positive control (gentamicin 0.1%) showed that all formulas can provide an inhibition zone against staphylococcus aureus, except KZ. Test results were analyzed using One Way Annova with sig (0,000) <p value (0,050) followed by Tukey's further tests. From this explanation it can be concluded that the formulation of ointment from extract combination of lemongrass leaves, green betel leaves and zeolites has antibacterial agent.

Cream Formulation Of Extract Of Maja Leaves (Crescentia cujete) As An Antimicrobial Against Staphylococcus aureus Siti Nurjanah; Yuli Wahyu Tri Mulyani; Laila Susanti; Samsuar Samsuar; Mashuri Yusuf; Meidaliyantisyah Meidaliyantisyah
Biota Vol 7 No 2 (2021): Jurnal Biota 2021
Publisher : Faculty of Science and Technology Universitas Islam Negeri Raden Fatah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19109/Biota.v7i2.7070

Maja (Crescentia cujete L) is a plant that has medicinal properties for various diseases. Leaves of Maja contain some compounds such which are thought to have the potential to be antibacterial. The purpose of this study was to determine the potential of maja leaf extract in cream dosage form and to prove the presence of Antibacterial activity against Staphylococcus aureus. The cream of Maja leaf extract was made into several formulations; (5, 10, 15 %) The results was the cream of Maja leaf extract was able to inhibit the growth of S. aureus with the largest inhibition zone at a concentration of 15% with an average of 11.52 ± 0.95mm. Cream formulations were evaluated physically; organoleptic was resulting F1 in brownish-green, F2 in brown, and F3 in dark brown. Homogeneity tests show that all formulations were homogeneous. The pH value of all formulations following the cosmetic standard was about 4.5 – 6.5. The standard viscosity value was between 2000 – 4000 cps. The stability test of cream preparations shows no changes in the form of low-temperature storage (4ºC), room temperature, and high temperature (40ºC), so that maja leaf extracts can be formulated in cream preparations and cream formulations

FRAKSI ETANOL DAUN LIDAH BUAYA (Aloe vera L.) SEBAGAI ANALGETIKA TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus) Mashuri Yusuf
JFL : Jurnal Farmasi Lampung Vol. 8 No. 2 (2019): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v8i2.146

Daun lidah buaya (Aloe vera L.) merupakan tanaman obat yang tumbuh subur di Indonesia. Salah satu kandungan utama daun lidah buaya (Aloe vera L.) adalah flavonoid yang memberikan berbagai macam aktivitas farmakologi salah satunya sebagai analgetika. Penelitian ini bertujuan untuk menguji efek analgetika fraksi etanol daun lidah buaya (Aloe vera L.) terhadap tikus putih jantan galur wistar (Rattus norvegicus) yang diinduksi secara termik. Hewan uji yang digunakan adalah 25 ekor tikus putih jantan yang dibagi ke dalam 5 kelompok, masing-masing terdiri dari 5 ekor tikus putih jantan. Kelompok 1 diberikan2 ml suspensi CMC 0,5%, kelompok 2 diberikan2 ml suspensi asam mefenamat, sedangkan kelompok 3, 4 dan 5 masing-masing diberikan fraksi etanol daun lidah buaya dengan dosis 6,37 mg/Kg BB, 12,74 mg/kg BB, 25,4 mg/kg BB. Pengujian efek analgetika dilakukan dengan cara memberikan rangsangan nyeri pada hewan uji menggunakan rangsangan panas pada suhu 65˚C. Respon tikus putih jantan yang diamati yaitu gerakan menjilat kaki dan atau melompat. Pengamatan dilakukan selama 1 menit sebelum pemberian zat uji kemudian berturut-turut pada menit ke-30 setelah pemberian bahan uji sampai menit ke-120. Data yang diperoleh dianalisa dengan menggunakan uji anova dan dilanjutkan uji Duncan. Hasil analisa uji anova menunjukkan rata-rata respon tikus putih jantan pada kelompok dosis III tidak berbeda secara bermakna dengan kelompok kontrol positif. Hasil penelitian menunjukkan bahwa fraksi etanol daun lidah buaya memiliki efek analgetika terhadap tikus putih jantan galur wistar. Dosis III 25,4 mg/Kg BB menunjukkan penurunan analgetika lebih besar dibanding dosis I dan II. Kata kunci : Analgetika, daun lidah buaya, tikus putih jantan

RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI PADA PASIEN HIPERTENSI RAWAT INAP DI RS DAERAH Dr. A. DADI TJOKRODIPO BANDAR LAMPUNG Mashuri Yusuf; Subur Widodo; Diah Pitaloka
JFL : Jurnal Farmasi Lampung Vol. 9 No. 1 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i1.329

Abstract Hypertension is one of non contagious diseases marked by the increase of systolic blood pressure > 140 mmHg and diastolic blood pressure > 90 mmHg. Hypertension becomes the main risk factor of other cardiovascular diseases. The number of hypertension occurance with or without companion increases every year. The purpose of this research is to know the rationality of anti - hypertension medicine usage on hypertension inpatients at RSUD of Dr. A. Dadi Tjokrodipo Bandar Lampung year of 2019 based on precise patient, precise indication, precise medicine, and precise dosage using reference standard of Guidelines JNCVIII. This research was a descriptive research with data collection of medical record retrospectively. The technique of sample selection used purposive sampling technique. The research results obtained from 82 samples based on the patients’ characteristics of genders such as 50 female patients (60,98%) and 42 male patients (39,02%). The patients’ characteristics based on age obtain mostly the patients are at age of 46-55 years old in the amount of 39 patients (47,6%). The patients’ characteristics based on the pattern of medicine usage obtain the most anti-hypertension used is amlodipin CCB class in the amount of 54 patients (45%). Rationality evaluation of anti-hypertension medicine usage obtains precise patient in the amount of 81 patients (99,8%), precise indication in the amount of 82 patients (100%), precise medicine in the amount of 61 patients (74,4%), and precise dosage in the amount of 82 patients (100%). The conclusion of this research is the usage of hypertension on the hypertension inpatients at Public Hospital of Dr. A. Dadi Tjokrodipo Bandar Lampung is already rational. Keywords: Anti-hypertension, Hypertension, Rationality of Medicine Usage

ANALISA TINGKAT PENGETAHUAN DAN PERILAKU TERHADAP PENGGUNAAN OBAT INFLUENZA DAN BATUK SECARA SWAMEDIKASI DI DESA MUARA BURNAI I KABUPATEN OGAN KOMERING ILIR Mashuri Yusuf; Subur Widodo; Aqbar Raka Irwansyah
JFL : Jurnal Farmasi Lampung Vol. 9 No. 2 (2020): JFL: Jurnal Farmasi Lampung
Publisher : Fakultas MIPA Universitas Tulang Bawang Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v9i2.341

Abtract Many Indonesian people do self-medication as an attempt to treat complaints / pain they experience, the benefit of self-medication is safe when used according to the rules, effective for eliminating complaints, cost efficiency, can play a role in making therapeutic decisions, self-medication is usually done to overcome complaints and minor illnesses that are often experienced by people, such as fever, pain, dizziness, cough, influenza, ulcers, intestinal worms, diarrhea, skin diseases and others. This study aims to determine the level of knowledge and behavior towards the use of influenza drugs and cough by self-medication in Muara Burnai I Village, Ogan Komering Ilir district. The research analyzed was descriptive observational. The sampling technique uses the accindental sampling method. The instrument used in this study was a questionnaire. The results of the analysis of the level of knowledge and behavior analysis showed that there was a relationship between the level of knowledge and the behavior of influenza drug use and cough by self-medication was analyzed using the Chi-Square test sample of 100 respondents. The results of this study indicate that 36% have high knowledge and 64% have low knowledge in self-influencing and cough swamedication while 43% have high behavior and 57% have low behavior in influenza and cough swamedication in Muara Burnai I Village, Ogan Komering Ilir District. Based on the Chi-Square test results showed that the value of p = 0,000 (0.05). Shows that there is a relationship between the level of knowledge and swamedication behavior in Muara Burnai I Village, Ogan Komering Ilir district. Keywords : Influenza and cough, drug use behavior, swamedication, knowledge level.

AKTIVITAS ANTIFUNGI MINYAK ATSIRI DAUN KEMANGI (Ocimum x africamum Lour.) TERHADAPTrichophyton rubrum dan Trichophyton mentagrophytes Annisa Mulia Anasis; Mashuri Yusuf; Sigit Prayoga
JFL : Jurnal Farmasi Lampung Vol. 10 No. 2 (2021): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v10i2.704

Abstract Traditional medicine using natural because it has small side effects and more economical than the synthetic drugs. One of the medicinal plants that for traditional medicine is basil (Ocimum x africamum Lour.).Basil plants contain active compounds such as alkaloids, saponins, flavonoids, triterpenoids, steroids, tannins, eugenol, phenols and essential oils that act as antifungals. Sweet basil essential oil can damage fungal cell membranes so that fungal cell molecules lyse which results in fungal cell death. The purpose of this study was to prove the antifungal activity of sweet basil essential oil as antifungal against T. rubrum and T. mentagrophytes. The essential oil from sweet basil leaves was obtained as much as 18 ml using the steam distillation method. Testing for antifungal activity was carried out using the agar dilution method/well method. The concentrations used in this study were 10%, 20%, 30%, 40%, 100%, positive control using ketoconazole and negative control using aquades with media Potato Dextrose Agar (PDA).Based on the results of research that has been carrier out, basil leaves essential oil has antifungal activity against with the largest inhibition greatest at 100% concentration with an inhibition zone diameter of 15,05 mm for T. rubrum and 19,11 mm for T. mentagrophytes Key words : antifungal, essential oil of sweet basil leaves, Trichophyton rubrum, Trichophyton mentagrophytes

PERBANDINGAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN BIDARA (Ziziphus spina-christi L.) MENGGUNAKAN PELARUT ETANOL DAN N-HEKSANA Nofita Nofita; Diah Ningrum Uli Rosidah; Mashuri Yusuf
Jurnal Ilmu Kedokteran dan Kesehatan Vol 9, No 3 (2022): Volume 9 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v9i3.5562

Daun bidara ini merupakan salah satu tumbuhan di Indonesia yang mempunyai potensi mengobati berbagai macam penyakit. Antioksidan didefinisikan sebagai senyawa yang mampu menunda, memperlambat, atau menghambat reaksi oksidasi. Antioksidan alami merupakan jenis antioksidan yang berasal dari tumbuhan dan hewan. Salah satu tanaman yang berpotensi sebagai antioksidan alami adalah daun bidara. Penelitian ini bertujuan untuk mengetahui perbandingan antioksidan ekstrak daun bidara (Ziziphus spina-christi L.) dengan menggunakan pelarut etanol dan n-heksana dengan metode DPPH secara spektrofotometri dengan panjang gelombang 520 nm. Hasil rendemen yang didapat dari ekstraksi perkolasi etanol yaitu 4,59 % sedangkan hasil rendemen dari perkolasi n-heksana yaitu 2,70%. Analisis kandungan senyawa pada daun bidara (Ziziphus spina-christi L.) menunjukkan bahwa daun bidara mempunyai kandungan senyawa alkaloid, flavonoid, tanin, dan saponin. Untuk hasil antioksidan didapatkan nilai IC50 pada ekstrak etanol sebesar 134,54 dan perkolasi n-heksana didapatkan nilai IC50 sebesar 221,50. Dan untuk hasil antioksidan vitamin C didapat nilai IC50 sebesar 18,4. Hasil statistik aktivitas menunjukkan terdapat perbedaan yang bermakna (p > 0,05) antara hasil ekstrak perkolasi etanol dan n-heksana.

Penetapan Kadar Fenolik Total Ekstrak Metanol Dan Fraksi Etil Asetat Kulit Bawang Merah (Allium cepa L.) Meilinda Meilinda; Tutik Tutik; Mashuri Yusuf; Putri Amalia
Jurnal Farmasi Malahayati Vol 5, No 2 (2022)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v5i2.6857

Kulit bawang merah (Allium cepa L.) mengandung senyawa fenolik yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui kadar fenolik total dari ekstrak metanol dan fraksi etil asetat kulit bawang merah. Penelitian ini dilakukan ekstraksi kulit bawang merah dan pemisahan fraksi etil asetat serta penetapan kadar fenolik menggunakan spektrofotometri UV-Vis. Hasil penelitian diperoleh rendemen ekstrak kulit bawang merah sebesar 2,54%. Pengujian skrining fitokimia terhadap ekstrak metanol kulit bawang merah mengandung alkaloid, flavonoid, saponin, dan tanin. Kandungan fenolik total pada ekstrak kulit bawang merah dan fraksi etil asetat pada konsentrasi 50 ppm, yaitu 0,0181 mgGAE/g ekstrak dan 0,0110 mgGAE/g ekstrak. Setelah di fraksinasi kadar fenolik pada ekstrak 50 ppm berkurang 39,2265 %, Sedangkan hasil kadar fenolik pada ekstrak kulit bawang merah dan fraksi etil asetat konsentrsi 100 ppm, yaitu 0,0349 mgGAE/g ekstrak dan 0,0174 mgGAE/g ekstrak. Setelah di fraksinasi kadar fenolik pada ekstrak 100 ppm berkurang 50,1432 %. Hasil pengukuran kadar menunjukkan bahwa kadar dari fraksi etil asetat lebih rendah dibandingkan ektrak metanol. Hal tersebut disebabkan sifat dari golongan senyawa fenolik yang bersifat polar dapat membentuk ikatan hidrogen dengan air.Kata kunci : Kulit bawang merah, fenolik, fraksi etil asetat, spektrofotometri UV-Vis

Analisis Kadar Senyawa Alkaloid dan Flavonoid Total Ekstrak Etanol Daun Pepaya (Carica papaya L.) Menggunakan Spektrofotometri UV-Vis Reza Alzanando; Mashuri Yusuf; Tutik Tutik
Jurnal Farmasi Malahayati Vol 5, No 1 (2022)
Publisher : Jurnal Farmasi Malahayati (JFM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jfm.v5i1.7032

Daun pepaya (Carica papaya L.) mengandung alkaloid, flavonoid, pseudokarpain, saponin, tanin, vitamin C, vitamin E, kolin, dan karposid. Alkaloid dapat berperan sebagai anti-leukemia, anti-tumor, anti-virus, dan anti-malaria. Flavonoid memiliki aktivitas anti-oksidan, anti-virus, anti-bakteri, anti-alergi, anti-radang dan anti-kanker. Penelitian ini bertujuan untuk mengetahui kadar alkaloid total dan flavonoid total pada ekstrak etanol daun pepaya dengan menggunakan metode spektrofotometri UV – Vis. Penentuan kadar alkaloid total ekstrak etanol daun pepaya ditentukan berdasarkan nilai absorbansi yang diukur pada panjang gelombang 275 nm dengan menggunakan pembanding kafein, sedangkan penentuan kadar flavonoid total ditentukan berdasarkan nilai absorbansi yang diukur pada panjang gelombang 436 nm dengan menggunakan pembanding kuersetin. Hasil penetapan kadar alkaloid total yang diperoleh pada ekstrak etanol daun pepaya sebesar 16,56 % sedangkan kadar flavonoid total yang diperoleh sebesar 9,41 %. Sehingga dari data tersebut terlihat bahwa senyawa alkaloid total lebih besar kadarnya dibanding senyawa flavonoid.

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