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All Journal Health Notions Jurnal Riset Kefarmasian Indonesia Health Media Jurnal Katalisator Jurnal Sains dan Kesehatan
Dhina Ayu Susanti
Postgraduate School Of Public Health Sciences, University Of Jember
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Analytical and Phytochemical Exploration of Bioinsecticide Granules Mixed Betel Leaf Extract (Piper betle) and Srikaya Seed Extract (Annona squamosa) Dhina Ayu Susanti; Ady Soesetijo; Dwi Wahyuni
Health Notions Vol 2, No 2 (2018): February
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.782 KB) | DOI: 10.33846/hn.v2i2.133

Abstract

One alternative in controlling Aedes aegypti larvae is with the use of bioinsecticides that are environmentally friendly, safe, and inexpensive. Betel leaf and srikaya seeds contain chemical compounds that can be used as bioinsectiside. The following paper deals with detection of phytochemical in the Granules Mixed Betel Leaf Extract and Srikaya Seed using Thin Layer Chromatography (TLC) and FTIR. The TLC analysis was performed Rf value for 0.91 flavonoid compound; alkaloids 0.49; saponins 0.29 and 0.65; tannin 0.89; and anthraquinone 0.22 and 0.45. The FTIR analysis was performed represented the presence of various functional groups which includes alcohol, alkana, nitrile, and ether.Keywords: Phytochemical, Bioinsecticide, Granula, TLC, FTIR
Identification of Function Groups of Ethanol Extract and n-Hexane Extract of Coriander Seeds (Coriandrum sativum) Using Infrared Spectrophotometer Dhina Ayu Susanti; Lindawati Setyaningrum
Health Media Vol 1 No 2 (2020)
Publisher : UrbanGreen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55756/hm.v1i2.32

Abstract

Coriander (Coriandrum sativum) is a popular spice plant in Indonesia. Some active compounds contained in coriander seeds can be used as natural analgesics. This study aims to identify the functional groups contained in coriander seed extract. The solvent used to make coriander seed extract is ethanol and n-hexane, while the extraction method uses sohxlet. The extract obtained was then identified by its functional group using an Infrared spectrophotometer. The results of the identification of functional groups in the ethanol extract of coriander seeds showed some uptake that appeared at a wavelength of 3371.29 cm-1; 2923.59 cm-1; 2853.95 cm-1; 1583.22 cm-1; 1400.71 cm-1, and 1074.80 cm-1. The results of the identification of functional groups in the n-Hexane extract of coriander seeds showed some uptake that appeared at wavelengths of 2923.32 cm-1; 2853.41 cm-1; 1745.36 cm-1; 1461.9 cm-1; 1376.54 cm-1, 1161.67 cm-1, and 919.32 cm-1.
PENETAPAN KADAR ALKALOID TOTAL PADA EKSTRAK N-HEKSAN DAN ETANOL BIJI KETUMBAR (Coriandrum sativum) MENGGUNAKAN SPEKTROFOTOMETER UV-Vis lindawati setyaningrum; Dhina Ayu Susanti
Jurnal Riset Kefarmasian Indonesia Vol 4 No 3 (2022): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v4i3.268

Abstract

Coriander (Coriandrum sativum) is one of the medicinal plants which is known to contain secondary metabolites such as flavonoids, tannins, terpenoids, saponins, steroids, and alkaloids. Alkaloids have therapeutic effects as antimalarials and cancer. Research in determining the alkaloids in coriander was carried out by separating the alkaloids from other substances using the soxhlet method extraction with two solvents ethanol and n-hexane. The total alkaloid content is determined using a UV-VIS spectrophotometer at wavelength 351,5 nm. The reaction of alkaloids with Bromocresol green (BCG) is obtained to form a yellow product. The use of berberine standard was obtained the total alkaloid content of ethanol and n-hexane extract in coriander seed (Coriandrum sativum) were 0.524% and 0.583% respectively, and the ratio of total alkaloid content of ethanol extract was smaller than that of n-hexane extract.
Aktivitas Antiinflamasi In Vitro dan In Vivo Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.): In Vitro and In Vivo Anti-Inflamatory Activities of Ethanol Extract Mangifera indica L. Leaves Sholihatil Hidayati; Firda Oktavianti; Dhina Ayu Susanti; Qurrotul Aini
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1195

Abstract

Inflammation is a normal process designed to protect oneself and promote healing of body tissues. The mechanism of action of flavonoids as antiinflammatory is through the inhibition of arachidonic acid and the secretion of lysosomal enzymes. The ethanol extract of Mangifera indica L. leaves (EEML) contains flavonoids and is widely used as a medicine empirically. This study was conducted to evaluate the antiinflammatory effect of EEML in vitro and in vivo. In vitro study of the antiinflammatory activity of EEML based on its effect on the stability of blood membranes using UV-Vis spectrophotometry method. While the in vivo activity was tested using the carrageenan induction method on white rats of the Wistar strain. In vitro activity was expressed as EC50 and in vivo activity was expressed as % edema reduction. The results showed that ethanol extract was able to increase membrane stability with an EC50 value of 8.56 ?g/ml better than positive control aspirin with EC50 21.57 ?g/ml. In vivo test results showed that the administration of EEML doses of 200 mg/kg.bw, 400 mg/kg.bw, and 800 mg/kg.bw was not significantly different from the positive control in reducing edema. EEML has shown antiinflammatory effects in vitro and in vivo, so it has the potential to be developed as an antiinflammatory agent.
OPTIMASI KONSENTRASI PELARUT TERHADAP KADAR FLAVONOID EKSTRAK DAUN PEPAYA JEPANG (Cnidoscolus aconitifolius) Sholihatil Hidayati; Dhina Ayu Susanti; Nuryatul Faizah; Aliyah Purwanti
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.1897

Abstract

Flavonoid merupakan senyawa polifenol yang terdapat dalam berbagai macam tanaman. Pelarut organik seperti etanol, metanol, aseton, dan isopropanol telah banyak digunakan digunakan untuk mengekstrak flavonoid dari sumber tanaman. Konsentrasi dari pelarut tersebut yang dapat menarik flavonoid dengan maksimal menjadi factor penting dari proses ekstraksi. Penelitian ini dilakukan untuk mengetahui konsentrasi pelarut etanol terbaik dari daun papaya jepang yang dapat menarik senyawa aktif secara optimal. Penelitian dilakukan dengan membuat ekstrak daun papaya jepang dengan 3 konsentrasi pelarut etanol yaitu 50%, 70% dan 96%. Skrining fitokimia dilakukan dengan metode tampak noda KLT meliputi identifikasi flavonoid, alkaloid, sapogenin, polifenol dan steroid. Flavonoid total ditetapkan dengan metode spektrofotometri menggunakan standar kuersetin. Hasil penelitian menunjukkan bahwa konsentrasi pelarut etanol mempengaruhi hasil ekstraksi senyawa aktif pada daun papaya jepang. Skrining fitokimia menunjukkan bahwa flavonoid dapat terekstraksi paling optimal pada penggunaan pelarut etanol dengan konsentrasi 70%, sedangkan alkaloid dapat terekstrasi optimal pada konsentrasi pelarut etanol 96%. Konsentrasi terbaik yang dapat menarik flavonoid total secara optimal adalah etanol 70% dengan nilai flavonoid total sebesar 418,46±3,28 mg QE/g ekstrak.  Hal ini menunjukkan bahwa etanol 70% dapat menjadi pilihan terbaik sebagai pelarut dalam pengembangan daun papaya jepang sebagai obat tradisional.
Co-Authors Ady Soesetijo Aliyah Purwanti Dwi Wahyuni Firda Oktavianti lindawati setyaningrum Nuryatul Faizah Qurrotul Aini Sholihatil Hidayati