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All Journal Medical Laboratory Technology Journal Jurnal Analis Kesehatan Kendari
Muhammad Ihza Lisan Shidqi
Department of Clinical/Medical Laboratory Science, Universitas Muhammadiyah Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Nursing Public Health

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Evaluation in Hematology and BCR-ABL Molecular Profiles in Patients with Chronic Myeloid Leukemia Undergoing Tyrosine Kinase Inhibitor Therapy Muhammad Ihza Lisan Shidqi; Budi Santosa; Muhamad Muslim; Haitami Haitami
Medical Laboratory Technology Journal Vol. 8 No. 2 (2022): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.462 KB) | DOI: 10.31964/mltj.v8i1.484

Abstract

Chronic myeloid leukemia (CML) is a myeloproliferative malignancy due to the formation of the BCR-ABL fusion gene in chronic myeloid leukemia. This condition causes excessive cell proliferation, resulting in an increase in the number of leukocytes. Tyrosine Kinase Inhibitor (TKI) is a first-line therapy that helps reduce the percentage of the Breakpoint Cluster Region–Abelson (BCR-ABL) fusion gene in patients with chronic myeloid leukemia. This study was conducted to determine evaluation in the hematological profiles (hemoglobin levels, leukocyte counts, platelet counts) and molecular BCR-ABL in patients with chronic myeloid leukemia before and after 12 months of tyrosine kinase inhibitors therapy. This analytic observational study was administered using a cross-sectional design to in analyzing the medical records of CML patients who underwent TKI therapy at the Sub Specialist Polyclinic of Internal Medicine Hematology Oncology Ulin Banjarmasin Indonesia Regional Hospital from March 2021-April 2022. Statistical test was performed which analysis results showed that 12-month tyrosine kinase inhibitor therapy could increase the hemoglobin levels, decrease leukocyte counts, platelet counts as well as decreasing the percentage of BCR-ABL gene fusion in patients with chronic myeloid leukemia. In conclusion, evaluation of tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia obtained significant differences in the hematological profiles and the molecular BCR-ABL. Further researchers are recommended to compare the type of tyrosine kinase inhibitor therapy between Imatinib and Nilotinib on the hematological and molecular profiles of BCR-ABL in patients with chronic myeloid leukemia with a larger sample count.
Gambaran Indeks Aterogenik Plasma Pada Penderita Diabetes Melitus Sunaidi, Yanti; Sulfiani; Sefhia Purnama Dita; Muhammad Ihza Lisan Shidqi; Eleventi Oktarina Putri; Antoni Aldo Danendra Sawal
Jurnal Analis Kesehatan Kendari Vol. 8 No. 1 (2025): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 8 (1) Desember 2025)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

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Abstract

Diabetes mellitus is a group of metabolic disorders characterized by elevated blood glucose levels due to abnormalities in insulin secretion or insulin resistance. This condition increases the risk of cardiovascular disease by triggering dyslipidemia, which is marked by elevated cholesterol, increased levels of low-density lipoprotein (LDL), increased triglycerides, and decreased high-density lipoprotein (HDL) in the blood. Dyslipidemia in diabetic patients is associated with a higher Atherogenic Index of Plasma (AIP), which plays a role in the development of atherosclerosis, a key factor in cardiovascular disease. The logarithmic ratio of triglycerides to HDL can be used to determine the AIP, which serves as a marker for assessing atherogenicity and the risk of cardiovascular disease. This study aimed to predict cardiovascular disease in patients with diabetes mellitus through the evaluation of AIP values. The research was descriptive, involving 32 subjects selected using purposive sampling, and conducted at Dr. Tadjuddin Chalid General Hospital, Makassar, South Sulawesi. Based on the results of 32 subjects: 0 subjects (0%) were categorized as having low cardiovascular risk AIP, with an average value of 0; 1 subject (3%) was in the moderate risk category, with an average AIP of 0.19; 31 subjects (97%) were in the high cardiovascular risk category, with an average AIP of 0.82. These findings indicate that most diabetic patients tend to have a high-risk cardiovascular disease, compared to moderate or low-risk categories.
Co-Authors Antoni Aldo Danendra Sawal Budi Santosa Eleventi Oktarina Putri Haitami Haitami Muhamad Muslim Sefhia Purnama Dita Sulfiani Sunaidi, Yanti