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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
FX Hendriyono
Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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PERBEDAAN KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA PADA ANAK SINDROM NEFROTIK RELAPS DAN REMISI DI RSUD ULIN BANJARMASIN Siti Annisa Rezki; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
Publisher : Homeostasis

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Abstract: Hyperlipidemia is one of an important characteristics of nephrotic syndrome (NS). This study aims to determine the differences between total cholesterol and triglyceride levels in childrens with relapse and remission NS in Ulin General Hospital Banjarmasin from January 2017 - August 2018. A total of 26 childrens with NS were selected by purposive sampling method according to inclusion criteria. Among these, 15 childrens were in relapse and 11 childrens were in remission. Hypercholesterolemia were found in 93% of childrens with relapse NS and in 27% of childrens with remission NS, while hypertriglyceride were found in 67% of childrens with relapse NS and in 36% of childrens with remission NS. The mean total cholesterol levels in childrens with relapse NS is 374±38 mg/dL, was higher than those in remission, which is 168±12 mg/dL. The mean triglyceride levels in childrens with relapse NS is 267±186 mg/dL, also higher than those in remission, which is 130±78 mg/dL. The results of the analysis using an unpaired T test with a confidence level of 95%. This study can concluded that there were significant differences between total cholesterol (p = 0,000) and triglyceride levels (p = 0,030) in children with relapse and remission NS. Keywords: relaps nephrotic syndrome, nephrotic syndrome, remission, total cholesterol, triglyceride Abstrak: Hiperlipidemia merupakan karakteristik penting pada sindrom nefrotik (SN). Penelitian ini bertujuan untuk mengetahui perbedaan kadar kolesterol total dan trigliserida pada anak SN relaps dan remisi di RSUD Ulin Banjarmasin periode Januari 2017 – Agustus 2018. Sebanyak 26 anak SN yang terbagi atas 15 SN relaps dan 11 SN remisi dipilih secara purposive sampling sesuai kriteria inklusi. Didapatkan kejadian hiperkolesterolemia sebanyak 93% pada SN relaps dan 27% pada SN remisi, sedangkan kejadian hipertrigliseridemia sebanyak 67% pada SN relaps dan 36% pada SN remisi. Rerata kadar kolesterol total dan trigliserida pada SN relaps lebih tinggi dari SN remisi. Rerata kadar kolesterol total pada SN relaps adalah 374±38 mg/dL dan SN remisi adalah 168±12 mg/dL. Rerata kadar trigliserida pada SN relaps adalah 267±186 mg/dL dan SN remisi adalah 130±78 mg/dL. Hasil analisis menggunakan uji T tidak berpasangan dengan tingkat kepercayaan 95%. Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat perbedaan bermakna antara kadar kolesterol total (p=0,000) dan trigliserida (p=0,030) pada anak SN relaps dan remisi. Kata-kata kunci: sindrom nefrotik relaps, sindrom nefrotik, remisi, kolesterol total, trigliserida
Perbedaan Jumlah Trombosit sebelum dan sesudah Kemoterapi Neoadjuvan pada Pasien Kanker Payudara Lathifah Laila Ulfa; FX Hendriyono; Sasongko Hadi Priyono
Homeostasis Vol 3, No 1 (2020)
Publisher : Homeostasis

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Abstrack: There are two approaches to treating locally advanced luminal subtypes of  breast cancer, that is by providing neoadjuvant chemotherapy and surgery. One of the effects of chemotherapy is myelosuppression. Myelosuppression will reduce production of blood cells both erythrocytes, leukocytes, and platelets. This study aims to determine the differences number of platelets before first cycle and third cycle of neoadjuvant chemotherapy in patients with locally advanced with luminal subtypes breast cancer at Ulin Hospital Banjarmasin January-June 2019 Period. Samples were taken by total sampling technique. Data analysis using a paired T-test. There were 17 subjects with locally advanced with luminal subtypes breast cancer who met the exclusion and inclusion criteria. The mean of  platelet count before first cycle was 311,706 / uL and before third cycle was 377,764 / uL. Paired T-test results p = 0.008 which showed differences from platelet counts before first cycle and thrid cycle neoadjuvant chemotherapy. Keywords: locally advanced subtypes luminal of breast cancer , chemotherapy neoadjuvant, platelets. Abstrak: Terdapat dua pendekatan untuk mengobati kanker payudara yang berada pada stadium lanjut lokal yaitu memberikan kemoterapi neoadjuvan serta pembedahan. Salah satu efek dari kemoterapi adalah mielosupresi. Mielosupresi akan menurunkan produksi sel darah baik itu eritrosit, leukosit dan trombosit.  Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan jumlah trombosit sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan pada pasien kanker payudara yang terdiagnosis stadium lanjut lokal subtipe luminal di RSUD Ulin Banjarmasin Januari-Juni 2019. Sampel diambil dengan teknik total sampling. Data dianalisis menggunakan uji T berpasangan. Didapatakan sebanyak 17 subjek yang memenuhi kriteria eksklusi dan inklusi. Hasil rerata jumlah trombosit sebelum siklus pertama sebesar 311.706/uL dan siklus ketiga sebesar 377.764/uL. Hasil uji T berpasangan didapatkan p =  0,008 yang berarti bahwa terdapat perbedaan bermakna dari jumlah trombosit sebelum siklus pertama dan siklus ketiga kemoterapi neoadjuvan. Kata-kata kunci: kanker payudara lanjut lokal subtipe luminal, kemoterapi neoadjuvan, trombosit.
Co-Authors Aghfierna Herza Berliana Azma Rosida Edi Hartoyo Hariadi Yuseran Ikrima Nurul Arifa Jessica Manoralisa Larissa Faisa Faisa Lathifah Laila Ulfa Marcella Pavita Meyta Saskia Regita Putri Mohammad Rudiansyah Nurul Muth Mainnah Prenggono, Muhamad Darwin Rifdah Amalina Winarno Rusyda Taqiya Rahmi Sasongko Hadi Priyono Sasongko Hadi Priyono Selli Muljanto Siti Annisa Rezki Triska Dianti Wahyuningrum