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All Journal Jurnal Penelitian Farmasi dan Herbal PharmaCine: Journal of Pharmacy, Medical and Health Science
Cantika Nurul Sa'adah
Universitas Singaperbangsa Karawang
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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STUDI FARMAKOVIGILANS PADA OBAT HERBAL Cantika Nurul Sa'adah
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.1067

Abstract

There is a trend of "back to nature" which has become the lifestyle of today's society, so that people return to using various natural ingredients in medicine. A drug side effect is any adverse and unwanted response to a drug that occurs at doses normally used in humans for the treatment of disease, diagnosis, prevention, or modification of physiological function. Pharmacovigilance is carried out with the aim of monitoring drug safety by detecting an increase in the incidence of Advers Drugs Reaction (ADR). This review was conducted to see an overview of the initial data/reports on the relationship between the use of herbal medicines and the incidence of ADR. As a result, it is known that the percentage of ADR events in various places is 19%, 12%, 13.36% and 10-15% with possible and probable categories. The types of herbal medicines used are white turmeric, fitsea, garcia, ginger water, turmeric, herbalife, niran, calcusol, vegeta, tensigard, diapet, herbal vegeta, diabetes herbs, hypertension herbs, cholesterol herbs, kidney stone herbs, anti-inflammatory analgesic herbs, herbal medicine for asthma and herbal medicine for diarrhea.
Studi Literatur : Kandidat Obat Baru Dan Target Kerja Obat Penyakit Systemic Lupus Erythematosus Audi Ichsani Aribowo; Lestari Mahardika Urbaningrum; Cantika Nurul Sa'adah; Bunga Nur Annisa; Nena Vauziah Sary; Christina Febiola Lubis; Lina Nurfadhila; Marsah Rahmawati Utami
PharmaCine : Journal of Pharmacy, Medical and Health Science Vol. 3 No. 2 (2022): PharmaCine : Journal of Pharmacy, Medical and Health Science
Publisher : Bachelor of Pharmacy Study Program, Faculty of Health Sciences, Universitas Singaperbangsa Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35706/pc.v3i2.7973

Abstract

Latar Belakang: Systemic lupus erythematosus (SLE) ialah penyakit dengan kerusakan pada sistem kekebalan tubuh, terutama dalam imunitas seluler dan humoral. SLE terjadi pada individu dengan predisposisi genetik, terutama pada gen HLA yang dipicu oleh faktor lingkungan. Pada kebanyakan kasus, SLE muncul akibat efek dari banyak varian gen. Ada banyak golongan obat yang biasa digunakan untuk pengobatan SLE seperti kortikosteroid, imunosupresan, NSAID, atau antibodi monoklonal spesifik yang diarahkan terhadap reseptor permukaan sel atau sitokin  Tujuan: memberikan gambaran dan informasi terkini tentang kandidat obat baru dan target kerja obat penyakit lupus. Metode: studi tinjauan pustaka dari Google Scholar, Science Direct, dan PubMed dengan kriteria inklusi dan eksklusi. Hasil target kerja obat tersebut melalui tiga jenis penelitian berupa in vivo, in vitro, dan in silico. Berdasarkan tinjauan pustaka yang sudah dilakukan, terdapat beberapa target kerja obat pada penyakit lupus/SLE yaitu reseptor PI3Kδ, Enzim NF-κB inducing kinase, IFN-γ, IL-3, TNF-α, TP53, VEGFA, IL6, CD4, CCR1, JAK2, XRCC5, XRCC6, RB1, MYC, TP53, IL-1 alpha, IL-5, IL-6, IL-17, Limfotoxin-alpha, IL-21, TLR7, TLR9, CAPS3, STAT3, STAT1, IFNα, FcγR2A, CD22, CD20. Lalu untuk hasil beberapa kandidat obat baru terdapat pada ekstrak daun Bryophyllum pinnatum, curcumin, Langchuangding, Hedyotis diffusa Willd, dan BIIB059. Semua target atau kandidat senyawa pengobatan lupus yang diteliti memiliki hasil yang baik untuk pengobatan lupus. Kata Kunci : Kandidat Obat Baru, Target Kerja Obat, Systemic Lupus Erythematosus.
Co-Authors Audi Ichsani Aribowo Bunga Nur Annisa Christina Febiola Lubis Lestari Mahardika Urbaningrum Lina Nurfadhila Marsah Rahmawati Utami Munir Alinu Mulki Nena Vauziah Sary