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All Journal Journal Syifa Sciences and Clinical Research (JSSCR)
Muhammad Taupik
Jurusan Farmasi Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo, Jl. Jenderal Sudirman No. 06 Kota Gorontalo 96128, Indonesia
Chemistry Medicine & Pharmacology

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Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Uji Penyembuhan Luka Bakar Gel Enzim Bromelin Menggunakan Carbopol 940 Secara In Vivo Nur Ain Thomas; Muhammad Taupik; Endah Nurrohwinta Djuwarno; Dizky Ramadani Putri Papeo; Nabila Novreini Djunaidi
Journal Syifa Sciences and Clinical Research Vol 5, No 2 (2023): Volume 5 Edisi 2 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i2.20364

Abstract

Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in  burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
Co-Authors A. Mu’thi Andy Suryadi Andi Makkulawu Ariani H. Hutuba Endah Nurrohwinta Djuwarno Mahdalena Sy Pakaya Nabila Novreini Djunaidi Nur Ain Thomas Papeo, Dizky Ramadani Putri