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All Journal Journal Syifa Sciences and Clinical Research (JSSCR) Indonesian Journal of Pharmaceutical Education International Journal of Health Science & Medical Research Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society
Andi Makkulawu
Universitas Negeri Gorontalo
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Rapid and Simultan Determination of Phenylbutazone in Herbal Remedies Using Infrared Spectroscopy Combined With Chemometric Ardi Nugroho; Mas Muhammad Luqman Imam Al – As’ari; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14382

Abstract

Phenylbutazone is one of common adulterated drug in herbal remedies. According to legal regulations in indonesia, it is prohibited to adulterate those ingredients in herbal remedies. So, it is an urgent need to develop rapid, and reliable method for detection and determination adulterants in herbal medicine. This study aims for the detection and determination of Phenylbutazone in herbal remedies using ATR-FTIR spectroscopic combined with chemometrics. Stepwise Multiple Linear Regression (SMLR) was used identify the relationship between concentrations and wave numbers. All samples (Unadulterated and adulterated) were classified and discriminated respectively to their added contents with perfect accuracy and precision. The results suggest that existence of the active substance could be successfully determined at the levels in the range of 0.01 to 85 mg in totally 100 mg of herbal remedies with RMSECV 0.016054643 and R2 0.9984 respectively by using ATR-FTIR technique combined with chemometrics.
Isolasi dan Karakterisasi Bakteri Endofit dari Akar Pare (Momordica charantia L.) Mahdalena Sy. Pakaya; Julianty Akuba; Dizky Ramadani Putri Papeo; Andi Makkulawu; Ade Ari Puspitadewi
Journal Syifa Sciences and Clinical Research Vol 4, No 1 (2022): Volume 4 Edisi 1 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i1.15536

Abstract

Endophytic bacteria are microbes that grow on plant tissue and can form a colony on plant tissue without producing a negative effect on the host. The endophytic bacteria have the potential to have the same activity and produce secondary metabolite as their host. The root of bitter melon (momordica charantia L.) has been known to have antibacterial activity, thus enabling the presence of endophytic bacteria, which also have antibacterial potential.This present research aims to isolate and characterize endophytic bacteria found in bitter melon (Momordica charantia L. The method used in the isolation stage is direct lanting so that the endophytic bacteria are obtained from plant tissue; macroscopic and microscopic characterization stage; inhibition test stage; inhibition test stage using disc method (Kirby-Bauer). In accordance with the results of macroscopic and microscopic characterization, the two bacteria indicate different characteristics.
Gambaran Penggunaan Obat Off-Label Pada Pasien Pediatrik Rawat Inap di Rumah Sakit Teti Sutriati Tuloli; Nur Rasdianah; Andi Makkulawu; Dizky Ramadani Putri Papeo; Maimun Datau
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.11449

Abstract

Off-label drugs can be interpreted as drugs that are used not in accordance with drug information, distribution permits and sales licenses from the Marketing Authorization (MA) related to indications, age, dosage, route of administration and contraindications. The use of off-label drugs in children occurs because of incomplete data on pharmacokinetics, pharmacodynamics and side effect of a drug. It is because clinical research in children is quite difficult and not in accordance with research ethics and morals, so it has the potential to cause errors in treatment and unwanted drug reactions. This study aims to describe the use of off-label drugs in hospitalized pediatric patients at RSUD of Dr. M.M Dunda Limboto, Gorontalo District, Gorontalo Province. This is an  observational study using cross sectional design and retrospective data collection. The sampling technique applies a purposive sampling technique with a total of 155 patients who meet the inclusion criteria during the January-June 2020 period. The finding shows that from 155 patient medical records, there are 172 (16,51%) off-label drug used with a total of 1042 drugs. The off-label drugs used in the indication category are 64,53%, the off-label drugs used in dose category are 17,44%, the off-label drugs used in age category are 14,53%, the off-label drugs used in route of administration category are 3,49% and the off-label drugs used in contraindications category are not found. The are the most off-label drugs used in each category, including domperidone (off-label in indications and dose), rhinofed (off-label in age) and salbutamol (off-label in route of administration).
Pengaruh Variasi Konsentrasi Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa) Terhadap Stabilitas Fisik Sediaan Krim Nur Ain Thomas; Robert Tungadi; Dizky Ramadani Putri Papeo; Andi Makkulawu; Yuni Sarah Manoppo
Indonesian Journal of Pharmaceutical Education Vol 2, No 2 (2022): Mei-Agustus 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i2.13532

Abstract

God's crown is one of the plants with various components with flavonoid as one of these components, which is an abundant plant metabolite component in nature that significantly functions for the plant's growth and antioxidants. This study aimed to examine The Concentration Variation Effect of 70% Ethanol Extract from God's Crown (Phaleria Macrocarpa) Towards The Physical Stability of Cream Preparations by variating the extract concentration. The formula concentration on the extract consists of FI (1%), FII (3%), FIII (5%), by stearic acid, paraffin liquid, alcohol cetyl, paraben propyl for the oil phase, aquadest, triethanolamine (TEA), and methylparaben for the water phase. Further evaluations include organoleptic test (smell, color, texture), pH test, homogeneity test, viscosity test, distribution test, and adhesion test. Each evaluation result found changes as intended by the research purpose, which is the effect of the extract's concentration variation on the physical stability of the cream preparations.
Standarisasi Mutu Tanaman Herbal Aur-Aur (Commelina longifolia L.) dan Tanaman Bungango (Flueggea virosa Royle) Andi Makkulawu; A. Mu’thi Andy Suryadi; Muhammad Taupik; Mahdalena Sy. Pakaya; Ariani. H Hutuba
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.16044

Abstract

In the developing materials for traditional medicines, it is necessary to standardize the quality of plant materials. Tuhus, quality, stability, and safety. This study aims to determine several standardization parameters and determine the flavonoid content of the 70% ethanol fraction of aur-aur leaves (Commelina longifolia L.) and bungango leaves (Flueggea virosa Royle) to ensure that the fractions have quality and measurable parameter values. The fraction was standardized with two parameters, thus specific and non-specific, and flavonoid content test using UV-Vis spectrophotometry method. The results of phytochemical screening, the fraction containing flavonoid compounds is 70% ethanol fraction. Standardization of specific parameters showed the organoleptic results of both aur-aur (Commelina longifolia L.) and bungango (Flueggea virosa Royle) leaf fractions in the form of a semi-solid viscous fraction, black in color, and characteristic odor. The content of water soluble extract and ethanol soluble extract of aur-aur (Commelina longifolia L.) leaf fraction were 22.84%, ethanol soluble extract 25.03%, while the fraction of Bungango (Flueggea virosa Royle) leaf was 30.70%. and 27.31%. Standardization of non-specific parameters showed the results of water content 21.40%, total ash content 8.92%, acid insoluble ash content 0.043%, drying shrinkage 10.48%. The results of non-specific standardization of bungango leaves (Flueggea virosa Royle) showed a moisture content of 14.45%, a total ash content of 9.62%, an acid insoluble ash content of 1.31%, a drying shrinkage of 10.64%. The results for the analysis of the flavonoid content of the 70% ethanol fraction of aur-aur leaves and bungango leaves were carried out at a wavelength of 438.36 nm. The total flavonoid content was calculated by the standard linear equation of quercetin, namely y= 0.0648x + (-0.0232) with a correlation coefficient (r2) = 0.9948 with the total flavonoid content of aur-aur leaf and bungango leaf each of 3.57. % and 9.578%.
Tingkat Pengetahuan Masyarakat Terhadap Tindakan Penggunaan Antibiotik Tanpa Resep Dokter Madania Madania; A. Mu’thi Andy Suryadi; Fika Nuzul Ramadhani; Andi Makkulawu; Dizky Ramadani Putri Papeo
Journal Syifa Sciences and Clinical Research Vol 4, No 3 (2022): Volume 4 Edisi 3 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i3.7141

Abstract

Antibiotics is a subtance that can kill or weaken an organism such as bacteria, parasite, or fungi.  The use of antibiotics always triggers a problem, such as the use of it without any medical prescription. It sometimes happens caused by some factors such as the lack of people’s knowledge concerning the consumption of antibiotics. This research aims at investigating the correlation between the respondent’s characteristics toward knowledge, attitude, and action. Also, it is to investigate the correlation between knowledge and attitude toward the consumption of antibiotics without medical prescription. The research design applies analytical observation with cross sectional approach. The research subjects are 96 respondents selected by purposive sampling technique. The research instrument is questionnaires consisting of questionnaire of knowledge, attitude, and action. The method of data analysis is multiple correlation. Findings reveal that the people’s level of knowledge is still low obtaining 47,7% of score, the people’s attitude is categorized negative (supporting the consumption of antibiotics without medical) obtaining 54,2%, the people’s action categorized not appropriate obtaining 57,3%, there is correlation between education and job toward knowledge, attitude, and action (p0,05), there is no correlation between age and sex toward knowledge, attitude, and action (p0,05), and there is a correlation between knowledge and attitude toward action (p=0,000).
Efek Antihiperurisemia Ekstrak Etanol Daun Pandan (Pandanus Amaryllifolius ) Pada Mencit (Mus Musculus) Widysusanti Abdulkadir; Dizky Ramadani Putri Papeo; Juliyanty Akuba; Andi Makkulawu
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.7719

Abstract

Hyperuricemia is a condition in which the kidneys fail to excrete uric acid, resulting in high levels of uric acid. (Kaneko et al., 2014). Uric acid will be excreted into the kidneys along with urine. The decrease of uric acid secretion into the kidney tubules due to interference of uric acid elimination to the kidneys which causes uric acid levels in the blood to increase (Ningtiyas Ramadhian, 2016). An adult male is suffering from hyperuricemia when his serum uric acid level is more than 7.0 mg/dl, while hyperuricemia in adult women occurs when the serum uric acid level is above 6.0 mg/dl. Hyperuricemia therapy management in the community is very diverse, ranging from traditional medicines and synthetic drugs. One of the traditional plants used as traditional medicine is pandan leaves. This study aimed to determine the anti-hyperuricemia effect of ethanol extract of Pandanus amaryllifolius leaves on mice (Mus musculus L.). The study involved 25 male mice which were divided into 5 groups; each group consisted of five male mice. Group I was a negative control with Na-CMC 1% w/v, while Group II was a positive control with Allopurinol 0.117 g w/v. Further, Groups III, IV, and V were given Ethanol Extract of 0.5 gr w/v, 1 g w/v, 1.5 g w/v of Pandan Leaves, respectively. The results showed that there was no significant decrease in uric acid levels in group I. Meanwhile, Groups II, III, IV, and V showed a significant reduction in uric acid levels with identical effectiveness. The results of the study were then tested using the One-Way ANOVA statistical test; the p-value was 0.01 (α 0.01). The best dose was 1.5 g of extract since there was a significant difference from the pandan leaves extract with 1.5 g (p 0.01). In conclusion, pandan leaves extract can reduce uric acid levels in the blood. This was evidenced by a decrease of 4.1 mg/dl in uric acid levels in mice during the experiment.
Formulasi dan Uji Kestabilan Fisik Lilin Aromaterapi Minyak Atsiri Bunga Melati (Jasminum sambac L) Besse Yuliana; Andi Makkulawu; Annisa Ramadhani Amal
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.18874

Abstract

Aromatherapy candles are alternative medicine (inhalation) namely inhalation, aroma vapor produced form a few drops esensial oils. Jasmine flower (Jasminum sambac L.) is used widely as Aromatherapy for the manufacture of essential oils, generally brownish yellow in  color with the characteristic odor. Contains chemical compounds of jasmine oil, namely lynalol 10. 13%, nerolidol 19.95%, and indole 4. 05%. Jasmine Flower essential oil Aromatherapy candle (Jasminum sambac L.) This type oh the research was experimental, including physical burning point tests, melting point tests and hedonic tests. The results showed that the preparations had made white and yellow colors, different aromas according to the concentration of the essential oil, the melting point 52-59℃ according to the requirements according to SNI, namely 42-60℃, the fastest burning time was the old formula K(-), formula 2and 3 the fastest burning time, and in the hedonic test, formulation 3 was the most favored by the panelists and the K(-) formulation was less favored by the panelists. The conclusion oh this research is that jasmine essential oil (Jasminum sambac L.) can be formulated aromatherapy candles preparations, jasmine flower essential oil (Jasminum sambac L.) in aromatherapy candles is physical stable and jasmine essential oil aromatherapy candles  (Jasminum sambac L.) has high level of liking by the panelists.
Pemberdayaan Masyarakat Melalui Pemanfaatan Daun Kelor Sebagai Pencegahan Stunting Dengan Pemberian Makanan Tambahan Andi Makkulawu; Lia Amalia
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (903.096 KB) | DOI: 10.3731/phar.soc.v1i2.18268

Abstract

Kelor merupakan salah satu jenis tanaman tropis yang sangat mudah didapatkan dan dikenali di Desa Lonuo Kecamatan Tilongkabila Kabupate Bonebolango. Masyarakat setempat menggunakan daun kelor sebagai pelengkap makanan berupa olahan sayuran. Daun kelor dikenal memiliki banyak manfaat dan mempunyai banyak nilai gizi. Kegiatan pengabdian masyarakat kali ini bertitiktolak pada pemberdayaan masyarakat desa melalui pengembangan dan pemanfaatan daun kelor selain sebagai pelengkap makanan berupa olahan sayuran tetapi juga sebagai hidangan lain seperti pudding, dimana hidangan ini lebih digemari oleh anak-anak sehingga bisa digunakan sebagai pemberian makanan tambahan sebagai pencegahan stunting. Tujuan dari kegiatan ini adalah perberdayaan masyarakat dengan memberikan pengetahuan pemanfaatan daun kelor sebagai makanan tambahan.
Edukasi Tentang Vaksinasi Covid-19 Pada Kalangan Mahasiswa dalam Program Apoteker Selalu Terpecaya Untuk Kesehatan Anda di Jurusan Farmasi, FOK, UNG Mohamad Aprianto Paneo; Multiani S Latif; Teti Sutriyati Tuloli; Andi Makkulawu; Djayadi Azis
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 1, No 2 (2022): Vol 1 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (784.629 KB) | DOI: 10.3731/phar.soc.v1i2.18594

Abstract

Vaksin Covid-19 mulai beredar setelah virus SARS CoV-2 melanda dunia, Pemberian Vaksin Covid- 19 ditujukan untuk meningkatkan kekebalan tubuh manusia dari serangan virus SARS CoV-2. Pro dan Kontra beredar dimasyarakat membuat kegelisahan untuk melaksanakan Vaksin Covid-19. Ikatan Apoteker Indonesia (IAI) melalui Program Apoteker Selalu Terpecaya Untuk Kesehatan Anda, yang dirangkaikan dengan World Pharmacist Day Tahun 2021 diwakili Oleh Apoteker Kota Gorontalo berkunjung di Jurusan Farmasi, Fakultas Olahraga dan Kesehatan Universitas Negeri Gorontalo untuk melaksanakan program edukasi vaksin tersebut. Metode edukasi dilaksanakan dengan model pembelajaran langsung, mahasiswa diberikan kuesioner dengan dua tahap, yaitu Pre-Kuesioner dan Post Kuesioner. Materi diberikan setelah Pre-Kuesioner dengan tujuan untuk melihat perbedaan pemahaman setelah diberikan edukasi. Tingkat pemahaman mahasiswa meningkat secara signifikan setelah diberikan edukasi, yaitu dari total presnetasi 30% menjadi 90%. Berdasarkan nilai tersebut, pemberian Edukasi kepada mahasiswa tentang vaksin Covid-19 sangat perlu, untuk mengantisipasi penyerapan informasi vaksin Covid-19 yang berkembang di dunia maya melalui jejaring internet, khususnya melalui media sosial.
Co-Authors A. Mu’thi Andy Suryadi A. Mu’thi Andy Suryadi Ade Ari Puspitadewi Annisa Ramadhani Amal Ardi Nugroho Ariani H. Hutuba Besse Yuliana Djayadi Azis Ekawaty Prasetya Fika Nuzul Ramadhani Jafar La Kilo Julianty Akuba Lia Amalia Madania, Madania Mahdalena Sy Pakaya Maimun Datau Mas Muhammad Luqman Imam Al – As’ari Mohamad Aprianto Paneo Muhammad Taupik Muhammad Taupik Multiani S Latif Nur Ain Thomas Nur Rasdianah Papeo, Dizky Ramadani Putri Robert Tungadi Teti Sutriati Tuloli Teti Sutriyati Tuloli Widysusanti Abdulkadir Yuni Sarah Manoppo