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All Journal PRIMER (Prima Medical Journal)
Arie Siah Putra Siahaan
Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Kadar Serum Interleukin-6 Tikus Wistar Jantan Pada Uji Toksisitas Akut Ekstrak Kunyit Putih Richardo Chandra; Adhayani Lubis; Arie Siah Putra Siahaan; Erny Tandanu; Fiska Maya Wardhani
PRIMER (Prima Medical Journal) Vol. 7 No. 2 (2022): Edisi Oktober
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v7i2.3163

Abstract

Latar belakang : Interleukin 6 ( IL–6 ) merupakan salah satu zat sitokin yang dikeluarkan bila terjadi respon inflamasi, hal ini sering disebabkan oleh adanya infeksi dari zat patogen seperti bakteri dan virus. Kunyit putih memiliki zat kurkumin yang mengandung diferuloylmethan dimana dapat berkhasiat sebagai antioksidan. Tujuan : Penelitian ini bertujuan untuk mengetahui efektifitas kunyit putih dalam menurunkan IL-6 pada tikus putih. Metode : Penelitian ini merupakan penelitian eksperimental mengunakan design post-only control. Penelitian ini dibagi atas VI kelompok dimana masing-masing kelompok diberikan perlakuan berbeda. Kelompok I : diberikan aquades, kelompok II : NaCMC 1%,  kelompok III-VI secara berurutan diberi ekstrak kunyit putih sebanyak 2000 mg; 750 mg; 500 mg; 250 mg yang diberikan per-oral. Setelah itu dilakukan pengukuran IL–6 mengunakan ELISA kit. Hasil : Berdasarkan analisis menggunakan uji Kruskal-Wallis didapatkan rerata kadar IL–6 pada masing-masing kelompok I-VI adalah 362,041 pg/ml; 405,609 pg/ml; 397,908 pg/ml; 355,071 pg/ml; 441,025 pg/ml;  443,593 pg/ml. Berdasarkan uji Mann-Whitney, terdapat perbedaan signifikan pada kelompok I dengan kelompok V dan kelompok VI. Didapatkan pemberian ekstrak kunyit putih dengan dosis 750 mg memiliki efektifitas terbaik dalam menurunkan kadar IL - 6 Kesimpulan : Pemberian ekstrak kunyit putih dengan dosis 750 mg memiliki efektifitas terbaik dalam menurunkan kadar IL – 6.
GAMBARAN KARAKTERISTIK PASIEN LIMFADENOPATIDI RUMAH SAKIT UMUM MADANI MEDAN TAHUN 2018-2019 Dicky Chandra Tafonao; Hermon Fanotona Marunduri; Evelyn Angie; Juliana Lina; Arie Siah Putra Siahaan
PRIMER (Prima Medical Journal) Vol. 8 No. 1 (2023): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v8i1.3200

Abstract

Lymphadenopathy's a disease in the form of inflammation of lymph glands caused by bacterial, viral, protozoan, rickettsia, or fungal infections. The purpose is to describe characteristics of lymphadenitis based on age, sex, gland location, and cytological diagnosis with lymphadenitis at Madani General Hospital Medan in 2018-2019. This research uses the retrospective descriptive method with a cross-sectional approach. Data were collected from medical records and then analyzed descriptively using the SPSS application. The results showed that there were 93 patients with lymphadenopathy. Patients with lymphadenopathy, mostly in adulthood, were 57 people (61.3%). Most patients with lymphadenopathy were female, 63 people (66.7%). The most common location was on the patient's right neck in 44 people (47.3%). The most common type was lymphadenitis in 53 cases (57%). Based on the relation between age characteristics and cytological diagnosis, most patients were adult patients diagnosed with lymphadenitis were 31 people. Based on the relation between sex characteristics and cytological diagnosis, the majority of patients were female with lymphadenitis, 53 people. Based on the relation between the characteristics of the location of lymph nodes and cytological diagnosis, the most common location of inflammation in the right neck of patients with lymphadenitis were 28 people.
Co-Authors Adhayani Lubis Dicky Chandra Tafonao Erny Tandanu Evelyn Angie Fiska Maya Wardhani Hermon Fanotona Marunduri Juliana Lina Richardo Chandra