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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya PRIMER (Prima Medical Journal) Jurnal Ilmiah Ilmu Terapan Universitas Jambi
Adhayani Lubis
Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Public Health

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Kadar Serum Interleukin-6 Tikus Wistar Jantan Pada Uji Toksisitas Akut Ekstrak Kunyit Putih Richardo Chandra; Adhayani Lubis; Arie Siah Putra Siahaan; Erny Tandanu; Fiska Maya Wardhani
PRIMER (Prima Medical Journal) Vol. 7 No. 2 (2022): Edisi Oktober
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v7i2.3163

Abstract

Latar belakang : Interleukin 6 ( IL–6 ) merupakan salah satu zat sitokin yang dikeluarkan bila terjadi respon inflamasi, hal ini sering disebabkan oleh adanya infeksi dari zat patogen seperti bakteri dan virus. Kunyit putih memiliki zat kurkumin yang mengandung diferuloylmethan dimana dapat berkhasiat sebagai antioksidan. Tujuan : Penelitian ini bertujuan untuk mengetahui efektifitas kunyit putih dalam menurunkan IL-6 pada tikus putih. Metode : Penelitian ini merupakan penelitian eksperimental mengunakan design post-only control. Penelitian ini dibagi atas VI kelompok dimana masing-masing kelompok diberikan perlakuan berbeda. Kelompok I : diberikan aquades, kelompok II : NaCMC 1%,  kelompok III-VI secara berurutan diberi ekstrak kunyit putih sebanyak 2000 mg; 750 mg; 500 mg; 250 mg yang diberikan per-oral. Setelah itu dilakukan pengukuran IL–6 mengunakan ELISA kit. Hasil : Berdasarkan analisis menggunakan uji Kruskal-Wallis didapatkan rerata kadar IL–6 pada masing-masing kelompok I-VI adalah 362,041 pg/ml; 405,609 pg/ml; 397,908 pg/ml; 355,071 pg/ml; 441,025 pg/ml;  443,593 pg/ml. Berdasarkan uji Mann-Whitney, terdapat perbedaan signifikan pada kelompok I dengan kelompok V dan kelompok VI. Didapatkan pemberian ekstrak kunyit putih dengan dosis 750 mg memiliki efektifitas terbaik dalam menurunkan kadar IL - 6 Kesimpulan : Pemberian ekstrak kunyit putih dengan dosis 750 mg memiliki efektifitas terbaik dalam menurunkan kadar IL – 6.
UJI TOKSISITAS AKUT EKSTRAK KUNYIT PUTIH TERHADAP KADAR GULA DARAH DAN KOLESTEROL Fiska Maya Wardhani; Gabriella Fransisca Ong; Livia Virgoh; Adhayani Lubis; Marah Halim Nasution
JURNAL KEDOKTERAN DAN KESEHATAN Vol 9, No 3 (2022)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V9I3.19028

Abstract

Kunyit putih memiliki kandungan zat utama kurkumin yang  mengandung diferuloylmethan sebagai antioksidan alami. Kurkumin memiliki manfaat sebagai antiinflamasi, antikanker, antifungal, antidiabetes dan antikolesterol. Kunyit putih banyak dibudidayakan di daerah Jawa, khususnya di Jawa Barat, Jawa Timur, terutama di hutan jati Jawa Tengah karena  obat tradisional dipercaya warga setempat mempunyai efek samping yang ringan daripada  obat modern, tetapi belum banyak penelitian mengenai toksisitas dan dosis aman dari kunyit putih. Tujuan penelitian ini untuk mengetahui dosis toksisitas akut  ekstrak kunyit putih (Curcuma zedoaria) terhadap kadar gula darah dan kolesterol. Penelitian eksperimental ini melibatkan 6 kelompok tikus dengan perlakuan yang berbeda, 2 kelompok kontrol yaitu : kelompok normal dan kelompok NaCMC 1%, dan 4 kelompok perlakuan dengan dosis 250 mg/KgBB, 500 mg/KgBB, 750 mg/KgBB, dan 2000 mg/KgBB. Kadar gula darah dan kolesterol diukur dengan spektrofotometri, setelah tikus diberi perlakuan selama 14 hari. Berdasarkan hasil uji yang telah dilakukan, dosis paling efektif untuk menurunkan kadar gula darah adalah 500mg/kgBB. Berdasarkan uji One Way Anova terdapat perbedaan KGD yang signifikan antara Kelompok Normal dan Na CMC 1% dengan EKP250, EKP500, EKP750, dan EKP2000 serta tidak terdapat perbedaan kolestrol yang signifikan antara Kelompok Normal dan Na CMC 1% dengan EKP250, EKP500, EKP750, dan EKP2000. 
LAPORAN KASUS SKIZOFRENIA PARANOID Adhayani Lubis
PRIMER (Prima Medical Journal) Vol. 8 No. 1 (2023): Edisi April
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/pmj.v8i1.3798

Abstract

Schizophrenia is a clinical syndrome of various psychopathologies involving cognition, emotion, perception, and other aspects of behavior. Schizophrenia is defined and diagnosed as a psychiatric disorder solely based on its clinical phenomenology. In this case, a 37-year-old man came with the main complaint of hearing disturbing whispers in his ear and believing that his family always talked about him. The patient is also suspicious of his parents and siblings, irritable, often alone, and unable to sleep. The patient also had auditory hallucinations, visions, and prominent delusions. The therapy given to patients was risperidone 2 x 1 mg orally / day and education for patients and their families. The patient's condition improved by showing a cooperative attitude that felt much calmer, and the patient never suspected his family and siblings again. Auditory hallucinations that appear can be controlled.
ADDRESSING HYPERTENSION IS CRUCIAL TO MITIGATING COGNITIVE DECLINE AND IMPROVING PATIENTS' QUALITY OF LIFE Dewi Pangestuti; Adhayani Lubis; Adi Raja Brando Lubis; Amirul Mukminin; Ira Aini Dania; Donalry Agus Saputra; Stenly Hely Sajow
Jurnal Ilmiah Ilmu Terapan Universitas Jambi Vol. 9 No. 1 (2025): Volume 9, Nomor 1, March 2025
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jiituj.v9i1.34442

Abstract

Hypertension, a condition characterized by persistent elevated blood pressure, often places individuals at risk of developing complications that can adversely impact their quality of life. One notable complication associated with hypertension is cognitive dysfunction. A study published in the Journal of Alzheimer's Disease (2020) demonstrated that individuals with long-standing hypertension exhibited an elevated risk of developing cognitive impairment and Alzheimer's disease. Preliminary research suggests that approximately 12.5 percent of hypertensive deaths may be attributable to underlying factors. Aims: This study aims to examine the cognitive deficits in patients with hypertension and summarise research on the relationship between hypertension and cognitive impairment. This analytical research study with a cross-sectional design, total sample of 84 individuals who suffer from hypertension, the ages of 60 and 79 years old. The sample selected using purposive sampling, instruments used in this study were medical record and Mini Mental State Examination (MMSE) questionnaire. The data was analyzed univariate and bivariate with the Chi Square statistical test. The MMSE cognitive function test revealed that out of 84 individuals with hypertension, 67.85% had normal cognitive function, while 32.14%) moderate cognitive impairment. The sample for the research consisted of 40 male individuals (47.61%) and 44 female individuals (52.38%). Hypertension can affect a person's cognitive function which has an impact on quality of life.
Co-Authors Adi Raja Brando Lubis Amirul Mukminin Arie Siah Putra Siahaan Dewi Pangestuti Donalry Agus Saputra Erny Tandanu Fiska Maya Wardhani Gabriella Fransisca Ong Ira Aini Dania Livia Virgoh Marah Halim Nasution Richardo Chandra Stenly Hely Sajow