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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Jurnal Kebidanan JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Indonesia Cendekia Journal of Pharmacy Tropical Health and Medical Research Journal Jurnal Farmasi Sains dan Praktis Jurnal Farmasi Kryonaut Poltekita: Jurnal Ilmu Kesehatan
Vitarani Dwi Ananda Ningrum
Jurusan Farmasi Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol 15, No 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Drug Utilization Study of Vancomycin in a Tertiary Hospital Ningrum, Vitarani Dwi Ananda; Ambariyah, Nurul; Fortuna, Camelia Dewi; Yulianto, Yulianto
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 1 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i1.2026

Abstract

Vancomycin possesses not only a narrow therapeutic range but also nephrotoxic effects, thus requiring intensive monitoring. This study aims to analyze the vancomycin use among the inpatients of a referral in Indonesia. This retrospective cross-sectional research collected a two-year data from medical records. The research involved all the patients who met the inclusion criteria. The majority of the 90 patients receiving vancomycin were men with the most age range of 18-60 years. The dominant indication of vancomycin use was sepsis typically caused by methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus haemolyticus. Meanwhile, the vancomycin dosing for the 1-<18 age range was mostly based on actual body weight, whereas that for other age categories took into account renal function. The effectiveness of vancomycin based on White Blood Cells and neutrophils was shown in 34.88% of patients examined for both parameters. In addition, 6.25% of the patients given a platelet count experienced suspected vancomycin-induced thrombocytopenia. No incidence of vancomycin-induced neutropenia and nephrotoxicity was found. Given that the risk of nephrotoxicity and the effectiveness of vancomycin are influenced by the steady-state concentrations and the area under the curve, this study recommends hospitals in Indonesia to provide Therapeutic Drug Monitoring (TDM) services.
Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol. 15 No. 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P>0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Medication Adherence in Patients with Chronic Disease at Primary Health Center in Yogyakarta Salma Fajar Puspita; Indah Erlinda; Dwi Tamara Imelda; Muslimatul Khotimah; Vitarani Dwi Ananda Ningrum
JURNAL KEBIDANAN Vol. 15 No. 2 (2025): October 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i2.13465

Abstract

Adhering to medication in chronic diseases like hypertension and diabetes mellitus can prevent complications and reduce hospitalizations. Primary Health Center (PHC), leads in managing patients with chronic diseases who are expected to comply with medication. This study aims to analyze the medication adherence level among patients with chronic diseases and its influencing factors. The research employed a cross-sectional design with a purposive sampling technique at a PHC in Bantul Regency, Yogyakarta. Data on the demographic and clinical characteristics of patients were collected from medical records. Meanwhile, the assessment of medication adherence used pill-count method and MMAS-8. Patients were categorized as adhering to the medication if the MMAS-8 score was 8 and ≥80% for the pill-count method. A total of 210 patients with the therapeutic dosage drug regimen for controlling chronic disease were included. The adherence rate among patients measured with MMAS-8 was primarily classified as low (72.86%). However, the pill-count method showed a compliance rate of over 90%. Based on MMAS-8, disease duration (0.022), caretaker (0.000), comorbidities (0.015), and number of medications (0.049) affected the adherence level in the elderly. However, only a gender was found in adults (0.032). Over half of chronically ill patients in PHC were found to have low adherence rates when assessed using MMAS-8. The contradictory medication adherence levels between the two tools require further studies to confirm the best approach in measuring adherence in the community setting. An effective, interactive, and collaborative approach by healthcare providers is needed to improve medication adherence.
KONTROL GLIKEMIK PASIEN PROGRAM RUJUK BALIK DIABETES MELITUS TIPE 2 DI WILAYAH KOTAGEDE DAN UMBULHARJO YOGYAKARTA Ardhiani, Menit; Ningrum, Vitarani Dwi Ananda
Cendekia Journal of Pharmacy Vol 9, No 3 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i3.344

Abstract

Diabetes melitus (DM) semakin menjadi ancaman bagi kesehatan di dunia karena menjadi salah satu penyebab utama kematian di seluruh dunia. Pemerintah melalui Badan Penyelenggara Jaminan Sosial Kesehatan mengadakan program rujuk balik untuk pasien diabetes melitus yang dinyatakan kondisinya stabil oleh dokter spesialis untuk selanjutnya dikelola di fasilitas kesehatan tingkat pertama. Penelitian ini bertujuan untuk menganalisis kontrol glikemik dan faktor-faktor yang memengaruhinya pada pasien program rujuk balik DM tipe 2 di wilayah kecamatan Kotagede dan Umbulharjo Yogyakarta. Studi ini menggunakan rancangan potong-lintang secara retrospektif berdasarkan data sekunder berupa catatan pengobatan pasien program rujuk balik DM tipe 2 yang dimiliki Apotek Ramadhan. Data dianalisis   menggunakan uji Chi-Square dan regresi logistik. Hasil uji  dinyatakan signifikan bila nilai p?0,05 dan nilai Prevalence Ratio (PR) untuk menginterpretasi derajat hubungan antar variabel. Penelitian ini melibatkan sebanyak 250 pasien dengan mayoritas berusia lanjut (65,6%), berjenis kelamin perempuan (53,6%), kategori IMT normal (50,4%), dan berpendidikan rendah (55,7%). Selain itu, sebagian besar pasien telah didiagnosis DM lebih dari lima tahun (56,9%), dengan jenis terapi insulin (44,0%), dan memiliki komorbid sebesar 68,4%. Sebanyak 56,4% pasien menunjukkan glukosa darah puasa yang tidak terkontrol. Faktor-faktor yang berkorelasi dengan pengendalian glikemik adalah jenis kelamin     (p 0,022, PR 1,314, 95% CI 1,046-1,651) dan jenis terapi obat  (p 0,001, PR 1,876, 95% CI  1,497-2,350). Penelitian ini menyimpulkan lebih dari 50% pasien memiliki kontrol glikemik yang belum mencapai target terapi. Studi ini merekomendasikan adanya penelitian lanjutan untuk menganalisis faktor-faktor yang memengaruhi kurang optimalnya terapi DM tipe 2  dalam mengontrol gula darah dan mencegah penyakit komplikasi di komunitas.
COMPARISON OF ACTUAL COSTS AND INA-CBGS TARIFFS UNDER THE JKN SYSTEM: FACTORS INFLUENCING HOSPITAL TARIFFS Yusran, Yusran; Ningrum, Vitarani Dwi Ananda; Sari, Seftika
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12705

Abstract

The Social Security Administration (BPJS), as the organizer of the National Health Insurance (JKN) program, applies the INA-CBGs tariff system. In the INA-CBGs system, payments are based on grouping patient cases into specific categories according to diagnoses and medical procedures performed. The hospital payment system has shifted from a fee-for-service model to a prospective payment system. BPJS no longer considers the actual costs incurred by hospitals but instead focuses on the standardized INA-CBGs tariffs. This study aims to examine previous research comparing real hospital costs with INA-CBGs tariffs, and to identify the factors that contribute to discrepancies between the two. A narrative literature review was conducted by searching for articles in the PubMed and Google Scholar databases. Data extraction was performed using predefined inclusion and exclusion criteria, and the article selection process followed the PRISMA method. From the selected articles, seven studies related to the comparison of real hospital costs and INA-CBGs tariffs and the factors influencing these discrepancies were identified. The review found that factors influencing real costs include the length of hospital stay, treatment class level, patient severity, and the presence of comorbidities.
Factors affecting glycemic control and kidney function in type 2 diabetes mellitus patients in Yogyakarta Ardhiani, Menit; Febrianti, Yosi; Ningrum, Vitarani Dwi Ananda; Wijaya, Diani Puspa
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art7

Abstract

Background: Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disease whose prevalence continues to increase and can cause various complications, one of which is diabetic nephropathy, which can lead to kidney failure. Objective: To evaluate the association of sociodemographic and clinical factors of diabetic type 2 patients with HbA1c and eGFR.Methods: A cross-sectional study was conducted among 170 diabetic patients at community pharmacies in Yogyakarta from January 2022 to January 2023. Data were collected from patients' medication records, laboratory results of HbA1c, creatinine, eGFR, and structured questionnaires. A Chi-square test was performed to analyze group differences in categorical variables.Results: Duration of diabetes mellitus (p = 0.021), comorbid hypertension (p = 0.040), and diabetes medication therapy (p < 0.001) were associated with good HbA1c control. Serum creatinine levels were significantly associated with age (p < 0.001). Age (p < 0.001), BMI (p = 0.039), education (p = 0.022), duration of diabetes (p = 0.044), and hypertension comorbidity (p = 0.040) were the factors that affected eGFR. However, no significant correlation was found between HbA1c and serum creatinine (r = 0.114; p = 0.134) or between HbA1c and eGFR (r = 0.026; p = 0.739).Conclusion: There is no significant correlation between glycemic control (HbA1c) and renal function markers (serum creatinine and eGFR) in type 2 diabetic patients.
EVALUASI TERAPI OBAT PADA SINDROM KORONER AKUT : SCOPING REVIEW Naintina, Ni Luh Yuni; Ningrum, Vitarani Dwi Ananda; Panduwiguna, Ivans
Jurnal Farmasi Kryonaut Vol 4 No 2 (2025): JFK
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59969/jfk.v4i2.146

Abstract

Latar Belakang: Sindrom Koroner Akut (SKA) merupakan penyebab utama kematian global, dengan terapi farmakologis sebagai bagian penting dalam manajemen klinis. Namun, efektivitas terapi obat, interaksi obat, dan parameter hematologi esensial yang relevan masih perlu dievaluasi secara sistematis. Tujuan: Scoping review ini bertujuan untuk mengkaji efektivitas terapi obat pada pengelolaan SKA, termasuk parameter hematologi pasien untuk keberlangsungan terapi yang akan diberikan. Metode: Scoping review dilakukan dengan pencarian literatur dari PubMed, Science Direct, dan Google Scholar menggunakan kata kunci terkait terapi obat dan parameter hematologi pada SKA. Artikel yang dipilih memenuhi kriteria inklusi dengan terapi farmakologis beserta hasil outcome klinis yaitu parameter hematologi pada penyakit Sindrom Koroner Akut yang mencakup STEMI, N-STEMI dan Agina Pektoris Tidak Stabil, artikel teks lengkap, rentang waktu 2020–2024, artikel review dan studi kasus dikecualikan. Hasil: Dari 3.697 artikel yang ditemukan, terdapat 10 artikel yang relevan sesuai dengan kriteria inklusi Hasil menunjukkan bahwa terapi obat pada Sindrom Koroner Akut yang mencakup APTS, NSTEMI dan STEMI ditemukan pada golongan antiplatelet, antikoagulan, β1-blockers, dan kombinasi risiko beserta parameter hematologi yang meliputi troponin, NLR, MLR, kadar hs-cTnI, leukosit, neutrofil, eosinofil, rasio leukosif dan PRA Kesimpulan: Evaluasi terapi farmakologis yang menyeluruh pada pasien dengan Sindrom Koroner Akut (SKA), terutama dalam hal interaksi obat dan pemilihan kombinasi terapi yang optimal dapat memberikan manfaat klinis yang lebih baik, sementara pemantauan biomarker hematologis seperti troponin, NLR, MLR, hs-cTnI , leukosit, neutrofil, eosinofil, rasio leukosif dan PRA menjadi alat prognostik penting untuk stratifikasi risiko. Kata Kunci: sindrome koroner akut, terapi obat, parameter hematologis
Co-Authors Ahmad Hamim Sadewa Ambariyah, Nurul Ani Khotul Faizah Ardhiani, Menit Arnia Megasari, Christina Wijayanti Dwi Hadi Setya Palupi Dwi Tamara Imelda Endang Sulistyowatiningsih Faizah, Ani Khotul Fortuna, Camelia Dewi Ikhsan, M. Robikhul Indah Erlinda Irwan Nuryana Kurniawan Ishar Maulana, Ishar Jayanto, Imam Laili Fitriyani M. Robikhul Ikhsan Mafruhah, Okti Ratna Mohammad Robikhul Ikhsan Mursidha Rakhmi Salicha Muslimatul Khotimah Naintina, Ni Luh Yuni Panduwiguna, Ivans Salma Fajar Puspita Silviana, Mega Suci Hanifah Sulistyowatiningsih, Endang Wijaya, Diani Puspa Yosi Febrianti, Yosi Yuantari, Rahma Yulianto Yulianto Yunilistiaingsih Yunilistiaingsih Yunilistiaingsih, Yunilistiaingsih Yusran Yusran