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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Jurnal Kebidanan Belitung Nursing Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia Cendekia Journal of Pharmacy Tropical Health and Medical Research Journal Jurnal Farmasi Sains dan Praktis Poltekita: Jurnal Ilmu Kesehatan
Vitarani Dwi Ananda Ningrum
Jurusan Farmasi Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol 15, No 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Drug Utilization Study of Vancomycin in a Tertiary Hospital Ningrum, Vitarani Dwi Ananda; Ambariyah, Nurul; Fortuna, Camelia Dewi; Yulianto, Yulianto
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 1 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i1.2026

Abstract

Vancomycin possesses not only a narrow therapeutic range but also nephrotoxic effects, thus requiring intensive monitoring. This study aims to analyze the vancomycin use among the inpatients of a referral in Indonesia. This retrospective cross-sectional research collected a two-year data from medical records. The research involved all the patients who met the inclusion criteria. The majority of the 90 patients receiving vancomycin were men with the most age range of 18-60 years. The dominant indication of vancomycin use was sepsis typically caused by methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus haemolyticus. Meanwhile, the vancomycin dosing for the 1-<18 age range was mostly based on actual body weight, whereas that for other age categories took into account renal function. The effectiveness of vancomycin based on White Blood Cells and neutrophils was shown in 34.88% of patients examined for both parameters. In addition, 6.25% of the patients given a platelet count experienced suspected vancomycin-induced thrombocytopenia. No incidence of vancomycin-induced neutropenia and nephrotoxicity was found. Given that the risk of nephrotoxicity and the effectiveness of vancomycin are influenced by the steady-state concentrations and the area under the curve, this study recommends hospitals in Indonesia to provide Therapeutic Drug Monitoring (TDM) services.
Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol. 15 No. 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P>0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Medication Adherence in Patients with Chronic Disease at Primary Health Center in Yogyakarta Salma Fajar Puspita; Indah Erlinda; Dwi Tamara Imelda; Muslimatul Khotimah; Vitarani Dwi Ananda Ningrum
JURNAL KEBIDANAN Vol. 15 No. 2 (2025): October 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i2.13465

Abstract

Adhering to medication in chronic diseases like hypertension and diabetes mellitus can prevent complications and reduce hospitalizations. Primary Health Center (PHC), leads in managing patients with chronic diseases who are expected to comply with medication. This study aims to analyze the medication adherence level among patients with chronic diseases and its influencing factors. The research employed a cross-sectional design with a purposive sampling technique at a PHC in Bantul Regency, Yogyakarta. Data on the demographic and clinical characteristics of patients were collected from medical records. Meanwhile, the assessment of medication adherence used pill-count method and MMAS-8. Patients were categorized as adhering to the medication if the MMAS-8 score was 8 and ≥80% for the pill-count method. A total of 210 patients with the therapeutic dosage drug regimen for controlling chronic disease were included. The adherence rate among patients measured with MMAS-8 was primarily classified as low (72.86%). However, the pill-count method showed a compliance rate of over 90%. Based on MMAS-8, disease duration (0.022), caretaker (0.000), comorbidities (0.015), and number of medications (0.049) affected the adherence level in the elderly. However, only a gender was found in adults (0.032). Over half of chronically ill patients in PHC were found to have low adherence rates when assessed using MMAS-8. The contradictory medication adherence levels between the two tools require further studies to confirm the best approach in measuring adherence in the community setting. An effective, interactive, and collaborative approach by healthcare providers is needed to improve medication adherence.
KONTROL GLIKEMIK PASIEN PROGRAM RUJUK BALIK DIABETES MELITUS TIPE 2 DI WILAYAH KOTAGEDE DAN UMBULHARJO YOGYAKARTA Ardhiani, Menit; Ningrum, Vitarani Dwi Ananda
Cendekia Journal of Pharmacy Vol 9, No 3 (2025): Cendekia Journal of Pharmacy
Publisher : Institut Teknologi Kesehatan Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/cjp.v9i3.344

Abstract

Diabetes melitus (DM) semakin menjadi ancaman bagi kesehatan di dunia karena menjadi salah satu penyebab utama kematian di seluruh dunia. Pemerintah melalui Badan Penyelenggara Jaminan Sosial Kesehatan mengadakan program rujuk balik untuk pasien diabetes melitus yang dinyatakan kondisinya stabil oleh dokter spesialis untuk selanjutnya dikelola di fasilitas kesehatan tingkat pertama. Penelitian ini bertujuan untuk menganalisis kontrol glikemik dan faktor-faktor yang memengaruhinya pada pasien program rujuk balik DM tipe 2 di wilayah kecamatan Kotagede dan Umbulharjo Yogyakarta. Studi ini menggunakan rancangan potong-lintang secara retrospektif berdasarkan data sekunder berupa catatan pengobatan pasien program rujuk balik DM tipe 2 yang dimiliki Apotek Ramadhan. Data dianalisis   menggunakan uji Chi-Square dan regresi logistik. Hasil uji  dinyatakan signifikan bila nilai p?0,05 dan nilai Prevalence Ratio (PR) untuk menginterpretasi derajat hubungan antar variabel. Penelitian ini melibatkan sebanyak 250 pasien dengan mayoritas berusia lanjut (65,6%), berjenis kelamin perempuan (53,6%), kategori IMT normal (50,4%), dan berpendidikan rendah (55,7%). Selain itu, sebagian besar pasien telah didiagnosis DM lebih dari lima tahun (56,9%), dengan jenis terapi insulin (44,0%), dan memiliki komorbid sebesar 68,4%. Sebanyak 56,4% pasien menunjukkan glukosa darah puasa yang tidak terkontrol. Faktor-faktor yang berkorelasi dengan pengendalian glikemik adalah jenis kelamin     (p 0,022, PR 1,314, 95% CI 1,046-1,651) dan jenis terapi obat  (p 0,001, PR 1,876, 95% CI  1,497-2,350). Penelitian ini menyimpulkan lebih dari 50% pasien memiliki kontrol glikemik yang belum mencapai target terapi. Studi ini merekomendasikan adanya penelitian lanjutan untuk menganalisis faktor-faktor yang memengaruhi kurang optimalnya terapi DM tipe 2  dalam mengontrol gula darah dan mencegah penyakit komplikasi di komunitas.
COMPARISON OF ACTUAL COSTS AND INA-CBGS TARIFFS UNDER THE JKN SYSTEM: FACTORS INFLUENCING HOSPITAL TARIFFS Yusran, Yusran; Ningrum, Vitarani Dwi Ananda; Sari, Seftika
Jurnal Farmasi Sains dan Praktis Vol 11 No 3 (September-December 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i3.12705

Abstract

The Social Security Administration (BPJS), as the organizer of the National Health Insurance (JKN) program, applies the INA-CBGs tariff system. In the INA-CBGs system, payments are based on grouping patient cases into specific categories according to diagnoses and medical procedures performed. The hospital payment system has shifted from a fee-for-service model to a prospective payment system. BPJS no longer considers the actual costs incurred by hospitals but instead focuses on the standardized INA-CBGs tariffs. This study aims to examine previous research comparing real hospital costs with INA-CBGs tariffs, and to identify the factors that contribute to discrepancies between the two. A narrative literature review was conducted by searching for articles in the PubMed and Google Scholar databases. Data extraction was performed using predefined inclusion and exclusion criteria, and the article selection process followed the PRISMA method. From the selected articles, seven studies related to the comparison of real hospital costs and INA-CBGs tariffs and the factors influencing these discrepancies were identified. The review found that factors influencing real costs include the length of hospital stay, treatment class level, patient severity, and the presence of comorbidities.
Home medication review and drug-related problems in patients with chronic diseases at primary health centers in Yogyakarta, Indonesia: A cross-sectional multicenter study Ningrum, Vitarani Dwi Ananda; Yunilistianingsih; Khotimah, Muslimatul; Shintia, Nirma Atin; Efendi, Septia Rahayu; Dewani, Cindy Pramudyah; Andini, Hana Trisna; Yuantari, Rahma
Belitung Nursing Journal Vol. 12 No. 1 (2026): January - February
Publisher : Belitung Raya Publisher - Belitung Raya Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33546/bnj.4185

Abstract

Background: The high incidence of Drug-Related Problems (DRPs), including medication adherence among patients with chronic diseases, especially during no direct monitoring by health workers, becomes a challenge to therapy success. Home Medication Review (HMR) is an alternative solution in primary healthcare services to avoid further complications. Objective: This study aimed to analyze DRPs, their affecting factors, and DRP interventions for patients with chronic diseases in primary health centers (Puskesmas) through HMR. Methods: A quantitative, cross-sectional observational study using purposive sampling was conducted in several Puskesmas in Yogyakarta from February to May 2023. The collaborative HMR involved healthcare providers at each Puskesmas. DRPs were assessed based on observations and semi-structured interviews. The DRP classification followed PCNE V9.1, and medication adherence was measured using both pill counts and self-report via the MARS-10 questionnaire. Data were analyzed using SPSS 25.0 to perform logistic regression with a 95% confidence level. Results: A total of 544 patients, comprising 269 adults and 275 older patients, were involved. Older patients experienced more DRPs than the adults (94.2% vs 84.8%). The most DRP experienced by both age groups was ineffective therapies, with the two most frequent causes being related to patient factors. Among the adults, hypertension comorbidity, number of medications, and BMI factors were associated with DRPs (p < 0.05). In contrast, no factors correlated with DRPs in the older patients. There was fair agreement between pill count and MARS-10 regarding medication adherence for both adults and older patients (kappa coefficients of 0.298 and 0.355, respectively). Conclusion: Patients in primary health facilities with hypertension and using at least three medications have over a three-fold increased risk of experiencing DRPs. Healthcare providers, including pharmacists, nurses, and physicians, should collaborate to identify medication-related issues and provide personalized advice and management plans to enhance medication adherence. This study highlights the need for a standardized, structured HMR program, not merely as a patient home visit but also to better control chronic diseases.
Tingkat Pengetahuan dan Kepedulian Masyarakat tentang Keamanan Penggunaan Kosmetik: Scoping Review Rahma, Rahma Sakti Oktavia; Vitarani Dwi Ananda Ningrum; Okti Ratna Mafruhah
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 22 No. 02 Desember 2025
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v22i2.27015

Abstract

Kosmetovigilans adalah praktik penting untuk menjamin keamanan penggunaan kosmetik di masyarakat. Di Indonesia, peran ini diemban oleh lembaga seperti BPOM, tetapi efektivitasnya bergantung pada pengetahuan, perspektif, dan sikap masyarakat dalam melaporkan efek samping serta memilih produk yang aman. Scoping review ini bertujuan menganalisis tingkat pengetahuan masyarakat tentang kosmetovigilans dan mengidentifikasi kesenjangan pengetahuan dan faktor-faktor yang memengaruhi kesadaran masyarakat terhadap kosmetovigilans. Scoping review dilakukan dengan pencarian literatur dari PubMed, Science Direct, dan Google Scholar menggunakan kata kunci knowledge of cosmetovigilance, awareness of cosmetic safety, public understanding cosmetovigilance, Factors Influencing Public Awareness of Cosmetovigilance. Artikel yang dipilih adalah studi yang membahas pengetahuan atau kesadaran masyarakat tentang kosmetovigilans, studi dalam bahasa Inggris atau Indonesia, dan studi yang diterbitkan dalam 5 tahun terakhir. Review ini menunjukkan kesenjangan antara kesadaran dan tindakan konsumen terkait keamanan kosmetik di berbagai wilayah. Di India, sebanyak 95,11% responden menyadari efek samping kosmetik, namun hanya 68,43% memahami konsep ‘keamanan kosmetik’. Sementara itu, di Arab Saudi, 74% responden menggunakan tabir surya, tetapi hanya 16% yang melakukannya secara rutin. Selain itu, 16,1% wanita melaporkan efek samping kosmetik. Di Sri Lanka, banyak mahasiswa mengalami jerawat dan alergi akibat kosmetik yang tidak sesuai. Adapun di Portugal, sebanyak 93% konsumen tidak mengetahui kadar THC yang aman pada produk kosmetik berbasis cannabis. Data ini menunjukkan perlunya edukasi dan regulasi yang lebih baik di berbagai wilayah. Meskipun kosmetik bermanfaat, banyak konsumen kurang sadar akan resikonya. Edukasi, regulasi yang ketat, dan sistem pelaporan yang baik dibutuhkan untuk melindungi konsumen. Kolaborasi pemerintah, industri, dan masyarakat menjamin kosmetik berkualitas.
Factors affecting glycemic control and kidney function in type 2 diabetes mellitus patients in Yogyakarta Ardhiani, Menit; Febrianti, Yosi; Ningrum, Vitarani Dwi Ananda; Wijaya, Diani Puspa
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art7

Abstract

Background: Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disease whose prevalence continues to increase and can cause various complications, one of which is diabetic nephropathy, which can lead to kidney failure. Objective: To evaluate the association of sociodemographic and clinical factors of diabetic type 2 patients with HbA1c and eGFR.Methods: A cross-sectional study was conducted among 170 diabetic patients at community pharmacies in Yogyakarta from January 2022 to January 2023. Data were collected from patients' medication records, laboratory results of HbA1c, creatinine, eGFR, and structured questionnaires. A Chi-square test was performed to analyze group differences in categorical variables.Results: Duration of diabetes mellitus (p = 0.021), comorbid hypertension (p = 0.040), and diabetes medication therapy (p < 0.001) were associated with good HbA1c control. Serum creatinine levels were significantly associated with age (p < 0.001). Age (p < 0.001), BMI (p = 0.039), education (p = 0.022), duration of diabetes (p = 0.044), and hypertension comorbidity (p = 0.040) were the factors that affected eGFR. However, no significant correlation was found between HbA1c and serum creatinine (r = 0.114; p = 0.134) or between HbA1c and eGFR (r = 0.026; p = 0.739).Conclusion: There is no significant correlation between glycemic control (HbA1c) and renal function markers (serum creatinine and eGFR) in type 2 diabetic patients.
Use of Favipiravir in Covid-19 Patients: A Narrative Review Ningrum, Vitarani Dwi Ananda; Fitria, Annisa; Hanur, Fadiyah Ulfa
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.73629

Abstract

COVID-19 is an acute respiratory disease resulting from the infection of SARS-COV-2 viruses and causes high morbidity, which requires appropriate treatment targets. Favipiravir is an antiviral that selectively inhibits RNA-dependent RNA polymerase (RdRp) of virus. This review aimed to identify several studies that prove the effectiveness and safety of using Favipiravir for COVID-19 patients. The search method used the electronic media PubMed and ScienceDirect with the keywords "Efficacy", "Favipiravir", "Treatment", "Safety", SARS-COV-2", and "Favipiravir induced", accompanied by the addition of the affixes "AND" and "OR" and selection by the publication date starting December 2019. The literature search resulted in eight (8) published articles that met the exclusion and inclusion criteria. The results of the review showed that concurrent administration of Favipiravir and Lopinavir/Ritonavir or Chloroquine, with a dosage of Favipiravir of 3200 mg/day followed by 1200 mg/day each in 2 divided doses, was considered adequate for improving the clinical symptoms of COVID-19 patients with mild-moderate symptoms in early administration. Meanwhile, administering Favipiravir with anti-IL-6 Tocilizumab for patients with severe symptoms showed a fairly good effect. The most frequently reported ADE (adverse drug events) in the use of Favipiravir were hyperuricemia and elevated alanine aminotransferase (ALT) levels. This review concluded that the best clinical response to Favipiravir is shown in COVID-19 patients with mild-to-moderate early symptoms.
Co-Authors Ahmad Hamim Sadewa Ambariyah, Nurul Andini, Hana Trisna Ani Khotul Faizah Annisa Fitria Ardhiani, Menit Arnia Megasari, Christina Wijayanti Dewani, Cindy Pramudyah Dwi Hadi Setya Palupi Dwi Tamara Imelda Efendi, Septia Rahayu Endang Sulistyowatiningsih Faizah, Ani Khotul Fortuna, Camelia Dewi Hanur, Fadiyah Ulfa Ikhsan, M. Robikhul Indah Erlinda Irwan Nuryana Kurniawan Ishar Maulana, Ishar Jayanto, Imam Khotimah, Muslimatul Laili Fitriyani M. Robikhul Ikhsan Mafruhah, Okti Ratna Mohammad Robikhul Ikhsan Mursidha Rakhmi Salicha Muslimatul Khotimah Okti Ratna Mafruhah Rahma, Rahma Sakti Oktavia Salma Fajar Puspita Shintia, Nirma Atin Silviana, Mega Solly Aryza Suci Hanifah Sulistyowatiningsih, Endang Wijaya, Diani Puspa Yosi Febrianti, Yosi Yuantari, Rahma Yulianto Yulianto Yunilistiaingsih Yunilistiaingsih Yunilistiaingsih, Yunilistiaingsih Yunilistianingsih Yusran Yusran