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All Journal Jurnal Ilmiah Farmasi Jurnal Farmasi Klinik Indonesia JURNAL PHARMASCIENCE Jurnal Kebidanan Pharmascience JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Farmasi Indonesia Tropical Health and Medical Research Journal Poltekita: Jurnal Ilmu Kesehatan
Vitarani Dwi Ananda Ningrum
Jurusan Farmasi Fakultas MIPA, Universitas Islam Indonesia, Yogyakarta
Religion Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengembangan dan Validasi Kuesioner untuk Menilai Miskonsepsi tentang Pengobatan pada Hipertensi dan Diabetes Melitus dengan Kejadian Gagal Ginjal Kurniawan, Irwan Nuryana; Yuantari, Rahma; Sulistyowatiningsih, Endang; Faizah, Ani Khotul; Ningrum, Vitarani Dwi Ananda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 7 No 3 (2020): J Sains Farm Klin 7(3), Desember 2020
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.7.3.202-209.2020

Abstract

Miskonsepsi tentang pengobatan menjadi salah satu faktor tingginya ketidakpatuhan pengobatan. Masyarakat beranggapan bahwa penggunaan obat rutin pada hipertensi dan diabetes mellitus (DM) dapat menyebabkan gagal ginjal. Penelitian ini bertujuan untuk menyediakan kuesioner valid dan reliabel yang dapat digunakan untuk mengukur miskonsepsi masyarakat tentang pengobatan jangka panjang pada hipertensi dan DM dengan kejadian gagal ginjal. Pengembangan kuesioner dilakukan dalam 5 tahap yakni konseptualisasi, konstruksi alat ukur, uji coba melalui studi 1 pada 240 mahasiswa/i medis dan non-medis, dan studi 2 pada 300 masyarakat di wilayah Kabupaten Sleman, tes revisi dan selanjutnya tahap analisis melalui uji reliabilitas alpha cronbach. Sementara itu, uji validitas dilakukan dengan membandingkan kuesioner ini dengan kuesioner terpercaya lainnya. Hasil skala pengetahuan tentang terapi hipertensi dan DM terkait kejadian gagal ginjal pada studi 1 dan studi 2 tersusun atas 4 variabel pengetahuan meliputi: pengetahuan terapi hipertensi dan DMT (α 0.742, α 823), miskonsepsi penggunaan obat rutin (α 0.835, α 0.805), pengetahuan obat penyebab gagal ginjal (α 0.582), (α 0.581), serta pengetahuan faktor risiko gagal ginjal (α  0.721, α 0.698). Hasil analisis ini menunjukkan bukti awal dan menyediakan instumen valid dan relevan untuk mengukur tingkat miskonsepsi masyarakat tentang pengobatan jangka panjang pada hipertensi dan DM terkait dengan gagal ginjal.
Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol 15, No 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Drug Utilization Study of Vancomycin in a Tertiary Hospital Ningrum, Vitarani Dwi Ananda; Ambariyah, Nurul; Fortuna, Camelia Dewi; Yulianto, Yulianto
Poltekita: Jurnal Ilmu Kesehatan Vol. 19 No. 1 (2025)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v19i1.2026

Abstract

Vancomycin possesses not only a narrow therapeutic range but also nephrotoxic effects, thus requiring intensive monitoring. This study aims to analyze the vancomycin use among the inpatients of a referral in Indonesia. This retrospective cross-sectional research collected a two-year data from medical records. The research involved all the patients who met the inclusion criteria. The majority of the 90 patients receiving vancomycin were men with the most age range of 18-60 years. The dominant indication of vancomycin use was sepsis typically caused by methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus haemolyticus. Meanwhile, the vancomycin dosing for the 1-<18 age range was mostly based on actual body weight, whereas that for other age categories took into account renal function. The effectiveness of vancomycin based on White Blood Cells and neutrophils was shown in 34.88% of patients examined for both parameters. In addition, 6.25% of the patients given a platelet count experienced suspected vancomycin-induced thrombocytopenia. No incidence of vancomycin-induced neutropenia and nephrotoxicity was found. Given that the risk of nephrotoxicity and the effectiveness of vancomycin are influenced by the steady-state concentrations and the area under the curve, this study recommends hospitals in Indonesia to provide Therapeutic Drug Monitoring (TDM) services.
Impact of the Appropriateness of Prophylactic Antibiotics toward Surgical Site Infections in Caesarean Sections in Hospital "X" Semarang Wijayanti, Christina; Palupi, Dwi Hadi Setya; Ningrum, Vitarani Dwi Ananda
JURNAL KEBIDANAN Vol. 15 No. 1 (2025): April 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i1.12672

Abstract

Caesarean delivery (caesarean section) continues to increase in Indonesia. Surgical Site Infection (SSI) is a serious issue that can increase morbidity and length of hospital stay. The use of prophylactic antibiotics has been proven to prevent the occurrence of surgical site infections (SSI) in caesarean sections. The hospital has established antibiotic use guidelines as the standard for antibiotic therapy and prophylactic antibiotic use in surgical procedures. This study aimed to see how well the use of antibiotics before caesarean sections matched the hospital's guidelines and how this related to the rate of surgical site infections (SSI). The cross-sectional method determined the relationship between the appropriateness of prophylactic antibiotics and the incidence of SSI. The study used retrospective data from caesarean section patients at Hospital "X" Semarang who received prophylactic antibiotics between January 2023 and June 2024. The research results showed no significant relationship (P>0.05) between the appropriateness of prophylactic antibiotic use and the incidence of SSI. The data showed that preventive antibiotics (ampicillin-sulbactam and cefazoline injection) were mostly used correctly in several areas: the right antibiotic was chosen 87% of the time, the correct dosage was used 83% of the time, the right way of giving the injection was followed 92.7% of the time, and the correct length of time for the injection was also followed 92.7% of the time. Nonetheless, there are some discrepancies, namely in the timing of post-cesarean antibiotic therapy (94%), and preventive antibiotic administration (57.7%). During that time, the SSI rate was 2.67%.
Medication Adherence in Patients with Chronic Disease at Primary Health Center in Yogyakarta Salma Fajar Puspita; Indah Erlinda; Dwi Tamara Imelda; Muslimatul Khotimah; Vitarani Dwi Ananda Ningrum
JURNAL KEBIDANAN Vol. 15 No. 2 (2025): October 2025
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v15i2.13465

Abstract

Adhering to medication in chronic diseases like hypertension and diabetes mellitus can prevent complications and reduce hospitalizations. Primary Health Center (PHC), leads in managing patients with chronic diseases who are expected to comply with medication. This study aims to analyze the medication adherence level among patients with chronic diseases and its influencing factors. The research employed a cross-sectional design with a purposive sampling technique at a PHC in Bantul Regency, Yogyakarta. Data on the demographic and clinical characteristics of patients were collected from medical records. Meanwhile, the assessment of medication adherence used pill-count method and MMAS-8. Patients were categorized as adhering to the medication if the MMAS-8 score was 8 and ≥80% for the pill-count method. A total of 210 patients with the therapeutic dosage drug regimen for controlling chronic disease were included. The adherence rate among patients measured with MMAS-8 was primarily classified as low (72.86%). However, the pill-count method showed a compliance rate of over 90%. Based on MMAS-8, disease duration (0.022), caretaker (0.000), comorbidities (0.015), and number of medications (0.049) affected the adherence level in the elderly. However, only a gender was found in adults (0.032). Over half of chronically ill patients in PHC were found to have low adherence rates when assessed using MMAS-8. The contradictory medication adherence levels between the two tools require further studies to confirm the best approach in measuring adherence in the community setting. An effective, interactive, and collaborative approach by healthcare providers is needed to improve medication adherence.
Co-Authors Ahmad Hamim Sadewa Ambariyah, Nurul Ani Khotul Faizah Arnia Megasari, Christina Wijayanti Dwi Hadi Setya Palupi Dwi Tamara Imelda Endang Sulistyowatiningsih Faizah, Ani Khotul Fortuna, Camelia Dewi Ikhsan, M. Robikhul Indah Erlinda Irwan Nuryana Kurniawan Ishar Maulana, Ishar Jayanto, Imam Laili Fitriyani M. Robikhul Ikhsan Mafruhah, Okti Ratna Mohammad Robikhul Ikhsan Mursidha Rakhmi Salicha Muslimatul Khotimah Salma Fajar Puspita Silviana, Mega Solly Aryza Suci Hanifah Sulistyowatiningsih, Endang Yosi Febrianti, Yosi Yuantari, Rahma Yulianto Yulianto Yunilistiaingsih Yunilistiaingsih Yunilistiaingsih, Yunilistiaingsih