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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Global Health research Proceedings of the International Conference on Nursing and Health Sciences Physical Therapy Journal of Indonesia
Sinu Andhi Jusup, Sinu Andhi
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Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Antidiabetic and Antioxidant Activities of 70% Ethanol-Diluted Extract of Piper Crocatum Leaves in Stretozotocin Induced Diabetic Rats Jusup, Sinu Andhi
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.01.1

Abstract

Red betel plant (Piper crocatum) has been empirically used to cure diabetes mellitus. However, data regarding this plant are still limited. The aim of this study was to find antidiabetic and antioxidant activities of 70% ethanol-diluted extract of Piper crocatum leaves. Thirty Wistar rats aged 4 months were divided into 6 groups (I-VI) randomly. The groups of I-IV were injected with 40 mg i.p streptozotosin to induce DM. All groups were treated for 21 days. Group I (normal control group) and group II (diabetic control group) were given normal saline, while group III, IV, and V were treated with various doses of 70% ethanol-diluted extract of Piper crocatum  leaves (50, 100, 200 mg/kg.b.w/day). Group VI (positive control group) was given glibenclamide 0,9 mg/kg.b.w/day. On day 21, the body weight, fasting blood glucose, plasma MDA, and insulin levels of all rats were examined. The data were processed using statistics to determine the effectiveness of antidiabetic and antioxidant activities of the extract. A significant decrease in fasting blood glucose and plasma MDA levels were observed in group III, IV, and V (p=0,00), when compared to group II (diabetic control group). A significant increase in body weight (p=0,04) and plasma insulin levels (p=0,008) occurred in group V only. In conclusion, seventy percent ethanol-diluted extract of Piper crocatum leaves has potential antidiabetic and antioxidant activities.
A Recent Update: Molecular Mechanism of Kombucha as A Probiotic for Obesity Management Nisa, Zulfia Rosyidatun; Jusup, Sinu Andhi; Yudhani, Ratih Dewi
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.3820

Abstract

The prevalence of obesity has continued to increase in the past decade which has an impact on several metabolic disorders in the body. Various efforts are made to reduce and overcome the effects of obesity such as pharmacological therapy. In addition, using natural ingredients such as probiotics is optimized to minimize the effects caused. The balance of gut microbiota has an important role in helping to improve dysbiosis, inflammation, and fatty liver in obesity. Method: This review used the scoping review necessary to collect and summarize scientific data as well as guide future investigations with the provision that articles are up to the last 10 years (2014) for kombucha as a drink rich in probiotics that could have potential as a natural therapy for obesity management. Results: A total of 244 articles were collected and 11 articles met the inclusion criteria. Conclusion: kombucha has beneficial effects and has the potential to improve obesity conditions from a variety of mechanisms.
Battery of tests for return-to-sport assessment after knee injury in athletes Lesmana, Syahmirza Indra; Sugiyanto; Hidayatullah, M. Furqon; Doewes, Muchsin; Jusup, Sinu Andhi
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.285

Abstract

Background: Knee injury is a common sports injury, and exercise therapy can be guided by functional and biological tests to assess healing and readiness to return to sport. This study aimed to develop a test battery to identify the most predictive functional test in determining the success of an exercise therapy program for sports injury. Methods: A test construction methodology was used, incorporating 8 field test instruments and TGF-β1 as a biological marker. Statistical methods, including multiple correlation and Wherry Doolittle test selection, were applied to develop a functional test model supporting post-injury sports therapy. Results: This study found no significant correlation between TGF-β1 and the single leg stance (p=0.160), single leg calf raise (p=0.902), vertical jump (p=0.344), shuttle run (p=0.794), and hop tests (p=0.555). However, significant correlations were found with the sit and reach test (p<0.001; r=0.471) and hexagonal agility test (p=0.019; r=-0.318). Multivariate linear regression showed that the single leg stance, sit and reach, and hexagonal agility tests were predictors of TGF-β1, with the single leg stance and sit and reach tests explaining 23% of its variance. Conclusion: Test battery arrangement for functional tests that were considered predictive include single leg stance and sit and reach tests, with low correlation values, which two tests in the form of single leg balance and sit and reach tests have a relationship with tissue healing. Additionally, several other tests were designed to determine the ability of athletes to RTS.
Potential of Cocoa Flavanols in Improving Cardiovascular Adaptation and Exercise: A Scoping Review Handana, Arya Dwi; Dewi, Yulia Lanti Retno; Jusup, Sinu Andhi
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6468

Abstract

Cardiovascular fitness, quantified as maximal oxygen consumption (VO₂Max), is a significant indicator of exercise tolerance and cardiovascular health. Sedentary behavior and aging are determinants that contribute to endothelial dysfunction, arterial stiffness, and reduced cardiac output, leading to a decline in VO₂Max. Cocoa Flavanols (CFs), rich in (−)-epicatechin, have been found to enhance endothelial function, nitric oxide bioavailability, and reduce blood pressure and hence might be beneficial for cardiovascular adaptation and VO₂Max improvement. This scoping review explores the potential of CFs to enhance cardiovascular function and exercise tolerance. Method: Two randomized controlled trials were employed in this scoping review. The first trial examined the effect of 30-day CF supplementation (1000 mg/day) on cardiorespiratory fitness in healthy elderly adults. The second trial examined the effect of 7-day CF supplementation (400 mg/day) on pulmonary oxygen uptake kinetics and exercise tolerance in middle-age sedentary adults. Results: In older adults, CF supplementation improved VO₂peak, oxygen pulse, exercise capacity, and endothelial function and lowered blood pressure in middle-aged sedentary adults, CFs improved VO₂ kinetics during moderate-intensity exercise, indicating enhanced oxygen delivery, but not exercise tolerance during severe-intensity exercise. Such results highlight CFs' positive effects on vascular health and efficiency of moderate-intensity exercise. Conclusion: Cocoa flavanols may enhance cardiovascular adaptation and exercise performance by improving endothelial function, reducing arterial stiffness, and optimizing oxygen uptake during exercise. Further studies are required to evaluate their effect on maximal exercise performance and long-term cardiovascular outcomes.
Co-Authors Handana, Arya Dwi M. Furqon Hidayatullah, M. Furqon Muchsin Doewes Nisa, Zulfia Rosyidatun SUGIYANTO Syahmirza Indra Lesmana Yudhani, Ratih Dewi yulia lanti retno dewi