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All Journal Jurnal Kedokteran Brawijaya INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Indonesian Journal of Global Health research Proceedings of the International Conference on Nursing and Health Sciences Smart Society Empowerment Journal Physical Therapy Journal of Indonesia Journal of Midwifery in Community
Sinu Andhi Jusup, Sinu Andhi
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Humanities Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antidiabetic and Antioxidant Activities of 70% Ethanol-Diluted Extract of Piper Crocatum Leaves in Stretozotocin Induced Diabetic Rats Jusup, Sinu Andhi
Jurnal Kedokteran Brawijaya Vol 29, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2016.029.01.1

Abstract

Red betel plant (Piper crocatum) has been empirically used to cure diabetes mellitus. However, data regarding this plant are still limited. The aim of this study was to find antidiabetic and antioxidant activities of 70% ethanol-diluted extract of Piper crocatum leaves. Thirty Wistar rats aged 4 months were divided into 6 groups (I-VI) randomly. The groups of I-IV were injected with 40 mg i.p streptozotosin to induce DM. All groups were treated for 21 days. Group I (normal control group) and group II (diabetic control group) were given normal saline, while group III, IV, and V were treated with various doses of 70% ethanol-diluted extract of Piper crocatum  leaves (50, 100, 200 mg/kg.b.w/day). Group VI (positive control group) was given glibenclamide 0,9 mg/kg.b.w/day. On day 21, the body weight, fasting blood glucose, plasma MDA, and insulin levels of all rats were examined. The data were processed using statistics to determine the effectiveness of antidiabetic and antioxidant activities of the extract. A significant decrease in fasting blood glucose and plasma MDA levels were observed in group III, IV, and V (p=0,00), when compared to group II (diabetic control group). A significant increase in body weight (p=0,04) and plasma insulin levels (p=0,008) occurred in group V only. In conclusion, seventy percent ethanol-diluted extract of Piper crocatum leaves has potential antidiabetic and antioxidant activities.
A Recent Update: Molecular Mechanism of Kombucha as A Probiotic for Obesity Management Nisa, Zulfia Rosyidatun; Jusup, Sinu Andhi; Yudhani, Ratih Dewi
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.3820

Abstract

The prevalence of obesity has continued to increase in the past decade which has an impact on several metabolic disorders in the body. Various efforts are made to reduce and overcome the effects of obesity such as pharmacological therapy. In addition, using natural ingredients such as probiotics is optimized to minimize the effects caused. The balance of gut microbiota has an important role in helping to improve dysbiosis, inflammation, and fatty liver in obesity. Method: This review used the scoping review necessary to collect and summarize scientific data as well as guide future investigations with the provision that articles are up to the last 10 years (2014) for kombucha as a drink rich in probiotics that could have potential as a natural therapy for obesity management. Results: A total of 244 articles were collected and 11 articles met the inclusion criteria. Conclusion: kombucha has beneficial effects and has the potential to improve obesity conditions from a variety of mechanisms.
Battery of tests for return-to-sport assessment after knee injury in athletes Lesmana, Syahmirza Indra; Sugiyanto; Hidayatullah, M. Furqon; Doewes, Muchsin; Jusup, Sinu Andhi
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.285

Abstract

Background: Knee injury is a common sports injury, and exercise therapy can be guided by functional and biological tests to assess healing and readiness to return to sport. This study aimed to develop a test battery to identify the most predictive functional test in determining the success of an exercise therapy program for sports injury. Methods: A test construction methodology was used, incorporating 8 field test instruments and TGF-β1 as a biological marker. Statistical methods, including multiple correlation and Wherry Doolittle test selection, were applied to develop a functional test model supporting post-injury sports therapy. Results: This study found no significant correlation between TGF-β1 and the single leg stance (p=0.160), single leg calf raise (p=0.902), vertical jump (p=0.344), shuttle run (p=0.794), and hop tests (p=0.555). However, significant correlations were found with the sit and reach test (p<0.001; r=0.471) and hexagonal agility test (p=0.019; r=-0.318). Multivariate linear regression showed that the single leg stance, sit and reach, and hexagonal agility tests were predictors of TGF-β1, with the single leg stance and sit and reach tests explaining 23% of its variance. Conclusion: Test battery arrangement for functional tests that were considered predictive include single leg stance and sit and reach tests, with low correlation values, which two tests in the form of single leg balance and sit and reach tests have a relationship with tissue healing. Additionally, several other tests were designed to determine the ability of athletes to RTS.
Potential of Cocoa Flavanols in Improving Cardiovascular Adaptation and Exercise: A Scoping Review Handana, Arya Dwi; Dewi, Yulia Lanti Retno; Jusup, Sinu Andhi
Indonesian Journal of Global Health Research Vol 7 No 4 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i4.6468

Abstract

Cardiovascular fitness, quantified as maximal oxygen consumption (VO₂Max), is a significant indicator of exercise tolerance and cardiovascular health. Sedentary behavior and aging are determinants that contribute to endothelial dysfunction, arterial stiffness, and reduced cardiac output, leading to a decline in VO₂Max. Cocoa Flavanols (CFs), rich in (−)-epicatechin, have been found to enhance endothelial function, nitric oxide bioavailability, and reduce blood pressure and hence might be beneficial for cardiovascular adaptation and VO₂Max improvement. This scoping review explores the potential of CFs to enhance cardiovascular function and exercise tolerance. Method: Two randomized controlled trials were employed in this scoping review. The first trial examined the effect of 30-day CF supplementation (1000 mg/day) on cardiorespiratory fitness in healthy elderly adults. The second trial examined the effect of 7-day CF supplementation (400 mg/day) on pulmonary oxygen uptake kinetics and exercise tolerance in middle-age sedentary adults. Results: In older adults, CF supplementation improved VO₂peak, oxygen pulse, exercise capacity, and endothelial function and lowered blood pressure in middle-aged sedentary adults, CFs improved VO₂ kinetics during moderate-intensity exercise, indicating enhanced oxygen delivery, but not exercise tolerance during severe-intensity exercise. Such results highlight CFs' positive effects on vascular health and efficiency of moderate-intensity exercise. Conclusion: Cocoa flavanols may enhance cardiovascular adaptation and exercise performance by improving endothelial function, reducing arterial stiffness, and optimizing oxygen uptake during exercise. Further studies are required to evaluate their effect on maximal exercise performance and long-term cardiovascular outcomes.
The baseline levels of receptors and cytokines in phorbol 12-myristate 13-acetate-induced THP-1 monocyte to macrophage cells Wulandari, Sri; Agusti Sholikah, Tri; Jusup, Sinu Andhi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7917

Abstract

Monocyte-derived macrophages regulate various aspects of inflammation. Phorbol 12-myristate 13-acetate (PMA)-induced THP-1 monocytes are widely used as monocyte-derived macrophage models suitable for studying the pathophysiology of inflammation and developing therapies. However, there is insufficient data concerning the baseline expression of pro-inflammatory receptors and the associated cytokine levels in THP-1-derived macrophage-like cells compared with their monocyte precursors. In this study, PMA-treated THP-1 cells were employed as models for monocyte-derived macrophage-like cells (M0). The mRNA levels of Toll-like receptors (TLR)4, receptor for advanced glycation end-product (RAGE), and TLR7 in THP-1 cells, both with and without PMA treatment, were evaluated using quantitative real-time polymerase chain reaction (RT-qPCR). ELISA was performed to quantify IL-6, TNF-α, and IL-18 levels in the THP-1 culture supernatant. The mRNA expression of TLR4, RAGE, and TLR7 was increased twofold in PMA-induced THP-1-derived macrophage-like cells compared to monocytes. IL-6 (p = 0.0277) and TNF-α (p = 0.0105) levels were significantly elevated in the culture supernatants of THP-1-derived macrophages. However, IL-18 levels did not show a significant increase. The upregulation of TLR4, RAGE, and TLR7 transcription was accompanied by elevated secretion of IL-6 and TNF-α during PMA-induced differentiation of THP-1-derived macrophage-like cells (M0), highlighting the polarization state and the specific role of macrophages in producing pro-inflammatory cytokines. This study provides baseline data on pro-inflammatory receptor expression and cytokine production in the THP-1-derived macrophage-like cells model for inflammatory research.
Edukasi Pencegahan dan Deteksi Dini Penyakit Kardiovaskular di Masa Pandemi COVID-19 Kusumawati, Ratna; Sulastomo, Heru; Indarto, Dono; Jusup, Sinu Andhi; Rahardjo, Setyo Sri; Purwaningtyas, Niniek; Susilawati, Tri Nugraha; Suselo, Yuliana Heri; Wulandari, Sri
Smart Society Empowerment Journal Vol 3, No 1 (2023): Maret
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i1.70327

Abstract

Pendahuluan: Jumlah kasus penyakit kardiovaskular (PKV) di dunia menunjukkan kecenderungan meningkat termasuk di Indonesia. Kabupaten Sukoharjo di Jawa Tengah melaporkan adanya peningkatan penyakit hipertensi dan diabetes mellitus (DM) yang menjadi faktor risiko penting PKV. Penyakit hipertensi dan DM merupakan penyakit penyerta utama pada kasus coronavirus disease 2019 (COVID-19) sehingga dapat memperburuk gejala dan menyebabkan kematian. Tujuan dari kegiatan pengabdian ini adalah memberikan edukasi tentang pencegahan dan deteksi dini PKV di wilayah Kecamatan Kartasura, Sukoharjo, Jawa Tengah di masa pandemi COVID-19.Metode: Kegiatan pengabdian dilaksanakan di RT 03 RW 02 desa Gowongan, Pucangan, Kartasura, Sukoharjo, Jawa Tengah. Metode pengabdian yang dilakukan berupa pelatihan pengukuran denyut nadi latihan, talk show  mengenai pencegahan dan deteksi dini PKV serta pemeriksaan kesehatan berupa pemeriksaan tekanan darah dan kadar gula darah.Hasil dan pembahasan: Hasil kegiatan pengabdian ini peserta mendapatkan informasi yang valid mengenai pencegahan dan deteksi dini PKV. Selain itu, kegiatan ini menstimulasi keperdulian peserta untuk melakukan upaya pencegahan dan deteksi dini melalui pemeriksaan tekanan darah dan kadar gula darah. Hasil lain yang didapatkan adalah peserta dapat melakukan pengukuran denyut nadi latihan secara mandiri untuk mengoptimalkan olahraga yang dilakukan.Kesimpulan: Edukasi pencegahan dan deteksi dini PKV kepada masyarakat talkshow, pelatihan dan layanan kesehatan telah terlaksana dengan baik. Kegiatan ini dapat memberikan informasi valid kepada masyarakat dan memacu keperdulian masyarakat untuk melakukan upaya pencegahan dan deteksi dini PKV.
Edukasi dan Pemeriksaan Kesehatan Anggota Klub Jantung Sehat Rahardjo, Setyo Sri; Jusup, Sinu Andhi; Indarto, Dono; Wulandari, Sri; Suselo, Yuliana Heri; Kusumawati, Ratna; Sulastomo, Heru; Purwaningtyas, Niniek; Susilawati, Tri Nugraha
Journal of Midwifery in Community Vol 1, No 2 (2023): Oktober
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jmc.v1i2.79502

Abstract

Data Riset Kesehatan Dasar (Riskesdas) di Indonesia secara nasional memperlihatkan bahwa penyakit tidak menular (PTM) terutama penyakit kardiovaskular (PKV) cenderung mengalami peningkatan. Hal tersebut terjadi juga di wilayah kota Surakarta. Tim Pengabdi berinisiatif melaksanakan kegiatan edukasi dan pemeriksaan kesehatan yang bertujuan untuk meningkatkan pengetahuan anggota Klub Jantung Sehat (KJS) terkait PKV sekaligus untuk skrining faktor risiko PKV yang meliputi hipertensi, hiperkolesterol, diabetes mellitus (DM), dan obesitas. Metode yang digunakan berupa penyuluhan dan pemeriksaan tekanan darah, gula darah sewaktu, kolesterol dan antropometri. Kegiatan pengabdian masyarakat ini diikuti oleh 85 anggota KJS dan diselenggarakan pada hari Minggu, 18 Juni 2023 jam 07.00 - 09.00 di Fakultas Keolahragaan Universitas Sebelas Maret (FKOR UNS) Jl. Menteri Supeno, Manahan, Banjarsari Kota Surakarta Jawa Tengah. Dari kegiatan pengabdian masyarakat ini pemahaman para anggota KJS terkait PKV melalui diskusi dan tanya jawab selama penyuluhan dan konseling selama pemeriksaan kesehatan mengalami peningkatan. Kegiatan sejenis perlu dilakukan secara rutin dan berkesinambungan sebagai upaya preventif dan promotif terhadap penyakit tidak menular di masyarakat.
Edukasi dan Deteksi Dini Penyakit Diabetes Melitus Susilawati, Tri Nugraha; Jusup, Sinu Andhi; Rahardjo, Setyo Sri; Indarto, Dono; Wulandari, Sri; Suselo, Yuliana Heri; Kusumawati, Ratna; Sulastomo, Heru; Purwaningtyas, Niniek
Journal of Midwifery in Community Vol 2, No 2 (2024): Oktober
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jmc.v2i1.93242

Abstract

Indonesia currently is experiencing a shift in disease patterns marked by a significant increase in the number of non-communicable diseases (NCDs), especially cardiovascular diseases, specifically diabetes mellitus (DM). A similar phenomenon also occurs in Surakarta city. Community service team conducts educational activities and health checks that aim to increase the knowledge of members of the Klub Jantung Sehat (KJS) related to cardiovascular disease as well as for screening risk factors for cardiovascular diseases including hypertension, hyperuricemia, diabetes mellitus (DM), and obesity. The methods used are counseling and checking blood pressure, uric acid, blood sugar at any time, and anthropometry. This community service activity was attended by 33 KJS members and was held on Sunday, 23 June 2024 at 07.00 - 09.00 at the Faculty of Sports, Sebelas Maret University (FKOR UNS) Jl. Menteri Supeno, Manahan, Banjarsari, Surakarta City, Central Java, however only 19 participants took part in the complete screening. The results achieved from this community service are an increase in the knowledge of KJS members related to cardiovascular diseases through discussions during counseling as well as during health checkups. The results of the health examination, it was found that 6 people (31.58%) had hypertension, 2 people (10.52%) had DM, and 11 people (57.89%) were found to meet the criteria of overweight and obesity. The members of KJS who had uric acid levels above normal were 10 people (52.63%). Similar activities should be carried out regularly and continuously as a preventive and promotive effort against non-communicable diseases in the community.
Co-Authors Agusti Sholikah, Tri Dono Indarto Handana, Arya Dwi Muchsin Doewes Muh. Furqon Hidayatullah Nisa, Zulfia Rosyidatun Purwaningtyas, Niniek Rahardjo, Setyo Sri Ratih Dewi Yudhani Ratna Kusumawati Sri Wulandari SUGIYANTO Sulastomo, Heru Suselo, Yuliana Heri Syahmirza Indra Lesmana Tri Nugraha Susilawati yulia lanti retno dewi