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All Journal The Indonesian Biomedical Journal Proceedings of the International Conference on Nursing and Health Sciences Cermin Dunia Kedokteran Biocaster : Jurnal Kajian Biologi Media Penelitian dan Pengembangan Kesehatan
Yudhani, Ratih Dewi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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Pharmacogenomics and Personalized Medicine in Type 2 Diabetes Yudhani, Ratih Dewi
Cermin Dunia Kedokteran Vol 42, No 6 (2015): Malaria
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.969 KB) | DOI: 10.55175/cdk.v42i6.997

Abstract

Type 2 diabetes has reached epidemic proportions worldwide and poses a considerable concern for public health. Although a variety of pharmacological treatments is available, response, doses and tolerability to drugs are highly variable and monotherapy often failed. A large interindividual variability in drug response has been noticed and contributing factors include age, sex, disease, drug and food interactions, comorbidity, as well as genetic factors. Poor therapeutic outcomes may be caused by variability of individual characteristics.Personalized medicine is an emerging concept for treating diseases, which involves determining specific information of a particular patient and then prescribing specific treatment. Pharmacogenetics holds the promise of bringing personalized medicine to drug dosing decisions, to reduce morbidity and mortality, and to improve life quality for T2DM patients.Diabetes Mellitus tipe 2 telah merupakan epidemi di seluruh dunia dan menjadi perhatian besar di bidang kesehatan. Meskipun berbagai terapi farmakologis telah tersedia, namun respon, dosis dan tolerabilitas penderita sangat bervariasi dan monoterapi sering gagal. Terdapat variabilitas besar terkait respon terapi diantara individu dan beberapa faktor yang berperandiantaranya usia, jenis kelamin, penyakit, interaksi obat dengan makanan, komorbiditas, serta faktor genetik. Variabilitas besar terkait respon terapi obat hipoglikemik sering dijumpai di klinik. Respon terapi tidak optimal mungkin karena pemilihan terapi tanpa memperhatikan karakteristik individual. Personalized medicine merupakan konsep terkini pemberian terapi. Pada konsep ini, pemilihan jenis terapi mempertimbangkan profil genetik maupun karakteristik individual. Farmakogenetik menjadi kunci mewujudkan personalized medicine sehingga diharapkan dapat mengurangi morbiditas dan mortalitas penyakit, serta meningkatkan kualitas hidup penderita Diabetes Mellitus Tipe 2.
Application of Pharmacogenomics on Drug Discovery and Development Yudhani, Ratih Dewi
Cermin Dunia Kedokteran Vol 41, No 3 (2014): Farmakologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (599.574 KB) | DOI: 10.55175/cdk.v41i3.1154

Abstract

Individual variations in the response to drugs and drug toxicity occur commonly in the clinical setting and in drug development research protocols. Cumulative evidence strongly suggests that genetic polymorphisms in drug metabolizing enzymes, transporters, receptors and other drug targets are contributing to inter-individual differences in the efficacy and toxicity of drugs. Pharmacogenomics refers to the application of genome-wide approaches in order to understand genetic influence on drug response and to develop novel drugs. This application of pharmacogenomics has implications in predicting a patient’s response to medications, reducing adverse events and improving rationality of drug development. Pharmacogenomics profoundly change the way clinical drug trials are conducted, as well as influencing drug development process. This review provides an overview of the pharmacogenomics application on drug discovery and development.Variasi respons individual dan toksisitas terhadap obat sering ditemui di klinik dan selama proses penelitian dan pengembangan obat baru. Beberapa bukti jelas mengindikasikan bahwa polimorfisme genetik pada gen-gen yang meregulasi ekspresi enzim yang terkait dengan metabolisme obat, transporter, reseptor dan target obat yang lain, berperan dalam menentukan perbedaan efikasi dan toksisitas suatu obat di antara individu. Farmakogenomik mengacu pada aplikasi genomik untuk memahami pengaruh genetik pada respons obat dan aplikasinya dalam proses penelitian dan pengembangan obat baru. Farmakogenomik dapat diaplikasikan untuk memprediksi respons individu terhadap pengobatan, mengurangi kejadian yang tidak diinginkan terkait dengan pemberian obat dan meningkatkan rasionalitas dalam proses pengembangan obat. Oleh karena itu, farmakogenomik menyebabkan pergeseran paradigma terkait penelitian dalam rangka penemuan obat baru di tahap preklinik dan bagaimana perancangan uji klinis obat. Tinjauan ini memberi gambaran aplikasi farmakogenomik pada proses penelitian dalam rangka penemuan dan pengembangan obat baru.
Farmakogenomik dan Terapi Kanker Yudhani, Ratih Dewi
Cermin Dunia Kedokteran Vol 41, No 6 (2014): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (162.658 KB) | DOI: 10.55175/cdk.v41i6.1127

Abstract

Variabilitas respons terapi dan indeks terapi obat antikanker (kemoterapi) yang sempit sering dijumpai dan masih menjadi tantangan bagi ahli onkologi. Farmakogenomik merupakan studi pewarisan genetik yang berpengaruh pada proses disposisi obat dan juga efeknya yang bertujuan mengoptimalkan pemilihan jenis obat dan penyesuaian dosis pada tiap pasien. Farmakogenomik penting diterapkan di bidang onkologi karena terapi kanker sering ditandai dengan toksisitas sistemik yang berat dan efikasi yang tidak terprediksi sebelumnya. Studi farmakogenomik bertujuan untuk memahami genetik yang mendasari perbedaan respons di antara individu dan memprediksi keamanan, toksisitas dan atau efikasi suatu pengobatan. Tinjauan ini mendiskusikan beberapa contoh penerapan farmakogenomik khususnya terkait polimorfisme genetik yang mempengaruhi hasil dari terapi kanker.The variability in treatment responses and narrow therapeutic index of anticancer drugs (chemotherapy) are consistently observed across patient populations and still pose challenges for oncologist. Pharmacogenomics is the study of inherited differences in interindividual drug disposition and effects, with the goal of selecting the optimal drug therapy and dosage for each patient. Pharmacogenomics is especially important for oncology as severe systemic toxicity and unpredictable efficacy are hallmarks of cancer therapies. Pharmacogenomics studies are aimed at elucidating the genetic basis of interindividual differences and using such genetic information to predict the safety, toxicity, and/or efficacy of the drugs. This review will discuss several clinical relevant examples of pharmacogenomics use, especially genetic polymorphism, to influence the clinical outcome of cancer therapy. 
A Recent Update: Molecular Mechanism of Kombucha as A Probiotic for Obesity Management Nisa, Zulfia Rosyidatun; Jusup, Sinu Andhi; Yudhani, Ratih Dewi
Proceedings of the International Conference on Nursing and Health Sciences Vol 5 No 1 (2024): January-June 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v5i1.3820

Abstract

The prevalence of obesity has continued to increase in the past decade which has an impact on several metabolic disorders in the body. Various efforts are made to reduce and overcome the effects of obesity such as pharmacological therapy. In addition, using natural ingredients such as probiotics is optimized to minimize the effects caused. The balance of gut microbiota has an important role in helping to improve dysbiosis, inflammation, and fatty liver in obesity. Method: This review used the scoping review necessary to collect and summarize scientific data as well as guide future investigations with the provision that articles are up to the last 10 years (2014) for kombucha as a drink rich in probiotics that could have potential as a natural therapy for obesity management. Results: A total of 244 articles were collected and 11 articles met the inclusion criteria. Conclusion: kombucha has beneficial effects and has the potential to improve obesity conditions from a variety of mechanisms.
The Role of Interleukin 1β, Fibroblast Growth Factor, Fibroblasts, Keratinocytes, Granulation Tissue and Collagen Density in the Wound Healing Phase (Study of Wound Healing in the Inflammation, Proliferation, and Remodeling Phases) Christanto, Antonius; Cilmiaty, Risya; Setiamika, Made; Yudhani, Ratih Dewi; Dirgahayu, Paramasari; Pamungkasari, Eti Poncorini; Nurwati, Ida
Biocaster : Jurnal Kajian Biologi Vol. 5 No. 3 (2025): July
Publisher : Lembaga Pendidikan, Penelitian, dan Pengabdian Kamandanu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/biocaster.v5i3.399

Abstract

This scoping review explores the roles of interleukin 1β, fibroblast growth factor, fibroblasts, keratinocytes, granulation tissue, and collagen density in the wound healing process, focusing on inflammation, proliferation, and remodeling phases. A systematic literature search identified studies investigating molecular and cellular mechanisms involved in wound repair. Findings reveal that fibroblast-derived exosomes carrying miR-93-5p inhibit autophagy, delaying diabetic wound healing. Controlled growth factor delivery enhances angiogenesis, fibroblast proliferation, and collagen deposition, accelerating tissue regeneration. SPRR1B+ keratinocytes facilitate rapid re-epithelialization, while granulation tissue provides essential scaffolding for cell migration and neovascularization. Elevated IL-1β impairs healing by increasing matrix metalloproteinases, degrading collagen. Natural compounds like red fruit oil and Binahong leaf extract promote angiogenesis and collagen synthesis. Genetic variations in inflammatory cytokines influence healing outcomes, indicating potential for personalized therapies. This review consolidates current evidence, providing insights into cellular and molecular interactions critical for effective wound repair and guiding future regenerative medicine strategies.
ANALYSIS OF BIOACTIVE COMPOUNDS POTENTIAL IN ETHANOL EXTRACT OF WATERMELONS (Citrullus lanatus) MESOCARP Fauziah, Melinda; Susanto, Agung; Yudhani, Ratih Dewi
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3252

Abstract

Semangka (Citrullus lanatus) merupakan buah tropis yang banyak dibudidayakan dan dikonsumsi di Indonesia. Namun, konsumsi masyarakat umumnya terbatas pada bagian daging buah, sedangkan mesokarp (lapisan putih antara kulit dan daging buah) sering kali dibuang sebagai limbah. Kondisi ini turut menyumbang peningkatan limbah organik dari sektor hortikultura yang belum dimanfaatkan secara optimal. Selain itu, mesokarp semangka diketahui mengandung senyawa bioaktif seperti flavonoid, fenolik, dan alkaloid yang memiliki aktivitas antioksidan, antiinflamasi, dan antidiabetik. Meskipun potensinya telah banyak dilaporkan, namun pemanfaatannya secara optimal dalam pengembangan agen terapi alami masih terbatas. Penelitian ini bertujuan untuk mengeksplorasi kandungan senyawa bioaktif dari ekstrak etanol mesokarp semangka dengan dua konsentrasi pelarut berbeda, yaitu etanol 70% dan etanol 96%, menggunakan metode maserasi. Desain penelitian yang digunakan berupa eksperimental laboratorik. Simplisia mesokarp semangka diekstraksi, kemudian dianalisis kadar total flavonoid, fenolik, dan alkaloid menggunakan metode spektrofotometri UV-Vis. Hasil menunjukkan rendemen pada etanol 70% sebesar 51.7%, lebih tinggi dibandingkan etanol 96% sebesar 44.65%. Kandungan flavonoid dan alkaloid lebih tinggi ditemukan pada ekstrak etanol 70% (masing-masing 4,01% dan 1438,03 µg/g), sementara kandungan fenolik lebih tinggi ditemukan pada etanol 96% (5,92%). Penelitian ini mengindikasikan bahwa pemilihan konsentrasi pelarut yang tepat sangat menentukan keberhasilan ekstraksi senyawa bioaktif dari mesokarp semangka, sehingga berpotensi dimanfaatkan sebagai bahan dasar dalam pengembangan agen antioksidan alami.
Red Rice Bran Ethanol Extract Reduces IL-1β as the Risk of Pancreas Fibrogenesis in Type 2 Diabetic Rat Model Wasita, Brian; Yudhani, Ratih Dewi; Pakha, Dyonisa Nasirochmi; Nurrohima, Diana; Muthmainah, Muthmainah; Wiyono, Nanang; Fakurazi, Shariza
The Indonesian Biomedical Journal Vol 17, No 1 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i1.3410

Abstract

BACKGROUND: Oxidative stress and inflammation contribute to pancreatic cell dysfunction that promote insulin resistance in type 2 diabetes (T2D). Red rice bran contains bioactive substances with anti-inflammatory and antioxidant properties which improved insulin resistance in obese mice. However, no studies have explored the potential of ethanol extract of red rice bran (EERRB) to prevent T2D progression, particularly pancreatic fibrosis complications. This study was conducted to investigate the effect of EERRB on inflammation measured with interleukin (IL)-1β and fibrosis of pancreatic tissue in a rat model of T2D. METHODS: Rats were induced with streptozotocin and nicotinamide to induce diabetes, and then separated into five groups. One group received no treatment, while the other four received 9 mg/kg/day acarbose, 165, 330, or 660 mg/kg/day EERRB orally for 21 days. Immunohistochemistry was conducted on pancreas tissues to measure the expression of IL-1β, while pancreatic fibrosis was assessed with Masson’s Trichrome staining.RESULTS: EERRB reduced the expression of pro-inflammatory cytokine, IL-1β, in pancreas tissue in a dose dependent manner. Significantly lower IL-1β expression were found in group receiving 660 mg/kg/day EERRB (10%) compared to diabetic with no treatment group (50%) (p<0.0001). Additionally, the IL-1β expression in the highest dose of EERRB group was comparable to the group receiving acarbose (10%). CONCLUSION: This finding suggests the beneficial effect of EERRB in the hyperglycemic condition that causes oxidative stress through blocking the IL-1β expression, hence alleviating the inflammation in pancreas tissue, and have a tendency in preventing pancreatic fibrosis progression, a process implicated in T2D pathogenesis. KEYWORDS: diabetes, inflammation, pancreatic fibrosis, red rice bran
Co-Authors Brian Wasita Christanto, Antonius Diana Nurrohima Dyonisa Nasirochmi Pakha Eti Poncorini Pamungkasari Fakurazi, Shariza Fauziah, Melinda Ida Nurwati Muthmainah Muthmainah Nanang Wiyono Nisa, Zulfia Rosyidatun Paramasari Dirgahayu Risya Cilmiaty, Risya Setiamika, Made Sinu Andhi Jusup, Sinu Andhi Susanto, Agung