Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biomedika Callosum Neurology Journal : Jurnal Berkala Neurologi Bali Majalah Kedokteran Neurosains Scientia Psychiatrica Sriwijaya Journal of Neurology Neurona
Ahmad Asmedi
Department Of Neurology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 16 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 16 Documents
Search

 1   2 
HUBUNGAN RED BLOOD CELL DISTRIBUTION (RDW) DENGAN NATIONAL INSTITUTES OF HEALTH STROKE SCALE (NIHSS) PADA PASIEN STROKE ISKEMIK AKUT YANG DIRAWAT DI UNIT STROKE RSUP DR. SARDJITO Ade Mayashita; Ahmad Asmedi; Tommy Rachmat; Siti Farida
Callosum Neurology Vol 1 No 2 (2018): Callosum Neurology Journal
Publisher : The Indonesia Neurological Association Branch of Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (189.693 KB) | DOI: 10.29342/cnj.v1i2.33

Abstract

Latar Belakang: Stroke iskemik menyebabkan terjadinya inflamasi sel. Sitokin inflamasi menyebabkan peningkatan Red-Blood-Cell Distribution Width (RDW) dan mencegah maturasi sel darah merah. Pemeriksaan RDW rutin dan murah dikerjakan, sehingga diharapkan dapat digunakan sebagai prediksi keparahan klinis pada pasien stroke. Tujuan: Untuk mengetahui hubungan RDW terhadap skor National Institutes of Health Stroke Scale (NIHSS) pasien stroke iskemik akut di Unit Stroke Rumah Sakit Umum Pusat (RSUP) Dr. Sardjito Yogyakarta. Metode Penelitian: Studi dengan rancangan potong lintang. Subjek penelitian adalah pasien stroke iskemik yang dirawat di Unit Stroke RSUP Dr. Sardjito periode Januari 2014 hingga Desember 2015. Diagnosis stroke iskemik akut ditegakkan berdasarkan anamnesis, pemeriksaan fisik, dan pemeriksaan Computed Tomography (CT)-scan kepala. Data NIHSS dan RDW diambil saat admisi dan diuji korelasi dengan tes Pearson. Nilai p<0,05 dianggap signifikan secara statistik. Hasil: Sebanyak 51 orang subjek dimasukkan dalam penelitian. Hasil analisis menunjukkan bahwa RDW serum berkorelasi terhadap NIHSS (r= 0,296; p=0,035).Simpulan: Terdapat korelasi positif antara kadar RDW dengan nilai NIHSS pada penderita stroke iskemik akut dengan kekuatan korelasi rendah, sehingga semakin tinggi kadar RDW, maka semakin tinggi nilai NIHSS. Kata Kunci: RDW, Stroke Iskemik Akut, Keparahan, NIHSS
PERAN PEMERIKSAAN ELEKTROFISIOLOGI DALAM DIAGNOSIS SINDROM MILLER-FISHER Ahmad Asmedi; Sekar Satiti; Lothar Matheus Manson Vanende Silalahi
Callosum Neurology Vol 3 No 2 (2020): Callosum Neurology Journal
Publisher : The Indonesia Neurological Association Branch of Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.556 KB) | DOI: 10.29342/cnj.v3i2.104

Abstract

Sindrom Miller-Fisher merupakan salah satu varian Sindrom Guillain-Barre yang memiliki gambaran klinis unik dengan trias klasik optalmoplegia, ataksia dan arefleksia. Pemeriksaan penunjang pada Sindrom Miller-Fisher berperan penting karena beberapa kondisi penyakit juga dapat bermanifestasi seperti trias klasik Sindrom Miller-Fisher. Penunjang berupa analisis cairan serebrospinal, pencitraan otak, biomarker antibodi GQ1b telah banyak digunakan untuk menegakkan diagnosis Sindrom Miller-Fisher namun memiliki keterbatasan. Pemeriksaan elektrofisiologi kemudian banyak diteliti karena selain menunjang diagnosis dapat menjelaskan proses penyakit Sindrom Miller-Fisher. Penulisan ini bertujuan untuk membahas peran pemeriksaan elektrofisiologi dalam diagnosis Sindrom Miller-Fisher. Hasil studi menunjukkan bahwa abnormalitas amplitude Sensory Nerve Action Potential (SNAP) dan H-reflex secara konsisten terjadi pada Sindrom Miller-Fisher. Abnormalitas amplitudo SNAP akan membaik dengan cepat dan reversibel sehingga diperlukan juga pemeriksaan elektrofisiologi serial untuk dapat menunjang diagnosis Sindrom Miller-Fisher. Temuan tersebut dapat diperkuat dengan hasil pemeriksaan konduksi saraf motorik, konduksi saraf sensorik dan F-wave yang normal. Kata Kunci: Sindrom Miller-Fisher, Elektrofisiologi, Diagnosis
PERAN PENANDA MOLEKULER PADA TERAPI GLIOMA Malueka, Rusdy Ghazali; Yudiyanta, Yudiyanta; Asmedi, Ahmad
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 35 No 1 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i1.40

Abstract

   ROLE OF MOLLECULAR MARKER IN GLIOMA THERAPYABSTRACTGliomas are the most common primary Central Nervouus System (CNS) tumors in adults.  Nowdays, glioma classification has been changed from morphological based to molecular based classification. Isositrat dehydrogenase (IDH) muttion gene, chromosome 1p19q codeletion, O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, epidermal growth factor receptor (EGFR) amplification, and vascular endothelial growth factor (VEGF) expression play important role in glioma management. These markers are important to be identified to help the diagnosis, determine the prognosis, predict the success of therapy, and develop targeted therapy and chemotherapy of glioma.IDH 1 and 2 gene mutation correlate with better outcome. 1p19q chromosome codeletion also a good prognosis indicator and strong predictor of chemosensitivity. MGMT gene expression level and methylation promoter gene status has a predictive value for glioblastoma patients who are treated with alkylation treatment, such as temozlamide. EGFR gene mutation correlates with aggressiveness and poor prognosis. VEGF over-expression is also comparable with the increasing stage of tumor. Clinical trial show promising therapeutic and safety for patients treated with anti-VEGF therapy, such as bevacizumab.Keywords: Chemotherapy, glioma, molecular marker, targeted therapyABSTRAKGlioma adalah tumor primer susunan saraf pusat (SSP) yang paling umum pada orang dewasa. Klasifikasi glioma saat ini beralih dari pedoman berbasis morfologi ke kriteria molekuler. Terdapat beberapa penanda (marker) molekuler yang berperan pada glioma, yaitu mutasi gen isositrat dehidrogenase (IDH), kodelesi kromosom 1p19q, metilasi promotor O6-metilguanin-DNA-metiltransferase (MGMT), amplifikasi epidermal growth factor receptor  (EGFR), serta ekspresi vascular endothelial growth factor (VEGF). Hal ini penting untuk diidentifikasi untuk membantu diagnosis, menentukan prognosis, memprediksi keberhasilan terapi, serta untuk pengembangan terapi target dan kemoterapi.Adanya mutasi pada gen IDH 1 dan 2 berkaitan dengan prognosis yang lebih baik. Demikian pula kodelesi kromosom 1p19q merupakan indikator prognosis yang baik dan prediktor kuat kemosensitivitas. Tingkat ekspresi dan status metilasi promotor gen MGMT memiliki nilai prediktif pada pasien glioblastoma yang diobati dengan obat alkilasi, seperti temozolomid. Mutasi gen EGFR berkaitan dengan agresivitas dan prognosis yang buruk. Demikian pula over- ekspresi VEGF pada glioma sebanding dengan peningkatan derajat tumor. Uji klinik menunjukkan manfaat terapeutik serta keamanan yang sangat menjanjikan bagi pasien dengan terapi anti-VEGF, seperti bevacizumab.Kata kunci: Glioma, kemoterapi, penanda molekuler, terapi target
Pathophysiology of Primary Headache Syndrome: A Narrative Literature Review Asmedi, Ahmad
Sriwijaya Journal of Neurology Vol. 1 No. 1 (2023): Sriwijaya Journal of Neurology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjn.v1i1.221

Abstract

Primary headache syndrome is a chronic recurrent type not associated with structural abnormalities or systemic disease and includes migraine, cluster, paroxysmal hemicrania, and tension headaches. This literature review aimed to describe the types of primary headaches and their pathophysiology. Migraine is an episodic neurological disorder characterized by headaches that last 4 to 72 hours. This disorder is diagnosed when two of the following features occur: unilateral headache, throbbing pain, the pain worsening with activity, moderate or severe pain intensity, and at least one of the following: nausea and/or vomiting, or photophobia and phonophobia. Cluster headaches are one of a group of rare disorders known as trigeminal autonomic cephalgia. Tension-type headache (TTH) is the most common type of recurring headache. It's not a vascular headache or a migraine. The mean age of onset is during the second decade of life. Usually mild to moderate bilateral headaches with a feeling of tight bands or pressure around the head.
TANTANGAN DIAGNOSTIK DAN PENATALAKSANAAN NEUROMYELITIS OPTIC SPECTRUM DISORDER: SEBUAH SERIAL KASUS Luthffia, Audiza; Asmedi, Ahmad; Harahap , Indra Sari Kusuma; Yudiyanta, Yudiyanta
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 2 (2025): Vol 41 No 2 (2025): Volume 41, No 2 - Maret 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i2.599

Abstract

Introduction: Neuromyelitis optic spectrum disease (NMOSD) is a rare inflammatory CNS disorder consisting of simultaneous optic neuritis and transverse myelitis. The diagnosis requires combinations of clinical characteristics, serologic testing of Aquaporin-4 (AQP4) antibody, and neuroimaging. Treatment includes steroids, plasma exchanges and immunosuppressants. Despite of treatment, NMOSD can lead to devastating sequelae and complications in unresponsive cases. Case Report: We report three cases of adult women with AQP4-antibody positive NMOSD. First case was referral from regional hospital with bilateral visual loss preceded by tetraparesis with relapse and remitting period since 4 years before admission. Second case was referral from regional hospital with persistent right eye visual loss 3 years before admission with acute left eye visual loss and paraparesis. Third case directly admitted to Dr. Sardjito Hospital with acute unilateral visual loss and tetraparesis. Plain head CT scan was performed in the first two cases with normal result and spinal cord MRI in all patients showed long extensive transverse myelitis. All patients received high dose IV Methylprednisolone with immunosuppressant either azathioprine or mycophenolic acid, and continued with plasma exchange for the first two patients. There was no significant improvement in all patients following therapy. Conclusion: All three cases had manifestations of optic neuritis and transverse myelitis, and two of them was referral from regional hospital. Limited access to AQP4-antibody testing and MRI remains a challenge in NMOSD diagnosis, which can lead to delayed in diagnosis. Clinician should suspect for NMOSD in the presence of optic neuritis and myelitis manifestations.
PROFIL SEROLOGI MYASTHENIA GRAVIS: TINJAUAN ATAS TIPE, KARAKTERISTIK, DAN RELEVANSI KLINIS AUTOANTIBODI Asmedi, Ahmad; Bayuangga, Halwan Fuad
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 41 No 5: Edisi Suplemen Neurona Bekerjasama dengan JogjaCLAN 2025
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v41i5.869

Abstract

Myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction characterized by muscle weakness and fatigability. Understanding the serological profile of MG is key to accurate diagnosis and management. This literature review discusses the types and characteristics of autoantibodies in MG and their clinical relevance. Autoantibodies against the acetylcholine receptor (Anti-AChR) are the most common, found in the majority of generalized MG cases, and their pathogenesis involves antigenic modulation, ligand blockade, and complement activation. This subtype has a strong correlation with thymic abnormalities such as hyperplasia and thymoma. Autoantibodies against MuSK and LRP4 define other MG subtypes with distinct clinical phenotype, MuSK-MG often presents with severe bulbar symptoms, while LRP4-MG tends to be milder. A recommended diagnostic approach is algorithmic, starting with Anti-AChR testing, followed by Anti-MuSK and Anti-LRP4 in seronegative cases. Mapping this serological profile enables neurologists to achieve a precise diagnosis, predict disease course, and determine personalized therapy strategies, including the choice of immunomodulators and evaluation for thymectomy. Thus, serological classification has become the foundation of a precision neurology approach in managing myasthenia gravis. Keywords: Anti-AChR, Anti-LRP4, Anti-MuSK, Myasthenia gravis, Thymoma
Co-Authors Ade Mayashita Bayuangga, Halwan Fuad Emi Tamaroh Harahap , Indra Sari Kusuma Harsono Harsono Harsono Harsono Ismail Setyopranoto Iwan Setiawan Iwan Setiawan Lothar Matheus Manson Vanende Silalahi Lucas Meliala Lucas Meliala Luthffia, Audiza Rusdy Ghazali Malueka Samekto Wibowo Samekto Wibowo Satiti, Sekar Sekar Satiti Siti Farida Tama, Whisnu Nalendra Tommy Rachmat Yudiyanta Yudiyanta, Yudiyanta