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All Journal Majalah Kedokteran Gigi Indonesia ODONTO Dental Journal Interdental Jurnal Kedokteran Gigi (IJKG) MDJ (Makassar Dental Journal) LOKATARA SARASWATI Odonto dental journal
Hendri Poernomo
Universitas Mahasaraswati Denpasar
Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences

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Journal : ODONTO Dental Journal

 1 
THE EFFECT OF PEGAGAN GEL (CENTELLA ASIATICA (L.) URBAN) ON WOUND HEALING PROCESSES IN MICE (MUS MUSCULUS) IN VIVO Hendri Poernomo; Setiawan DS
ODONTO : Dental Journal Vol 9: Special Issue 1. April 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.0.137-146

Abstract

Background : Tooth extraction and incision are procedures that are often performed in dentistry that cause injury and damage to oral tissues. Injuries to the oral tissue must be treated immediately so as not to interfere with the stomatognathic system. Pegagan (Centella asiatica (L.) Urban) is one of the medicinal plants used to accelerate wound healing. The purpose of the study was to determine the effect of giving extract pegagan gel on the oral mucosal wounds of mice (Mus musculus) in various concentrations on the number of fibroblast cells.Methods : The research method used experimental post test only control group design. Data analysis used One Way Anova test and Least Significant Difference (LSD) test. The experimental used were 24 male mice aged 6-8 weeks weighing 20-25 grams and healthy, divided into 4 (four) groups. The extraction wounds were smeared with 5%, 10%,15% concentration of pegagan extract gel and the placebo was smeared for 1 minute and done twice a day. Experimental animals were decapitated on day 5 without pain and continued with the stage of making microscopic preparations of tissue taken and fixed with buffer formalin 10% for a maximum of 24 hours.Results : The results showed that the average number of fibroblasts in the administration of extract pegagan gel was 15% with 400 cells, 10% was 291 cells, 5% was 262 cells and the average CMC Na gel group was 74 cells.Then continued with the One Way Anova test and the Least Significant Difference (LSD) test and results showed the average number of fibroblast cells in the four groups after being given treatment was significantly different with a significant level (ρ) < 0.05 and followed by a post hoc test, it is known that the gel extract pegagan 5%, 10%, and 15% can increase the number of fibroblast cells.Conclusion : Extract pegagan gel 15% more increased the number of fibroblast cells than extract pegangan gel10% and 5%.
Sub-Acute Toxicity and Allergy Studies of Bidara Leaf (Ziziphus Mauritiana) Extract as A Wound Healing Material Ma'ruf, Mochammad Taha; Dewi, Putu Sulistiawati; Poernomo, Hendri
Odonto : Dental Journal Vol 10, No 2 (2023): December 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.2.194-201

Abstract

Background: In dentistry, the wound healing process is often encountered in tooth extractions, incisions, oral and facial surgery, gingival flaps and biopsies. Post-tooth extraction wound is a medium that allows pathogenic microbes to breed and infect the wound. Wound management must be carried out as soon as possible to restore mucosal integrity so as to prevent bacterial infections penetrates the body. Bidara (Ziziphus mauritiana) is one of the plants used as traditional medicine by the community. Research on this plant as a medicinal raw material is increasing, so further research needs to be carried out to prove the safety of this medicinal plant. This study aims to determine the effects of sub-acute toxicity and allergic reactions caused after administering bidara leaf extract on the liver histopathology of mice. Methods: In vivo laboratory experimental study using a post-test only control group design with 24 mice (Mus musculus). The research sample consisted of 4 groups, namely the control group given 0.3% Na-CMC, the treatment group given bidara leaf extract at a dose of 500 mg/kg BW, 600 mg/kg BW, and 700 mg/kg BW. The treatment extract was given orally for 28 days. Results: The results of the study showed that the dose of bidara leaf extract had an effect on the liver histopathology of mice, namely at doses of 600 mg/kg BW and 700 mg/kg BW it had a toxic effect that was visible from changes in liver cell structure. Allergy tests showed that bidara leaf extract did not cause allergic reactions in mice. Conclusion: It can be concluded that bidara leaf extract (Ziziphus mauritiana) does not cause allergies and at certain doses does not have toxicity in the liver of animals study.
Co-Authors Ari Sucitra Dewi Hiro, Sebastian Pernando Kadek Dwi Dessy Sapitri Laksmi Novrina Dewi Luh Gede Pradnyani Maya Sari Dewi Maya Sari Dewi, Maya Sari Ma’ruf, Mochammad Taha Mbiliyora, Paskarani Mochammad Taha Ma'aruf Mochammad Taha Ma’ruf Ni Wayan Arni Sardi PA Nindya Winda Wati Putu Sulistiawati Dewi Reza Pramana Senopati Senopati Senopati, Senopati Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Setiawan Taha Ma'aruf Wati, PA Nindya Winda Yuni Darma Dewi