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All Journal Jurnal Ilmiah Farmasi Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Majalah Farmaseutik Indonesian Journal of Chemistry
Purwantiningsih Purwantiningsih
Department Of Pharmacology And Clinical Pharmacy, Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Medicine & Pharmacology Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
EFFECT OF THE JUICE OF GINGER RHIZOMES ON THE PHARMACOKINETICS OF SULFAMEZATHINE IN RATS ., Purwantiningsih; Hakim, Lukman
INDONESIAN JOURNAL OF PHARMACY Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (95.267 KB) | DOI: 10.14499/indonesianjpharm0iss0pp250-255

Abstract

The rhizome of ginger (Zingiber officinale, Rosc.) has been widely consumed by people as food ingredient or a traditional drug. In the previous research there was evidence that the ginger juice influenced the pharmacokinetics of propranolol, a representative of drugs with high extraction ratio. The aim of this research is to study the effect of ginger juice on another high ER drug, sulfamezathine. To achieve the aim of this study, rats were divided into two groups to get the blood and urine data. The animals at the blood data group were divided into two groups. The group I (N=6) was given sulfamezathine (50 mg/kg BW) through intra peritoneal injection and the group II (N=6) was pretreated with the ginger juice orally (4 ml/kg BW) an hour prior to administration of sulfamezathine. The blood samples were withdrawn at various intervals after the drug administration. The unchanged sulfamezathine concentration was determined using a modified Bratton-Marshall method. From this blood data the values of Ka, Cmaks, Tmaks, Vdss, AUC, Cl and T1/2el were computed. Urine data was obtained by using two groups of rats with the same treatment as above. The sulfamezathine was counted from urine which accumulated for 24 hours to obtain the value of Fel. The results of this research showed that significant decreases in Cmaks (16.72%) and AUC (22.92%) values have occurred, with increasing values of Vdss (18.39%), ClT (38.29%), ClR (213.11%) and Fel 24 hours (128.58%) values. Key words : ginger rhizome, pharmacokinetics, sulfamezathine, rats
Antimicrobial activity and Identification of fungus associated Stylissa flabelliformis sponge collected from Menjangan Island West Bali National Park, Indonesia Erna Prawita Setyowati; Silvia Utami Tunjung Pratiwi; Purwantiningsih Purwantiningsih; Oka Samara
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1684.892 KB) | DOI: 10.14499/indonesianjpharm29iss2pp66

Abstract

The Fungus is a very important microorganism as a producer of bioactive secondary metabolites. Active substances of microbial origin have been sought through the process of screening methods to obtain antimicrobial compounds. The purpose of this study was to isolate fungi associated with sponge taken from Menjangan Island National Park West Bali (Indonesia) and identify fungi that have antimicrobial activity. Isolation of fungus from sponge was carried out by spread plate method using Saboroud Saline Agar medium. Each fungi will be tested to Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922 and Candida albicans ATCC 10231. Identification of fungi is based on the observation of macroscopic, microscopic and also using 16rRNA/ITS phylogeny tree. The results showed that S. flabelliformis sponge had 10 fungal isolates. Most of them have antimicrobial activity. The name associated with a sponge fungus is These 10 fungus are Aspergillus flavus strain UPMZ02, Aspergillus fumigatus strain CD1621, Trichoderma reesei strain JCM 2267, Aspergillus nomius strain KUB105, Aspergillus sp. strain TLWK-09, Aspergillus flavus strain MC-10-L, Penicillium sp. strain RMA-2, Aspergillus sp. strain TLWK-09, Aspergillus fumigatus and Trichoderma reesei strain TV221 
Co-Authors Abas Hj Hussin Akhmad Kharis Nugroho Charles S. Vairappan Datin Maryati Mohd. Endang Lukitaningsih Endang Lukitaningsih Erna Prawita Setyowati Indah Purwantini, Kit Lam Chan Lukman Hakim Lukman Hakim Marchaban Marchaban Nur Amalia Rosyada Oka Samara Oktavia Eka Puspita Retno Murwanti Sekar Ayu Pawestri Sekar Ayu Pawestri Silvia Utami Tunjung Pratiwi Subagus Wahyuono Tri Murti Andayani Vera Fauziati