Garuda - Garba Rujukan Digital

Pelepasan Fero Sulfat Dari Cangkang Kapsul Alginat Transparan: Pengaruh Jenis Cangkang dan Penyimpanan Natalia Sitorus; M. Timbul Simanjuntak; Hakim Bangun*
Journal of Pharmaceutics and Pharmacology Vol 1, No 1 (2012)
Publisher : Journal of Pharmaceutics and Pharmacology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.02 KB)

Background : In general capsules are made of gelatin and this kind of capsule will immediate release when reach the stomach so that the gelatin capsule cannot avoid the side effects of ferrous sulfate that can irritate the stomach. Alginate capsule shells are hard capsule shell that prevent the irritating effects of ferrous sulfate to the stomach. Objectives : To observe the effect of capsule shells transparent variety and the effect of storage against the release of ferrous sulfate from alginate capsule shell. Methods : Transparent alginate capsules used were 2 types of transparent alginate capsules: 1) made from sodium alginate 300-400 cp and 2) made from sodium alginate 500-600 cp. Both capsules were size 0 and obtained from Laboratory of Physical Pharmacy, Faculty of Pharmacy, University of Sumatera Utara. Ferrous sulfate release test was conducted by paddle method in medium pH 1,2 and ferrous content was determined by using visible spectrophotometer at wavelength of 510 nm. Ferrous sulfate capsules were stored for 3 months at room temperature (280C, RH 70%) and temperature 400C, RH 75%. Results : Ferrous sulfate was oxidized during storage and the oxidation of alginate capsule made from sodium alginate 300-400 cp was faster than that of from sodium alginate 500-600 cp. Ferrous sulfate release was faster from capsule shell made from sodium alginate 300-400 cp than that of made from sodium alginate 500-600 cp. Conclusion : Transparent alginate capsules shell from sodium alginate with lower viscosity produce faster release of ferrous sulfate but produce lower stability of ferrous sulfate during storage. Keywords: alginate capsules shell, ferrous sulfate, viscosity, storage ABSTRAK Latar belakang : Pada umumnya cangkang kapsul terbuat dari gelatin dan kapsul ini akan segera pecah setelah sampai di lambung sehingga kapsul gelatin tidak dapat menghindari efek samping fero sulfat yang dapat mengiritasi lambung. Cangkang kapsul alginat merupakan cangkang kapsul keras yang dapat mencegah efek iritasi dari fero sulfat terhadap lambung. Tujuan : Untuk melihat pengaruh jenis cangkang kapsul alginat transparan dan pengaruh penyimpanan terhadap pelepasan fero sulfat dari cangkang kapsul alginat. Metode penelitian : Cangkang kapsul alginat transparan yang digunakan ada 2 jenis yaitu kapsul alginat transparan yang dibuat dari natrium alginat 300-400 cp dan natrium alginat 500-600 cp. Cangkang kapsul yang dibuat merupakan cangkang kapsul dengan ukuran 0. Kedua jenis kapsul diperoleh dari Laboratorium Farmasi Fisik, Fakultas Farmasi, USU. Uji pelepasan fero sulfat dilakukan dengan metode dayung dalam medium pH 1,2 dan penetapan kadar fero dengan spektrofotometer visibel pada panjang gelombang 510 nm. Fero sulfat disimpan selama 3 bulan pada suhu kamar (280C, RH 70%) dan suhu (400C, RH 75%). Hasil : Fero sulfat mengalami oksidasi selama penyimpanan dan peruraian lebih cepat pada kapsul alginat yang dibuat dari natrium alginat 300-400 cp daripada yang dari natrium alginat 500-600 cp. Pelepasan fero sulfat lebih cepat dari cangkang kapsul yang dibuat dari natrium alginat 300-400 cp daripada yang dari natrium alginat 500-600 cp. Kesimpulan : Cangkang kapsul transparan yang dibuat dari natrium alginat dengan viskositas lebih rendah menghasilkan pelepasan fero lebih cepat, tetapi menghasilkan oksidasi fero sulfat yang lebih cepat pada penyimpanan. Kata kunci: cangkang kapsul alginat; fero sulfat; viskositas; penyimpanan *Korespondensi penulis: hakimb17@yahoo.com

Formulation and Evaluation of Sustained Release Microcapsule of Metronidazole Natassya Manda Leo; Hakim Bangun; Urip Harahap
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.643

The oral conventional metronidazole dosage forms have a short duration of action due to gastric emptying process, hence the treatment of ulcus pepticum using metronidazole become less effective. Due to retaining the dosage form in the stomach, a preparation form of sustained released drug delivery systems has been developed. The aim of this study was to developed a sustained released drug delivery systems of metronidazole using alginate and chitosan as polymers that could last longer in stomach. The formulation consisted of variatons in chitosan 0.5%, 0.75% and 1%. The drug released test was carried out using paddle method in simulated gastric medium pH 1.2 at 37°C. The dissolution test results showed that formula with 0.75% of chitosan giving the best sustained released effect and the kinetics drug realeased of microcapsule followed Higuchi order. Based on the results of the study, it can be concluded that microcapsules of metronidazole with a combination of alginate and chitosan can be prepared as sustained released formulation.

PENGARUH PENGGUNAAN POLIMER HPMC DAN POLIVINIL PIROLIDON TERHADAP KARAKTERISTIK FISIK TRANSDERMAL PATCH NATRIUM DIKLOFENAK Nurmalia Zakaria; Hakim Bangun; Azizah Vonna; Frida Oesman; Zahra khaira; Fara Fajriana
Journal of Science and Health Darussalam Vol. 1 No. 2 (2021): Jurnal Sains dan Kesehatan Darussalam
Publisher : Akademi Analis Farmasi dan Makanan Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56690/jskd.v1i2.21

Natrium diklofenak adalah salah satu obat anti inflamasi non-steroid (NSAID) yang mengalami first pass effect metabolism dan menyebabkan terjadinya iritasi lambung. Efek yang tidak diinginkan tersebut dapat dinindari dengan memformulasikan natrium diklofenak menjadi sediaan transdermal patch. Transdermal patch adalah sediaan topikal berbentuk koyo dimana bahan obat mampu mengalami penetrasi melintasi jaringan kulit dan obat tersedia secara sistemik. Penelitian ini bertujuan untuk melihat pengaruh penggunaan Hidroxi propyl Methyl Cellulosa (HPMC) dan Polivinil Pirolidon (PVP) sebagai basis terhadap karakteristik fisik sediaan. Penelitian ini dilaksanakan di Laboratorium Farmasi Akademi Analis Farmasi dan Makanan Banda Aceh, Laboratorium Farmasi Fisik Universitas Sumatera Utara dan Laboratorium Teknologi Akademi Farmasi Pemerintah Aceh, pada bulan November 2020-Februari 2021. Metode penelitian bersifat eksperimental dimana formula menggunakan dua jenis polimer HPMC (FA) dan PVP (FB), dengan parameter uji karakteristik fisik meliputi organoleptis, ketebalan, keseragaman bobot, daya tahan lipat, pH, dan kelembaban. Hasil penelitian menunjukan adanya pengaruh dari penggunaan HPMC dan PVP terhadap karakteristik fisik sediaan yaitu bentuk patch FA memiliki permukaan yang kering, sedangka patch FB memiliki permukaan yang basah dan lengket. Nilai karakteristik fisik FA lebih kecil dibandingkan FB meliputi ketebalan, keseragaman bobot, daya tahan lipat, pH dan persen kelembaban, tetapi kedua formula memiliki karakteristik fisik yang memenuhi kriteria persayaratan pacth. Kata Kunci : HPMC, Polivinil Pirolidon (PVP), Transdermal Patch Natrium Diklofenak, Karakteristik Fisik

The Effect of Ethanol Extract of Avocado Leaf (Persea Americana Mill.) on Reduction of Gastric Acid in Aspirin Induced Rats Simbolon, Rohana Oktofariday; Dalimunthe, Aminah; Bangun, Hakim
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.972

One of the most prevalent dangerous illnesses is arthritis. The pathophysiology of gastritis is an imbalance of aggressive and protective factors. Nonsteroidal anti-inflammatory drugs are known as aggressive agents for the development of gastritis. Gastritis can be managed using avocado leaves. Finding out how an avocado leaf ethanol extract changed the amount of stomach acid in aspirin-treated rats was the aim of the investigation. Secondary metabolite content and characterisation were examined in the avocado leaf ethanol extract. Gastric acid reduction was performed by examining gastric acid concentration, number of ulcers, ulcer index, and pH in aspirin-induced rats. Ethanol extract of avocado leaves contains alkaloids, flavonoids, saponins, steroids, tannins and glycosides. Characterization obtained moisture content of 12.60%, total ash content of 1.34% and acid insoluble ash content of 0.17%. Acid concentration in the administration of avocado leaf ethanol extract 400 mg/KgBW is 16.00 ± 2.65 significantly different from the negative control 27.67 ± 2.52. The number of ulcers on the administration of avocado leaf ethanol extract 400 mg/KgBW 1.67 ± 2.08 is significantly different from the negative control 5.33 ± 0.58. When avocado leaf ethanol extract 400 mg/ kgBW is administered, the ulcer index (0.003 ± 0.005) differs significantly from the negative control (0.014 ± 0.013). pH in the administration of avocado leaf ethanol extract 400 mg / kgBW 5.53 ± 0.57 is significantly different from the negative control 2.57 ± 0.12. The ethanol extract of avocado leaf 400 mg/kgBW has a reducing gastric acid effect.

Comparison of Antibacterial Activity of Ethanol Extract and Nanoparticles of Crassocephallum Crepidioides S.Moore Against Staphylococcus Aureus Candrika, Candrika; Dalimunthe, Aminah; Bangun, Hakim
Journal La Medihealtico Vol. 5 No. 2 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i2.1160

This research seeks to examine the width of the inhibitory zone of extracts and nanoparticles of Crassocephalum crepidioides leaf simplisia, which have many advantages such as wound therapy, diarrhea relief, anti-inflammatory properties, and antibacterial effects. The antibacterial activity of Crassochepallum crepidioides (Benth) was evaluated by using the ethanol extract and nanoparticles. S. Moore departs. The agar diffusion technique was used to test it on paper plates. 0.1 ml of bacterial inoculum was introduced into a sterile petri dish, followed by the addition of 15 ml of Mueller Hinton agar media at a temperature range of 45-50ºC. Subsequently, multiple paper plates were immersed in a test solution containing a strong leaf ethanol extract and nanoparticles with different concentrations. Characterization reveals that Crassocephalum crepidioides is composed of many bioactive components, including alkaloids, flavonoids, saponins, tannins, and steroids. The analysis of the extract revealed that it contained 5.92% water, 12.86% total ash, 1.55% acid-insoluble ash, 14.33% water-soluble essence, and 9.34% ethanol-soluble essence. The nanoparticles had a size of 64.37 nm and exhibited antibacterial activity of extract ethanol at a concentration of 50% with a diameter of 12,00 mm. The minor concentration of the extract had a diameter of 3,166 mm, while the nanoparticles showed antibacterial activity at a concentration of 50% with a diameter of 10,53 mm. The minor concentration of the nanoparticle had a diameter of 3,00 mm The activity test results of the ethanol extract of Crassochepallum crepidioides with nanoparticles demonstrated that the inhibitory diameter of the ethanol extraction results remained more strong compared to the nanoparticles of simplisia powder.

PENGARUH PENGGUNAAN POLIMER HPMC DAN POLIVINIL PIROLIDON TERHADAP KARAKTERISTIK FISIK TRANSDERMAL PATCH NATRIUM DIKLOFENAK Nurmalia Zakaria; Hakim Bangun; Azizah Vonna; Frida Oesman; Zahra khaira; Fara Fajriana
Journal of Science and Health Darussalam Vol. 1 No. 2 (2021): Jurnal Sains dan Kesehatan Darussalam
Publisher : Akademi Analis Farmasi dan Makanan Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56690/jskd.v1i2.21

Natrium diklofenak adalah salah satu obat anti inflamasi non-steroid (NSAID) yang mengalami first pass effect metabolism dan menyebabkan terjadinya iritasi lambung. Efek yang tidak diinginkan tersebut dapat dinindari dengan memformulasikan natrium diklofenak menjadi sediaan transdermal patch. Transdermal patch adalah sediaan topikal berbentuk koyo dimana bahan obat mampu mengalami penetrasi melintasi jaringan kulit dan obat tersedia secara sistemik. Penelitian ini bertujuan untuk melihat pengaruh penggunaan Hidroxi propyl Methyl Cellulosa (HPMC) dan Polivinil Pirolidon (PVP) sebagai basis terhadap karakteristik fisik sediaan. Penelitian ini dilaksanakan di Laboratorium Farmasi Akademi Analis Farmasi dan Makanan Banda Aceh, Laboratorium Farmasi Fisik Universitas Sumatera Utara dan Laboratorium Teknologi Akademi Farmasi Pemerintah Aceh, pada bulan November 2020-Februari 2021. Metode penelitian bersifat eksperimental dimana formula menggunakan dua jenis polimer HPMC (FA) dan PVP (FB), dengan parameter uji karakteristik fisik meliputi organoleptis, ketebalan, keseragaman bobot, daya tahan lipat, pH, dan kelembaban. Hasil penelitian menunjukan adanya pengaruh dari penggunaan HPMC dan PVP terhadap karakteristik fisik sediaan yaitu bentuk patch FA memiliki permukaan yang kering, sedangka patch FB memiliki permukaan yang basah dan lengket. Nilai karakteristik fisik FA lebih kecil dibandingkan FB meliputi ketebalan, keseragaman bobot, daya tahan lipat, pH dan persen kelembaban, tetapi kedua formula memiliki karakteristik fisik yang memenuhi kriteria persayaratan pacth. Kata Kunci : HPMC, Polivinil Pirolidon (PVP), Transdermal Patch Natrium Diklofenak, Karakteristik Fisik

Incompatibility in the administration of intravenous parenteral preparations in the intensive care unit (ICU) in one of the hospitals in Indonesia Tobing, Johnson L.; Bangun, Hakim; Arianto, Anayanti
Science Midwifery Vol 13 No 1 (2025): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i1.1824

The prescribing and administration of intravenous injection drug therapy to patients in hospitals is increasing to achieve immediate pharmacological effects but can have a high risk of incompatibility. Therefore, it is necessary to check for intravenous injection incompatibility before administering it. Identify incompatible pairs of intravenous injectable drugs in intensive care (ICU) rooms of hospitals in Indonesia. Survey of the incompatibility of Electronic Prescribing (E-Prescribing) of intravenous injection drugs in the ICU room retrospectively using the Lexicomp application. From the results of retrospective identification of electronic prescriptions for the period from January 2022 to May 2023, data was obtained on the number of patients of 165 people, consisting of 91 people receiving compatible prescriptions and 74 patients receiving incompatible prescriptions. The number of intravenous injection drugs used was 60 types with the number of incompatible drug pairs 102 and the frequency of incompatible drugs 303. From the results of the evaluation of the incompatibility mechanism of intravenous drug injection pairs, it was found that 68 pairs of acid-base reactions, 18 pairs of mixed solvent dilution, 8 pairs of gas formation, 6 pairs of broken emulsions and 2 pairs of ionic reactions. Identification of patients' electronic prescriptions is still found to be incompatible with drug pairs, therefore it is necessary to take precautions.

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search