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Risiko Kepadatan Hunian dan Kelembaban pada Kejadian TB Paru di Wilayah Kerja Puskesmas Tamalate Kota Makassar Ayu Puspitasari; Harpiana Rahman; Nurhikmawati Abdullah
Jurnal Penelitian Kesehatan SUARA FORIKES 2024
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf15nk111

Pulmonary tuberculosis is caused by the bacteria Mycobacterium tuberculosis and is an infectious disease. An unhealthy home environment can contribute to the high incidence of pulmonary tuberculosis. The aim of this study was to analyze the effect of residential density and humidity on the incidence of pulmonary tuberculosis in the working area of the Tamalate Community Health Center. The study implemented a case-control design with a 1:1 proportion. The case sample size and control sample size were 30 people each. Data was collected by filling out a questionnaire and then analyzed using the Chi-square test and odds ratio. The results showed that for residential density, p value = 0.161 and odds ratio = 0.224; while for humidity, p value = 0.000 and odds ratio = 3.727. It was concluded that the risk factor for the incidence of pulmonary tuberculosis in the working area of the Tamalate Health Center, Makassar City, was humidity.Keywords: pulmonary tuberculosis; environment; humidity ABSTRAK Tuberkulosis paru disebabkan oleh bakteri Mycobacterium tuberculosis dan termasuk penyakit menular. Lingkungan rumah yang tidak sehat dapat berkontribusi pada tingginya kejadian tuberkulosis paru. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh kepadatan hunian dan kelembaban terhadap kejadian tuberkulosis paru di wilayah kerja Puskesmas Tamalate. Penelitian menerapkan rancangan kasus-kontrol dengan proporsi 1:1. Ukuran sampel kasus dan sampel kontrol masing-masing adalah 30 orang. Data dikumpulkan melalui pengisian kuisioner lalu dianalisis menggunakan uji Chi-square dan odds ratio. Hasil penelitian menunjukkan bahwa untuk kepadatan hunian, nilai p = 0,161 dan odd ratio = 0,224; sedangkan untuk kelembaban, nilai p = 0,000 dan odd ratio = 3.727. Disimpulkan bahwa faktor risiko kejadian tuberkulosis paru di wilayah kerja Puskesmas Tamalate Kota Makassar adalah kelembabanKata kunci: tuberkulosis paru; lingkungan; kelembaban

Umur, Durasi Duduk dan Low Back Pain pada Sopir Bus Trans Mamminasata Ayu Puspitasari; Nurhikmawati Abdullah; Rezky Aulia Yusuf; Nurul Hikmah Baharuddin; Nurfachanti Fattah
Jurnal Penelitian Kesehatan SUARA FORIKES Vol 14, No 3 (2023): Juli - September 2023
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf14306

Low back pain is a form of work related musculoskeletal disorders. This disorder is often found among workers, including drivers who drive buses. The aim of this study was to analyze the relationship between age and sitting duration and the incidence of low back pain in Trans Mamminasata bus drivers. This research is a quantitative analytical research using a cross-sectional design. This research involved 98 bus drivers selected using accidental sampling technique. Data was collected by filling out a questionnaire, then analyzed using the Chi-square test. The p value in the correlation analysis between age and the incidence of low back pain is 0.000, as well as in the correlation analysis between sitting duration and the incidence of low back pain. Furthermore, it was concluded that age and sitting duration were related to the incidence of low back pain in Trans Mamminasata bus drivers.Keywords: low back pain; bus driver; sitting duration; age ABSTRAK Low back pain merupakan salah satu bentuk dari work related musculoskeletal disorders. Gangguan ini banyak dijumpai pada para pekerja, termasuk para sopir yang mengemudikan bus. Tujuan penelitian ini adalah untuk menganalisis hubungan antara umur dan durasi duduk dengan kejadian low back pain pada sopir bus Trans Mamminasata. Penelitian ini merupakan penelitian kuantitatif analitik dengan menggunakan desain cross-sectional. Penelitian ini melibatkan 98 sopir bus yang dipilih dengan teknik accidental sampling. Data dikumpulkan melalui pengisian kuesioner, lalu dianalisis menggunakan uji Chi-square. Nilai p pada analisis korelasi antara umur dengan kejadian low back pain adalah 0,000, demikian pula pada analisis korelasi antara durasi duduk dengan kejadian low back pain. Selanjutnya disimpulkan bahwa umur dan durasi duduk berhubungan dengan kejadian low back pain pada sopir bus Trans Mamminasata.Kata kunci: low back pain; sopir bus; durasi duduk; umur

Pathophysiological Mechanisms Linking Myocardial Infarction to Cardiac Arrest: A Literature Review Andi Suleha; Akina Maulidhany Tahir; Fadillah Maricar; Priscilla Sasmita Rido; Nurhikmawati Nurhikmawati
Journal of Community Health Provision Vol. 6 No. 2 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i2.978

Myocardial infarction (MI) is a leading cause of cardiac arrest and sudden cardiac death worldwide. The pathophysiological link involves complex interactions between cellular, electrophysiological, hemodynamic, and neurohormonal mechanisms. The objective of the research to comprehensively review the pathophysiological mechanisms linking myocardial infarction to cardiac arrest. The methods of the research was a descriptive-analytic literature review was conducted using PubMed, ScienceDirect, SpringerLink, and Google Scholar databases (2021–2025). Study selection followed PRISMA guidelines. The results of the showed that eight studies were included. Key mechanisms include myocardial ischemia leading to ATP depletion and acidosis, ionic imbalance, arrhythmogenic substrate formation, sympathetic overactivation, inflammatory response and oxidative stress, and hemodynamic collapse. Cardiac arrest following MI is primarily driven by fatal ventricular arrhythmias and pump failure. Understanding these mechanisms is essential for improving prevention and management strategies.

Literature Review: Myocardial infarction in Young Adult Ratu Trya Maharani; Nurhikmawati Nurhikmawati; Akina Maulidhany Tahir; Fadillah Maricar; Purwati Pole Rio
Journal of Asian-african Focus in Health Vol. 4 No. 1 (2026): Journal of Asian-african Focus in Health
Publisher : ScieClouds Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71435/736437

Myocardial infarction (MI) has traditionally been considered a disease of older adults; however, recent evidence indicates an increasing incidence among younger populations. This trend has raised significant clinical and public health concerns because MI occurring during productive years is associated with substantial long-term health, social, and economic consequences. Understanding the risk factors, clinical characteristics, and outcomes of MI in young adults is essential for improving prevention and management strategies. This study aimed to systematically review the current literature regarding myocardial infarction in young adults, with a particular focus on risk factors, clinical characteristics, and patient outcomes. A literature review was conducted using articles retrieved from PubMed, ScienceDirect, and Google Scholar. The search covered publications from 2021 to 2026 using keywords related to myocardial infarction, young adults, acute coronary syndrome, and cardiovascular risk factors. Articles were screened according to predefined inclusion and exclusion criteria. Following the selection process, 20 eligible studies consisting of observational studies, cohort studies, registry analyses, case series, and review articles were included in the final analysis. he findings demonstrate that myocardial infarction in young adults is a growing global health issue. Traditional risk factors, particularly smoking, dyslipidemia, obesity, hypertension, diabetes mellitus, and family history of cardiovascular disease, remain the primary determinants of disease occurrence. Emerging risk factors, including psychosocial stress, sleep disorders, autoimmune diseases, chronic inflammation, and substance abuse, also contribute significantly. Clinically, young patients commonly present with typical chest pain and predominantly single-vessel coronary artery disease, although non-atherosclerotic mechanisms such as spontaneous coronary artery dissection and myocardial infarction with non-obstructive coronary arteries are increasingly recognized. While short-term outcomes are generally more favorable than in older patients, long-term risks of recurrent cardiovascular events and persistent morbidity remain substantial. Myocardial infarction in young adults is a multifactorial condition requiring comprehensive risk assessment, early prevention, and long-term management strategies to reduce future cardiovascular burden.

Benefits of Cardiac Rehabilitation After Myocardial Infarction: A Literature Review Lintang Dyah Ayu Pangukir; Nurhikmawati Nurhikmawati; Purwati Pole Rio; Wisudawan Wisudawan; Akina Maulidhany Tahir
Journal of Community Health Provision Vol. 6 No. 2 (2026): Journal of Community Health Provision
Publisher : PSPP JOURNALS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55885/jchp.v6i2.1036

Cardiac rehabilitation is an essential component of secondary prevention after myocardial infarction, providing multidimensional benefits beyond pharmacological therapy and coronary revascularization. This literature review aims to examine the clinical, functional, psychological, and preventive benefits of cardiac rehabilitation in patients after myocardial infarction. This study employed a narrative literature review design using secondary data from scientific articles obtained through databases such as PubMed, Google Scholar, ScienceDirect, SpringerLink, Elsevier, and other reputable journal sources. Articles were selected based on their relevance to post myocardial infarction cardiac rehabilitation, including outcomes related to cardiac function, left ventricular ejection fraction, exercise capacity, recurrent cardiovascular events, hospitalization, mortality, quality of life, and rehabilitation delivery models. A total of 15 scientific articles met the inclusion criteria and were analyzed in this review. The findings indicate that cardiac rehabilitation after myocardial infarction improves left ventricular function, exercise capacity, and health related quality of life. It also contributes to reducing major adverse cardiovascular events, recurrent myocardial infarction, rehospitalization, and long-term cardiovascular mortality. Home based cardiac rehabilitation, tele rehabilitation, and mobile health-based rehabilitation were found to have comparable effectiveness to conventional center based rehabilitation, particularly in improving access, adherence, and continuity of care. The review also highlights the importance of early initiation, patient adherence, gender sensitive approaches, and program standardization to optimize rehabilitation outcomes. In conclusion, cardiac rehabilitation should be recognized as an integral and evidence-based strategy in the comprehensive management of post myocardial infarction patients. Its implementation should be expanded through flexible, accessible, and patient centered models to improve long term cardiovascular outcomes.

Literature Review of Visit to Visit Lipid Variability as a Predictor of Cardiovascular Events Aidina Trini Aulia; Nurhikmawati Nurhikmawati; Akina Maulidhany Tahir; Fadillah Maricar; Purwati Pole Rio
Journal La Medihealtico Vol. 7 No. 1 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i1.2943

Cardiovascular disease remains a major global health problem due to its substantial contribution to morbidity and mortality. The World Health Organization reports that cardiovascular disease is the leading cause of death worldwide, accounting for approximately 17.9 million deaths each year. In Indonesia, reports from the Ministry of Health show a persistent increase in cardiovascular disease prevalence. Dyslipidemia, defined as an imbalance in blood lipid levels, is a major modifiable risk factor associated with cardiovascular events, making lipid control a key focus of preventive strategies. Visit to visit lipid variability (VLV) refers to fluctuations in lipid parameters such as total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides across different clinical visits over a certain period. Recent studies indicate that higher variability in lipid levels is independently associated with an increased risk of coronary heart disease, stroke, and cardiovascular mortality. This study adopted a literature review design to examine the role of VLV as a predictor of cardiovascular events. Ten national and international journal articles were selected based on predefined inclusion and exclusion criteria. The reviewed evidence consistently shows that high variability in lipid levels, particularly LDL-C and HDL-C, is linked to a greater risk of myocardial infarction, stroke, acute coronary syndrome, and cardiovascular-related death in various populations, including patients with diabetes mellitus and familial hypercholesterolemia. Conversely, maintaining stable lipid levels over time is associated with a reduced risk of adverse cardiovascular outcomes. These findings highlight the importance of continuous lipid monitoring and long-term lipid stability as essential components in efforts to prevent and control cardiovascular disease.

Literature Review : Hubungan antara Kejadian Hiperurisemia pada Pasien Congestive Heart Failure Nadiyah Nurfadhilah; Akina Maulidhany Tahir; Endy Adnan; Nurhikmawati Nurhikmawati
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.961

Congestive heart failure (CHF) is a progressive clinical syndrome associated with high morbidity and mortality. Hyperuricemia has been suggested to contribute to the development and progression of CHF through several pathophysiological mechanisms, including oxidative stress, endothelial dysfunction, inflammation, and ventricular remodeling. This literature review aimed to evaluate the association between hyperuricemia and the incidence, severity, complications, and prognosis of CHF based on current scientific evidence. A narrative literature review was conducted using secondary data obtained from national and international scientific journals, textbooks, and other relevant scientific sources published between 2015 and 2026. The reviewed evidence consistently demonstrated that hyperuricemia is associated with poorer clinical outcomes in patients with heart failure. Elevated serum uric acid (UA) levels were correlated with higher New York Heart Association (NYHA) functional class, impaired hemodynamic status, increased risk of CHF occurrence, hospital readmission, and mortality across various heart failure phenotypes. Several studies also identified serum UA as an independent predictor of disease severity and prognosis in patients with heart failure. In conclusion, hyperuricemia is significantly associated with the severity and clinical outcomes of CHF and may serve as an important prognostic biomarker. However, current evidence regarding the effectiveness of uric acid-lowering therapy in improving heart failure prognosis remains inconsistent; therefore, serum UA cannot yet be recommended as a definitive therapeutic target.

The correlation between hyperuricemia and the risk of congestive heart failure: a cross-sectional study in Indonesia Farah Nadia; Sri Julyani; Hanna Aulia Namirah; Irna Diyana Kartika; Nurhikmawati Nurhikmawati
International Journal of Health Science and Technology Vol. 7 No. 1 (2025): July
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/ijhst.v7i1.3959

Congestive Heart Failure (CHF) is a leading cause of morbidity and mortality worldwide and is the second most common cause of death in Indonesia. One factor that has recently gained attention is hyperuricemia, a condition characterized by elevated serum uric acid levels, which is closely linked to the pathogenesis of cardiovascular diseases. The underlying mechanism involves increased activity of the enzyme xanthine oxidase, which triggers oxidative stress, endothelial dysfunction, and systemic inflammation, all of which contribute to the progression of CHF. This study aims to examine the relationship between serum uric acid levels and the incidence of CHF at RSUD (Regional General Hospital) I Lagaligo, East Luwu Regency. This study employed observational analytic approach with cross-sectional design. Data were collected from the medical records of 102 CHF patients treated between January 2023 and June 2024. Uric acid levels and CHF types were classified based on ejection fraction (EF). Data analysis was done using the Chi-Square test. The results showed a significant association between uric acid levels and the type of CHF (p < 0.001). Among patients with reduced ejection fraction, 83.7% had elevated uric acid levels, while 55% of patients with preserved ejection fraction had normal levels. Conclusion: There is a significant correlation between uric acid levels and CHF. Monitoring uric acid levels has the potential to serve as a clinical indicator in the evaluation and management of CHF patients.

Literature Review: Myocardial infarction in Young Adults Ratu Trya Maharani; Nurhikmawati Nurhikmawati; Akina Maulidhany Tahir; Fadillah Maricar; Purwati Pole Rio
Journal of Asian-african Focus in Health Vol. 4 No. 1 (2026): Journal of Asian-african Focus in Health
Publisher : ScieClouds Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar

Myocardial infarction (MI) has traditionally been considered a disease of older adults; however, recent evidence indicates an increasing incidence among younger populations. This trend has raised significant clinical and public health concerns because MI occurring during productive years is associated with substantial long-term health, social, and economic consequences. Understanding the risk factors, clinical characteristics, and outcomes of MI in young adults is essential for improving prevention and management strategies. This study aimed to systematically review the current literature regarding myocardial infarction in young adults, with a particular focus on risk factors, clinical characteristics, and patient outcomes. A literature review was conducted using articles retrieved from PubMed, ScienceDirect, and Google Scholar. The search covered publications from 2021 to 2026 using keywords related to myocardial infarction, young adults, acute coronary syndrome, and cardiovascular risk factors. Articles were screened according to predefined inclusion and exclusion criteria. Following the selection process, 20 eligible studies consisting of observational studies, cohort studies, registry analyses, case series, and review articles were included in the final analysis. he findings demonstrate that myocardial infarction in young adults is a growing global health issue. Traditional risk factors, particularly smoking, dyslipidemia, obesity, hypertension, diabetes mellitus, and family history of cardiovascular disease, remain the primary determinants of disease occurrence. Emerging risk factors, including psychosocial stress, sleep disorders, autoimmune diseases, chronic inflammation, and substance abuse, also contribute significantly. Clinically, young patients commonly present with typical chest pain and predominantly single-vessel coronary artery disease, although non-atherosclerotic mechanisms such as spontaneous coronary artery dissection and myocardial infarction with non-obstructive coronary arteries are increasingly recognized. While short-term outcomes are generally more favorable than in older patients, long-term risks of recurrent cardiovascular events and persistent morbidity remain substantial. Myocardial infarction in young adults is a multifactorial condition requiring comprehensive risk assessment, early prevention, and long-term management strategies to reduce future cardiovascular burden.

Analisis Kejadian Kardiomegali pada Pasien Hipertensi dan Indeks Massa Tubuh (IMT) Berlebih di RS Ibnu Sina YW-UMI Makassar Farhani Amaliyah Mursyidin; Sri Julyani; Rahmawati Rahmawati; Nurhikmawati Nurhikmawati; Akina Maulidhany Tahir
MAHESA : Malahayati Health Student Journal Vol 5, No 12 (2025): Volume 5 Nomor 12 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i12.19776

ABSTRACT Enlargement of the heart organ, known as cardiomegaly, develops as a compensatory response to pressure overload and volume overload, which causes increased tension in the muscular walls of the heart. The onset of cardiomegaly can be triggered by hypertension and obesity. During prolonged high blood pressure conditions, the heart is forced to perform extra work in distributing blood to various parts of the body. Obesity leads to increased TNF-alpha produced by adipose cells. TNF-alpha then forms bonds with receptors in the myocardium and results in a series of myocyte apoptosis and fibrosis processes that lead to cardiomegaly. This study was conducted to observe the incidence of cardiomegaly in patients with hypertension and excessive Body Mass Index (BMI) who were treated at Ibnu Sina YW-UMI Hospital Makassar. The method applied was descriptive observational through a cross-sectional design. Sample collection was conducted through secondary data. Data analysis was performed using univariate and bivariate approaches. From a total of 119 samples, it was found that 32 samples (26.9%) had cardiomegaly with hypertension, 30 samples (25.2%) had cardiomegaly with excessive BMI, and 57 samples (47.9%) had cardiomegaly with both hypertension and excessive BMI. The research results showed a significant relationship between hypertension and excessive BMI with the incidence of cardiomegaly (p= 0.01). Based on observations, the largest number of samples was found in the group of patients with hypertension who had excessive BMI, reaching 57 samples for cardiomegaly cases. Keywords: Cardiomegaly, Hypertension, Body Mass Index (BMI) ABSTRAK Pembesaran organ jantung yang disebut kardiomegali timbul sebagai respon kompensatoris akibat pressure overload maupun volume overload, yang menyebabkan bertambahnya ketegangan pada dinding muskular jantung. Munculnya kardiomegali dapat dipicu oleh kondisi hipertensi serta kegemukan. Saat kondisi tekanan darah tinggi berlangsung lama, organ jantung dipaksa melakukan kerja ekstra dalam mendistribusikan darah ke berbagai bagian tubuh. Kondisi kegemukan mengakibatkan peningkatan TNF alfa yang diproduksi sel adiposa. TNF alfa kemudian membentuk ikatan dengan reseptor di miokard dan mengakibatkan rangkaian proses apoptosis miosit dan fibrosis yang berujung pada kardiomegali. Penelitian ini dilaksanakan guna mengamati jumlah kejadian kardiomegali pada pasien hipertensi dan Indeks Massa Tubuh (IMT) berlebih yang dirawat di RS Ibnu Sina YW-UMI Makassar. Metode yang diterapkan ialah observasional deskriptif melalui desain cross sectional. Teknik pengumpulan sampel dilakukan melalui data sekunder. Analisis data secara univariat dan bivariat. Diketahui dari total 119 sampel, yang mengalami kardiomegali dengan hipertensi sebanyak 32 sampel (26,9%), kardiomegali dengan IMT berlebih sebanyak 30 sampel (25,2%), dan kardiomegali dengan hipertensi dan IMT berlebih sebanyak 57 sampel (47,9%). Hasil penelitian menunjukkan hubungan yang signifikan dalam keterkaitan hipertensi dan IMT berlebih dengan kejadian kardiomegali (p= 0,01). Berdasarkan pengamatan, jumlah sampel terbesar ditemukan pada kelompok pasien dengan hipertensi yang memiliki IMT berlebih, mencapai 57 sampel untuk kejadian kardiomegali. Kata Kunci: Kardiomegali, Hipertensi, IMT Berlebih

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