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All Journal Majalah Kedokteran Sriwijaya Indonesian Journal of Biomedicine and Clinical Sciences
Yenny Febriany
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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ASSOCIATION OF DERMATOGLYPHIC PATTERNS WITH OVARIAN CANCER Yenny Febriany; Triwani Triwani; Herman Yasin; Joko Marwoto
Majalah Kedokteran Sriwijaya Vol 54, No 3 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i3.19659

Abstract

Ovarian cancer passed down in the family through inheritance of BRCA1 and BRCA2 genes that have been mutated. The objective of this research was to explore the relationship between dermatoglyphic patterns and ovarian cancer. Research method used an observational analytic using case-control design taking place at Obstetrics Inpatient Ward in RSUP Dr. Mohammad Hoesin Palembang. Samples of case and control groups were selected by using consecutive sampling method (Non probability). This method included all patients that meet the inclusion criteria as part of the sample in order to fullfill number of samples required to perform the analysis, and sample selection was done during certain period. Chi-Square test was used to analyze correlation between fingerprint patterns (Arch, Loop, and Whorl) and ovarian cancer. Independent sample t-test used to find average discrepancy of TRC (Total Ridge Count) and ATD angle. These statistical analyses were done by using SPSS for Windows. Research result indicated that most ovarian cancer samples had dermatoglyphic pattern; followed by Loop (52.4%) Whorl (44.2%), and Arch (3.3%). Dankmeijer and Furuhata indices of ovarian cancer were 3.91 and 68.45, respectively. There was a significant relationship between ovarian cancer patients’ and non-ovarian cancer patients’ fingerprints pattern, with Whorl pattern p value = 0.004 and Loop pattern p value = 0.005. There was no significant difference of Total Ridge Count (TRC) between ovarian cancer patients and non-ovarian cancer patients, with p value = 0.238. There was no significant difference of average angle of right ATD, with p value = 0.893, and average angle of left ATD, with p value = 0.323, between ovarian cancer patients and non-ovarian cancer patients.
Secondhand smoke exposure and its role in the pathogenesis of preeclampsia: a narrative review of molecular and epidemiological perspectives Yenny Febriany; Irfannuddin; Mohammad Zulkarnain; Yusuf Effendi
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 2 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i2.19209

Abstract

Preeclampsia (PE) is a pregnancy complication characterized by hypertension after 20 wk of gestation, often accompanied by proteinuria or organ dysfunction. This condition is linked to genetic, environmental factors, and exposure to secondhand smoke (SHS). This study explores the relationship between SHS exposure and PE risk through a narrative literature review. Epidemiological and molecular studies data demonstrate that SHS exposure increases PE risk via oxidative stress, inflammation, and angiogenic disruptions. The analysis reveals that SHS exposure enhances reactive oxygen species (ROS) production, triggers systemic inflammation through the NF-κB pathway, and impairs angiogenic function by lowering the PlGF/sFlt-1 ratio. The risk significantly increases with exposures ≥2 hr/d or weekly frequencies ≥4 d, particularly in poorly ventilated domestic and occupational settings. Biomarkers such as cotinine and carbon monoxide (CO) are employed to assess exposure levels, providing robust evidence that duration and intensity of exposure are pivotal in PE pathogenesis. These findings highlight the importance of preventive strategies, including smoking bans, public health education, and integration of biomarker-based assessments into prenatal care. Future research should aim to clarify the molecular and epigenetic mechanisms involved and explore therapeutic interventions to mitigate SHS-induced damage.
Co-Authors Herman Yasin Irfannuddin Irfannuddin Joko Marwoto Triwani Triwani Yusuf Effendi Zulkarnain, Mohammad