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All Journal Medula JURNAL PENELITIAN PERAWAT PROFESIONAL
Exsa Hadibrata
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Journal : Medula

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Pengaruh Jus Tomat (Solanum lycopersicum) terhadap Tebal Epitel Seminiferus Tikus Putih Galur Sprague dawley yang Diinduksi Gentamisin Fahmi Ikhtiar; Exsa Hadibrata
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.382

Abstract

Aminoglycosides including gentamicin have been used successfully for decades in the treatment of gram-negative bacterial infections. However, gentamicin produces testicular toxicity, resulting in limited therapeutic doses. Lycopene, one of the antioxidants in tomatoes, has singlet-oxygen and free radical scavenging capacity. Moreover, lycopene serves as a promising intervention for testicular toxicity associated with oxidative stress. Researchers wanted to see the effect of tomato juice on the seminiferous tubules of white rats. This type of research is experimental research with post test only control group design. The rats used were 29 male white rats (Rattus novergicus) which were divided into 5 groups, namely the negative control group as normal control. The positive control group was given gentamicin 20 mg/kgBW. Treatment groups 1, 2, and 3 were the treatment groups with gentamicin 20 mg/kgBW and tomato juice 25%, 50%, and 100%. Gentamicin was given for 10 days and tomato juice was given for 24 days. Data analysis was carried out using the One Way Annova method and continued with Post Hoc. After statistical testing, there was a significant effect of giving tomato juice on seminiferous epithelial thickness induced by gentamicin in white rats of the Sprague Dawley strain (p<0.05).
Ewing Sarkoma: Ulasan Singkat Keganasan: Indonesia Rafi Gutra Aslam; Helmi Ismunandar; Risal Wintoko; Exsa Hadibrata; Anisa Nuraisa Jausal
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.336

Abstract

A malignancy that identified first by James Ewing in 1921. Ewing sarcoma is a malignancy of the bones caused by abnormal activity of progenitor cell mesenchymal occurs by a genetic factor where the patient had a combination of translocation chromosome non-random in t(11; 22) (q24;q12) or t(21; 22) (q22; q12). The patient will have pathognomonic findings of periosteal reaction similar to "Onion skin", lesions like “Moth-eaten”, and “Codman’s Triangle” in radiology findings. Second highest malignancy bone prevalent worldwide after osteosarcoma. This malignancy occurs commonly in the male gender, incidence peaked in the approximately first decade in life with a prognosis range of about 5 years more or less. The malignancy occurs in the metaphysis-diaphysis part of the bone that has a variety of prognoses based on stage, metastasis, and therapy. Literature Review method is used in this article writing by article, journal, and book that review shortly about Ewing sarcoma from multi-aspect of etiology, epidemiology, pathogenesis and pathophysiology, clinical manifestations, treatment, staging, prognosis, complication, and education as the last topic. Prognosis of Ewing Sarcoma patient will be better if given multimodal therapy including chemotherapy, radiotherapy, and operation that adjusted with the condition in every patient. Nevertheless, further research is needed about best treatment in goals to extend patient survivability and enhance prognoses approximately in 3 years.
Co-Authors Anisa Nuraisa Jausal Fahmi Ikhtiar Helmi Ismunandar Mars Dwi Tjahyo Rafi Gutra Aslam Risal Wintoko Suharmanto Suharmanto