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Rafi Gutra Aslam
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Labyrinthitis: Comprehensive Literature Review Of Inner Part Ear Infection Rafi Gutra Aslam; Putu Ristyaning Ayu Sangging; Rani Himayani
Medula Vol 13 No 4.1 (2023): Medula - Edisi Spesial (Special Sense)
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.1.684

Abstract

Labyrinthitis (Internal otitis) is an inflammation process of the ear labyrinth located in the inner part of the ear. Labyrinthitis has distinctive symptoms that combine from hearing ability and balance disturbance that cause  sensorineural type deafness and vertigo. This paper uses the literature review method as a  chosen method that chooses from bibliographic that last 15 years ago to discuss comprehensively about labyrinthitis. Labyrinthitis  is a condition that generally happens in elder age because the disturbance of the vestibulocochlear system  that has similarity with other health problem such as Ménière disease, patient history and advance examination comprehensively needed to rule out labyrinthitis with another health related to balance and hearing  problem. Labyrinthitis prognosis is bonam if treatment occurs as soon as possible and there is no expansion found into another region adjacent to the ear structure that potentially cause severe complication. Despite of severe complication is rare in post-antibiotic era, complication  could still happen in few patient and become life threatening problem because of it’s site adjacent with brain anatomy structure, therefore treatment could  be given to the patient with this condition. Further research need to discuss about another therapy option that available to treat the Labyrinthitis from every classification such as viral, bacteria, autoimmune, immunodeficiency, ossificant, and even the recent one associated with COVID-19 pandemic.
Ewing Sarkoma: Ulasan Singkat Keganasan: Indonesia Rafi Gutra Aslam; Helmi Ismunandar; Risal Wintoko; Exsa Hadibrata; Anisa Nuraisa Jausal
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.336

Abstract

A malignancy that identified first by James Ewing in 1921. Ewing sarcoma is a malignancy of the bones caused by abnormal activity of progenitor cell mesenchymal occurs by a genetic factor where the patient had a combination of translocation chromosome non-random in t(11; 22) (q24;q12) or t(21; 22) (q22; q12). The patient will have pathognomonic findings of periosteal reaction similar to "Onion skin", lesions like “Moth-eaten”, and “Codman’s Triangle” in radiology findings. Second highest malignancy bone prevalent worldwide after osteosarcoma. This malignancy occurs commonly in the male gender, incidence peaked in the approximately first decade in life with a prognosis range of about 5 years more or less. The malignancy occurs in the metaphysis-diaphysis part of the bone that has a variety of prognoses based on stage, metastasis, and therapy. Literature Review method is used in this article writing by article, journal, and book that review shortly about Ewing sarcoma from multi-aspect of etiology, epidemiology, pathogenesis and pathophysiology, clinical manifestations, treatment, staging, prognosis, complication, and education as the last topic. Prognosis of Ewing Sarcoma patient will be better if given multimodal therapy including chemotherapy, radiotherapy, and operation that adjusted with the condition in every patient. Nevertheless, further research is needed about best treatment in goals to extend patient survivability and enhance prognoses approximately in 3 years.
Co-Authors Anisa Nuraisa Jausal Exsa Hadibrata Helmi Ismunandar Rani Himayani Risal Wintoko Sangging, Putu Ristyaning Ayu