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PERBEDAAN KADAR ASAM URAT TIKUS PUTIH (Rattus norvegicus) SETELAH PEMBERIAN KACANG TANAH (Arachis hypogaea L.) Nabila Nuranjumi; agustyas tjiptaningrum; sofyan musyabiq; hanna mutiara
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.412

Abstract

The excessive uric acid levels in the body can increase the risk of hyperuricemia. The formation of uric acid starts from the synthesis of purines which produce inosine, adenine and guanine monophospate that will be degraded into uric acid. Peanuts contain purines so if it is consumed in excess, it can increase blood uric acid levels. To know the difference in the average blood uric acid levels of rats given peanuts at a dose of 1gr/200grBB, 2gr/200grBB, 4gr/200grBB and not given peanuts. This research used experimental research with post test control group design approach. The sample in this research used 28 rats that divided into 4 groups; K1 were only given standard feed, P1 were given 1gr / 200grBB peanuts, P2 were given 2gr/200grBB peanuts and P3 were given 4gr/200grBB peanuts in everyday for 28 days. Then measuring the blood uric acid levels of rats. The average blood uric acid level of rats before intervention (K1) is 3,28mg/dl, and after intervention is 3,87mg/dl (P1), 4,20mg/dl (P2) and 5,03mg/dl (P3). There is a significant difference between P2 and K1 (p=0,005 ), P3 and K1 (p=0,000 ). There is no a significant difference between P1 and K1 (p=0,130 ). There is a significant difference in the average blood uric acid level of rats given peanuts at a dose of 2gr/200grBB, 4gr/200grBB and not given peanuts. There is no significant difference in the average blood uric acid level of rats given peanuts at a dose of 1gr/200grBB and not given peanuts.
Tatalaksana Malaria Berat Gigaramadan Sema; Hanna Mutiara; Tri Umiana Soleha
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.584

Abstract

Malaria is a disease caused by the infection of Plasmodium parasite. Severe Malaria is accompanied by complications such as cerebral Malaria, seizures, acute kidney failure, hemodynamic shock, and so on. intravenous artesunate is the first-line treatment for severe Malaria caused by all Plasmodium species. Early RRT therapy is necessary to manage acute renal failure, also careful fluid resuscitation is important to prevent lethal pulmonary edema. Delayed-onset hemolysis following Artesunate administration necessitate hemoglobin checks and post-treatment monitoring. ACT treatment is the first line treatment after complications have subsided, followed by primaquine administration to treat relapse cases. G6PD testing is required before primaquine administration to prevent hemolysis.  
Perbandingan Pemeriksaan Tinja Metode Sedimentasi Formol-ether dengan Metode Kato-Katz dalam Mendeteksi Soil-transmitted Helminth.: . Rilianda Abelira; Hanna Mutiara
Medula Vol 13 No 4 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i4.672

Abstract

Soil-transmitted Helminth (STH) is the most common intestinal parasitic infection that contribute to the global disease burden. Various health problems may occur due to this infection. STH infections can be diagnosed by microscopic examination of the stool. WHO recommends the Kato-Katz method as the gold standard for detecting STH, but this method is less sensitive to mild infections. Another method recommended for mild infections is the formol-ether concentration (FEC) method. Some studies show different results for the comparison of these two methods. This study aims to compare the result of the stool examination between FEC method and the Kato-Katz method in detecting STH. Evaluation of examination methods is important in the search for accurate diagnostic techniques.This study used stored stool samples. The study design was descriptive analytic with cross sectional approach. The sampling technique used is consecutive random sampling. Data were analyse based on STH frequency with McNemar's comparative statistical test. The microscopic picture of the FEC method is clearer than the microscopic picture of Kato-Katz method. The results of stool examination using the FEC method and the Kato-Katz method obtained positive results of 6 samples (20%) and negative samples of 24 samples (80%), same result for both method. The type of worm eggs found was Ascaris lumbricoides with 6 samples (100%). Hookworms (A.duodenale and N. americanus) found by FEC method was 2 samples (33.3%) of 6 positive samples. McNemar test results obtained p value of 1,000 (> α 0.05).There is no statistically significant difference from the results of the comparison of stool examination with the FEC method and the Kato-Katz method using McNemar test.
Co-Authors agustyas tjiptaningrum Gigaramadan Sema Nabila Nuranjumi Rilianda Abelira Sofyan Musyabiq Wijaya Tri Umiana Soleha