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PEMANFAATAN KULIT MANGGIS (Garcinia mangostana L) SEBAGAI FORMULASI TABLET ANTI KANKER YANG PRAKTIS DAN EKONOMIS Shalahuddin Al Madury; Farida Fakhrunnisa; Azizah Amin
Khazanah: Jurnal Mahasiswa Vol. V, No. 2, Januari 2013
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/khazanah.vol5.iss2.art1

Based on data from the World Health Organization (WHO 2010) deadly disease cancer is number two in the world after heart disease. Therefore, there is need for intensive treatment to overcome these health problems, as proclaimed in the draft long-term development of health of the Republic of Indonesia. One of the plants can be used as an anticancer is mangosteen, Garcinia mangostana L. This plant contains a compound-mangostin xanthone especially play a role in cancer treatment with antioxidants that work crate scavenge free radicals so that a non-radical compounds. Required best alternative in tablet dosage that use more practical and economical as the innovation of the preparation syrups tend to be more complicated and expensive. The method used in this study using the literature method. From the discussion carried out could be concluded that mangosteen peel extract (Garcinia mangostana L) is effective for the treatment of cancer with good stability and a practical and economical, so is very potential to be accepted by society.

REVIEW: PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITY OF Strobilanthes crispus Amin, Azizah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1252

Strobilanthes crispus (S. crispus), called keji beling leaves, is a plant belonging to the genus Strobilanthes and family Acanthaceae. Keji beling (S.crispus) has been applied by Indonesians to cure some diseases like diabetes and dissolve kidney stones. The aim of this review article is to compile an update on the phytochemical studies and pharmacological activity of S. crispus. A literature review was carried out by searching for articles in the Scopus, PubMed, and Google Scholar data bases between 2014-2024. Studies have shown that the leaves of S. crispus contain flavonoids, phenolics, alkaloids, tannins, terpenoids, phytosterols, and fatty acids. Current pharmacological studies have revealed that the extracts, fractions, or secondary metabolites of S. crispus possess antimicrobial, antioxidant, antidiabetic, anti-urothelial, immunomodulatory, wound healing, cytotoxic, and anti-cancer activities. Although previous studies have provided information about S. crispus, pharmacological and phytochemical data are still limited. Further studies are still necessary to explore the bioactive compounds, toxicity, safety and future development of S.crispus as herbal medicine Keywords: keji beling, Strobilanthes crispus, phytochemical constituent, pharmacological activity

Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.

Optimization And Characterization of Silver Nanoparticle Biosynthesis Using Parijoto Fruit (Medinilla speciosa) Water Extract With Box-Behnken Design Nurjana, Qinta Laily; Amin, Azizah; Annisa, Viviane; Munawiroh, Siti Zahliyatul
Journal of Food and Pharmaceutical Sciences Vol 13, No 2 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21683

Silver nanoparticles in the medical field are used as additives in vaccines, anti-diabetic agents, wound and bone healing, biosensors and anticancer therapy in medical applications. One of the plants that can act as a reducing agent in the biosynthesis of silver nanoparticles is the parijoto fruit (Medinilla speciosa). This study aims to optimize and characterize the biosynthesis of silver nanoparticles from the water extract of parijoto fruit (M. speciosa) with a box-behnken design. The method used in this study starts from the manufacture of water extract of parijoto fruit (M. speciosa) then continued with the biosynthesis of silver nanoparticles. The formula for the biosynthesis of silver nanoparticles will be optimized with a box-behnken design and characterized by Particle Size Analyzer (PSA), Fourier Transform Infrared (FTIR), and Transmission Electron Microscopy (TEM). The results obtained in this study will be analyzed using descriptive techniques. The optimization results with the Behnken box design showed an optimal formula with an extract concentration of 1%, a sonication time of 6 minutes, and a sonicator pulser of 30. The particle size obtained was 85 ± 0.1 nm with a PI of 0.486 ± 0.006 and a zeta potential of -27.3 ± 1.5. The FTIR spectrum showed C=O, C-O and O-H groups indicating flavonoid compounds as bioreductant agents. The morphology of silver nanoparticles showed instability. (4) Conclusions:the optimization of silver nanoparticles from parijoto fruit water extract (M. speciosa) have been discovered used the Box-Behnken design and has good silver nanoparticle characteristics.

UPAYA PENGEMBANGAN EKONOMI MASYARAKAT DENGAN PEMBUATAN SEDIAAN OBAT TRADISIONAL DI KECAMATAN TEGALREJO, KOTA YOGYAKARTA, DAERAH ISTIMEWA YOGYAKARTA Romadhonsyah, Fitra; Amin, Azizah; Jumaryatno, Pinus; Riyanto, Riyanto; Haryanto, Yon; Karunia, Bibit Cahya; Hartanto, Hartanto; Azzami, Muhyiddin Fathan
As-Sidanah Vol 7 No 2 (2025): OKTOBER
Publisher : LP2M Universitas Ibrahimy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35316/assidanah.v7i2.327-343

Jamu is one of Indonesia's traditional medicines that is widely consumed by the public. According to a national survey in 2023, nearly 50% of Indonesians use jamu for treatment or maintaining their health. Public interest in jamu has been increasing in recent years, creating more opportunities to generate new jobs. However, a major challenge is the lack of knowledge among entrepreneurs and the public about processing raw materials for jamu and developing innovative products. The purpose of this community service program is to enhance knowledge and skills in processing raw materials into innovative jamu products with high market value. The program's partners are the members of RT 15/RW 5, Tegalrejo District, Yogyakarta. A total of 52 members of RT 15/RW 5 Tegalrejo participated in this activity. The method used in this community service program is service learning, involving the UII pharmacy department and the community on the topic of traditional medicine production, including providing basic information about traditional medicine to the community and conducting preliminary tests to assess initial understanding.. It is followed by a training on making jamu products, such as instant ginger powder, beras kencur drinks, and butterfly pea flower drinks. The activity concludes with a post-test. The results show that this community service program improves understanding of traditional medicine and enhances the community's skills in producing marketable traditional medicine products, which can serve as business ideas in the traditional medicine sector.

Melastoma malabathricum as a Natural Antioxidant Modulator: A Systematic Review of Its Molecular Mechanisms in Reducing Reactive Oxygen Species Vega, Nadia; Amin, Azizah; Anami Riastri
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 11 No. 1 (2026)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v11i1.44386

Melastoma malabathricum L. (MM) exhibits antioxidant potential, reducing oxidative stress caused by free radicals, as demonstrated by various research methods, including phytochemical, in vitro, and in vivo tests. This study aims to compile a comprehensive review of the scientific literature on the phytochemical profile and antioxidant activity of MM, as well as its mechanism of action in suppressing oxidative stress. The research method employed a review, with searches conducted in databases such as ScienceDirect, Scopus, and PubMed. The articles were then systematically selected according to PRISMA guidelines. The screening criteria included full-text articles published in English between 2016 and 2025, focusing on original research relevant to the antioxidant properties of MM. A total of 40 articles were deemed eligible after screening. MM shows potential as a natural antioxidant, with the most bioactive compounds being flavonoids such as quercetin and kaempferol. In vivo tests showed increases in enzymatic and non-enzymatic antioxidant systems, accompanied by decreases in oxidative stress biomarkers such as MDA, and modulation of key molecular pathways involving nitric oxide (NO). These results support the potential of MM in preventing oxidative stress associated with degenerative diseases.

Antioxidant and Antibacterial Activity of Plectranthus scutellarioides (L.) R.Br. Ethanol Extract against Staphylococcus aureus Anami Riastri; Yuliana Safitri; Azizah Amin
AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) Vol. 10 No. 3 (2026)
Publisher : Asia Pacific Network for Sustainable Agriculture, Food and Energy (SAFE-Network)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29165/ajarcde.v10i3.1096

Plectranthus scutellarioides (L.) R.Br., commonly known as Coleus scutellarioides, has been traditionally recognized for its medicinal properties, yet the synergy between its antioxidant capacity and its antibacterial efficacy against clinical pathogens, using modern extraction techniques remains limited and underexplored. This study aimed to evaluate the antioxidant activity and antibacterial efficacy of the ethanol extract of P. scutellarioides leaves against Staphylococcus aureus. The extract was obtained by ultrasonic-assisted extraction (UAE) using 96% ethanol as the solvent. Antioxidant activity was assessed through DPPH radical scavenging and ferric reducing antioxidant power (FRAP) assays. The antibacterial potential was determined by minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) using the dilution method. The ethanolic extract of P. scutellarioides exhibited antioxidant activity with an IC50 value of 154.54 ppm for DPPH and 146.47 ppm for FRAP assays, compared to vitamin C controls with IC50 values of 3.54 ppm and 3.57 ppm, respectively. Furthermore, the extract showed antibacterial activity against S. aureus with MIC and MBC values of 1.95 mg/mL and 3.90 mg/mL, respectively. These findings demonstrate that the ethanol extract of P. scutellarioides leaves possesses moderate antioxidant and significant antibacterial activities, highlighting its potential as a natural source for therapeutic agents. Contribution to Sustainable Development Goals (SDGs):SDG 3: Good Health and Well-BeingSDG 9: Industry, Innovation, and InfrastructureSDG 12: Responsible Consumption and ProductionSDG 15: Life on Land

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