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All Journal Oto Rhino Laryngologica Indonesiana Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Kedokteran Ibnu Nafis
Adi Koesoema Aman, Adi Koesoema
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Peran reseptor vascular endothelial growth factor (VEGF) pada konka hipertrofi disebabkan oleh rinitis alergi Zachreini, Indra; Dahlan Lubis, Muhammad Nadjib; Aman, Adi Koesoema; Suprihati, Suprihati
Oto Rhino Laryngologica Indonesiana Vol 46, No 2 (2016): Volume 46, No. 2 July - December 2016
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (856.531 KB) | DOI: 10.32637/orli.v46i2.160

Abstract

Latar belakang: Konka hipertrofi walaupun tidak mengancam jiwa, namun dapat menyebabkan gangguan kualitas hidup akibat sumbatan hidung. Patogenesis terjadinya konka hipertrofi adalah akibat airway remodelling terutama pada konka nasal inferior. Vascular endothelial growth factor (VEGF) merupakan salah satu faktor angiogenik yang berperan dalam proses neovaskularisasi. Bagaimana peran angiogenik reseptor VEGF pada konka hipertrofi yang terjadi pada rinitis alergi, sampai saat ini belum jelas dan belum banyak diteliti. Tujuan: Mengetahui peran VEGF sebagai faktor angiogenesis pada konka hipertrofi yang terjadi pada rinitis alergi. Metode: Penelitian ini bersifat observasional analitik dengan rancangan case control pada sampel penelitian yang memenuhi kriteria inklusi. Reseptor VEGF diperiksa secara imunohistokimia, di mana nilainya terdiri dari nilai negatif dan positif. Hasil: Pada penelitian ini, didapati nilai odds ratio 0,11 dan 95% CI 0,013-0,982. Hal tersebut menunjukkan bahwa reseptor VEGF berperan sebagai faktor protektif pada konka hipertrofi yang terjadi pada rinitis alergi. Kesimpulan: Reseptor VEGF dianggap berperan sebagai faktor protektif terjadinya konka hipertrofi yang terjadi pada rinitis alergi.Kata kunci: Reseptor vascular endothelial growth factor, konka nasal hipertrofi, rinitis alergi, imunohistokimia ABSTRACT Background: Although hypertrophic turbinate is not life threatening, this condition often decreases quality of life, resulted from nasal obstruction. Pathogenesis of hypertrophic turbinate resulted from airway remodeling especially in inferior turbinate. Vascular endothelial growth factor (VEGF) is one of angiogenic factors which has a role in neovascularitation process. However, it is still unclear what is the role of VEGF receptor in angiogenic of allergic rhinitis, and until now there were very few studies about this matter. Purpose: To identify the role of VEGF as an angiogenic factor in hypertrophic turbinate caused by allergic rhinitis. Methods: This study was an analytical observation by case control method. VEGF receptors were examined by immunohistochemistry with negative and positive result. Result: This study found odds ratio 0.11 and 95% CI 0.013-0.982, which means that VEGF receptor was a protective factor in hypertrophic turbinate caused by allergic rhinitis. Conclusion: VEGF receptor was considered as a protective factor for the occurrence hypertrophic turbinate caused by allergic rhinitis.Keywords: Vascular endothelial growth factor receptor, hypertrophic turbinate, allergic rhinitis, immunohistochemistry
ACTIVATED PARTIAL THROMBOPLASTIN TIME AND FIBRINOGEN IN PEDIATRIC NEPHROTIC SYNDROME DURING RELAPSE AND REMISSION Tarigan, Trianita; Aman, Adi Koesoema; Ramayani, Oke Rina
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1410

Abstract

         Nephrotic Syndrome (NS) is a complicated kidney disease disorder, one of the most important complications is thromboembolism which can affect the circulation, either arterial or venous in both pediatric and adult patients. Patients at risk of thromboembolism should have an angiography examination for diagnosis. There have been several studies conducted on patients with a nephrotic syndrome showing the risk of thromboembolism. This study included twelve patient of pediatric nephrotic syndrome consisting of males and females. The patient experiences a period of relapse and became a remission. Patients participating in the study were 3 to 17 years old. There were significant differences in fibrinogen in which the fibrinogen content of NS patients in children at relapse was higher compared with the time of remission (390.08 ± 164.87 vs. 273.17 ± 150.56; p=0.042). There was no significant difference in Activated Partial Thromboplastin Time (APTT) results in SN patients in relapse compared to remission (34.17 ± 5.65 vs. 30.08 ± 8.49; p=0.236). The high levels of fibrinogen in the relapse period indicate the presence of hypercoagulable state, along with other examinations such as high cholesterol and low albumin. In this study, there was no significant difference in APTT among SN patients during relapse compared with remission while in the fibrinogen examination a significant difference was found. Therefore, fibrinogen examination is important to be analyzed in order to avoid SN complications. 
KADAR D-DIMER PLASMA DI STROK ISKEMIK AKUT Mayke, Yessi; Aman, Adi Koesoema; Anwar, Y.
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1105

Abstract

Ischemic stroke is a clinical sign of brain dysfunction or tissue damage caused by lack of blood flow to the brain that disrupts theblood and oxygen requirements in the brain tissue. In Indonesia, stroke is the third ranks after heart disease and malignancy. The promptdiagnosis can reduce morbidity and mortality. CT-scan is the gold standard, but it has some limitations that are difficult to recognize theearly signs of ischemia on the first day and the cost of the related treatment is expensive. Because of these limitations, such case requireanother sign that is noninvasive, sensitive, specific, easier and cheaper to detect the presence of thrombus while the cause of ischemicstroke is D-dimer. This study was design to know the diagnostic value of plasma levels of D-dimer of the CT-scan in acute ischemic strokeby determination. A cross-sectional study was conducted, where forty patients with inclusion criteria were taken from The NeurologyDepartment. The research was done at the Department of Clinical Pathology RSUP.H.Adam Malik/FK USU Medan. CT-scan as the goldstandard for the D-dimer examination Plasma levels of D-dimer using latex agglutination method with a cut-off 500/mL. Statisticalanalysis using a 2×2 table to determine the sensitivity, specificity, positive predictive value, negative predictive value, prevalence and thelikelihood ratio. The result found were as follows: sensitivity 77.7%, specificity 53.8%, positive predictive value 77.7%, negative predictivevalue 53.8%, prevalence 67.5%, likelihood ratio positive 1.74 and the likelihood ratio negative 0.43. Based on this study, the level plasmaD-dimer could possibly can be used as an exclusion diagnostic in acute ischemic stroke case.
CORRELATION BETWEEN PLATELET TO LYMPHOCYTE RATIO AND CORONARY ARTERY NARROWING Marziah, Enny; Aman, Adi Koesoema; Ketaren, Andre Pasha
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 24, No 3 (2018)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v24i3.1331

Abstract

Coronary Heart Disease (CHD) is one of the most common diseases of the cardiovascular system, characterized by atherosclerotic lesions. Atherosclerotic vascular processes are multifactorial. One of the factors is the process of inflammation. Platelet to Lymphocyte Ratio (PLR) is a marker that predicts the atherosclerotic coronary burden. The purpose of this research was to determine the correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients. This research was an analytical observation with a cross-sectional design, conducted on 54 patients with CHD who underwent angiography at the Adam Malik Hospital, Medan in February–October 2016. We examined platelet count, absolute lymphocyte count and percentage of coronary artery narrowing and coronary artery narrowing in CHD patients. There is a weak correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients ((r=0.276)). The result of the statistic test showed no significant correlation of platelet to lymphocyte ratio and coronary artery narrowing patients (p=0.043). In this study there is a weak correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients.
Profile Laboratory of Thalassemia in the General Hospital Dr. Zainoel Abidin Banda Aceh Mutiawati, Vivi Keumala; Aman, Adi Koesoema
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2218

Abstract

Thalassemia refers to the globin gene abnormality that affects the a and b globin genes. A comprehensive peripheral blood laboratory examination, Mentzer index, blood morphology, and Hb analysis were all performed on every patient with thalassemia who attended treatment as part of this analytical observational study. This research aims to know the profile of laboratory examinations of thalassemia patients in the Dr. Zainoel Abidin General Hospital (RSUZA) Banda Aceh. The study's target population was 547 individuals, with 278 males and 269 females making up the male and female split, respectively (50.7% and 49.3%). With a total of 197 subjects (36.4%), this study revealed that the subjects were most frequently found in the age range of 0–5 years. Only 8 subjects, or 1.5%, of the population in the over-65 age group, were detected. The typical value of the erythrocyte index further fell and was discovered in 469 participants with a value of 85.3%. A total of 504 patients, or 91.6%, had more elevated RDW features. Results for the Mentzer index with 432 subjects were determined to be 13 were 78.5%. In the 450-subject hypochromic microcytic group, subjects were most frequently observed (81.8%). Blood morphology features from 505 participants, or 91.8% of the total, showed no additional blood morphology characteristics in normoblasts, and from 361 subjects, or 65.6% of the total, showed no target cells. When a person has anemia or a family history of thalassemia, it is strongly advised that they get a full blood count (CBC). The proper laboratory testing is still necessary for the health issue of thalassemia. 
The Relationship between Plasminogen Activator Inhibitors and the Severity of COVID-19 Troeman, Kyna; Aman, Adi Koesoema; Nasution, Malayana Rahmita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2245

Abstract

The fibrinolysis process is assisted by plasminogen activators and inhibitors by converting plasminogen into plasmin, which later will promote the fibrinolysis process. Incomplete fibrinolysis increases the risk of thrombosis in patients with COVID-19. Plasminogen Activator Inhibitor (PAI-1) plays an important role as acute phase reactants to be used as a marker to assess the prognosis and mortality of COVID-19 patients. This study aimed to elaborate on whether fibrinolysis shutdown occurs in COVID-19 patients using PAI-1 as a marker of fibrinolysis. This was a cross-sectional analytical study from November 2022 to May 2023. This research consisted of a total of 39 patients with COVID-19, hospitalized at Haji Adam Malik General Hospital, Medan. PAI-test in COVID-19 patients was carried out with the ELISA method using Chemwell Analyzer. The severity of COVID-19 measured by clinical examination was divided into moderate, severe, and critical. The association between the two variables was subjected to a comparative test followed by a correlation test to explore the association between the two variables with an independent T-test. In this study, the median PAI-1 level was 1.77 ng/mL (0.71–11.49 ng/mL). The highest PAI-1 levels were observed in the critical severity group, followed by the severe and moderate group of 8.54 ng/mL (5.76–10.84), 2.45 ng/mL (0.71–11.49), and 1.29 ng/mL (0.73–3.77), respectively. There was a significant relationship between PAI-1 levels and the severity of COVID-19 patients (p=0.003). PAI-1 cut-off value of 1.89 ng/mL may predict the degree of COVID-19 severity with sensitivity of 88.9%, specificity of 90.5%, and accuracy of 89.7%. This study classified the severity of COVID-19 into two categories, which are moderate (n=21) and severe-critical (n=18) to obtain the AUC value of PAI-1. PAI-1 can be used to predict the severity of COVID-19 disease with a moderate level (AUC >70–80%). This phenomenon can be secondary to enhanced platelet aggregation, inflammation micro thrombosis, and impaired fibrinolysis. Fibrinolysis disorders lead to a fibrin buildup and increased levels of PAI-1 in the circulation.
PERBEDAAN HASIL HITUNGAN DARAH LENGKAP SEBELUM DAN SESUDAH FASE INDUKSI PADA ANAK DENGAN LEUKEMIA LIMFOBLASTIK AKUT: DIFFERENCES IN COMPLETE BLOOD COUNT RESULTS BEFORE AND AFTER THE INDUCTION PHASE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA Siregar, Yoga Rhamada; Aman, Adi Koesoema; Nasution, Malayana Rahmita; Arto, Nindia Sugih; Permatasari, Ranti
Jurnal Kedokteran Ibnu Nafis Vol. 14 No. 1 (2025): Juni 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v14i1.858

Abstract

Leukemia Limfoblastik Akut (LLA) merupakan kanker darah tersering pada anak-anak dengan manifestasi klinis utama berupa anemia, leukositosis, dan trombositopenia. Penelitian ini bertujuan mengevaluasi perbedaan hasil hitung darah lengkap (hemoglobin, leukosit, trombosit) sebelum diagnosis dan setelah fase induksi terapi pada pasien anak dengan LLA. Penelitian ini merupakan studi observasional analitik retrospektif terhadap 40 pasien anak LLA di RSUP H. Adam Malik Medan tahun 2023. Hasil penelitian menunjukkan peningkatan bermakna kadar hemoglobin (5,86±2,46 g/dL vs 11,70±1,30 g/dL), penurunan jumlah leukosit (15.640 vs 6.655 sel/µL), dan peningkatan jumlah trombosit (35.375±41.097 vs 303.000±119.108 sel/µL) setelah fase induksi terapi (p<0,05). Kesimpulan penelitian ini adalah terdapat perbedaan signifikan parameter darah lengkap sebelum diagnosis dibandingkan setelah fase induksi, yang menunjukkan respons baik terhadap terapi induksi pada pasien LLA anak.
Co-Authors Anwar, Y. Dahlan Lubis, Muhammad Nadjib Ketaren, Andre Pasha Marziah, Enny Nasution, Malayana Rahmita Nindia Sugih Arto, Nindia Sugih Oke Rina Ramayani, Oke Rina Permatasari, Ranti Siregar, Yoga Rhamada Suprihati - Tarigan, Trianita Troeman, Kyna Vivi Keumala Mutiawati, Vivi Keumala Yessi Mayke, Yessi Zachreini, Indra