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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) SCRIPTA SCORE Scientific Medical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran Ibnu Nafis
Nasution, Malayana Rahmita
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The Relationship between Body Mass Index (BMI) and Degree of Hypertension in Hypertensive Patients Angelina, Clara; Azmeila, Selly; Nasution, Malayana Rahmita; Sitorus, Mega Sari
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 3 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i3.14965

Abstract

Background: Hypertension is a global health problem that attacks 1.28 billion adults aged 30-79 years. Hypertension is a chronic disease characterized by an increase in systolic blood pressure ≥140 mmHg and/or diastolic ≥ 90 mmHg. Calculation of Body Mass Index (BMI) is a method for determining nutritional status in adults. An increase in the BMI value is followed by an increase in blood pressure, thus increasing the chance of developing hypertension as well as the degree of hypertension. This study aims to determine the relationship between BMI and the degree of hypertension in hypertensive sufferers at Prof. Chairuddin P. Lubis Hospital Medan. Method: This research uses a cross-sectional design and descriptive-analytical research methods. The samples for this study are 84 people obtained from secondary data of medical records and used simple random sampling techniques. The collected data is analyzed by a statistical program using the Fisher-Exact test with a significance level of p < 0.05. Results: Most hypertension degrees are hypertension stage 2 and the classification of BMI is obese 1. There is a relationship between BMI and the degree of hypertension (p=0.02). Conclusion: Most of the patients are hypertension stage 2 and obese 1. There is a relationship between BMI and hypertension in hypertensive patients. It means BMI is a risk factor for hypertension.  
Relationship between Elementary Students’ Activity Patterns and the Occurrence of Refractive Disorder Sitorus, Francisca Teratai Anindithya; Aldy, Fithria; Amra, Aryani Atiyatul; Nasution, Malayana Rahmita
SCRIPTA SCORE Scientific Medical Journal Vol. 6 No. 1 (2024): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v6i1.16055

Abstract

Background: Refractive disorder is circumstance in which the eye fails to focus the light coming from an object onto the retina resulting in blurred shadows. One of the risk factors that cause or increase the progressivity of refractive disorder is environmental factors. Environmental factors are avoidable factors and are related to the social aspects of a child, such as a child's habitual patterns in carrying close range activities (reading, using a computer, playing video games, and watching television), and also outdoor activities. Objective: To examine the correlation between student activity patterns and the occurrence of refractive disorder. Methods: This study used an analytical method with a cross sectional design. The data used are primary data obtained directly through visus examination with the Snellen Chart and filling out questionnaires by elementary school students. Results: Based on the results of the Chi-square test, it was found that there was a significant relationship (p < 0,05) between the duration, distance and position of the body when reading books with the occurrence of refractive disorder. There was also a significant relationship (p < 0,05) between duration, distance and body position when using gadgets with the occurrence of refractive disorder. Conclusion: There is a significant relationship between the activity patterns of the students when reading books and when using gadgets with the occurrence of the refractive disorder.   Latar Belakang: Kelainan refraksi adalah keadaan di mana mata gagal untuk memfokuskan cahaya yang berasal dari suatu objek ke retina sehingga dihasilkan bayangan yang kabur. Salah satu faktor yang berisiko menyebabkan maupun meningkatkan progresivitas kelainan refraksi adalah faktor lingkungan. Faktor lingkungan merupakan faktor yang dapat dihindari dan berkaitan dengan aspek sosial seorang anak, seperti pola kebiasaan seseorang dalam melakukan aktivitas jarak dekat (membaca, menggunakan komputer, bermain video games, dan menonton televisi), dan juga aktivitas di luar ruangan. Tujuan: Untuk mengetahui hubungan antara pola aktivitas siswa dengan terjadinya kelainan refraksi. Metode: Penelitian ini menggunakan metode analitik dengan desain cross sectional. Data yang digunakan adalah data primer yang diperoleh secara langsung melalui pemeriksaan visus dengan Snellen Chart serta pengisian kuesioner oleh siswa/i sekolah dasar. Hasil: Berdasarkan hasil uji Chi-square didapati adanya hubungan yang signifikan (p < 0,05) antara durasi, jarak dan posisi tubuh ketika membaca buku dengan terjadinya kelainan refraksi. Didapati juga adanya hubungan yang signifikan (p < 0,05) antara durasi, jarak dan posisi tubuh ketika menggunakan gawai dengan terjadinya kelainan refraksi. Kesimpulan: Terdapat hubungan yang signifikan antara pola aktivitas para siswa  pada saat membaca buku ataupun pada saat menggunakan gawai dengan terjadinya kelainan refraksi.
The Relationship between Plasminogen Activator Inhibitors and the Severity of COVID-19 Troeman, Kyna; Aman, Adi Koesoema; Nasution, Malayana Rahmita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2245

Abstract

The fibrinolysis process is assisted by plasminogen activators and inhibitors by converting plasminogen into plasmin, which later will promote the fibrinolysis process. Incomplete fibrinolysis increases the risk of thrombosis in patients with COVID-19. Plasminogen Activator Inhibitor (PAI-1) plays an important role as acute phase reactants to be used as a marker to assess the prognosis and mortality of COVID-19 patients. This study aimed to elaborate on whether fibrinolysis shutdown occurs in COVID-19 patients using PAI-1 as a marker of fibrinolysis. This was a cross-sectional analytical study from November 2022 to May 2023. This research consisted of a total of 39 patients with COVID-19, hospitalized at Haji Adam Malik General Hospital, Medan. PAI-test in COVID-19 patients was carried out with the ELISA method using Chemwell Analyzer. The severity of COVID-19 measured by clinical examination was divided into moderate, severe, and critical. The association between the two variables was subjected to a comparative test followed by a correlation test to explore the association between the two variables with an independent T-test. In this study, the median PAI-1 level was 1.77 ng/mL (0.71–11.49 ng/mL). The highest PAI-1 levels were observed in the critical severity group, followed by the severe and moderate group of 8.54 ng/mL (5.76–10.84), 2.45 ng/mL (0.71–11.49), and 1.29 ng/mL (0.73–3.77), respectively. There was a significant relationship between PAI-1 levels and the severity of COVID-19 patients (p=0.003). PAI-1 cut-off value of 1.89 ng/mL may predict the degree of COVID-19 severity with sensitivity of 88.9%, specificity of 90.5%, and accuracy of 89.7%. This study classified the severity of COVID-19 into two categories, which are moderate (n=21) and severe-critical (n=18) to obtain the AUC value of PAI-1. PAI-1 can be used to predict the severity of COVID-19 disease with a moderate level (AUC >70–80%). This phenomenon can be secondary to enhanced platelet aggregation, inflammation micro thrombosis, and impaired fibrinolysis. Fibrinolysis disorders lead to a fibrin buildup and increased levels of PAI-1 in the circulation.
PERBEDAAN HASIL HITUNGAN DARAH LENGKAP SEBELUM DAN SESUDAH FASE INDUKSI PADA ANAK DENGAN LEUKEMIA LIMFOBLASTIK AKUT: DIFFERENCES IN COMPLETE BLOOD COUNT RESULTS BEFORE AND AFTER THE INDUCTION PHASE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA Siregar, Yoga Rhamada; Aman, Adi Koesoema; Nasution, Malayana Rahmita; Arto, Nindia Sugih; Permatasari, Ranti
Jurnal Kedokteran Ibnu Nafis Vol. 14 No. 1 (2025): Juni 2025
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/jkin.v14i1.858

Abstract

Leukemia Limfoblastik Akut (LLA) merupakan kanker darah tersering pada anak-anak dengan manifestasi klinis utama berupa anemia, leukositosis, dan trombositopenia. Penelitian ini bertujuan mengevaluasi perbedaan hasil hitung darah lengkap (hemoglobin, leukosit, trombosit) sebelum diagnosis dan setelah fase induksi terapi pada pasien anak dengan LLA. Penelitian ini merupakan studi observasional analitik retrospektif terhadap 40 pasien anak LLA di RSUP H. Adam Malik Medan tahun 2023. Hasil penelitian menunjukkan peningkatan bermakna kadar hemoglobin (5,86±2,46 g/dL vs 11,70±1,30 g/dL), penurunan jumlah leukosit (15.640 vs 6.655 sel/µL), dan peningkatan jumlah trombosit (35.375±41.097 vs 303.000±119.108 sel/µL) setelah fase induksi terapi (p<0,05). Kesimpulan penelitian ini adalah terdapat perbedaan signifikan parameter darah lengkap sebelum diagnosis dibandingkan setelah fase induksi, yang menunjukkan respons baik terhadap terapi induksi pada pasien LLA anak.
Pengaruh Merokok terhadap Kadar Asam Urat pada Pria Dewasa yang Mengonsumsi Tuak di Kelurahan Sigulang-gulang Kecamatan Siantar Utara Tambunan, Novri Angelina; Nasution, Malayana Rahmita
SCRIPTA SCORE Scientific Medical Journal Vol. 2 No. 2 (2021): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v2i2.3404

Abstract

Background: Uric acid (UA) is a nitrogen compound (C5H4N4O3/2, 6, 8-trihydroxypurine) which is the final product of purine catabolism nucleoside adenosine and guanosine. Uric acid levels are influenced by age, purine intake, alcohol consumption, body mass index (BMI), physical activity, hypertension, heart disease, certain medications, and impaired renal function. Objectives: This study aims to determine the influence of smoking on uric acid levels in adult men who drink tuak. Methods: This study used an analytic method using a cross-sectional design. Data retrieval is performed only once for collecting primary data with measuring instruments in the form of a questionnaire and Autocheck to measure uric acid levels. The population in this study is all adult men in Sigulang–gulang, North Siantar. Consecutive sampling was used to determine the number of samples. The data obtained will then be processed and analyzed using SPSS software. Results: The results show that there are differences in uric acid levels in adult men who smoke and drink tuak compare to adult men who do not smoke and drink tuak with a significant p values (6,01±1,09 vs 7,31±1,20; p<0,001). Conclusion: This study concluded that there is an influence of smoking on uric acid levels in adult men who drink tuak. Keywords: smoking, tuak, uric acid   Latar Belakang: Asam Urat (AU) adalah senyawa nitrogenik (C5H4N4O3/2,6,8-trihidroksipurin) yang merupakan produk akhir katabolisme purin nukleosida adenosin dan guanosin. Kadar asam urat dipengaruhi oleh usia, asupan senyawa purin, konsumsi alkohol, indeks massa tubuh (IMT), aktivitas fisik, hipertensi, penyakit jantung, obat-obatan tertentu dan gangguan fungsi ginjal. Tujuan: Tujuan penelitian ini adalah untuk mengetahui pengaruh merokok terhadap kadar asam urat pada pria dewasa yang mengonsumsi tuak. Metode: Penelitian ini merupakan penelitian dengan metode analitik dengan desain penelitian cross sectional. Pengambilan data dilakukan hanya satu kali untuk mengumpulkan data primer dengan alat ukur berupa kuesioner untuk mengetahui kebiasaan konsumsi tuak dan merokok dan Autocheck untuk mengukur kadar asam urat. Populasi dalam penelitian ini adalah seluruh pria dewasa di Kelurahan Sigulang-gulang, Kecamatan Siantar Utara. Penentuan sampel dilakukan dengan cara consecutive sampling. Data yang telah dikumpul akan diolah dan dianalisis dengan menggunakan software SPSS. Hasil: Hasil penelitian menunjukkan terdapat perbedaan kadar asam urat pada pria dewasa yang merokok dan mengonsumsi tuak dengan pria dewasa yang tidak merokok dan mengonsumsi tuak dengan nilai p bermakna (6,01±1,09 vs 7,31±1,20; p<0,001). Kesimpulan: Penelitian ini menyimpulkan terdapat pengaruh merokok terhadap kadar asam urat pada pria dewasa yang mengonsumsi tuak. Kata Kunci: asam urat, merokok, tuak
Co-Authors Adi Koesoema Aman, Adi Koesoema Amra, Aryani Atiyatul Angelina, Clara Azmeila, Selly Fithria Aldy Nindia Sugih Arto, Nindia Sugih Permatasari, Ranti Siregar, Yoga Rhamada Sitorus, Francisca Teratai Anindithya Sitorus, Mega Sari Tambunan, Novri Angelina Troeman, Kyna