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All Journal JFL : Jurnal Farmasi Lampung Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Riset Kefarmasian Indonesia Mattawang: Jurnal Pengabdian Masyarakat Jurnal Farmasi Komunitas Indonesian Journal of Biomedicine and Clinical Sciences
Supomo
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Formulation of Antiacne Cream Dosage Form Containing Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract Supomo; Apriliana, Anita; Purnawati, Titin; Risqi, Ainur
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (860.169 KB) | DOI: 10.32734/idjpcr.v1i1.207

Abstract

Abstract. The aim of this study was to formulate ethanolic extract of mangosteen (Garcinia mangostana L.) pericarp (EEMP) in the antiacne cream dosage form. The formulae were made with 3 varied concentrations of 0.5%, 1.5% and 4.5%. The tests carried out in this study were organoleptic cream preparations (odor, color, texture), homogeneity, pH, determination of the type of cream, spreadability, and the antibacterial activity against Staphylococcus epidermidis. The results of physical property evaluations showed that the EEMP indicated the pH value of 6, the spredability of the cream increased along with the increasing length of storage time. Duncan Test on the measurement of diameter dispersibility based on storage time showed that there were significant differences between the spreadability of the cream B and C. The cream produced was easy to wash indicating oil in water (o/w) type. The results of antibacterial activity test applying agar diffusion method using Mueller Hinton medium Agar (MHA) indicated that the inhibition zones of formulae II and III were 5.2 and 6 mm, respectively. Whereas, the formula I as well as the negative control showed no inhibition zones. It can be concluded that the EEMP can be formulated as an antiacne cream. The best cream formula was the formula II with the results of physical properties test were quite stable and able to produce inhibition zone against Staphylococcus epidermidis. Keywords: Garcinia mangostana, cream, antiacne, antibacterial, Staphylococcus epidermidis.
Effort to Prevent COVID-19 STIKES Samarinda (STIKSAM) by Distributing Hand Sanitizer in Air Hitam Village of Samarinda City: Upaya Pencegahan COVID-19 STIKES Samarinda (STIKSAM) dengan Menyalurkan Hand Sanitizer di Kelurahan Air Hitam Kota Samarinda Syamsul, Eka Siswanto; Supomo; Ansyori, Achmad Kadri
Mattawang: Jurnal Pengabdian Masyarakat Vol. 2 No. 2 (2021)
Publisher : Yayasan Ahmar Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (604.338 KB) | DOI: 10.35877/454RI.mattawang338

Abstract

Due to the COVID-19 pandemic outbreak, the availability of handwashing products in Samarinda City has become a rare item. The purpose of this activity is to prevent COVID-19 through the use of Hand Sanitizer. This method in this service includes several stages, namely preparation that includes the preparation of tools and materials, the production process with the stages of mixing materials into hand sanitizer products, and the packaging process that is inserting the finished hand sanitizer into small bottles measuring 20 ml, 100 ml and Container 5 L, as well as labelling the brand hand sanitizer, and subsequently the distribution process in RT 27, 28 , 29 and 30 Black Water Village. Civitas Akademika STIKES Samarinda (STIKSAM) and Ikatan Keluarga Alumni (IKA STIKSAM) make hand sanitizer in accordance with WHO regulations, hand sanitizer distribution process in rt 27, RT 28, RT 29 and RT 30 Black Water Village and COVID-19 referral hospital (AW Hospital. Sjahranie and I.A. Moeis Hospital) went smoothly. Mayor of Samarinda H. Syaharie Ja'ang appreciated and reviewed the activities of Hand Sanitizer making at STIKES Samarinda campus. Abstrak Akibat wabah pandemi COVID-19 ketersediaan produk pencuci tangan di Kota Samarinda menjadi barang langka. Tujuan kegiatan ini yaitu melakukan upaya pencegahan COVID-19 melalui penggunaan Hand Sanitizer. Metode pada pengabdian ini meliputi beberapa tahap yaitu persiapan yang meliputi penyiapan alat dan bahan, proses produksi dengan tahapan pencampuran bahan-bahan menjadi produk hand sanitizer, dan proses pengemasan yaitu memasukan hand sanitizer yang sudah jadi ke dalam botol-botol kecil berukuran 20 ml, 100 ml maupun Dirigen 5 L, serta labelling merek hand sanitizer, dan selanjutnya proses pendistribusian di RT 27, 28, 29 dan 30 Kelurahan Air Hitam. Civitas Akademika STIKES Samarinda (STIKSAM) dan Ikatan Keluarga Alumni (IKA STIKSAM) membuat hand sanitizer sesuai ketentuan WHO, proses pendistribusian hand sanitizer di wilayah RT 27, RT 28, RT 29 dan RT 30 Kelurahan Air Hitam dan Rumah sakit rujukan COVID-19 (RSUD AW. Sjahranie dan RSUD I.A. Moeis) berjalan dengan lancar. WaliKota Samarinda H. Syaharie Ja’ang mengapresiasi dan meninjau kegiatan pembuatan Hand Sanitizer di kampus STIKES Samarinda.
UJI TOKSISITAS EKSTRAK Baccaurea lanceolata TERHADAP Artemia salina Leach DENGAN METODE BSLT: - Noorhayati; Supomo; Fatimah, Nurul
JFL : Jurnal Farmasi Lampung Vol. 13 No. 1 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i1.1172

Abstract

Limpasu (Baccaurea lanceolata) secara empiris memiliki khasiat untuk mengobati demam, diare, dan kesehatan kulit. Pemakaian dengan jumlah yang melebihi batas takaran dapat menyebabkan keracunan (ketoksikan), sehingga harus diuji untuk memastikan keamanannya dengan melakukan uji toksisitas ekstrak etanol kulit buah limpasu. Tujuan penelitian ini untuk mengetahui nilai Lethal Concentration 50 (LC50) ekstrak etanol kulit buah limpasu terhadap larva udang Artemia salina Leach. Penelitian yang dilakukan adalah penelitian eksperimental dengan tahapan antara lain: pembuatan simplisia, determinasi tumbuhan, ekstraksi, skrining fitokimia, pembuatan larutan seri dengan konsentrasi 0 sebagai kontrol (negatif), 100,150, 200 dan 250 ppm. Pengujian dilakukan dengan metode Brine Shrimp Lethality Test (BSLT) menggunakan larva udang yang berumur 24 jam dan dibagi dalam 5 kelompok pengujian. Tiap kelompok pengujian terdiri dari 10 ekor larva dengan 3 kali pengulangan. Analisis data dari hasil uji toksisitas menggunakan metode analisis probit untuk menghitung LC50. Hasil penelitian yang didapat menunjukkan bahwa ekstrak etanol kulit buah limpasu mengandung senyawa alkaloid, flavonoid dan triterpenoid. Pada hasil uji toksisitas diperoleh dengan nilai LC50 sebesar 254,97 µg/mL sehingga ekstrak etanol kulit buah limpasu termasuk dalam kategori toksik terhadap larva udang Artemia salina Leach.
Correlation between type of surgery and incidence of postoperative venous thromboembolism (VTE) Supomo; Budi Mulyono; Usi Sukorini; Adika Zhulhi Arjana; Tandean Tommy Novenanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11888

Abstract

Venous thromboembolism (VTE) is a significant complication in patients after undergoing major surgery. The type of surgery is believed correlated with the incidence of VTE. This study aimed to evaluate the correlation between type of surgery and incidence of VTE among patients who underwent major surgery. It was a retrospective study conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of patients who underwent major surgery and were diagnosed with VTE between 2016 and 2020. Patients were grouped by surgery type, and length of stay (LoS). All caused deaths were also analyzed. Among 29,120 patients who underwent major surgery, 76 (0.26%) experienced VTE with females patients accounting for 75%. The mean age of the patients was 55 yr. All VTE cases had the mean LoS of 25 d. The highest proportion of patients who experienced VTE were patients who underwent tumor removal (67.0%) followed by trauma patients (18.4%). A significant difference in the incidence of mortality between the surgical groups was reported (p = 0.02). Post-cardiology had the highest risk of mortality (OR=7.46; 95% CI: 0.322 - 172.61) while age had the lowest risk of mortality (OR=1.01; 95% CI: 0.953 - 1.071). In conclusion, surgery type is correlated with the incidence of VTE. Surgery due to cancer and trauma has a higher risk of VTE compared to the others.
Laboratory findings of postoperative venous thromboembolism (VTE) in Dr. Sardjito General Hospital, Yogyakarta Supomo; Mulyono, Budi; Sukorini, Usi; Arjana, Adika Zhulhi; Novenanto, Tandean Tommy
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13627

Abstract

Venous thromboembolism (VTE) is a significant risk, especially for older individuals. Indonesian studies found 37.1% VTE incidence in bedridden patients over 40 and 2.1% in major surgeries. Surgery, like hip fractures, raises the risk temporarily. Diagnosis relies on tests like ultrasound with Doppler, Wells score, and neutrophil-to-lymphocyte ratio (NLR). This study aimed to evaluate the laboratory findings of postoperative VTE. A retrospective analysis was conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of VTE patients who underwent major surgery. The laboratory data, including complete blood count characteristics for every month for three months after postsurgery and DVT presentation when it occurred on the diagnostic day were collected. In total of 27 patients involved in this study, VTE cases were more common in digestive (41.2%) and obstetric gynecology surgeries (29.4%) for females, and nervous (44.4%) and cardiovascular surgeries (22.2%) for males. Females had a higher prevalence of Well Score ≥3 (82.4% vs 40%; p=0.058) and longer VTE therapy durations (65.50 ± 46.51 vs 39.60 ± 41.04 d; p=0.172). Males had more unilateral VTE occurrences (90.9 vs 56.3%; p=0.070) and a higher proportion of total occlusion cases (60 vs 37.5%; p=0.422). NLR exhibited a significant decrease from the 1st to the 2nd month (10.52 vs 3.64; p=0.009), followed by an insignificant increase in the 3rd month (3.64 vs 3.98; p=0.878). Notably, NLR trended downward in the 2nd month examination. In conclusion, VTE occurs in 0.21% of postoperative patients, with the highest incidence observed in post-gynecological surgery patients. The NLR can serve as a diagnostic tool for VTE in extremities, as an elevated NLR indicates the presence of a more proximal thrombus.
Tingkat Pengetahuan, Sikap, dan Penggunaan Immunomodulator Herbal pada Pandemi COVID- 19 di Kecamatan Wonoayu, Sidoarjo Priyoherianto, Andri; Fitriany, Erna; Zuanta Pangestuti; Supomo
Jurnal Farmasi Komunitas Vol. 12 No. 1 (2025): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v12i1.48196

Abstract

Penggunaan immunomodulator untuk tetap menjaga daya tahan tubuh adalah upaya yang dilakukan untuk mencegah luasnya penyebaran kasus COVID-19. Penggunaan immunomodulator herbal berhubungan erat dengan tingkat pengetahuan dan sikap masyarakat. Tujuan penelitian ini adalah untuk mengetahui tingkat pengetahuan dan sikap masyarakat Kecamatan Wonoayu, Sidoarjo terhadap penggunaan immunomodulator herbal pada masa pandemic COVID-19. Jenis penelitian ini adalah deskriptif. Sampel yang diambil memenuhi kriteria inklusi dan eksklusi berjumlah 86 orang dengan teknik purposive  sampling. Instrumen penelitian yang digunakan adalah kuesioner yang dibagikan kepada masyarakat di Kecamatan Wonoayu Kabupaten Sidoarjo. Responden dengan pengetahuan tergolong baik sebesar 12,8%, cukup sebesar 51,2%, dan kurang baik sebesar 36,0%. Sikap masyarakat termasuk berkategori baik sebesar 37,2% dan kurang sebesar 27,9%. Dapat disimpulkan dari penelitian ini bahwa pengetahuan, sikap dan penggunaan immuniherbal sudah cukup baik. Meskipun demikian, perlunya peningkatan edukasi guna memperkuat konsistensi antara pengetahuan, sikap, dan tindakan masyarakat terhadap penggunaan imunomodulator herbal dalam upaya menjaga daya tahan tubuh selama pandemi.
KARAKTERISASI DAN SKRINING FITOKIMIA SIMPLISIA DAN ESKTRAK BUAH BAKAU HITAM (Rhizopora mucronata Poir) Sa'adah, Hayatus; Kavung, Clara Agatha; Supomo
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 2 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v7i2.608

Abstract

Black mangrove (Rhizopora mucronata Poir) is a species of mangrove plant that lives in mangrove forests which contains secondary metabolites and contains natural antioxidants and antibacterials which are widely used by coastal communities and consumed as food and medicine. The benefits of a natural ingredient with medicinal properties need to be scientifically proven through research. As a first step, characterization of simplicia and extracts was carried out as well as phytochemical screening. Characterization is intended to determine the quality of simplicia and black mangrove fruit extract as well as the content of secondary metabolite compounds. Characterization includes specific and non-specific parameters. In the first stage, black mangrove fruit was extracted by maceration using 96% ethanol solvent and a yield of 23.77% was obtained. Specific characterization test results include organoleptic tests with direct observation results on simplicia in the form of powder. dark brown color, slightly astringent taste, with a distinctive aroma and in the organoleptic test the ethanol extract is a thick extract, blackish brown in color, bitter taste with a characteristic aroma. The average level of dissolved compounds in simplicia water was 7.3% and the extract was 11.33%, while the average level of dissolved compounds in simplicia ethanol was 24% and the extract was 88.33%. The results of non-specific characterization tests include determining the average water content of the simplicia at 15% and the extract at 18%. The average total ash content test for simplicia was 8.3397% and the extract was 10.4976%, while the average acid insoluble ash content test for simplicia was 0.2329% and extract was 0.8144%. The average specific gravity of the extract was 0,98 g/mL and aquadest 0,94 g/mL, results of the microbial contamination test, the total plate number for simplicia was 4.6 x 10-3 colonies/g and the extract was 4.3 x 10-3 colonies/g, while the yeast mold number in simplicia 2.1 x 10-2 colonies/g and in extract 1.3 x 10-2 colonies/g. The results of the phytochemical screening test for simplicia and black mangrove fruit extract were positive for containing metabolite compounds, namely secondary alkaloids, flavonoids, tannins, steroids and terpenoids.
Co-Authors Adika Zhulhi Arjana Andri Priyoherianto Anita Apriliana, Anita Ansyori, Achmad Kadri Budi Mulyono Eka Siswanto Syamsul ERNA FITRIANY, ERNA Hayatus Sa`adah Kavung, Clara Agatha Mulyono, Budi Noorhayati Novenanto, Tandean Tommy Nurul Fatimah Purnawati, Titin Risqi, Ainur Tandean Tommy Novenanto Usi Sukorini Zuanta Pangestuti