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All Journal Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Gotong Royong : Jurnal Pengabdian, Pemberdayaan Dan Penyuluhan Kepada Masyarakat (J-P3KM) Riset Informasi Kesehatan Jurnal Abdimas Kesehatan Jurnal Akademika Baiturrahim Jambi
M. Henityo Agung As'adi
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Religion Chemistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Formulation of fenofibrate nanocrystals with wet milling method M. Henityo Agung As'adi; Ilham Kuncahyo; Teuku Nanda Saifullah Sulaiman
Riset Informasi Kesehatan Vol 12 No 1 (2023): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30644/rik.v12i1.761

Abstract

Background: Fenofibrate is an antihyperlipidemic belonging to BCS class II, practically insoluble in water and has high lipophilicity, so it is proven that the inhibitor of the rate of absorption of fenofibrate from the digestive tract is slow to dissolve. This study aims to increase the solubility of fenofibrate by forming nanocrystals. Method: Formation of nanocrystals using the wet milling method Result: The fenofibrate nanocrystals produced a particle size of 775.966 nm, a zeta potential of -21.302 mV, and a solubility of 5.977 μg/mL. Conclusion : The optimum formula with tween 80 components, grinding speed and grinding time in the manufacture of fenofibrate nanocrystals using the Factorial Design method obtained 0.2% tween 80, grinding speed of 500 rpm and grinding time of 1 hour. The critical parameter test results for the optimum formula obtained a particle size of 775.966 nm, a zeta potential of -21.302 mV and a solubility of 5.977 µg/mL. The DSC test showed that there was a difference in the melting point peaks and a decrease in crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The FTIR test showed no difference in functional groups between pure fenofibrate and fenofibrate nanocrystals. The XRD test showed that there was a difference in peak crystal intensity between pure fenofibrate and fenofibrate nanocrystals. The SEM analysis shows that there are differences in shape and magnification used between pure fenofibrate and fenofibrate nanocrystals.
Spray Gel Formulation of Ethanolic Extract Senduduk Leaves (Melastoma malabatricum) Against Antioxidant Activity, SPF, and Chemical Components Analysis with LC-MS/MS Yulion, Rizky; Andriani, Lili; Asadi, Henityo Agung; 'Aliyah, Siti Hamidatul; Mariska, Ruri Putri; Perawati, Santi; Hasanah, Rifdatul
Indonesian Journal of Chemical Studies Vol. 2 No. 2 (2023): Indones. J. Chem. Stud., December 2023
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v2i2.37

Abstract

Senduduk leave (Melastoma malabathricum) is one of the species in the melastomaceae family that has long been used by local Indonesian people, one of which is the Suku Anak Dalam (SAD) for various needs and also as traditional medicine. The study aimed to examine the antioxidant activity of ethanolic extract of senduduk leaves. The extract was then formulated into spray gel preparations as UV-B sunscreen. The research method used was starting from sampling, determination, making samples, soxhlet, determining the IC50 value, spray gel preparation formulation, formulation stability test, measuring sun protection factor (SPF) values, and identifying extract chemical components with the LC-MS/MS instrument. The results was that the ethanolic extract of senduduk leaves had an IC50 value of 49.73 μg/mL with the best SPF value at a concentration of 70 ppm, which is 19.98. Spray gel preparations with a concentration of 70 ppm have an IC50 value of 44.22 μg/mL, an SPF value of 24.96, and a potent antioxidant intensity. So, extract spray gel can potentially have activity as antioxidants and can be used as UV-B sunscreen. The compounds identified include quercetin, quercitrin, DEET, n-boc-3-pyrrolidinone, medicarpine, taxinine, and other compounds. The ethanol extract of the soxhlet results showed more promising results for further tests of in-vitro, in-vivo, and in-silico bioactivity studies.
Edukasi Logo Obat, Dagusibu dan Bud Serta Cek Kesehatan Guru Rizky Yulion; Aisa Dinda Mitra; Henityo Agung Asadi; Regina Amanda; Indra Gunawan; Ahmad Rozan Dewansyah; Tita Aulya Novira
Jurnal Abdimas Kesehatan (JAK) Vol 6, No 1 (2024): Januari
Publisher : Sekolah Tinggi Ilmu Kesehatan Baiturrahim Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v6i1.657

Abstract

Community service activities were carried out at SMA N 1 Muaro Jambi with the educational theme of drug logos, dagusibu, and Beyorn Use Date (BUD) as well as free health checking activities for educators at SMA N 1 Muaro Jambi. The topic was raised to provide education delivery to respondents with formal education and is expected to have a positive impact on the surrounding location. The topic also supports the program of the Central Board of the Indonesian Pharmacists Association (PP-IAI). This activity was carried out by making 10 questions designed that referred to the theme and topic of the activity consisting of pre-test and post-test, the next data was carried out through statistical tests using Paired T-tests. Tangible differences were obtained in respondents who received educational exposure (P<0.05). With data on 23 respondents, There is an increase in the educational value of respondents on community service materials. These results also confirm the understanding of the material educational theme of drug logos, dagusibu, and Beyorn Use Date (BUD) provided to respondents. In the Health examination, information was obtained, the respondents suffered from health problems as evidenced by the results of health checks, especially on blood pressure. In conclusion, education on pharmacy topics obtained satisfactory results for high school students
Pendampingan Edukasi Mengenai Makanan Dan Minuman Pemicu Penyakit Degeneratif DM Pada Anak Usia Dini Trifah, Rahmadha; As’adi, M. Henityo Agung; Nurhayati, Nurhayati; Sundari, Popy; Hafsari, Winda Galuh
Gotong Royong: Jurnal Pengabdian, Pemberdayaan Dan Penyuluhan Kepada Masyarakat Vol. 4 No. 2 (2025): Gotong Royong (JP3KM) Juni 2025
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/jp3km.v4i2.76

Abstract

Penyakit degeneratif seperti diabetes melitus (DM) kini tidak lagi hanya menyerang orang dewasa, tetapi juga mulai mengancam anak-anak akibat pola makan yang tidak sehat. Program pengabdian ini bertujuan untuk memberikan edukasi kepada siswa usia dini dan pendidik mengenai pentingnya memilih makanan dan minuman sehat dalam mencegah DM. Metode yang digunakan meliputi survei awal, edukasi menggunakan alat bantu yang interaktif dan sesuai usia. Hasil menunjukkan peningkatan pengetahuan dan perilaku pada siswa dan pendidik. Program ini diharapkan menjadi langkah preventif awal terhadap penyakit degeneratif melalui edukasi gizi sejak dini.
Pemanfaatan Tanaman Herbal sebagai Alternatif dalam Pengobatan Hipertensi di Desa Mersam Kabupaten Batang Hari Agung As’adi, M.Henityo; Nabhaki, Firelza; Ripani, Izani Fathya; Arista, Dina; Susanti, Siti Melvy; Lestari, Wiwik; Wahyuni, Intan Sri; Sandy, Sapna Ari; Hayeti, Triana Najma; Prianggie, Sherly Alensia
Jurnal Abdimas Kesehatan (JAK) Vol. 7 No. 2 (2025): Juni
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jak.v7i2.917

Abstract

One type of community service is Real Work Lectures (KKN), which aims to apply knowledge and skills in social life. In Mersam Village, Mersam District, Batanghari Regency, Jambi, there is a real work program with the theme "Community Movement for Health Care, Response to Safe Use of Medicines and Cosmetics." The aim of this campaign is to increase public awareness about healthy lifestyles, appropriate use of medication, and choosing safe cosmetics. Initial surveys, health education, junior pharmacist courses, and pharmaceutical product expos are the methods used in this activity. The results show that the public understands better the correct use of medicines, the use of herbal plants, and checking the safety of cosmetics through BPOM. Utilization of digital media as a method of continuing education and collaboration with health workers can support program sustainability.
Karakteristik Fisik dan Uji Aktivitas Antiokidan dengan Metode DPPH Sediaan Sheet Mask Ekstrak Biji Kakao Meirista, Indri; As'adi, M. Henityo Agung; Putri, Dzakiah Adillah
Jurnal Akademika Baiturrahim Jambi Vol. 14 No. 2 (2025): September
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v14i2.950

Abstract

Healthy skin can reflect a person's health. Healthy, clean and bright skin is everyone's dream, especially for women. Antioxidants protect the body from damage caused by free radicals. Free radicals can cause cell damage such as skin wrinkles, dark spots, and dullness. Cocoa beans (Theobroma Cacao Linn) contain catechins, epicatechins, and proanthocyanidins which have antioxidant properties. This study aims to determine how the physical characteristics of cocoa bean extract (Theobroma Cacao Linn) sheet mask and how the antioxidant activity of cocoa bean extract (Theobroma Cacao Linn) sheet mask preparations are produced. This research method is experimental, the data is processed statistically using microsoft excel diagram and visualized in the form of bar graphs. Extraction using percolation method using 96% ethanol solvent then the extract was identified with phytochemical screening test. Formulations were made with different concentrations of active substances and physical properties were carried out including organoleptic test, homogeneity test, viscosity test, pH test, stability test, moisture effectiveness test, irritation test, liking test, and antioxidant test of sheet mask preparations. The results of this study in each evaluation test showed that cocoa bean extract (Theobroma Cacao Linn) sheet mask preparations can be formulated as strong category antioxidant sheet mask preparations with IC50 values in formula 1 of 78.12 µg/ml, formula 2 of 67.08 µg/ml, and formula 3 of 55.2 µg/ml. The physical characteristics of cocoa bean extract (Theobroma Cacao Linn) sheet mask formula 0, formula 1, formula 2, and formula 3 sheet mask preparations can be said to be suitable for use on the face because they pass all tests and fall into the range that has been set.
Formulasi dan Evaluasi Sifat Fisik Sediaan Shampo dari Ekstrak Daun Sungkai (Peronema Canescens Jack) Mariska, Ruri Putri; As'adi, M. Henityo Agung; Ibriyanti, Silda
Jurnal Akademika Baiturrahim Jambi Vol. 14 No. 2 (2025): September
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v14i2.959

Abstract

Shampoo is one of the scalp care preparations used to clean dirt on the scalp and dandruff. Shampoo preparations with active ingredients made from natural ingredients have good effectiveness and safer safety compared to the use of shampoos whose active ingredients are taken from synthetic materials. One of the active ingredients comes from nature that can be used as a shampoo preparation, namely the sungkai plant (Peronema canescens Jack). Sungkai leaves have secondary metabolites, namely alkaloids, flavonoids, terpenoid-steroids, and tannins. Flavonoids are secondary metabolites that function as antioxidants and antibacterials. The purpose of this study was to determine which one can produce the best formula for shampoo preparations from sungkai leaf extract (Peronema canescens Jack) and to determine the characteristics of the physical properties of sungkai leaf shampoo preparations (Peronema canescens Jack). Shampoo preparations were tested for organoleptic, pH, stability, foam height, viscosity and preference. The evaluation results obtained were analyzed descriptively. The results of this study in each evaluation test of shampoo preparations have met the requirements and good formulas, namely in formula 1.
Co-Authors 'Aliyah, Siti Hamidatul Achmad Noerkhaerin Putra Ahmad Rozan Dewansyah Aisa Dinda Mitra Arista, Dina Hafsari, Winda Galuh Hasanah, Rifdatul Hayeti, Triana Najma Ibriyanti, Silda Ilham Kuncahyo, Ilham Indra Gunawan Indri Meirista Lili Andriani Nabhaki, Firelza Nurhayati Nurhayati Prianggie, Sherly Alensia Putri, Dzakiah Adillah Regina Amanda Ripani, Izani Fathya Rizky Yulion Rizky Yulion Ruri Putri Mariska Sandy, Sapna Ari Santi Perawati, Santi Sundari, Popy Susanti, Siti Melvy Teuku Nanda Saifullah Sulaiman Tita Aulya Novira Trifah, Rahmadha Wahyuni, Intan Sri Wiwik Lestari