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FORMULASI SEDIAAN LIP BALM DARI VCO (Vigin coconut oil) DENGAN PENAMBAHAN SARI BUAH CERI (Eugenia reidwartiana ) SEBAGAI PEWARNA ALAMI rose intan perma sari
Jurnal Ilmiah Pharmacy Vol 9, No 2 (2022)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v9i2.414

ABSTRAK Lip balm merupakan sediaan perawatan pada kulit bibir yang digunakan untuk melindungi bibir terhadap kerusakan seperti bibir kering dan akibat paparan sinar matahari. Penelitian ini bertujuan memformulasi lip balm dari VCO (Virgin Coconut Oil) dengan penambahan sari buah ceri (Eugenia reidwartiana). VCO dan sari buah ceri diformulasi dalam bentuk sediaan Lip balm dengan menggunakan variasi konsentrasi VCO 0%, 5%, 7%, 9% dan sari buah ceri konsetrasi 0%, 10%, 13%, 16%. Lip balm dari VCO dengan penambahan sari buah ceri dilakukan evaluasi sifat fisik sediaan meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar dan uji stabilitas. Kesimpulan dari evaluasi terhadap 4 formula lip balm bahwa formula (f3) dengan konsentrasi VCO 9% dan sari buah ceri konsentrasi 16% memiliki karakteristik mendekati standar, dengan bentuk fisik setengah padat, nilai pH 5 yang tergolong interval baik homogen, daya sebar baik dan warna pink cerah.Kata Kunci : Virgin Coconut Oil, Sari buah ceri, Lip balm.

ISOLASI DAN KARAKTERISASI SERBUK ENZIM BROMELIN DARI BATANG NANAS (ANANAS COMOSUS (L.) MERR).: ISOLATION AND CHARACTERIZATION OF BROMELIN ENZYME POWDER FROM Pineapple Stem (ANANAS COMOSUS (L.) MERR). Rose Intan Perma Sari; Salman; Erizal Zaini
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.432

Bromelin merupakan unsur pokok dari nanas yang penting dan berguna dalam bidang farmasi dan makanan, untuk mendapatkan enzim bromelin dari buah nanas diperlukan proses isolasi enzim bromelin. Tujuan dari penelitan ini adalah untuk mengisolasi dan mengkarakterisasi serbuk enzim bromelin dari batang nanas (Ananas Comosus (L.) Merr). Isolasi enzim bromelin dari batang nanas telah dilakukan dengan menggunakan pelarut dapar fosfat pH 7.0 disentrifugasi pada 3.500 rpm selama 15 menit. Serbuk enzim bromelin diperoleh dengan menggunakan metoda freeze drying dan didapat persentase randemen sebesar 2,032 %. Karakterisasi dari serbuk enzim bromelin terdiri dari pengukuran kosentrasi protein, penentuan aktivitas enzim dan aktivitas spesifik enzim. Pengukuran konsentrasi protein menggunakan metoda Biuret memberikan hasil konsentrasi sebesar 1,66±0,003 mg/ml. Penetuan aktivitas enzim menggunakan metoda Murachi memberikan hasil aktivitas enzim sebesar 43,09±0,01 U/ml dan aktivitas spesifik enzim sebesar 26,02±0,003 U/mg.

EDUKASI PEMBUATAN JAMU YANG BAIK DAN AMAN PADA KELOMPOK JAMU GENDONG DI KOTA BENGKULU Suci Rahmawati; Nori Wirahmi; Camelia Dwi Putri Masrijal; Rose Intan Permasari; Oky Hermansyah; Samwilson Slamet
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 6, No 7 (2023): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v6i7.2252-2256

Usaha Jamu Gendong (UJG) is a herbal medicine business carried out by individuals using traditional medicine ingredients in the form of fresh liquid to be sold directly to consumers. This service activity was aimed to increasing knowledge and providing skills on how to make good and safe jamu for UJG group in Bengkulu City. This activity was carried out on October 22, 2022 with 20 participants. This service activity is carried out using discussion and demonstration methods. Evaluation of activities is carried out by giving questionnaire sheets given before and after the activity. The results of the questionnaire evaluation obtained that the average score of 20 participants before and after the activity was 90.6 and 99.2, respectively. From the implementation of the activities, it can be concluded that there is an increase in the knowledge of the herbal medicine group regarding how to make good and safe traditional medicines.

TESTING THE ACTIVITY AND FORMULATION OF NATURAL HAND SOAP BASED ON NATURAL SURFACTANTS OF LERAK FRUIT (Sapindus rarak DC.) AGAINST Staphylococcus aureus Rose Intan Perma Sari; Natasha Ardinata; Oky Hermansyah; Suci Rahmawati; Camelia Dwi Putri Masrijal
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1151

Lerak (Sapindus rarak DC.) is a fruit belonging to the Sapindaceae family that usually grows in tropical forests. Lerak fruit flesh contains the main active compound, saponin. Saponin is a natural surfactant with foaming and emulsifying properties. The use of synthetic surfactants in the manufacture of hand soap sold on the market can have negative impacts, such as irritation and denaturation of proteins in the outer epidermis layer in humans if exposed too often. This study aimed to determine whether lerak can be formulated into natural hand soap as a natural surfactant and determine its antibacterial activity against Staphylococcus aureus bacteria. Lerak fruit solutions were prepared using a maceration method. The resulting solution was then formulated into hand soap at concentrations of 10%, 30%, and 50%. The evaluation of the natural hand soap preparation from the lerak fruit included organoleptic evaluation, homogeneity, pH, viscosity, foam height, and antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. Based on the research results, Lerak Fruit (Sapindus rarak DC.) can be formulated as a natural surfactant in hand soap at concentrations of 0%, 10%, 30%, and 50%. Based on the evaluation of the physical properties in the foam height test, F1, F2, and F3 met the requirements, whereas F0 did not meet the requirements in the foam stability test because it did not contain lerak fruit extract, so no foam formed ...

EDUKASI PEMBUATAN JAMU YANG BAIK DAN AMAN PADA KELOMPOK JAMU GENDONG DI KOTA BENGKULU Suci Rahmawati; Nori Wirahmi; Camelia Dwi Putri Masrijal; Rose Intan Permasari; Oky Hermansyah; Samwilson Slamet
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 6, No 7 (2023): Martabe : Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v6i7.2252-2256

Usaha Jamu Gendong (UJG) is a herbal medicine business carried out by individuals using traditional medicine ingredients in the form of fresh liquid to be sold directly to consumers. This service activity was aimed to increasing knowledge and providing skills on how to make good and safe jamu for UJG group in Bengkulu City. This activity was carried out on October 22, 2022 with 20 participants. This service activity is carried out using discussion and demonstration methods. Evaluation of activities is carried out by giving questionnaire sheets given before and after the activity. The results of the questionnaire evaluation obtained that the average score of 20 participants before and after the activity was 90.6 and 99.2, respectively. From the implementation of the activities, it can be concluded that there is an increase in the knowledge of the herbal medicine group regarding how to make good and safe traditional medicines.

Penentuan Kandungan Vitamin D2 Pada Ekstrak Etil Asetat Jamur Sawit (Volvariella volvacea) Dengan Metode Spektrofotometeri UV-Vis Oky Hermansyah; Apriyanti Apriyanti; Suci Rahmawati; Rose Intan Perma Sari; Dwi Dominica
Jurnal Pharmacopoeia Vol 5 No 1 (2026): Maret 2026
Publisher : Poltekkes Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jp.v5i1.1245

Dari hasil berbagai penelitian vitamin D memiliki peran yang signifikan tidak hanya penting dalam kesehatan tulang, namun juga imunitas, membantu pemulihan pada penyakit infeksi pernafasan, penyakit diabetes dan kolesterol. Salah satu sumber alami vitamin D adalah jamur, banyak penelitian yang mengungkapkan kandungan vitamin D pada jamur, seperti jamur tiram atau jamur merang padi, namun belum ada yang melaporkan kandungan vitamin D pada jamur sawit (Volvariella volvaceae). Jamur sawit ini banyak dihasilkan di daerah penghasil kelapa sawit seperti di Provinsi Bengkulu, khususnya di Kecamatan Pino. Tujuan penelitian ini adalah untuk menentukan kandungan vitamin D (ergokalsiferol) dalam esktrak etil asetat jamur sawit yang dihasilkan disekitar perkebunan kelapa sawit di Kecamatan Pino. Jamur sawit diolah menjadi simplisia dan diekstraksi menggunakan pelarut etil asetat melalui proses maserasi, kemudian diuapkan untuk mendapatkan ekstrak kental. Dari hasil proses ekstraksi didapatkan rendemen sebesar 1,076%. Ekstrak kental ini kemudian ditentukan kadar vitamin D-nya menggunakan Spektrofotometer UV-Vis dengan vitamiin D2 (ergokalsiferol BPFI) sebagai standar. Dari hasil pengujian, diperoleh kurva larutan standar vitamin D dengan koefisien regresi (r) sebesar 0,997 dan persamaan garis y=0,0337x+0,011. Absorbansi sampel yang diperoleh kemudian diplot ke dalam persamaan garis dan kadarnya dihitung, hasilnya didapatkan kadar vitamin D2 (ergokalsiferol) pada sampel. Dari hasil studi ini, dapat disimpulkan bahwa jamur sawit yang diperoleh di sekitar perkebunan kelapa sawit Kecamatan Pino di Provinsi Bengkulu mengandung vitamin D2 (ergokalsiferol) dengan kadar 0,1363% atau sekitar 54,52 IU/gram.

Hubungan Pengetahuan dengan Sikap Masyarakat pada Penggunaan Antibiotik di Kelurahan Pondok Besi Kota Bengkulu Miftahuljannah Miftahuljannah; Oky Hermansyah; Maria Eka Patri Yulianti; Tri Danang Kurniawan; Rose Intan Perma Sari
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i2.7891

This study aims to analyze the relationship between the level of knowledge and attitudes of the community towards antibiotic use in Pondok Besi Village, Bengkulu City. This study used a quantitative method with an observational analytical design through a cross-sectional approach. The study sample consisted of 104 respondents obtained using proportional cluster random sampling technique. Data were collected through questionnaires that had been tested for validity and reliability, then analyzed using Univariate and Univariate analysis with the Chi-Square test. The results showed that the majority of respondents had a good level of knowledge (48.1%) and a good attitude (51.0%) towards antibiotic use. The Univariate analysis showed a significant relationship between knowledge and attitudes of the community, where respondents with better knowledge tended to have more positive attitudes towards antibiotic use. These findings indicate that knowledge plays an important role in shaping public attitudes towards the rational use of antibiotics. Therefore, continuous improvement of health education is essential to strengthen understanding and shape appropriate attitudes towards antibiotic use to prevent antimicrobial resistance at the community level.

Aktivitas Antibakteri Kombinasi Ekstrak Etanol Kulit Kopi Robusta dan Serai Wangi terhadap Escherichia coli Ibrahim Ayattulah; Suci Rahmawati; Dwi Kurnia Putri; Tri Danang Kurniawan; Rose Intan Perma Sari
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v5i2.7972

Antibacterial activity of a combination of 70% ethanol extracts of Robusta coffee peel (Coffea canephora) and citronella grass (Cymbopogon nardus) against Escherichia coli was evaluated using the disc diffusion (Kirby–Bauer) method. The extracts were obtained through maceration with 70% ethanol and combined in a 1:1 ratio at concentrations of 10%, 20%, 40%, 60%, and 80%. The parameter observed was the diameter of the inhibition zone formed around the discs. The results showed no antibacterial activity at concentrations of 10% and 20%. At 40%, the inhibition zone was 4.87 mm (weak category), increasing to 5.43 mm (moderate category) at 60% and 7.53 mm (moderate category) at 80%. The positive control (ciprofloxacin) exhibited an inhibition zone of 23.31 mm (very strong category), while the negative control (DMSO) showed no inhibition. Statistical analysis using One Way ANOVA indicated significant differences among treatments (p<0.05). In conclusion, the combination of 70% ethanol extracts of Robusta coffee peel and citronella grass demonstrated concentration-dependent antibacterial activity against Escherichia coli, although the activity remained in the weak to moderate category.

Penentuan Kadar Vitamin D2 Pada Ekstrak Etanol 96% Jamur Sawit (Volvariella Volvacea) Dengan Metode High Performance Liquid Chromatography (HPLC) Assyifa Ainalaysia; Oky Hermansyah; Maria Eka Patri Yulianti; Putri Mulia; Rose Intan Perma Sari; Sutra Elvyanti
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13345

Vitamin D plays a crucial role in maintaining bone and dental health and enhancing the body’s immune system function. Vitamin D deficiency has spurred the exploration of alternative sources of vitamin D from natural food sources that may contain vitamin D₂. The palm mushroom (Volvariella volvacea) is one such natural food source known to contain vitamin D₂. This study aims to determine the vitamin D₂ content in a 96% ethanol extract of the palm mushroom (Volvariella volvacea). The vitamin D₂ content was determined using High Performance Liquid Chromatography (HPLC) with a BPFI standard vitamin D₂ reference standard. The results showed that the yield of the 96% ethanol extract of the palm mushroom was 10%. The maximum wavelength of the vitamin D₂ standard reference was obtained at 265 nm with an optimized mobile phase of Pro HPLC acetonitrile : Pro HPL methanol (90:10) and a flow rate of 1 mL/minute. The linear equation of the vitamin D2 calibration curve is y = 669.36x + 654.54 with a correlation coefficient (r) of 0.997, indicating good linearity of the analytical method. From this study, it can be concluded that palm mushrooms have potential as a source of vitamin D2.

Uji Efektivitas Antikolestrol Ekstrak Etanol 96% Daun Kelor (Moringa oleifera L.) Terhadap Kelinci Jantan (Oryctolagus cuniculus) Aulia Nur Afifah; Muhammad Farid; Rose Intan Perma Sari; Suci Rahmawati; Dwi Dominica
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13397

Kolesterol merupakan faktor risiko utama penyakit kardiovaskular dengan prevalensi yang terus meningkat. Penggunaan obat sintetik seperti simvastatin efektif menurunkan kadar kolesterol, namun berpotensi menimbulkan efek samping sehingga diperlukan alternatif dari bahan alami. Daun kelor (Moringa oleifera L.) mengandung senyawa aktif seperti flavonoid, saponin, dan fenolik yang berpotensi sebagai antikolesterol. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak etanol 96% daun kelor terhadap kadar kolesterol pada kelinci jantan (Oryctolagus cuniculus). Penelitian ini menggunakan metode eksperimental dengan rancangan pretest-posttest randomized control group design. Sebanyak 5 ekor kelinci jantan dibagi menjadi kelompok kontrol normal, kontrol positif (simvastatin), kontrol negatif (Na-CMC), serta dua kelompok perlakuan ekstrak dengan dosis 156 mg/kgBB dan 312 mg/kgBB. Induksi hiperkolesterolemia dilakukan menggunakan pakan tinggi lemak selama 7 hari, kemudian kadar kolesterol diukur pada hari ke-0, ke-7, dan ke-14. Hasil menunjukkan bahwa kontrol positif mengalami penurunan paling signifikan dari 185 mg/dL menjadi 105 mg/dL (43,24%). Kelompok ekstrak dosis 156 mg/kgBB dan 312 mg/kgBB juga mengalami penurunan menjadi 113 mg/dL (19,29%) dan 108 mg/dL (34,15%), sedangkan kontrol negatif hanya menurun sebesar 10,62%. Disimpulkan bahwa ekstrak etanol daun kelor memiliki aktivitas menurunkan kadar kolesterol, namun efektivitasnya masih lebih rendah dibandingkan simvastatin.

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