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All Journal IJMS - Indonesian Journal on Medical Science CERATA Jurnal Ilmu Farmasi Journal of Fundamental and Applied Pharmaceutical Science JANAKA : JURNAL PENGABDIAN MASYARAKAT KEWIRAUSAHAAN INDONESIA Indonesian Journal on Medical Science (IJMS) Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) CERATA GEMASSIKA: Jurnal Pengabdian kepada Masyarakat Multidisciplinary Innovations and Research in Applied Engineering
Siwi Hastuti, Siwi
PS. Farmasi, Politeknik Kesehatan Bhakti Mulia Sukoharjo
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Antimicrobial Urinary Catheters: Fabrication Strategies and Their Role in Preventing Catheter-Associated Urinary Tract Infections - A Narrative Review Priwintoko, Baharudin; Anggiri, Refonda Rias; Hastuti, Siwi
Multidisciplinary Innovations and Research in Applied Engineering Vol. 2 No. 2 (2025)
Publisher : Akademi Inovasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70935/rmfgdt72

Abstract

Catheter-associated urinary tract infections (CAUTIs) are among the most frequent healthcare-associated infections, primarily caused by biofilm formation on catheter surfaces. This narrative review summarizes recent progress in antimicrobial urinary catheter development, focusing on substrate materials, functional agents, and fabrication strategies. Common substrates such as silicone, polyurethane, and thermoplastic elastomers provide biocompatibility and durability but require modification to achieve antimicrobial performance. Strategies including surface coatings (e.g., dip- and spray-coating, sol–gel, and layer-by-layer deposition), impregnation, composite blending, and hybrid designs have been investigated to deliver sustained antimicrobial release, antifouling resistance, and improved patient comfort. Coating-based methods enable localized control of active agents, while bulk modifications ensure durability despite surface wear. Emerging approaches highlight multifunctional systems that integrate antimicrobial, antifouling, and lubricious properties, supported by precision techniques such as nanostructured coatings and bioinspired surface engineering. By linking material selection with fabrication design, this review underscores the need for scalable and cost-effective strategies that combine long-term antimicrobial protection, mechanical integrity, and regulatory compliance. Future research directions include hybrid fabrication methods, sustainable manufacturing, and clinical translation to reduce the global burden of CAUTIs.
FORMULASI DAN UJI SIFAT FISIK EKSTRAK ETANOL DAUN JATI (Tectona grandis L.,f.) PADA SEDIAAN LIP BALM Parmadi, Anom; Hastuti, Siwi; Ary Pratama, Bangkit
Duta Pharma Journal Vol. 5 No. 2 (2025): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/a8m5dy13

Abstract

Latar Belakang: Bahan alam banyak dimanfaatkan dalam industri kosmetik, salah satunya daun jati yang mengandung berbagai senyawa bioaktif seperti saponin, flavonoid, alkaloid, tanin, dan pigmen antosianin. Antosianin berperan sebagai pewarna alami sekaligus antioksidan sehingga berpotensi dikembangkan sebagai sediaan lip balm. Tujuan: Penelitian ini bertujuan untuk memperoleh ekstrak daun jati sebagai sumber zat warna antosianin serta mengevaluasi karakteristik fisik dan preferensi panelis terhadap sediaan lip balm yang diformulasikan dengan variasi basis. Metode: Penelitian dilakukan secara eksperimental. Ekstraksi daun jati dilakukan melalui proses maserasi menggunakan pelarut etanol 70%, menghasilkan rendemen sebesar 14,47% b/b. Ekstrak kemudian diformulasikan menjadi lip balm dengan variasi basis, kemudian diuji sifat fisiknya meliputi homogenitas, bentuk, warna, aroma, pH, daya lekat, dan daya sebar. Evaluasi preferensi dilakukan menggunakan uji hedonik. Analisis statistik pada daya lekat dan daya sebar menggunakan uji ANOVA. Hasil: Sediaan lip balm yang dihasilkan memiliki bentuk semi padat, homogen, berwarna oranye, beraroma aromatik, pH rata-rata 5, dan tidak menyebabkan iritasi. Uji preferensi menunjukkan bahwa Formula 2 merupakan yang paling disukai panelis. Uji statistik menunjukkan bahwa variasi basis memberikan pengaruh signifikan terhadap daya lekat (p = 0,001 < 0,05) dan daya sebar (p = 0,000 < 0,05). Formula 2 dengan komposisi basis cera flava 5% dan lanolin 50% memenuhi seluruh parameter evaluasi fisik dan memiliki tingkat penerimaan panelis tertinggi. Kesimpulan: Ekstrak daun jati dapat digunakan sebagai sumber zat warna antosianin untuk sediaan lip balm. Formula 2 merupakan formula terbaik berdasarkan hasil evaluasi sifat fisik dan preferensi panelis.
Analgesic and anti-inflammatory activity of the combination of ethanol extract of Seligi leaves (Phyllanthus buxifolius Muell Arg.) and sweet potato leaves (Ipomoea batatas L.) in mice Hastuti, Siwi; Rahmatillah, Annie; Rias Anggiri, Refonda
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.30354

Abstract

Research on the analgesic and anti-inflammatory properties of Seligi leaves (Phyllanthus buxifolius Muell. Arg) and sweet potato leaves (Ipomoea batatas L) has been conducted, but a combination of the two has never been reported. Pain and inflammation are interrelated diseases caused by the activity of pain and inflammation mediators. Analgesics and anti-inflammatories will suppress the activity of phospholipase and cyclooxygenase. This study aims to analyze the analgesic and anti-inflammatory activity of a combination of ethanol extracts of Seligi leaves and sweet potato leaves. The analgesic test was conducted using the acetic acid-induced writhing method in mice. The anti-inflammatory test was performed by inducing edema in the mice's soles with carrageenan. Phytochemical screening results revealed that both Seligi leaves and sweet potato leaves contain alkaloids, flavonoids, tannins, and saponins. The combination of ethanol extracts of Seligi leaves and sweet potato leaves at doses of 100, 200, and 400 mg/kgBW showed analgesic effects of (17.40 ± 0.59)%, (31.68 ± 0.46)%, and (57.54 ± 0.09)%, respectively. Acetosal, as a positive control at a dose of 65 mg/kgBW, had an analgesic effect of (82.73 ± 0.12)%. The combination of ethanol extract of Seligi leaves and sweet potato leaves at doses of 100, 200, and 400 mg/kgBW exhibited anti-inflammatory properties of (19.91 ± 0.50)%, (24.15 ± 0.24)%, and (54.91 ± 0.25)%, respectively. Diclofenac sodium, as a positive control at a dose of 19.5 mg/kgBW, had an anti-inflammatory effect of (80.56 ± 0.13)%. Negative control served as a reducing factor. One-way ANOVA uncovered significant differences in the means of the outcome variables between groups. Further post hoc LSD tests indicated that all pairs of groups were significantly different (p<0.05). Seligi leaves and sweet potato leaves can reduce pain and inflammation in mice, suggesting they could be developed into new drug ingredients.
Co-Authors Anggiri, Refonda Rias Anom Parmadi Anom Parmadi, Anom Bangkit Ary Pratama Caesar Ramadhan, Ganang Chabibah, Umu Febriana Rahmadani Iriyanti, Ivontia Is Kustanti, K Kustanti, Kustanti Oksi Putri, Risma Priwintoko, Baharudin Rahmatillah, Annie Rejeki - Politeknik Kesehatan Bhakti Mulia, Sri Rias Anggiri, Refonda Sari, Diah Kemala Sarwiji, Joko Sri Kusumaningsih, Wiji Sukmawati, Sekar Sri Susi Endrawati Yundari, Yundari