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Perbandingan Efektivitas dan Keamanan Early dengan Delayed Kolesistektomi Laparoskopik untuk Kolesistitis Akut: Systematic Review dan Meta-Analisis dari 18 RCT Farizky Jati Ananto; Andi Abdillah; Probo Yudha Pratama Putra; Eko Setyo Herwanto
Cermin Dunia Kedokteran Vol. 49 No. 8 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i8.289

Abstract

Pendahuluan. Secara teoritis, pada tata laksana kolesistitis akut, kolesistektomi laparoskopik lebih menguntungkan dibandingkan kolesistektomi konvensional. Namun, masih terdapat perdebatan mengenai perbedaan efektivitas dan keamanan antara early laparoscopic cholecystectomy (ELC) dengan delayed laparoscopic cholecystectomy (DLC). Metode: Meta-analisis evidence based dibuat pada November 2019 untuk menilai dan membandingkan efektivitas dan keamanan dari keduanya, menggunakan artikel di PubMed, Science Direct, Cochrane Library, ClinicalTrial.gov, dan Research Gate. Prosedur meta-analisis sesuai diagram dan alur PRISMA guideline, dilakukan dan diolah dengan program RevMan V.5.3. Hasil: Total 1.010 kasus ELC dan 1.072 kasus DLC dari 18 penelitian. Didapatkan perbedaan yang signifikan pada total lama perawatan di rumah sakit (MD 3,27 hari; 95% CI –4,32 hingga –2,23; p < 0,00001). Tidak didapatkan perbedaan signifikan pada durasi operasi (MD 8,36 menit; 95 % CI –0,15 hingga 16,88; p = 0,05) dan konversi menjadi operasi terbuka (RR 0,97; 95% CI 0,77 hingga 1,22; p = 0,80). Untuk komplikasi kebocoran bilier (OR 1,23; 95% CI 0,71 hingga 2,14; p = 0,46), perforasi kandung empedu (OR 1,14; 95% CI 0,64 hingga 2,06; p = 0,65), dan infeksi luka pasca-operasi (OR 0,99; 95% CI 0,60 hingga 1,63; p = 0,96) tidak didapatkan perbedaan signifikan. Hanya injuri duktus bilier yang memiliki perbedaan signifikan (OR 0,34; 95% CI 0,15 hingga 0,78; p = 0,01) Simpulan: Untuk tata laksana kolesistitis akut, ELC memiliki efektivitas dan keamanan lebih baik dibandingkan DLC ditinjau dari total lama perawatan di rumah sakit dan injuri duktus bilier. Introduction: Theoretically, in the management of acute cholecystitis, laparoscopic cholecystectomy has advantages compared to conventional cholecystectomy. However, there is still discussion on the appropriate timing of laparascopic cholecystectomy. Meta-analysis was made on the effectiveness and safety of early laparoscopic cholecystectomy (ELC) compared to delayed laparoscopic cholecystectomy (DLC). Method: A systematic review and meta-analysis was conducted in November 2019 from PubMed, Science Direct, Cochrane Library, ClinicalTrial.gov, and Research Gate to compare the effectiveness and safety of both treatments. The meta-analysis procedure was in accordance with the PRISMA flow and diagram guidelines, and processed with the RevMan V.5.3 program. Results: A total of 1010 ELC cases and 1072 DLC cases from 18 studies were included. Significant difference was found in total duration of hospital stay (MD –3.27 days, 95% CI –4.32 to –2.23, p <0.00001). No significant difference was found for operation time (MD 8.36 minutes, 95% CI –0.15 to 16.88, p = 0.05) and conversion to open surgery (RR 0.97, 95% CI 0.77 to 1.22, p = 0.80). No significant difference was found for complications such as bile leakage (OR 1.23, 95% CI 0.71 to 2.14, p = 0.46), gallbladder perforation (OR 1.14, 95% CI 0.64 to 2.06, p = 0.65), and wound infection (OR 0.99, 95 % CI 0.60 to 1.63, p = 0.96). The only significant difference was found in bile duct injury complication (OR 0.34, 95% CI 0.15 to 0.78, p = 0.01). Conclusion: In the management of acute cholecystitis, ELC has better effectiveness and safety compared to DLC in terms of total hospital stay and bile duct injury.
Karakteristik penderita Gangguan Kecemasan Menyeluruh Pada Grave’s Disease dengan gambaran EKG Sick Sinus Syndrome (SSS) R. Mohamad Javier; Andisa Fadhila Rialdi; Syarif Syamsi Ahyandi; Ericko Julian Limanto; Ehwanul Handika; Badrul Munir; Pertiwi Febriana Chandrawati; Andi Abdillah; Maisuri T. Chalid; Himawan Wicaksono; A. Rusli Budi Ansyah; I Nyoman Mudana
Syntax Idea 137-156
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/syntax-idea.v5i2.2135

Abstract

Sekitar 60%-80% kasus hipertiroidisme diakibatkan oleh Graves’ disease dimana wanita pada usia 20-50th lebih dominan dibandingkan laki-laki. Graves’ disease adalah suatu kelainan autoimun, adanya thyroid stimulating immunoglobulin (TSI), atau bisa disebut dengan thyroid stimulating antibody (TSAb) yang disekresikan di kelenjar tiroid berikatan dengan reseptor thyroid stimulating hormone (TSH) di kelenjar tiroid. Sehingga merangsang kelenjar tiroid untuk bekerja memproduksi hormon tiroksin berdasarkan rangsangan dari reseptor TSH. Rangsangan terus menerus dari TSAb mengakibatkan keadaan hipertiroidisme dan tiromegaly. Keadaan hipertiroidisme menyebabkan denyut jantung melemah dan gambaran pola EKG yang menunjukkan sindrom sinus sakit termasuk bradikardia sinus (denyut jantung <40 bpm), jeda sinus (jeda tiba-tiba nodus sinus lebih pendek dari 2-3 detik), dan henti sinus. Tujuan, Mengetahui karakteristik penderita gangguan kecemasan menyeluruh pada graves disease dengan gambaran EKG sick sinus syndrome (SSS). Metode, Penelitian ini merupakan Systematic Review dengan menggunakan metode Preferred Reporting Items for Systematic Reviews and Meta-analyses atau biasa disebut PRISMA, metode ini dilakukan secara sistematis dengan mengikuti tahapan atau protokol penelitian yang benar. Sumber diambil dari situs PubMed dan situs Google Scholar dengan jurnal terbitan tahun 2017-2022 lalu dilakukan screening didapatkan hasil 15.486. Hasil, Dilakukan klasterisasi jurnal dan didapatkan jumlah jurnal terindex scopus Q1 sejumlah 2 jurnal, Q2 2 jurnal, terindeks Sinta S1 1 jurnal, sehingga terdapat 5 jurnal yang diekstraksi. Kesimpulan, Mayoritas jurnal membahas mengenai usia dan gaya hidup yang berkaitan dengan karakteristik terjadinya grave disease serta faktor risiko grave disease ditentukan berdasarkan usia serta grave disease berhubungan dengan gangguan kecemasan, gambaran EKG sick sinus syndrome (SSS).
Kajian Literatur: Analisis Pengaruh Suhu Dingin Ekstrem Terhadap Radang Dingin Pada Pekerja Tempat Penyimpanan Beku Andi Abdillah; Ainun Tungga Dewi; Rubayat Indradi; Desy Andari
ARTERI : Jurnal Ilmu Kesehatan Vol 4 No 3 (2023): Mei
Publisher : Puslitbang Sinergis Asa Professional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/arteri.v4i3.251

Abstract

Frostbite is a disease caused by continuous exposure to extreme cold and is very susceptible to cold storage workers. This paper focuses on the study of Frostbite due to exposure to cold temperatures in the cold storage room. This study uses a literature study method using search results through the research results library and a review of 30 references that have been presented in reputable international journals indexed by Scopus Q1, Q2 and Q3. Besides that, national journals indexed by Sinta and book references are also used. The results of this study indicate a relationship between an increase of temperature in the cold room with an increase in intercellular fluid in human body tissue to freeze due to extreme cold temperatures. The first phase of frostbite treatment is to remove the sufferer from the environment with extreme cold temperatures as soon as possible. Increasing body temperature from the inside (with food / drink / medicine) and the outside (warm water) is a good option for the first phase. In the second phase, sufferers need professional help in the medical field. Avoid breaking the clear liquid layer. The third and fourth phases require first aid to avoid secondary infection.
Perbandingan Efektivitas dan Keamanan Early dengan Delayed Kolesistektomi Laparoskopik untuk Kolesistitis Akut: Systematic Review dan Meta-Analisis dari 18 RCT Farizky Jati Ananto; Andi Abdillah; Probo Yudha Pratama Putra; Eko Setyo Herwanto
Cermin Dunia Kedokteran Vol 49 No 8 (2022): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i8.289

Abstract

Pendahuluan. Secara teoritis, pada tata laksana kolesistitis akut, kolesistektomi laparoskopik lebih menguntungkan dibandingkan kolesistektomi konvensional. Namun, masih terdapat perdebatan mengenai perbedaan efektivitas dan keamanan antara early laparoscopic cholecystectomy (ELC) dengan delayed laparoscopic cholecystectomy (DLC). Metode: Meta-analisis evidence based dibuat pada November 2019 untuk menilai dan membandingkan efektivitas dan keamanan dari keduanya, menggunakan artikel di PubMed, Science Direct, Cochrane Library, ClinicalTrial.gov, dan Research Gate. Prosedur meta-analisis sesuai diagram dan alur PRISMA guideline, dilakukan dan diolah dengan program RevMan V.5.3. Hasil: Total 1.010 kasus ELC dan 1.072 kasus DLC dari 18 penelitian. Didapatkan perbedaan yang signifikan pada total lama perawatan di rumah sakit (MD 3,27 hari; 95% CI –4,32 hingga –2,23; p < 0,00001). Tidak didapatkan perbedaan signifikan pada durasi operasi (MD 8,36 menit; 95 % CI –0,15 hingga 16,88; p = 0,05) dan konversi menjadi operasi terbuka (RR 0,97; 95% CI 0,77 hingga 1,22; p = 0,80). Untuk komplikasi kebocoran bilier (OR 1,23; 95% CI 0,71 hingga 2,14; p = 0,46), perforasi kandung empedu (OR 1,14; 95% CI 0,64 hingga 2,06; p = 0,65), dan infeksi luka pasca-operasi (OR 0,99; 95% CI 0,60 hingga 1,63; p = 0,96) tidak didapatkan perbedaan signifikan. Hanya injuri duktus bilier yang memiliki perbedaan signifikan (OR 0,34; 95% CI 0,15 hingga 0,78; p = 0,01) Simpulan: Untuk tata laksana kolesistitis akut, ELC memiliki efektivitas dan keamanan lebih baik dibandingkan DLC ditinjau dari total lama perawatan di rumah sakit dan injuri duktus bilier. Introduction: Theoretically, in the management of acute cholecystitis, laparoscopic cholecystectomy has advantages compared to conventional cholecystectomy. However, there is still discussion on the appropriate timing of laparascopic cholecystectomy. Meta-analysis was made on the effectiveness and safety of early laparoscopic cholecystectomy (ELC) compared to delayed laparoscopic cholecystectomy (DLC). Method: A systematic review and meta-analysis was conducted in November 2019 from PubMed, Science Direct, Cochrane Library, ClinicalTrial.gov, and Research Gate to compare the effectiveness and safety of both treatments. The meta-analysis procedure was in accordance with the PRISMA flow and diagram guidelines, and processed with the RevMan V.5.3 program. Results: A total of 1010 ELC cases and 1072 DLC cases from 18 studies were included. Significant difference was found in total duration of hospital stay (MD –3.27 days, 95% CI –4.32 to –2.23, p <0.00001). No significant difference was found for operation time (MD 8.36 minutes, 95% CI –0.15 to 16.88, p = 0.05) and conversion to open surgery (RR 0.97, 95% CI 0.77 to 1.22, p = 0.80). No significant difference was found for complications such as bile leakage (OR 1.23, 95% CI 0.71 to 2.14, p = 0.46), gallbladder perforation (OR 1.14, 95% CI 0.64 to 2.06, p = 0.65), and wound infection (OR 0.99, 95 % CI 0.60 to 1.63, p = 0.96). The only significant difference was found in bile duct injury complication (OR 0.34, 95% CI 0.15 to 0.78, p = 0.01). Conclusion: In the management of acute cholecystitis, ELC has better effectiveness and safety compared to DLC in terms of total hospital stay and bile duct injury.