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All Journal BALI MEDICAL JOURNAL (BMJ) MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan
Mansyur Arief, Mansyur
Postgraduate Program Faculty of Medicine, Hasanuddin University, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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ANALISIS NILAI CLOTHING TIME, PROTHROMBINE TIME DAN ACTIVATED PARTIAL THROMBOPLASTINE TIME PADA REMAJA OBES Nelly, Nelly; Arief, Mansyur; Patellongi, Ilham Jaya
Jurnal Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 5 (2018): MAGNA MEDICA
Publisher : Jurnal Berkala Ilmiah Kedokteran dan Kesehatan

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Abstract

Berdasarkan estimasi WHO, obesitas menjadi masalah kesehatan di dunia. Selain karena insidennya meningkat,juga karena obesitas menimbulkan berbagai komplikasi penyakit metabolik dan vaskuler  seperti sindrom metabolik, penyakit jantung, stroke dan gangguan pembekuan darah. Mengingat insiden obesitas pada saat ini telah mengalami pergeseran dari dewasa ke usia anak dan remaja serta berbagai komplikasi yang ditimbulkan oleh obesitas itu sendiri  maka dianggap perlu dilakukan deteksi dini adanya gangguan hemostasispada obesitas usia anak dan remaja untuk mencegah komorbiditas obesitas dikemudian hari. Desain penelitian ini adalah cross sectional study yang dilakukan di SMA Katolik Rajawali  Makassar dengan menggunakan sampel  siswa yang berumur sekitar 10-18 tahun. Dilakukan pemeriksaan antropometrik dan pemeriksaan nilai Clothing Time (TT), Prothrombine Time (PT) dan Activated Partial Thromboplastine Time(aPTT). Obesitas dinyatakan berdasarkan Kategori IMT yang ditentukan berdasarkan ambang batas Z-Score sedangkan kategorilingkar pinggang ditentukan berdasarkan Waist Circumfrence for Hong Kong Chinese Children (2008). Data dianalisis dengan independent t-test untuk menilai perbedaan nilai CT, PT dan aPTT pada remaja obes dan berat badan normal sedangkan  uji korelasi pearson digunakan untuk melihat adanya hubungan antara IMT dan LP dengan nilai CT, PT dan aPTT pada remaja obes. Subyek adalah siswa siswi SMA Katolik Rajawali Makassar dengan rerata umur 15 tahun terdiri dari 33 orang laki-laki (22 obesitas,11 normal) dan 16 perempuan (5 obesitas,11 normal). Didapatkan perbedaan bermakna antara nilai CT, PT dan aPTT pada remaja obes dan berat badan normal. Nilai rata-rata CT, PT dan  pada kelompok normal adalah masing-masing aPTT 11±1,23; 13,86 ± 0,63 detik ; 32,90 + 1,77 detik dan pada kelompok obes adalah nilai CT,PT dan aPTT adalah 9 ±1,7; 13,11 + 0,59 detik dan 31,92+3,82 detik. Selain itu, terdapat korelasi negatif antara nilai CT,PT dan LP pada remaja obes namun tidak ditemukan adanya korelasi antara IMT dan LP dengan nilai aPTT pada remaja obes. Nilai CT, PT dan aPTT pada remaja obes cenderung memendek dibandingkan dengan berat badan normal.Semakin tinggi nilai IMT dan LP, maka nilai CT, PT dan aPTT semakin memendek.   Keywords : obesitas, remaja CT,PT,aPTT
Dynamics of Human Mesenchymal Stem Cells, M1 Microglia/Macrophage, and Fractalkine in Ischemic Stroke Patients Herminawati, Lucia; Wijaya, Andi; Arief, Mansyur; As’ad, Suryani
BALI MEDICAL JOURNAL Vol 5 No 1 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: About 85% of strokes are ischemic strokes, caused by occlusion of cerebral artery that induced brain inflammation. A deep understanding of ischemic stroke mechanism will lead to better neurorestorative treatment. Objective: This study investigates the dynamics of human mesenchymal stem cells, fractalkine, and M1 microglia/macrophage in ischemic stroke patients. Results: We found the same fractalkine levels and M1 microglia/macrophage cells on patients with stroke onset 0 to 14 days, then decrease until 30 days of stroke onset. MSCs was increase 7 days after stroke onset, peaked by 14 days, then decreased until 30 days after stroke ischemic onset. Conclusions: This study found an interaction between microglia/macrophage, fractalkine, and MSCs on ischemic stroke patients, so therapeutic strategy could be developed.
Angiogenesis in Ischemic Stroke Patients Aged 30 - 80 years at Gatot Subroto Army Central Hospital (RSPAD) Jakarta Hidayat, Andri; Arief, Mansyur; Wijaya, Andi; As’ad, Suryani
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Angiogenesis, is one of the neurorepair process which plays an important role after ischemic stroke incident. vascular-endothelial growth factor (VEGF), Angiopoietin-1 (ANG1) and fibroblast growth factor (FGF) are the angiogenic factors involved in the process of angiogenesis. In this study we observed VEGF, ANG1 and FGF concentration to represent the angiogenesis process occurred in ischemic stroke patients with different onset time. Methods: This was a cross sectional study involving 63 ischemic stroke subjects aged 30 – 80 years old from The Central Hospital of the Army (RSPAD) Gatot Subroto Jakarta. Subjects were divided into 3 groups due to stroke onset time.: < than 7 days (Group A: 11 subjects), onset 7 – 30 days (Group B: 26 subjects) and > 30 days (Group C: 26 Subjects). VEGF, FGF and ANG1 serum levels were measured using multiplex method with luminex Magpix instrument. Results: VEGF, ANG1, and FGF were not significantly different between all groups. We did not find any significant correlation in all groups except FGF with ANG1 in group C. VEGF and ANG1 levels found to be highest in group B, and FGF levels in group A. Conclusions: VEGF, FGF and ANG1 increased soon after ischemic injury. FGF immediately increased in first week after onset and then decreased. VEGF and ANG1 levels reach their peak levels between 7-30 days after injury, showed that the optimal process of angiogenesis occurs in this period. There is no significant correlation between VEGF, FGF and ANG1 in all groups but we found a correlation between FGF and ANG1 in subjects with onset > 30 days after injury.
Co-Authors ANDI WIJAYA Andri Hidayat, Andri Lucia Herminawati, Lucia Nelly Nelly Patellongi, Ilham Jaya Suryani As’ad