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Angiogenesis in Ischemic Stroke Patients Aged 30 - 80 years at Gatot Subroto Army Central Hospital (RSPAD) Jakarta Hidayat, Andri; Arief, Mansyur; Wijaya, Andi; Asâ€™ad, Suryani
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Background: Angiogenesis, is one of the neurorepair process which plays an important role after ischemic stroke incident. vascular-endothelial growth factor (VEGF), Angiopoietin-1 (ANG1) and fibroblast growth factor (FGF) are the angiogenic factors involved in the process of angiogenesis. In this study we observed VEGF, ANG1 and FGF concentration to represent the angiogenesis process occurred in ischemic stroke patients with different onset time. Methods: This was a cross sectional study involving 63 ischemic stroke subjects aged 30 – 80 years old from The Central Hospital of the Army (RSPAD) Gatot Subroto Jakarta. Subjects were divided into 3 groups due to stroke onset time.: < than 7 days (Group A: 11 subjects), onset 7 – 30 days (Group B: 26 subjects) and > 30 days (Group C: 26 Subjects). VEGF, FGF and ANG1 serum levels were measured using multiplex method with luminex Magpix instrument. Results: VEGF, ANG1, and FGF were not significantly different between all groups. We did not find any significant correlation in all groups except FGF with ANG1 in group C. VEGF and ANG1 levels found to be highest in group B, and FGF levels in group A. Conclusions: VEGF, FGF and ANG1 increased soon after ischemic injury. FGF immediately increased in first week after onset and then decreased. VEGF and ANG1 levels reach their peak levels between 7-30 days after injury, showed that the optimal process of angiogenesis occurs in this period. There is no significant correlation between VEGF, FGF and ANG1 in all groups but we found a correlation between FGF and ANG1 in subjects with onset > 30 days after injury.

UPAYA MASYARAKAT MELAYU KECAMATAN PANGEAN KABUPATEN KUANTAN SINGINGI DALAM MENCEGAH DAN MEMBERANTAS PENYALAHGUNAAN DAN PEREDARAN GELAP NARKOTIKA DAN PREKURSOR NARKOTIKA BERDASARKAN UNDANG-UNDANG NOMOR 35 TAHUN 2009 TENTANG NARKOTIKA Hidayat, Andri; Erdianto, Erdianto; Tiaraputri, Adi
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Hukum Vol 8, No 1 (2021): Januari - Juni 2021
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Ilmu Hukum

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Narcotics based on article 1 paragraph (1) of Law Number 35 of 2009concerning Narcotics which reads "narcotics are substances or drugs derivedfrom plants, both synthetic and semisynthetic, which can cause a decrease orchange in consciousness, loss of taste, reduce to eliminate taste. pain, and canlead to dependence, which are differentiated into groups as attached in this Law". Narcotics precursors are substances or starting materials or chemicals that canbe used in the manufacture of narcotics which are differentiated in the table asattached to this Law.This type of research can be classified into sociological juridicalresearch where the research tests the effectiveness of the current law. Thissociological research is a type that is viewed from the purpose of legal research.Sociological or empirical legal research consists of legal identification(unwritten) and research on the effectiveness of the law.The research objectives of this thesis are; First, public participation isseen from Article 104 of Law Number 35 Year 2009 concerning narcotics, whichstates that â€œthe public has the widest opportunity to participate in helping toprevent and eradicate the abuse and illicit trafficking of narcotics and narcoticprecursors. The two efforts made by the Malay community of Pangean District inpreventing the circulation and abuse of narcotics.From the research results, based on two problem formulations it can beconcluded. First, so far the community has not fully participated in the preventionand trafficking of narcotics and narcotics precursors, it can be seen from theincreasing number of use and circulation of narcotics in Pangean sub-district.Second, preventive efforts have been made to the maximum extent possible by thevillage apparatus working together with the Police to disseminate information onthe dangers of narcotics abuse and narcotic precursors. However, the problem isin the form of implementation or real action from the community.Keywords: Narcotics, Community Efforts, Prevention

Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.

PENGARUH WORKING CAPITAL TURNOVER (WCTO), TOTAL ASSET TURNOVER (TATO), DAN DEBT TO EQUITY RATIO (DER) TERHADAP RETURN ON ASSET (ROA) PADA PERUSAHAN MANUFAKTUR TEMBAKAU YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) PERIODE 2013-2023 Hidayat, Andri; Nurismalatri
Journal of Research and Publication Innovation Vol 2 No 4 (2024): OCTOBER
Publisher : Journal of Research and Publication Innovation

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This research aims to determine the influence of the variables Working Capital Turnover (WCTO), Total Asset Turnover (TATO), and Debt To Equity Ratio (DER) on Return On Assets (ROA) in tobacco manufacturing companies listed on the Indonesian Stock Exchange (BEI). This type of research is quantitative. The data analysis technique used is panel data regression with an 11 (eleven) year time series, namely the 2013-2023 period and 4 (four) tobacco manufacturing companies. Based on the results of the partial test (T test) of Working Capital Turnover (WCTO), the T value is 1.264558 with a significance of 0.2133. Because Tcount < Ttable (1.264558 <1.68385) and the significance value > significant level (0.2133 > 0.05). So the conclusion is that Working Capital Turnover (WCTO) has no effect on Return On Assets (ROA). The research results for Total Asset Turnover (TATO), obtained a T value of 9.618405 with a significance of 0.0000. Because Tcount > Ttable (9.618405 > 1.68385) and the significance value < significant level (0.0000 < 0.05). So the conclusion is that Total Asset Turnover (TATO) has a positive effect on Return On Assets (ROA). Meanwhile, the Debt To Equity Ratio (DER) obtained a T value of 0.489860 with a significance of 0.6269. Because Tcount < Ttable (0.489860<1.68385) and the significance value > significant level (0.6269>0.05). So the conclusion is that Debt To Equity Ratio (DER) has no effect on Return On Assets (ROA). The results of simultaneous hypothesis testing (F test) can be seen that the Fcount value is 31.68553, which is greater than the Ftable of 2.838745 or 31.68553 > 2.838745, while the significance value of 0.000000 is smaller than 0.05 or 0.000000 < 0.05, so it can be concluded that Working Capital Turnover (WCTO), Total Asset Turnover (TATO) and Debt To Equity Ratio (DER) simultaneously have a significant effect on Return On Assets (ROA).

Pengembangan Repositori Institusi di Politeknik Negeri Sambas muhammad usman; Hidayat, Andri
Sehati Abdimas Vol 6 No 1 (2023): Prosiding Sehati Abdimas 2023
Publisher : PPPM POLTESA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47767/sehati_abdimas.v6i1.704

Repositori merupakan media penyimpanan digital institusi untuk mengumpulkan, menyediakan, dan membagikan karya ilmiah karya sivitas akademika. Keberadaan perangkat lunak repositori institusi dapat dirasakan manfaatnya oleh institusi perguruan tinggi sebagai penggunanya, mulai dari aspek kemudahan pengaksesan hingga peningkatan nilai akreditasi dan pemeringkatan perguruan tinggi. Penelitian ini bertujuan untuk melakukan pengembangaan repositori institusi di Politeknik Negeri Sambas. Metode penelitian yang digunakan adalah pendekatan eksperimental dimana penulis melakukan percobaan beberapa platform yang banyak digunakan oleh Perguruan Tinggi di Indonesia yang meliputi SLiMS, Eprints dan Dspace, mulai dari proses instalasi, konfigurasi, upload data, IP config, hingga melakukan perbandingan modul-modul yang tersedia. Berdasarkan penelitian dan pengembangan sistem, dapat disimpulkan bahwa platform Eprints telah memenuhi standar dan kriteria sebagai perangkat lunak repositori institusi di Politeknik Negeri Sambas. Kata kunci: Repositori, Open Source, Eprints, Perangkat Lunak,

The Effect of Giving Black Rice Extract Ointment (Oryza Sativa L. Indica) on the Growth of Wistar Rat (Rattus Novergicus) Hair Follicles Kartini, Nancy; Denhara Wijaya, Cindy; Hidayat, Andri
International Journal of Health and Pharmaceutical (IJHP) Vol. 4 No. 2 (2024): May 2024
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v4i2.320

Hair loss affects many people worldwide. Hair loss is common and can be treated with vitamins and minerals. Black rice (Oryza sativa l. indica) contains phenolic and anthocyanin-rich flavonoids. The study examined whether black rice extract ointment accelerated Wistar rat (Rattus norvegicus) hair follicle growth. This was an actual experiment with 30 mice. The research involved acclimating test animals in the lab, manufacturing black rice extract, and making ointment. After an Ointment Evaluation Test, Phytochemical Screening was performed. Test the FT-IR Functional Group. DPPH testing will determine antioxidant activity. Finally, four groups (control group, treatment groups 1, 2, and 3 with 10%, 20%, and 30% ointments) received treatment for 21 days. Study results were handled using SPSS. The normality test showed 0.652 > 0.05 significance, while the Independent Samples T-Test showed 0.00 < 0.05 significance. Alkaloids, flavonoids, tannins, and steroids/triterpenoids make black rice an antioxidant, according to the active compound test. For average hair growth, 10% black rice ointment dose therapy yielded 0.681 cm, 20% 0.769 cm, and 30% 0.851 cm. The study found that black rice extract contains high antioxidants (ppm concentration value <50) that can prevent premature skin aging and promote hair and skin health.

Dampak Edukasi Obat bagi Pemahaman dan Perilaku Pasien DM II di RSUP. H. Adam Malik Medan Febriyanti Gulo, Putri; Suandy, Suandy; Hidayat, Andri; Neswita, Elfia
Ranah Research : Journal of Multidisciplinary Research and Development Vol. 6 No. 5 (2024): Ranah Research : Journal Of Multidisciplinary Research and Development (Juli 20
Publisher : Dinasti Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38035/rrj.v6i5.975

Konseling merupakan praktik esensial bagi apoteker karena memberikan keuntungan besar bagi pasien. Salah satu layanan vital dalam farmasi adalah konseling. Penelitian di RSU Pusat Haji Adam Malik Medan menggunakan kuesioner pre-tes dan pos-tes, melibatkan 50 peserta. Data dianalisis dengan regresi linear sederhana, validitas dan reliabilitas diuji, serta dilakukan uji t perpasangan dan chi square crosstab. Hasil analisis uji t berpasangan menunjukkan bahwa konseling secara signifikan meningkatkan perilaku pasien dalam mengikuti terapi, dengan nilai signifikansi yang sangat rendah, yaitu 0,001, yang kurang dari taraf signifikansi 0,05, menjelaskan adanya perbedaan signifikan pretest dan posttest dalam pemahaman dan perilaku pasien terhadap diabetes. Pasien lebih tahu tentang penyakit mereka dengan konseling, yang membantu mereka mengubah perilaku mereka dan pengobatannya. Mayoritas responden adalah wanita (68% atau 34 orang), sementara pria hanya 32% atau 16 orang, menunjukkan dominasi responden adalah kaum hawa.

Desain Illustrasi Digital Motif Kain Tenun Lunggi Kabupaten Sambas Menggunakan Teknik Gambar Pixel Art Salahuddin, Salahuddin; Hidayat, Andri
Educativo: Jurnal Pendidikan Vol 1 No 2 (2022): Jurnal Teknik, Komputer, Agroteknologi dan Sains (Marostek)
Publisher : PT. Marosk Zada Cemerlang

Penelitian ini menggunakan metode kualitatif dengan lokasi penelitian Desa Semberang Kecamatan Sambas sebagai pusat tenun di Kabupaten Sambas, untuk teknik pengambilan data penulis melakukan observasi, studi literatur, dan wawancara. Hasil analisis kendala yang dihadapi oleh pengrajin adalah pembuatan motif bersifat konvensional menggambar pola dikertas menggunakan pensil, sehingga permintaan berkurang karena produk sulit dipreview dimana hasil produk belum terlihat, kemungkinan kesalahan pembuatan motif dan kombinasi pewarnaan bisa terjadi. Untuk mengatasi permasalahan penulis memberikan solusi membuat media desain grafis yang dikembangkan berupa desain motif Ilustrasi digital. Tujuan dari penelitian adalah pembuatan desain motif tenun lunggi Sambas menggunakan Ilustrasi digital dengan Teknik pixel art. Ciri khas gambar pixel art adalah gambar digital yang memiliki motif mozaik atau kotak-kotak pixel. Berdasarkan hasil penelitian dapat ditarik kesimpulan bahwa dengan memanfaatkan komputerisasi desain grafis pembuatan desain motif tenun songket Sambas menggunakan Ilustrasi digital dapat dilakukan, konsumen dapat melihat preview motif dan warna yang diterapkan pada struktur kain sebelum kain diproduksi sehingga mempermudah koreksian terkait dengan warna motif kurang besar,garis kurang lengkung, warna tidak sesuai motif. Dengan desain melalui ilustrasi digital komputer kesalahan produksi bisa diatasi, menghemat waktu dan biaya serta sebagai media priview sebelum produk diproduksi.

Factors influencing family planning acceptors' use of IUD contraception in the working area of Medan Amplas District Abdullah, Armelia Adel; Kaban, Lenni Apriani; Novianti, Desi; Hidayat, Andri; Ongko, Nicholas Xavier; Rosar, Naufal; Marpaung, Hans Hotma Haposan; Siregar, Lisdawaty; Sherliana, Ferra; Lizar, Budi Septhian; Angkasa, Celvin
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.7437

Indonesia's high population growth rate is a big problem and needs serious handling from all parties of society and government The family planning movement is carried out to build a prosperous family in order to create optimal human resources. The family planning program is one of the most effective ways to improve family resilience, health, and safety of mothers, children, and women. Descriptive quantitative research, where this study aims to determine the factors that influence family planning acceptors on the use of IUD contraceptives in the Medan Amplas working area in 2024 using a cross-sectional design where the independent variable and the dependent variable are identified at the same time. The results of this study are There is an influence of education (P<0.05), mileage (P<0.05), knowledge (P<0.05), attitude (P,0.05), attitude (P<0.05), husband support (P<0.05), health worker support (P<0.05), The most dominant factor affecting the use of IUD contraceptives is the variable Husband support Exp (B) = 2.50 means that if there is husband's support for the use of IUD contraceptives then there are 2.5 times the mother wants to participate as an acceptor of IUD contraceptives. It is expected to Improve the Awareness Campaign Program by holding campaigns that target husbands and other family members, explaining the importance of their support in the use of contraceptives.

Skrinning fitokimia komponen bioaktif Parem Karo Sembiring, Novitaria Br.; Lubis, Asyrun Alkhairi; Karo, Reh Malem Br; Hidayat, Andri
Buletin Kedokteran & Kesehatan Prima Vol. 2 No. 2 (2023): September
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v2i2.4798

Param Karo atau disebut juga Kuning Bergeh, memiliki khasiat untuk menurunkan suhu tubuh ketika demam. Berdasarkan wawancara dengan pembuat param Karo, di Kelurahan Pekan Bahorok, Sumatera Utara, sediaan ini terbuat dari buah pala (Piperis Nigri Fructus), jahe (Zingiberis Officinalis Rhizoma), bangle (Zingiber purpureum), lempuyang (Zingiber cassumunar), kencur (Kaemferia galanga), temulawak (Curcuma xanthoriza), temu kunci (Boesenbergia pandurata), dan tepung beras (Oryza Sativa) yang dihaluskan, kemudian dibentuk bulat-bulat ukuran kecil. Penelitian ini bertujuan untuk mengidentifikasi metabolit sekunder Param Karo yang belum pernah diteliti. Metode penelitian ini eksperimental dengan menguji metabolit sekunder param Karo menggunakan reagen-reagen skrinning fitokimia. Hasil pengujian skrinning fitokimia param Karo positive mengandung alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Sehingga dapat disimpulkan param Karo mengandung metabolit sekunder seperti alkaloid, flavonoid, fenol, tannin, monoterpene, seskuiterpen, triterpenoid, dan saponin. Meskipun, bahan-bahan dalam pembuatan param Karo sudah melewati proses pemanasan, komponen senyawa bioaktif khususnya metabolit sekunder tidak rusak dan dapat dipertahankan.

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