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All Journal BALI MEDICAL JOURNAL (BMJ) Biology, Medicine, & Natural Product Chemistry Majalah Kesehatan FKUB Oto Rhino Laryngologica Indonesiana Jurnal Ilmu Kedokteran Keluarga Malang Otorhinolaryngology Head and Neck Surgery Journal
Iriana Maharani, Iriana
Otolaryngology Head&Neck Surgery Department of Medical Faculty Brawijaya University / Dr. Saiful Anwar Regional Public Hospital
Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Journal : Biology, Medicine,

 1 
Correlation of Allergic Rhinitis Patient Questionnaire with Skin Prick Test Results at Saiful Anwar Regional Hospital Maharani, Iriana; Kurniadi, Melody Audria
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.33-36

Abstract

Objective: To determine the optimal cut-off value of the Allergic Rhinitis Patient Questionnaire as a diagnostic tool and its correlation with Skin Prick Test (SPT) results; Methods: The data used were medical records at the ENT Polyclinic dr. Saiful Anwar Hospital with cross sectional method then the data was processed with the SPSS application; Results.: Demographic data are dominated by males (56.3%) with an age range of 19-59 years (74.7%). The most common symptom complained was nasal congestion (71.3%). The trigger of symptoms is dominated by dust allergens (77%). The most common classification of Allergic Rhinitis (AR) is moderate – severe (50.6%) with Visual Analogue Scale (VAS) score > 5 and dominated by complaints of sleep disturbances (57.5%). The optimal limit value of the Allergic Rhinitis Patient Questionnaire is 10, where patients with a score value ³ 10 can be assumed to suspect AR. There is a significant correlation between the results of the assessment using the Allergic Rhinitis Patient Questionnaire and the results of the SPT examination. Conclusion: Patients with a total score of Allergic Rhinitis Patient Questionnaire ³ 10 were assumed to be suspected of AR and the results of the questionnaire assessment correlated with the SPT results.
Correlation of BMP2 with Degree of Osteitisin Primary CRS with and without nasal Polyps Handoko, Edi; Santoso, David; Maharani, Iriana; P.W, Yuyun Yueniwati; Agustina, Tanti
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.43-50

Abstract

Chronic rhinosinusitis (CRS) is an inflammation of the nasal mucosa and paranasal sinuses, persisting for over12 weeks. CRS involves a remodeling process and opacification known as osteitis, resulting from type 2 and non-type two inflammation. Osteitis severity is assessed using CT scans and the Global Osteitis Scoring Scale (GOSS). Bone morphogenetic protein-2 (BMP-2) is crucial in osteogenesis and bone remodeling. However, no research has shown a relationship between BMP-2 concentration and osteitis degree, as measured by GOSS, in CRS patients with or without nasal polyps. The objective of this study is to analyze the relationship between BMP-2 concentration and osteitis degree measure with GOSS in primary CRS. A cross-sectional analytic observational study was conducted using primary RSK as the study population. BMP-2 concentration, a marker for bone remodeling, used ELISA. The osteitis of the paranasal sinus walls was assessed with a CT scan and quantified using the GOSS method.  The study included 44 patients, with 8 of them serving as the control group. It was found that BMP-2 concentration (ng/mL) had a linear relationship with the GOSS degree in patients with CRS, showing a correlation of 0.583 (deviation >0.05). Further analysis revealed a significant correlation between BMP-2 concentration and GOSS, with a coefficient of 0.857 (considered very significant, in the range of 0.76-0.99). This strong correlation indicates that as BMP-2 concentration strongly correlates with the occurance of osteitis, which were measured by GOSS. BMP-2, as a marker for osteitis in CRS, shows a significant and linear correlation with the severity degree of osteitis measured by GOSS.
Co-Authors -, Soehartono A.A. Ketut Agung Cahyawan W Agustina, Tanti ApriIia, Nanin Baehaqi DAVID SANTOSO Ghutama, Bio Swadi Handoko, Edi Harahap, Surya Parlaungan Kurniadi, Melody Audria Laksmi Dewi, Ni Putu Marulitua, Christian Hendrik Prasetyo, Samuel Putra, Aditya Shantika Rus Suheryanto, Rus Sri Listyoko, Aditya Tallane, Sarah Tamania Widasmara, DheIya Wirattami, Ayunita Tri Yuyun Yueniwati