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All Journal Amerta Nutrition Jurnal Ilmu Kedokteran dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Heart Science Journal
Saskia Dyah Handari
Departmen Of Cardiology And Vascular Medicine, Faculty Of Medicine, Universitas Ciputra, Surabaya.
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Multi-modality cardiac imaging in aorta and aortic valve from evaluation to post treatment Suprapta, Aloysius Yuwono; Handari, Saskia Dyah
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.4

Abstract

Aorta and aortic valve disease are crucial but usually found unintentionally while doing imaging evaluation. Genetic and non-genetical issues can be the source of the disease. Proper evaluation using multimodality of imaging can give an early diagnosis and proper treatment according to recent situation.  Aortic disease and aortic valve disease can result from genetic and non-genetic problems. Echocardiography (transthoracic or transesophageal) can be the first modality to evaluate this disease. Further modalities (computed tomography angiography, magnetic resonance imaging, and positron electromagnetic) can be used as supporting data to make more accurate analyses for diagnosis and evaluation post-treatment. Although they give more accurate images, there are some limitations in each modality. Knowing the benefits and limitations of each modality can make better use of the tools. Multimodality imaging is enhancing in detection of aortic disease and aortic valve disease. Understanding the benefits and limits of each imaging technique is essential for determining the best modality
Non-invasive multimodality cardiac stress test imaging: Role of echocardiography, cardiac computed tomography, cardiac magnetic resonance, and nuclear medicine Kahadi, Cik; Handari, Saskia Dyah
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.3

Abstract

Coronary artery disease, or CAD, is the major cause of mortality and morbidity globally, with significant socioeconomic impact. Based on European Society of Cardiology or ESC guidelines in Chronic Coronary Syndrome (CCS), multimodality imaging strategies are highly suggested in evaluating the patient who suspected CAD. Non-invasive imaging modalities can assess the anatomy of coronary artery by using Coronary Computed Tomography Angiography (CCTA) or assess functional stress testing with inducible myocardial ischemia by using Stress Echocardiography (SE), Myocardial CT Perfusion (CTP), Cardiac Magnetic Resonance (CMR), Single Photon Emission Computed Tomography (SPECT), or Positron Emission Tomography (PET). Nowadays, it’s important to recognize the limitations and capabilities of each imaging method, especially before selecting a functional testing focused on ischemia compared to an anatomy of coronary imaging. This paper describes an overview of non-invasive imaging modalities for the general diagnosis of CAD patients. Non-invasive multimodality cardiac stress test imaging is enhancing the diagnosis of significant stenosis of the coronary artery. Understanding the benefits and limits of each imaging is essential for determining the best modality we used.
Cardiac computed tomography beyond anatomical coronary artery disease assessment: A contemporary review Vori, Ira; Handari, Saskia Dyah
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.9

Abstract

Cardiac computed tomography (CT) has undergone a remarkable transformation over the past two decades, evolving from a purely anatomical imaging modality to a comprehensive cardiac assessment tool. This review examines recent technological advancements and expanded clinical applications of cardiac CT. Contemporary systems, equipped with dual-energy imaging, wide-detector arrays, and sophisticated reconstruction algorithms, now enable functional assessment through myocardial perfusion imaging and CT-derived fractional flow reserve (CT-FFR), alongside advanced plaque characterization. Technical developments have improved temporal and spatial resolution while optimizing radiation exposure through refined dose management protocols. The integration of anatomical and functional data has proven particularly valuable in triple rule out at emergency department and also a guide for revascularization decisions, as physiological significance often supersedes anatomical severity in clinical decision-making. Additionally, cardiac CT has emerged as an essential tool in pre-procedural planning for structural heart interventions, including transcatheter aortic valve replacement, left atrial appendage (LAA) closure, and mitral valve (MV) interventions. The modality also demonstrates significant utility in electrophysiology applications, particularly in planning pulmonary vein isolation procedures. Recent guidelines from major cardiovascular societies have incorporated these advances, positioning cardiac CT as a first-line diagnostic tool for stable chest pain and a cost-effective gatekeeper for invasive procedures. Future directions include expanded applications in quantitative plaque assessment, artificial intelligence integration, and personalized risk stratification, promising to further enhance the role of cardiac CT in clinical practice.
Successful unroofing of anomalous aortic origin of the left coronary artery with intramural course in patient with near syncope Firdaus, Achmad Jauhar; Handari, Saskia Dyah; Prasetya, Indra; Tjahjono, Cholid Tri
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.17

Abstract

BACKGROUND: Left Anomalous Coronary Artery from the Opposite Sinus of Valsalva (L-ACAOS) refers to a congenital heart defect in which the left coronary artery originates from the right coronary sinus of Valsalva. This condition may increase the risk of sudden cardiac death (SCD), especially for those participating in intense physical exertion. This paper presents a case of a malignant type L-ACAOS in a young male who underwent successful surgical correction. CASE: A 35-year-old male without any known coronary artery disease risk factors presents with angina and near syncope while competing in a marathon run. He regularly participates in endurance sporting events without any complaints. However, in the last two years, he has begun to complain of angina during exertion. The ECG examination showed early repolarization in the inferior and lateral leads with no significant lab abnormalities. This led to coronary computed tomography angiography (CCTA), which revealed that the left coronary artery originates from the right coronary sinus and runs between the pulmonary trunk and ascending aorta, indicating a malignant-type anomalous coronary artery. He then undergoes a surgical correction with unroofing of the left main coronary artery and relocate the LMCA orifice to the left sinus. The procedure proceeded uneventfully with satisfactory results. CONCLUSION: Anomalous coronary arteries are concerning because they are associated with increased risks of SCD. The intramural course is associated with a higher risk of SCD due to stenosis caused by lateral compression that leads to ischemia and potentially fatal arrhythmias, making early detection and intervention critical.
WHO risk chart associated with the presence of coronary plaque on coronary computed tomographic angiography in asymptomatic indonesian population Indrihapsari, Pratiwi; Saskia Dyah Handari; Cholid Tri Tjahjono
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.11

Abstract

Background: Cardiovascular risk assessment tools, like the WHO Risk Chart, often categorize asymptomatic individuals as low risk, even when they have unmanaged cardiovascular risk factors. Among these patients, estimation of CAD is associated with significant differences in CACS; however, the relationship between WHO Risk Chart and CACS has not been studied. Objective: We studied WHO Risk Chart’s ability to detect for coronary plaque throughout CACS via CCTA. Methods: A total of 440 subjects aged 40 to 74 years old, who underwent CCTA for health checkup between January 2023 and December 2024 were enrolled. Clinical information was gathered from medical records, including risk factors, CACS, and CCTA results. Statistical analysis was performed using SPSS 24, applying univariate, bivariate, and multivariate regression analyses to identify correlations. Results: The WHO Risk Chart showed a significant correlation with CACS and the presence of coronary plaque (p <0.05). In total, 148 individuals were identified with normal coronary arteries, while 292 individuals presented with coronary plaque. Notable differences were found among genders, WHO Risk Chart, smoking status, hypertension, dyslipidemia, diabetes mellitus, and CACS levels between the two groups (p<0.05). The correlation coefficient suggests that an increase in the WHO Risk Chart is associated with a rise in CACS, indicating a bidirectional relationship between these two parameters. Conclusion: In an asymptomatic population from Indonesia, the WHO Risk Chart shows a strong positive correlation with CACS.
The Effect of Exercise Training as Adjuvant Treatment on Functional Capacity in Congenital Heart Disease with Negative Vaso Reactivity Test Pulmonary Hypertension Patient at Saiful Anwar Hospital Malang Pratiwi, Irma Kamelia; Martini, Heny; Tjahjono, Cholid Tri; Anjarwani, Setyasih; Handari, Saskia Dyah
Heart Science Journal Vol. 4 No. 3 (2023): The Essensial Role of the Metabolic Syndrome in the Development of Cardiovascul
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2023.004.03.3

Abstract

BackgroundPulmonary hypertension associated with congenital heart disease (CHD) is an important subgroup that accounts for approximately 11% of all patients with PAH. Physical limitations are one of the main symptoms of hemodynamic changes in patients with PH. Objective This study aimed to evaluate the effect of physical exercise therapy for 12 weeks as an additional therapy with PDE-5 inhibitors on the functional capacity of patients with Congenital Heart Disease accompanied by Pulmonary Artery Hypertension (CHD – PH). MethodThis research was an analytic experimental study with a prospective cohort research method. This study used data sources obtained from medical records to adjust subjects based on inclusion and exclusion criteria, initial cardiac training test examination data was carried out at IPJT in patients selected as subjects. The patient's clinical outcomes were followed in the next 12 weeks. ResultThis research was conducted on 16 samples divided into two groups, namely the control and study groups. The evaluation after 12 weeks found that there was an increase in mileage as measured through the 6MWT submaximal test and a better duration of physical activity in the study group tested through the Endurance Shuttle Walk Test (ESWT). This is consistent with the effect of physical exercise, which suppresses systemic inflammation and causes vasodilation, thereby increasing oxygen delivery to the tissues. This causes more optimal aerobic metabolism and reduces lactate production. So that the patient did not quickly feel tired during activities. However, there was no significant increase in the Incremental Shuttle Walk Test. This could be due to the relatively short training duration of 12 weeks. Conclusion A positive correlation exists between physical exercise and increased functional capacity of patients with CHD who were evaluated using 6MWT and ESWT.
Hubungan Antara Stres Dan Risiko Kardiovaskular Berdasar Jakvas Scoring System: Studi Pada Ojek Online Di Surabaya Handari, Saskia Dyah; Ginting, Adhitya; Panggabean, Ronald Torang Marsahala; Adrianto, Hebert; Suryadarma, Antonius Yansen; Christine, Catarina Lilian; Dion, Aldy; Jefri, Wilhelmus; Putri, Firda Aulia; Damayanti, Ni Nyoman Rere; Yasa, Oka Suputra
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 11 (2025): Volume 12 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i11.20686

Abstract

Stres kerja merupakan salah satu faktor risiko utama yang dapat memengaruhi kesehatan kardiovaskular. Salah satu profesi pekerjaan yang berisiko stres adalah pengemudi ojek online. Penelitian memiliki tujuan untuk melihat hubungan tingkat stres dengan skor JAKVAS. Penelitian ini adalah penelitian observasional analitik dengan pendekatan cross sectional. Responden adalah 75 orang sopir transportasi online laki-laki yang mengendarai sepeda motor dari 5 wilayah Surabaya, yang diambil dengan accidental sampling. Pengukuran tingkat stress menggunakan kuesioner Perceived Stress Scale (PSS). Pengukuran risiko kardiovaskular menggunakan Jakarta Cardiovascular Score (JAKVAS). Data dianalisis statistik dengan menggunakan program jamovi, menggunakan statistik deskriptif dan uji chi square. Hasil penelitian didapatkan skor JAKVAS terbanyak adalah kategori high risk (40%),  mayoritas responden memiliki tingkat stress berat (37,3%), tidak terdapat hubungan yang bermakna secara statistik antara tingkat stres dan skor JAKVAS (χ² = 4,396; df = 4; p = 0,355). Meskipun hubungan keduanya tidak signifikan, tingginya proporsi responden dengan risiko kardiovaskular tinggi menegaskan perlunya skrining rutin pada profesi dengan beban kerja tinggi seperti pengemudi ojek online.
Co-Authors Adhitya Ginting Agung, Purwakaning Purnomo Anjarwani, Setyasih Antonius Yansen Suryadarma Caesario, Fahreza Cholid Tri Tjahjono Cholid Tri Tjahjono Christine, Catarina Lilian Damayanti, Ni Nyoman Rere Dion, Aldy Djanggan Sargowo Firdaus, Achmad Jauhar Fransiska Anggreni Sihotang Galuh, Lukitasari Ayu Hebert Adrianto Imam Mi&#039;raj Suprayoga Indra Prasetya Indrihapsari, Pratiwi Jefri, Wilhelmus Kahadi, Cik Kusuma, Irwin Prijatna Martini, Heny Mirna Rahmasari Muhammad Firdaus Nidom, Astria Novitasari Panggabean, Ronald Torang Marsahala Pratiwi, Irma Kamelia Putri, Firda Aulia Rahimah, Anna Fuji Satrijo, Budi Sembiring, Yan Efrata Suprapta, Aloysius Yuwono Victor Kurniawan Yuwono Vori, Ira Yasa, Oka Suputra Yurike Dhika Adhela