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All Journal Collaborative Medical Journal (CMJ) Journal of Innovation Research and Knowledge
Uly Astuti Siregar
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Humanities Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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UJI AKTIVITAS ANTIFUNGI BAKTERI ASAM LAKTAT ASAL DADIH TERHADAP Aspergillus flavus Olvaria Misfa; Viola Anggraini Asrizal; Eliya Mursyida; Uly Astuti Siregar
Collaborative Medical Journal Vol 6 No 1 (2023): Januari
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v6i1.3254

Abstract

Primary gastrointestinal aspergillosis (AGP) is an inflammation of the gastrointestinal tract from the duodenum to the rectum. Aspergillus flavus (A. flavus) is one of the fungi that causes aspergillosis. This infection occurs due to aflatoxin from A. flavus which can cause damage to the gastric mucosa. The use of antifungals for long-term treatment can cause toxicity effects and also resistance, so alternative treatments are needed. Dadih is a fermented product of buffalo milk which contains lactic acid bacteria (LAB). Lactic acid bacteria produce acetic acid, lactic acid, and bacteriocin which can inhibit the growth of the fungus A. flavus. LAB species capable of suppressing the growth of A. flavus were Lactococcus lactis, Lactobacillus casei subsp. pseudoplantarum and Lactobacillus plantarum, and Lactobacillus brevis. To determine and analyze the antifungal activity of lactic acid bacteria from curd against Aspergillus flavus. This study used a post test-only design with a control group. The sample used was LAB isolate from curd, while the test fungus used was A. flavus. This study begins with rejuvenation of LAB isolates, then classification of LAB and pathogens, as well as inhibition test using the well diffusion method. The data obtained were analyzed using One-Way ANOVA test and Bonferroni Post hoc test.: LAB isolates from curd were Gram-positive bacteria in the form of bacilli and cocobasil, with negative catalse test results. The average diameter of the inhibition zones of LAB 1, LAB 2, and LAB against A. flavus were 8.55mm, 10.23mm, and 6.20mm. The results of the ANOVA test showed that there was a significant difference between the three LABs. The results of the Bonferron Post hoc test showed that there was a significant difference between LAB 2 isolates and positive controls against LAB 3. Meanwhile, there was no significant difference between LAB 2 and BAL 3 isolates against LAB 1 isolates. LAB isolate from curd was able to inhibit the growth of the fungus A. flavus.
COMBINATION TREATMENT EFFECT OF HABBATUSSAUDA (NIGELLA SATIVA) AND ALLOPURINOL FOR HYPERURICEMIA Utomo, Feriandri; Suci Rahmayanti; Uly Astuti Siregar
Journal of Innovation Research and Knowledge Vol. 3 No. 9: Februari 2024
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jirk.v3i9.7505

Abstract

More than 50% of hyperuricemia patients could not maintain a reduction in serum urate at the most commonly used dose of Allopurinol as initial urate lowering drug. Habbatussauda (Nigella sativa) has been shown to increase excretion of urate in pre clinical studies. This research studied the combination effects of Habbatussauda and Allopurinol to induce the effects and to reduce the required high doses of Allopurinol. The design of this study was experimental using a pretest posttest with control group design. This study used 24 mice (Mus muscullus) which were divided into: the negative control group (aquadest), the positive control group that was given Kalium Oxonat as an induction of hyperuricaemia and Allopurinol, the treatment group 1 (Kalium Oxonat and Habbatussauda), and the treatment group 2 (Kalium Oxonat and combination of Allopurinol and Habbatussauda). Statistical analysis was carried out to test the differences in blood urate level before and after treatment, using One-Way ANOVA and Post Hoc Bonferroni. This study found decrease in urate level in the positive control group and all treatment groups which was significantly different between groups (p < 0,05). Nevertheless, the reduction in urate level in Allopurinol group was greater insignificantly than in Habbatussauda and Allopurinol combination group (p > 0,05). This study concluded that Habbatussauda does not have the potential to increase antihyperuricemia effect of Allopurinol.
Co-Authors Eliya Mursyida Olvaria Misfa Suci Rahmayanti Utomo, Feriandri Viola Anggraini Asrizal