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Aulia Rahman
Bagian Ilmu Kesehatan Kulit Dan Kelamin, Fakultas Kedokteran Universitas Sebelas Maret/RS Dr.Moewardi , Surakarta, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Peranan Ekstrak Solanum lycopersicum L terhadap Ekspresi Basic Fibroblast Growth Factors (bFGF) dan Pencegahan Skar Hipertro k pada Tikus Strain Wistar Aulia Rahman; Indah Julianto; Prasetyadi Mawardi
Cermin Dunia Kedokteran Vol 46, No 5 (2019): Pediatri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i5.476

Abstract

Tujuan. Mengetahui peranan ekstrak Solanum lycopersicum L(tomat) pada ekspresi basic fibroblast growth factor (bFGF) dan mencegah skar hipertrofik. Metode. Penelitian eksperimental laboratorik dengan rancangan post test only control group design di Laboratorium Bagian Farmasi Universitas Setia Budi selama 28 hari menggunakan 30 ekor hewan coba tikus strain Wistar yang dibagi 3 kelompok. Pada seluruh tikus dibuat perlukaan di area punggung. Kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal. Kelompok 2 dengan perlakuan topikal Intrasite® gel. Kelompok 3 tanpa perlakuan. Penilaian ekspresi bFGF berdasarkan pemeriksaan imunohistokimia dengan vectastain. Penilaian scar elevation index (SEI) berdasarkan pemeriksaan histopatologi dengan pewarnaan hematoksilin-eosin (HE) di Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Sebelas Maret Surakarta. Hasil. Tidak ada perbedaan bermakna ekspresi bFGF pada ketiga kelompok. Didapatkan perbedaan bermakna penilaian SEI; di kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal tidak terbentuk skar hipertrofik. Simpulan. Tidak terdapat perbedaan bermakna ekspresi bFGF pada seluruh kelompok tikus. Pada kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel tidak terbentuk skar hipertrofik.Objective. To observe the role of Solanum lycopersicum L (tomato) extract on basic fibroblast growth factor (bFGF) expression and in hypertrophic scarring prevention. Method. A laboratory experimental research with posttest only control group design, conducted at the Pharmacy Section, Setia Budi University, on 30 Wistar strain rats divided into 3 groups. All rats were injured in the back area. Group 1 were treated with topical Solanum lycopersicum L 20% gel. Group 2 were treated with topical Intrasite® gel. Group 3 without any treatment, all for 28 days. bFGF expression was assessed immunohistochemically with vectastain; scar elevation index (SEI) was histopathologically assessed with hemotoxicillin-eosin (HE) staining in Anatomy Pathology Laboratory of Faculty of Medical Sebelas Maret University. Results. No significant differences in bFGF expression in the three groups. SEI assessment analysis also showed no significant differences; however, no hypertrophic scars formed in group 1. Conclusion. No significant differences in bFGF expression in all three groups. No hypertrophic scars formed in Solanum lycopersicum L 20% gel treatment. 
Kejadian Karsinoma Sel Basal di RSUD Dr. Moewardi Surakarta Berdasarkan Subtipe Histopatologi menurut Jenis Kelamin, Usia, Lokasi Anatomi, Diameter Tumor Synthia Sari Toha; Aulia Rahman; Moerbono Mochtar; Indah Julianto; Nugrohoaji Dharmawan; Prasetyadi Mawardi; Brian Wasita; Novan Adi Setyawan
Cermin Dunia Kedokteran Vol 46, No 4 (2019): Dermatologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.490

Abstract

Latar Belakang: Karsinoma sel basal (KSB) merupakan kanker kulit non melanoma berasal dari lapisan basal epidermis sel yang tidak mengalami keratinisasi. Penyakit ini dapat bersifat agresif (A) dan non agresif (NA) berdasarkan histopatologi. Tujuan: Analisis jenis KSB berdasarkan jenis kelamin, usia dan lokasi anatomi, diameter tumor. Metode: Penelitian observasional analitik dengan pendekatan cross sectional, pada bulan April – Agustus 2018. Sampel berjumlah 19 preparat pasien karsinoma sel basal di Poli Kulit dan Kelamin RSUD dr. Moewardi yang memenuhi kriteria inklusi dan eksklusi. Sampel dibagi dalam kelompok KSB A dan KSB NA berdasarkan histopatologi. Hasil: Sebagian besar kasus wanita (68,4%) dengan KSB A; rata-rata usia 57,5 ± 17,5 tahun dan sebagian besar petani 25,2%. Lokasi terbanyak di mid face pada KSB A (57,9%) dan KSB NA (10,5%); diameter > 2 cm pada KSB A (52,6%) dan KSB NA (47,4%). KSB A 5.3 kali lebih banyak daripada KSB NA. Simpulan: Kasus KSB terutama pada wanita, usia >50 tahun, petani, lokasi di mid face, diameter >2cm. Background: Basal cell carcinoma (BCC) is a non-melanoma skin cancer originating from the basic epidermal layer of non keratinized cells. Histopathologically it can be aggressive (A) or not (NA). Objective: To analyze histopathological BCC subtype based on gender, age, anatomic location, tumor diameter. Methods: An analytical cross sectional observational study. The study was conducted on 19 basal cell carcinoma patients in Dermatovenereology Clinic dr. Moewardi General Hospital in April - August 2018 who fulfilled the criteria. The samples were divided histopathologically into A BCC and NA BCC groups. Results: Most patients were women (68.4%) with A BCC; the average age is 57.5 ± 17.5 and the occupation were mostly farmers (25.2%). The location were mostly in midface in A BCC (57.9%) and NA BCC (10.5%); diameter > 2 cm in A BCC (52.6%) and NA BCC (47.4%). A BCC was 5.3 times more prevalent than NA BCC. Conclusion: BCC cases were mostly women, age > 50 years, farmer, location in mid face, diameter > 2 cm.
Diagnosis Luka Tungkai Kronis Anggana Rafika Paramitasari; Muhammad Risman; Aulia Rahman; Khalida Rieka Sulaikha; Harijono Kariosentono; Nurrachmat Mulianto
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i1.534

Abstract

Luka kronis adalah luka yang tidak dapat mengalami proses penyembuhan luka sesuai urutan dan dalam rentang waktu normal. Mayoritas luka kronis didapatkan di ekstremitas inferior dengan penyebab antara lain insufisiensi vena (45-60%), insufisiensi arteri (10-20%), diabetes (15-25%), ulkus dekubitus (1-5%), dan lain-lain (10-15%). Masing-masing penyebab memberikan gambaran klinis berbeda, begitu pula terapinya. Oleh karena itu gambaran klinis, patogenesis, dan diagnosis banding penting diketahui.Chronic wounds are characterized by failure to progress through a proper timely sequence of wound repair or without restoring to normal anatomy and function. Chronic wounds in lower leg including foot is a condition caused by venous insufficiency (45-60%), artery insufficiency (10-20%,) diabetes mellitus (15-25%), decubitus ulcer (1-5%), or other causes (10-15%). Each etiology has different clinical manifestations and therapy. Treatment of leg ulcers needs evaluation of many different etiologies. 
Peranan Ekstrak Solanum lycopersicum L terhadap Ekspresi Basic Fibroblast Growth Factors (bFGF) dan Pencegahan Skar Hipertrofik pada Tikus Strain Wistar Aulia Rahman; Indah Julianto; Prasetyadi Mawardi
Cermin Dunia Kedokteran Vol. 46 No. 5 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i5.464

Abstract

Tujuan. Mengetahui peranan ekstrak Solanum lycopersicum L (tomat) pada ekspresi basic fibroblast growth factor (bFGF) dan mencegah skar hipertrofik. Metode. Penelitian eksperimental laboratorium dengan rancangan post-test only control group design di Laboratorium Bagian Farmasi Universitas Setia Budi selama 28 hari menggunakan 30 ekor hewan coba tikus strain Wistar yang dibagi 3 kelompok. Pada seluruh tikus dibuat perlukaan di area punggung. Kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal. Kelompok 2 dengan perlakuan topikal gel transparan (berisi kombinasi karboksimetilselulosa 2,3% dan propilen glikol 20%). Kelompok 3 tanpa perlakuan. Penilaian ekspresi bFGF berdasarkan pemeriksaan imunohistokimia dengan vectastain. Penilaian scar elevation index (SEI) berdasarkan pemeriksaan histopatologi dengan pewarnaan hematoksilin-eosin (HE) di Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Sebelas Maret Surakarta. Hasil. Tidak ada perbedaan bermakna ekspresi bFGF pada ketiga kelompok. Didapatkan perbedaan bermakna penilaian SEI; di kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal tidak terbentuk skar hipertrofik. Objective: To observe the role of Solanum lycopersicum L (tomato) extract on basic fibroblast growth factor (bFGF) expression and in hypertrophic scarring prevention. Method. A laboratory experimental research with post-test only control group design, conducted at the Pharmacy Section, Setia Budi University, on 30 Wistar strain rats divided into 3 groups. All rats were injured in the back area. Group 1 were treated with topical Solanum lycopersicum L 20% gel. Group 2 were treated with topical transparent gel (contain carboxymethylcellulose polymer 2,3 % and propylene glycol 20%). Group 3 without any treatment, all for 28 days. bFGF expression was assessed immunohistochemically with vectastain; scar elevation index (SEI) was histopathologically assessed with hemotoxicillin-eosin (HE) staining in Anatomy Pathology Laboratory of Faculty of Medical Sebelas Maret University. Results. No significant differences in bFGF expression in the three groups. SEI assessment analysis also showed no significant differences; owever, no hypertrophic scars formed in group
Kejadian Karsinoma Sel Basal di RSUD Dr. Moewardi Surakarta Berdasarkan Subtipe Histopatologi menurut Jenis Kelamin, Usia, Lokasi Anatomi, dan Diameter Tumor Synthia Sari Toha; Aulia Rahman; Moerbono Mochtar; Indah Julianto; Nugrohoaji Dharmawan; Prasetyadi Mawardi; Brian Wasita; Novan Adi Setyawan
Cermin Dunia Kedokteran Vol. 46 No. 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.478

Abstract

Latar Belakang: Karsinoma sel basal (KSB) merupakan kanker kulit non-melanoma berasal dari lapisan basal epidermis sel yang tidak mengalami keratinisasi. Penyakit ini dapat bersifat agresif (A) dan non-agresif (NA) berdasarkan histopatologi. Tujuan: Analisis jenis KSB berdasarkan jenis kelamin, usia, lokasi anatomi, dan diameter tumor. Metode: Penelitian observasional analitik dengan pendekatan cross-sectional, pada bulan April 2018 – Agustus 2018. Sampel berjumlah 19 preparat pasien karsinoma sel basal di Poli Kulit dan Kelamin RSUD dr. Moewardi yang memenuhi kriteria inklusi dan eksklusi. Sampel dibagi dalam kelompok KSB A dan KSB NA berdasarkan histopatologi. Hasil: Sebagian besar kasus wanita (68,4%) dengan KSB A; rata-rata usia 57,5 ± 17,5 tahun dan sebagian besar petani 25,2%. Lokasi terbanyak di mid face pada KSB A (57,9%) dan KSB NA (10,5%); diameter >2 cm pada KSB A (52,6%) dan KSB NA (47,4%). KSB A 5,3 kali lebih banyak daripada KSB NA. Simpulan: Kasus KSB terutama dijumpai pada wanita, usia >50 tahun, petani, lokasi di mid face, dan diameter >2 cm. Background: Basal cell carcinoma (BCC) is a non-melanoma skin cancer originating from the basic epidermal layer of non-keratinized cells. Histopathologically, it can be aggressive (A) or not (NA). Objective: To analyze histopathological BCC subtype based on gender, age, anatomic location, tumor diameter. Methods: An analytical cross sectional observational study. The study was conducted on 19 basal cell carcinoma patients in Dermatovenereology Clinic dr. Moewardi General Hospital in April 2018 - August 2018 who fulfilled the inclusion and exclusion criteria. The samples were divided histopathologically into A BCC and NA BCC groups. Results: Most patients were women (68.4%) with A BCC; the average age was 57.5 ± 17.5 years old and the occupation of the patients was mostly farmers (25.2%). The location was mostly in midface in A BCC (57.9%) and NA BCC (10.5%); diameter > 2 cm in A BCC (52.6%) and NA BCC (47.4%). A BCC was 5.3 times more prevalent than NA BCC. Conclusion: BCC cases were mostly women, at the age of >50 years, farmer, located in mid face, and diameter >2 cm.
Diagnosis Luka Tungkai Kronis Anggana Rafika Paramitasari; Muhammad Risman; Aulia Rahman; Khalida Rieka Sulaikha; Harijono Kariosentono; Nurrachmat Mulianto
Cermin Dunia Kedokteran Vol 46 No 1 (2019): Obstetri-Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i1.523

Abstract

Luka kronis adalah luka yang tidak dapat mengalami proses penyembuhan luka sesuai urutan dan dalam rentang waktu normal. Mayoritas luka kronis didapatkan di ekstremitas inferior dengan penyebab antara lain insufisiensi vena (45-60%), insufisiensi arteri (10-20%), diabetes (15-25%), ulkus dekubitus (1-5%), dan lain-lain (10-15%). Masing-masing penyebab memberikan gambaran klinis berbeda, begitu pula terapinya. Oleh karena itu gambaran klinis, patogenesis, dan diagnosis banding penting diketahui. Chronic wounds are characterized by failure to progress through a proper timely sequence of wound repair or without restoring to normal anatomy and function. Chronic wounds in lower leg including foot is a condition caused by venous insufficiency (45-60%), artery insufficiency (10-20%,) diabetes mellitus (15-25%), decubitus ulcer (1-5%), or other causes (10-15%). Each etiology has different clinical manifestations and therapy. Treatment of leg ulcers needs evaluation of many different etiologies.
Peranan Ekstrak Solanum lycopersicum L terhadap Ekspresi Basic Fibroblast Growth Factors (bFGF) dan Pencegahan Skar Hipertrofik pada Tikus Strain Wistar Aulia Rahman; Indah Julianto; Prasetyadi Mawardi
Cermin Dunia Kedokteran Vol 46 No 5 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i5.464

Abstract

Tujuan. Mengetahui peranan ekstrak Solanum lycopersicum L (tomat) pada ekspresi basic fibroblast growth factor (bFGF) dan mencegah skar hipertrofik. Metode. Penelitian eksperimental laboratorium dengan rancangan post-test only control group design di Laboratorium Bagian Farmasi Universitas Setia Budi selama 28 hari menggunakan 30 ekor hewan coba tikus strain Wistar yang dibagi 3 kelompok. Pada seluruh tikus dibuat perlukaan di area punggung. Kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal. Kelompok 2 dengan perlakuan topikal gel transparan (berisi kombinasi karboksimetilselulosa 2,3% dan propilen glikol 20%). Kelompok 3 tanpa perlakuan. Penilaian ekspresi bFGF berdasarkan pemeriksaan imunohistokimia dengan vectastain. Penilaian scar elevation index (SEI) berdasarkan pemeriksaan histopatologi dengan pewarnaan hematoksilin-eosin (HE) di Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Sebelas Maret Surakarta. Hasil. Tidak ada perbedaan bermakna ekspresi bFGF pada ketiga kelompok. Didapatkan perbedaan bermakna penilaian SEI; di kelompok 1 dengan perlakuan Solanum lycopersicum L 20% gel topikal tidak terbentuk skar hipertrofik. Objective: To observe the role of Solanum lycopersicum L (tomato) extract on basic fibroblast growth factor (bFGF) expression and in hypertrophic scarring prevention. Method. A laboratory experimental research with post-test only control group design, conducted at the Pharmacy Section, Setia Budi University, on 30 Wistar strain rats divided into 3 groups. All rats were injured in the back area. Group 1 were treated with topical Solanum lycopersicum L 20% gel. Group 2 were treated with topical transparent gel (contain carboxymethylcellulose polymer 2,3 % and propylene glycol 20%). Group 3 without any treatment, all for 28 days. bFGF expression was assessed immunohistochemically with vectastain; scar elevation index (SEI) was histopathologically assessed with hemotoxicillin-eosin (HE) staining in Anatomy Pathology Laboratory of Faculty of Medical Sebelas Maret University. Results. No significant differences in bFGF expression in the three groups. SEI assessment analysis also showed no significant differences; owever, no hypertrophic scars formed in group
Kejadian Karsinoma Sel Basal di RSUD Dr. Moewardi Surakarta Berdasarkan Subtipe Histopatologi menurut Jenis Kelamin, Usia, Lokasi Anatomi, dan Diameter Tumor Synthia Sari Toha; Aulia Rahman; Moerbono Mochtar; Indah Julianto; Nugrohoaji Dharmawan; Prasetyadi Mawardi; Brian Wasita; Novan Adi Setyawan
Cermin Dunia Kedokteran Vol 46 No 4 (2019): Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i4.478

Abstract

Latar Belakang: Karsinoma sel basal (KSB) merupakan kanker kulit non-melanoma berasal dari lapisan basal epidermis sel yang tidak mengalami keratinisasi. Penyakit ini dapat bersifat agresif (A) dan non-agresif (NA) berdasarkan histopatologi. Tujuan: Analisis jenis KSB berdasarkan jenis kelamin, usia, lokasi anatomi, dan diameter tumor. Metode: Penelitian observasional analitik dengan pendekatan cross-sectional, pada bulan April 2018 – Agustus 2018. Sampel berjumlah 19 preparat pasien karsinoma sel basal di Poli Kulit dan Kelamin RSUD dr. Moewardi yang memenuhi kriteria inklusi dan eksklusi. Sampel dibagi dalam kelompok KSB A dan KSB NA berdasarkan histopatologi. Hasil: Sebagian besar kasus wanita (68,4%) dengan KSB A; rata-rata usia 57,5 ± 17,5 tahun dan sebagian besar petani 25,2%. Lokasi terbanyak di mid face pada KSB A (57,9%) dan KSB NA (10,5%); diameter >2 cm pada KSB A (52,6%) dan KSB NA (47,4%). KSB A 5,3 kali lebih banyak daripada KSB NA. Simpulan: Kasus KSB terutama dijumpai pada wanita, usia >50 tahun, petani, lokasi di mid face, dan diameter >2 cm. Background: Basal cell carcinoma (BCC) is a non-melanoma skin cancer originating from the basic epidermal layer of non-keratinized cells. Histopathologically, it can be aggressive (A) or not (NA). Objective: To analyze histopathological BCC subtype based on gender, age, anatomic location, tumor diameter. Methods: An analytical cross sectional observational study. The study was conducted on 19 basal cell carcinoma patients in Dermatovenereology Clinic dr. Moewardi General Hospital in April 2018 - August 2018 who fulfilled the inclusion and exclusion criteria. The samples were divided histopathologically into A BCC and NA BCC groups. Results: Most patients were women (68.4%) with A BCC; the average age was 57.5 ± 17.5 years old and the occupation of the patients was mostly farmers (25.2%). The location was mostly in midface in A BCC (57.9%) and NA BCC (10.5%); diameter > 2 cm in A BCC (52.6%) and NA BCC (47.4%). A BCC was 5.3 times more prevalent than NA BCC. Conclusion: BCC cases were mostly women, at the age of >50 years, farmer, located in mid face, and diameter >2 cm.
Diagnosis Luka Tungkai Kronis Anggana Rafika Paramitasari; Muhammad Risman; Aulia Rahman; Khalida Rieka Sulaikha; Harijono Kariosentono; Nurrachmat Mulianto
Cermin Dunia Kedokteran Vol 46 No 1 (2019): Obstetri-Ginekologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i1.523

Abstract

Luka kronis adalah luka yang tidak dapat mengalami proses penyembuhan luka sesuai urutan dan dalam rentang waktu normal. Mayoritas luka kronis didapatkan di ekstremitas inferior dengan penyebab antara lain insufisiensi vena (45-60%), insufisiensi arteri (10-20%), diabetes (15-25%), ulkus dekubitus (1-5%), dan lain-lain (10-15%). Masing-masing penyebab memberikan gambaran klinis berbeda, begitu pula terapinya. Oleh karena itu gambaran klinis, patogenesis, dan diagnosis banding penting diketahui. Chronic wounds are characterized by failure to progress through a proper timely sequence of wound repair or without restoring to normal anatomy and function. Chronic wounds in lower leg including foot is a condition caused by venous insufficiency (45-60%), artery insufficiency (10-20%,) diabetes mellitus (15-25%), decubitus ulcer (1-5%), or other causes (10-15%). Each etiology has different clinical manifestations and therapy. Treatment of leg ulcers needs evaluation of many different etiologies.
Co-Authors Anggana Rafika Paramitasari Anggana Rafika Paramitasari Brian Wasita Brian Wasita Dharmawan, Nugrohoaji Harijono Kariosentono Harijono Kariosentono Indah Julianto Indah Julianto Indah Julianto Indah Julianto Khalida Rieka Sulaikha Khalida Rieka Sulaikha Moerbono Mochtar Moerbono Mochtar Muhammad Risman Muhammad Risman Novan Adi Setyawan Novan Adi Setyawan Nugrohoaji Dharmawan Nurrachmat Mulianto Nurrachmat Mulianto Prasetyadi Mawardi Prasetyadi Mawardi Prasetyadi Mawardi Prasetyadi Mawardi Synthia Sari Toha Synthia Sari Toha