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All Journal Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Medical and Health Science Journal Asian Journal of Health Research JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Widya Khairunnisa Sarkowi
Division Of Biomedical Sciences And Medical Education, Faculty Of Medicine, IPB University, Bogor, 16680, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Efficacy and Safety Comparison Between Lorazepam and Diazepam in Treating Convulsive Status Epilepticus in Children: An Evidence-Based Case Report Muhammad Habiburrahman; Widya Khairunnisa Sarkowi
Asian Journal of Health Research Vol. 2 No. 1 (2023): Volume 2 No 1 (April) 2023
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v2i1.62

Abstract

Introduction: Indonesia still recommends diazepam for epilepsy, but the International League Against Epilepsy increasingly favours lorazepam. Some reports indicate diazepam being less effective and causing side effects. This report presents a difficult-to-treat convulsive status epilepticus (CSE) case in a 10-month infant who received diazepam, questioning if intravenous/rectal lorazepam is a better initial therapy than diazepam for hospitalized children with CSE. Methods: Following the patient-intervention-comparison-outcome (PICO) formula, we searched for evidence in four journal databases (Pubmed, Proquest, EBSCOHost, and Cochrane). Studies meeting inclusion and exclusion criteria were appraised. Results: Through three systematic reviews and meta-analyses, our clinical query was addressed. One study revealed that rectal lorazepam was more effective in stopping seizures than rectal diazepam (RR 2.86). Meanwhile, two studies found that intravenous lorazepam exhibited similar efficacy in seizure cessation compared to intravenous diazepam (RR 1.04 and OR 1.03, respectively). Both drugs showed no significant difference in the time required to stop seizures or the necessity for additional doses or adjunctive medications to achieve such cessation, nor in the likelihood of refractory seizure within 24 hours. Two studies indicated that intravenous lorazepam had a reduced risk of respiratory depression (RR 0.71 and OR 0.62, respectively). Regardless of the administration route, lorazepam was linked to a lower probability of ICU admission (RR 0.15) than diazepam. Conclusion: Intravenous lorazepam and diazepam are equally effective for treating CSE, but rectal lorazepam is considered better at stopping seizures and preventing their recurrence compared to diazepam. Furthermore, lorazepam is deemed safer, especially when given intravenously.
Genetic Variants Associated with Gefitinib Adverse Events in Non-Small Cell Lung Cancer: A Systematic Review Integrated with Protein-Protein Interaction Network and Structural Modelling Rangga Pradipa, Agya Marsaa; Al Ayyubi, Muhammad Shalahudin; Romadhona, Sabila; Sarkowi, Widya Khairunnisa; Nugraha, Widya Eka
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.vi.v12i2.1049

Abstract

Introduction: Lung cancer remains the leading cause of cancer-related death worldwide, with non–small cell lung cancer (NSCLC) accounting for approximately 85% of cases. Gefitinib is a tyrosine kinase inhibitor frequently used in NSCLC with favorable outcome. However, many patients develop severe adverse effects which might be influenced by genetic variability. Therefore, we aim to systematically review the gene variants and its association with gefitinib-related adverse effects in NSCLC patients, as well as investigate the biological process involved. Methods: A systematic search was conducted according to PRISMA guidelines across PubMed, Scopus, and Cochrane. Studies investigating the association between genetic variations with gefitinib-related adverse effects in NSCLC were included. Risk of bias was assessed using the Cochrane RoB-E. Extracted data encompassed study and patient characteristics, adverse effects, and gene variations. Significant genes identified from included studies were analyzed through PPI network analysis, and the hub proteins found were visualized through Chimera. Results: Sixteen studies involving 1,176 patients were included, with Japanese populations being the most studied. Gene variants of CYP2D6, CYP3A4, ABCB1, ABCG2, EGFR, FOXO3, IKBKB, and AKT1 were found to be associated with adverse effects such as hepatotoxicity, skin rash, and diarrhea among NSCLC patients. Metabolism and inflammatory pathways might be involved in gefitinib-related adverse effects. Conclusion: Genetic variations in CYP2D6, CYP3A4, ABCB1, ABCG2, EGFR, FOXO3, IKBKB, and AKT1 may influence gefitinib-associated adverse effects, highlighting the need of pharmacogenomic testing to guide personalized treatment and improved patient safety. Keywords: Genetic Variants, Gefitinib, Non-Small Cell Lung Cancer, Adverse Effects, Protein-protein interaction
Association of Maternal Age with Mental Health in Pregnant Women in Agricultural Communities : A Cross-Sectional Study in Bogor, Indonesia Ryadi, Yusuf; Sumulyo, Ganot; Sarkowi, Widya Khairunnisa; Hanif, Aisyah Amanda; Dewi, Mira
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 14 No. 1 (2026): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educatio
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V14.I1.2026.54-61

Abstract

Background: Mental health issues such as depression and anxiety during pregnancy can significantly impact pregnancy outcomes. Agriculture is a high-stress industry that might increase the risks of depression and anxiety. Women in agricultural communities often experience a dual burden from physically demanding labor and reproductive responsibilities, with limited access to mental health services and social support—making them particularly vulnerable. Aims: This study aimed to identify factors contributing to depression and anxiety among pregnant women in an agricultural community in Bogor Regency. Methods: This cross-sectional study was conducted from August to October 2023 in Bogor Regency, West Java. A total of 69 pregnant women attending Cijeruk Primary Health Care were involved. Data were collected via interviews and medical records. Depression and anxiety levels were assessed using the Hamilton Depression Rating Scale (HDRS) and Hamilton Anxiety Rating Scale (HARS). Results: The majority of subjects (>60%) had no depression or anxiety. The prevalence of severe and very severe depression was 10.1%, and 5.8% for severe and very severe anxiety. Maternal age was negatively correlated with both depression (r = -0.317, p = 0.008) and anxiety scores (r = -0.332, p = 0.005). No significant associations were found between HDRS scores and other factors such as gestational age, education level, household income, physical activity, or farming family background. Conclusion: The correlation between maternal age and depression and anxiety scores highlights the importance of promoting mature age in premarital counseling. Further research is needed to explore broader determinants of maternal mental health in agricultural communities with larger, more diverse samples.
Infodemiology of Anthrax in Indonesia: Insights from Google Trends (2014–2024) Risti Sifa' Fadhillah; Putri Utami; Widya Khairunnisa Sarkowi; Dinda Iryawati
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8008

Abstract

Background: Anthrax remains a persistent zoonotic disease in Indonesia, with recurrent outbreaks reported in endemic provinces such as Yogyakarta, Gorontalo, Central Java, and East Nusa Tenggara. Outbreak control is further challenged by the circulation of misinformation, which shapes community perceptions and undermines prevention efforts. Digital epidemiology offers opportunities to complement conventional surveillance by capturing public information-seeking behavior, yet its application in anthrax research in Indonesia remains limited. Methods: This study analyzed temporal and spatial dynamics of public interest in anthrax using Google Trends data from January 2014 to December 2024. Two search terms, antraks (Indonesian) and anthrax (English), were examined to assess monthly patterns, regional distribution, and related search queries. Descriptive analyses were performed to identify peaks of interest, geographic differences, and themes of related and rising queries. Results: Overall search activity was low and stable throughout the 11 years, with distinct peaks corresponding to outbreaks, most notably in July 2023 during the Yogyakarta outbreak. Regional analysis revealed Yogyakarta and Gorontalo as the dominant provinces of search activity. Linguistic patterns showed that antraks was more widely used in western Indonesia, while anthrax was relatively more frequent in eastern provinces. Related queries reflected demand for basic knowledge of symptoms, transmission, and prevention, while rising queries aligned with outbreak-related events. Conclusion: Online search patterns mirror epidemiological risk, cultural context, and digital access. Infodemiology provides timely insights that may enhance outbreak preparedness and risk communication. Integrating digital surveillance with conventional monitoring can support more effective and locally relevant health education strategies for anthrax control in Indonesia.
Co-Authors Aisyah Amanda Hanif Al Ayyubi, Muhammad Shalahudin Dinda Iryawati Fadhillah, Risti Sifa' Muhammad Habiburrahman Nugraha, Widya Eka Putri Utami Rangga Pradipa, Agya Marsaa Romadhona, Sabila Sumulyo, Ganot Yusuf Ryadi