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All Journal Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Natural
AZALIA IZDHIHAR AZWAR
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Physics Public Health

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Isolation of active compound as anti acne from ethanol extract Artocarpus camansi leaves AZALIA IZDHIHAR AZWAR; MUHAMMAD BAHI; ROSNANI NASUTION; NURDIN NURDIN; MARIANNE MARIANNE
Jurnal Natural Volume 23 Number 1, February 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i1.27036

Abstract

Acne vulgaris or acne is a chronic inflammatory skin disease in adolescents and adults affecting one self-confidence. The result of the research shows the ethanol extract, subfraction, pure isolate, and gel extract of Artocarpus camansi are active in inhibiting the growth of Propionibacterium acnes. The ethanol extract with the highest inhibition zone was at the concentration of 0.5 and 2% with 9.1±0.62 mm and 8.5±0.7 mm with the activity of 47.07% and 43% respectively (in comparison with the chloramphenicol 30 μg 19.33±0.47mm). The gel extract had the highest activity at 2%, with an inhibition zone of 8±0.50 mm and the activity of 43.97%. Anti-acne activity for all subfractions had an activity of 32.5-33.3% while the pure isolate was at 42.10 - 45.63%. Physical properties of the gel extract were evaluated for four weeks by examining the pH test obtained with a range of 5.8-6.7, viscosity in the range of 18460-19668 cP, spreadability in the range of 5.45-7.20 cm, adhesion observation above 4 seconds, and homogeneity in a concentration of 0.5-7.5%. The pure isolate has a melting point of 147 ℃, presumed to be γ-sitosterol and appropriate with the screening phytochemicals results with the presence of steroid.
Isolation of active compound as anti acne from ethanol extract Artocarpus camansi leaves AZALIA IZDHIHAR AZWAR; MUHAMMAD BAHI; ROSNANI NASUTION; NURDIN NURDIN; MARIANNE MARIANNE
Jurnal Natural Volume 23 Number 1, February 2023
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v23i1.27036

Abstract

Acne vulgaris or acne is a chronic inflammatory skin disease in adolescents and adults affecting one self-confidence. The result of the research shows the ethanol extract, subfraction, pure isolate, and gel extract of Artocarpus camansi are active in inhibiting the growth of Propionibacterium acnes. The ethanol extract with the highest inhibition zone was at the concentration of 0.5 and 2% with 9.1±0.62 mm and 8.5±0.7 mm with the activity of 47.07% and 43% respectively (in comparison with the chloramphenicol 30 μg 19.33±0.47mm). The gel extract had the highest activity at 2%, with an inhibition zone of 8±0.50 mm and the activity of 43.97%. Anti-acne activity for all subfractions had an activity of 32.5-33.3% while the pure isolate was at 42.10 - 45.63%. Physical properties of the gel extract were evaluated for four weeks by examining the pH test obtained with a range of 5.8-6.7, viscosity in the range of 18460-19668 cP, spreadability in the range of 5.45-7.20 cm, adhesion observation above 4 seconds, and homogeneity in a concentration of 0.5-7.5%. The pure isolate has a melting point of 147 ℃, presumed to be γ-sitosterol and appropriate with the screening phytochemicals results with the presence of steroid.
Antibacterial Activities of Perfume: Combination Flower Magnolia alba, Cananga odorata and Mimusops elengi L, Fixed with Pogostemon cablin Oil Nasution, Rosnani; Azwar, Azalia Izdhihar; Helwati, Hira; Marianne
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 1 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (787.644 KB) | DOI: 10.32734/idjpcr.v2i1.814

Abstract

Abstract: The making of perfume from the combination Magnolia alba (M. alba) flower oil, Cananga odorata (C. odorata) and Mimusops elengi L (M. elengi) fixed with Pogostemon cablin oil (P. cablin) have been done. Essential oil of M. alba and C. odorata was distilled by water distillation and extraction essential oil of M. elengi flower using n-hexane evaporated solvent method. Composition perfume through organoleptic test obtained with a ratio of 4% v/v, 4% v/v, and 2% v/v for each essential oil M. alba, C. odorata and M. elengi. Antibacterial activity of the perfume and each of the volatile oil was performed by the disc diffusion method. Antibacterial activity test showed that perfumes were able to inhibit the growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria, but less active. Antibacterial activity of the perfume was more active against E. coli with an inhibitory zone of 8.3 mm and 39.81% inhibitory power than S. aureus bacterial 7.3 mm inhibition zone with 37.55% inhibitory power. Perfumes after storage for one, and two months had better antibacterial activity than before storage with an average inhibitory zone of 11-15 mm and inhibitory power of 50- 68,18%. Keywords: Antibacterial, E. Coli, C. Odorata, M. alba, M. elengi, P. cablin, , S. aureus
Co-Authors . Marianne Hira Helwati MARIANNE MARIANNE MUHAMMAD BAHI Nurdin MH Nurdin MH ROSNANI NASUTION Rosnani Nasution