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Anti Acne Cream Formulation Ethanol Extract of Katuk Leaves (Sauropus androgynus (L.) Merr against Staphylococcus Epidermis and Staphylococcus Aureus Juvita Herdianty; Arif Wijayanto
Journal of Global Research in Public Health Vol. 7 No. 2 (2022): December
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jgrph.v7i2.402

Acne is a skin problem that generally occurs during puberty. Under normal conditions, during puberty, there are Staphylococcus epidermal bacteria and Propionibacterium acnes that proliferate so that inflammation occurs, causing acne on the skin. Since ancient times, our ancestors believed in the use of natural ingredients to treat various diseases, one of which was katuk leaves. Katuk plants have secondary metabolic compounds such as alkaloids, saponins, flavonoids and tannins. The potential of Katuk leaves has been tested for many pharmacological activities, such as antibacterial, antihypertensive, anti-infective, antihyperlipidemic, antianemic and also increases milk production. Katuk leaves are often used in the form of extracts as antibacterial, so it needs to be developed into a pharmaceutical preparation to increase its use. One of the pharmaceutical preparations is cream preparations to treat the causes of acne. This study aims to determine the ability of katuk leaf extract cream to act as an antibacterial against Staphylococcus Epidermis and Staphylococcus Aureus bacteria.. The design of this study is an experimental method, making katuk leaf extract by maceration method by immersing in 70% ethanol solution for 5 days. After 5 days, the pulp and filtrate were separated and then evaporated using a Vacuum Rotary Evaporator to obtain a thick extract. The preparation of katuk leaf extract cream was carried out with a concentration of 10%, 15%, 20% and an antibacterial test was carried out using the pitting method. The antibacterial test results of the katuk leaf cream extract showed an inhibition zone marked with a clear area around the well. Katuk leaf extract cream was able to inhibit the growth of S. aureus and S. epidermis bacteria with the best concentration in formula 3, namely the concentration of katuk leaf extract of 20%.

Formulation and Physical Stability Test Preparation of Anti-Acne Gel Extract of Tebu Leaves (Saccharum officinarum (Linn) as Antibacterial Against Staphylococcus Epidermis Arif Wijayanto; Juvita Herdianty
Journal of Global Research in Public Health Vol. 7 No. 2 (2022): December
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jgrph.v7i2.403

Increased processing of Tebu as sugar causes the resulting waste, namely the shoots of Tebu leaves. The phenolic and flavonoid compounds in Tebu are reported to have strong antioxidant, anti-inflammatory, antimutation and tyrosine inhibitor activities. Infectious diseases are diseases caused by the presence of pathogenic microbes, one of which causes infection, namely bacteria. Utilization of Tebu waste is expected to produce alternative products in the form of antibacterial preparations, especially anti-acne. Staphylococcus epidermis is one of the bacteria that causes infection on skin with acne. This study aims to determine the physical stability of the preparation Tebu leaf extract anti acne gel and its antibacterial activity against Staphylococcus Epidermis bacteria. Methods: This research design is an experimental method, making Tebu leaves extract by weighing as much as 400 grams of fine powder of Tebu leaves then put in a maceration container, closed then added 70% 2 liters of ethanol until completely submerged and stored for 24 hours protected from direct sunlight while stirring occasionally. Then filtered, separated the dregs and filtrate. The dregs were re-extracted with the same amount of new 70% ethanol for 2 days. The obtained 70% ethanol filtrate was evaporated to obtain a thick extract using a Vacuum Rotary Evaporator. Tebu leaves extract gel was made at a concentration of 5%, 10%, 15% and an antibacterial test was carried out using the well diffusion method. Results: The results of the physical stability test of the acne extract cream showed that the results met the requirements both in terms of pH, dispersion test, homogeneity. The results of the antibacterial test of Tebu leaves extract showed the presence of a zone of bacterial inhibition which was indicated by the presence of a clear area around the well. Conclusion: The results of the evaluation showed that the Tebu leaves extract gel met the requirements for the physical quality of the gel preparation, both organoleptic, pH, viscosity, adhesion, and spreadability. Tebu leaves extract gel was able to inhibit the growth of S. epidermis bacteria with the best concentration in 3rd formula, consentration 15% Tebu leaves extract gel.

Lip Cream Formulation With Natural Dyes From Secang Wood Leather Luluk Aniqoh Meliana; Juvita Herdianty; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.65

Colorants are an important part of decorative cosmetics, including in lip cream preparations. Secang bark (Caesalpinia Sappan) contains chemical compounds of flavonoids, polyphenols, tannins and essential oils. Researchers formulate lip cream preparations by utilizing natural pigments contained in the bark of secang wood. The preparations were made with various concentrations of sappan bark extract, namely 15%, 20%, and 25%. Evaluation of the preparations made is an evaluation of physical quality including organoleptic tests, homogeneity, pH, spreadability, adhesion, smearing power, photostability, and stability tests by centrifugation method. Evaluation of safety was carried out through irritation test with patch test method and preference test. The results of the evaluation of lip cream preparations showed that all formulas had good greasing power and homogeneity, were physically stable which was characterized by no separation, and had good dispersibility, spreadability, and stable pH value. All preparations during storage for 21 days did not show changes in texture and odor. Then in terms of color, both organoleptically and photostability testing did not show a decrease in color intensity. Based on respondents' responses, the most preferred formula is formula II with the addition of an extract of 20%.

Antibacterial Test of Liquid Soap Preparations Rambutan Peel Extract (Nephelium lappaceum Linn) the Growth of Staphylococcus Aureus Juvita Herdianty; Luluk Aniqoh Meliana Putri; Arif Wijayanto
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.66

Long-term use of antibiotics leads to resistance. Rambutan fruit is a fruit which grows seasonally, but the utilization of the fruit skin is still lacking. Several studies have been carried out but limited to the flesh and leaves. The purpose of this study was to utilize rambutan peel waste into a liquid soap preparation and then carry out an antibacterial test against Staphylococcus aureus bacteria. The content of compounds from the skin of rambutan fruit (Nephelium lappaceium Linn) is thought to have antibacterial properties. The content test was carried out using a phytochemical screening method. The screening results of rambutan peel extract showed the presence of alkaloids, flavonoids, saponins, and tannins. The antibacterial test method used the well diffusion method with concentrations of 20% 40%, 60% positive control of Biore liquid soap and negative control of soap base. The test parameters for liquid soap preparations include: organoleptic test, homogeneity test, pH test, foam height. The results showed the best concentration of 60% had the ability as an antibacterial against Staphylococcus aureus.

Test The Wound Healing Activity Of Nephelium Lappaceium Fructus Cortex Extract Ointment On New Zealand Rabbits Arif Wijayanto; Luluk Aniqoh Meliana Putri; Juvita Herdianty
Strada Journal of Pharmacy Vol. 4 No. 2 (2022): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v4i2.67

Nephelium lappaceium Linn.(Rambutan) is a natural ingredient rich in active substances that are beneficial to human health. In this study, the use of Nephelium lappaceium fructus cortex was used for the healing of open wounds where Nephelium lappaceium fructus cortex contains tannins which are expected to help heal open wounds. The content test was carried out using the phytochemical screening method of Nephelium lappaceium fructus cortex extract which showed the presence of alkaloids, flavonoids, saponins, and tannins, then a wound healing test was carried out with Nephelium lappaceium fructus cortex extract which was divided into 5 groups randomly, namely normal, negative control (Vaseline album) , positive control (Betadine salp® each gram contains 10% Povidone Iodine), presented topically 7.5% and 15% Nephelium lappaceium fructus cortex extract ointment. The back skin of New Zealand rabbits is 3-5 months old, weighs 1500–2000grams, has normal and healthy activities and has agile activities, is normal and in healthy condition, then was injured with a punch biopsy with a diameter of 5 mm, a depth of ± 0.5 mm, then treatment according to the test group for 21 days. Parameters measured included wound diameter in rabbits. The results showed that the ointment extract of Nephelium lappaceium fructus cortex 15% had an open wound healing activity which was comparable to a positive control with an open wound healing activity of 0.2mm.

Formulation Of Mephenamic Acid Granules With Pvp And Avicel Mixture On The Physical Of Granules Juvita Herdianty; Arif Wijayanto; Atary Anggita
Strada Journal of Pharmacy Vol. 5 No. 1 (2023): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v5i1.87

Mefenamic acid is a drug that is often used to relieve pain. Mefenamic acid is a drug used as an analgesic, antipyretic, and non-steroidal anti-inflammatory drug (NSAID). In the BCS (Biopharmaceutical Classification System) it is included in the class II category, namely its low solubility with high permeability. To overcome this, it is necessary to make efforts to increase solubility to obtain good bioavailability. This study aims to formulate granules using a mixture of Polyvinyl Pyrrolidone (PVP) and Avicel for the physical properties of the granules in three formulations. Preparation of granules using the wet garnulation method by making three formulations with varying concentrations of PVP, namely 1%, 2% and 3%. The results of the evaluation of the physical properties of mefenamic acid granules showed that the flow properties of the three formulas met the requirements, namely > 10 grams/second. The water content test showed that the three formulas met the requirements with a range of 2-5%, while the angle of repose test of the three formulas was only formula 1 which met the requirements, namely less than <30o.

Formulation of capsule preparations with variations in aerosil concentration on the results of preparation evaluation Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 2 No. 1 (2020): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v2i1.132

Capsules can be defined as a solid dosage form, where one or more types of drugs and/or other inert ingredients are contained in a shell or small container that can dissolve in water (Ansel 2005). Gelatin is a suitable material for making capsule shells because it is edible and soluble, forms a strong, thin-layered shell and changes from solution to gel form slightly above ambient temperature. Gelatin immediately dissolves in water at body temperature and does not dissolve if the temperature drops below 30°C (Agoes, 2008). Based on the test results, the disintegration time for F1 capsules is 2.12 minutes; F2 is 2.21 minutes; and F3, namely 2.27 minutes. These three formulas meet the requirements, namely not less or equal to 15 minutes. Based on the test results, F1 3.44 seconds, F2 3.76 seconds, F3 3.24 seconds, the flow speed of these three formulas meets the flow speed requirements, namely flow speed ≥ 10 g/second. The flow speed of the three formulas is in the good category, namely 2-10 g/sec which is said to be very good while it is said to be good. The flow speed is good because Aerosil has a very small and fine particle size. Apart from being an absorbent, aerosols are also able to improve flow properties by reducing friction between particles and by averaging test results from angles of repose F1 45°, F2 43° and F3 53°. In the weight uniformity test at F 1,2,3 it does not meet the requirements for factors that influence weight uniformity, namely lack of accuracy, different drug weights due to uneven distribution.

FORMULATION OF GRANULES AND TABLETS ACTIVE INGREDIENT PARACETAMOL IBUPROFEN AND ITS EVALUATION RESULTS Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 3 No. 2 (2021): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i2.139

Granulation is a process of increasing the powder size where a powder mixture that has a small cohesive force is changed into a larger particle size. Granulation begins with mixing the required active ingredients, so that a form of active ingredient is achieved through a mixing process (Musnamar, 2005). Dry granulation (slugging) is processing active ingredient and excipient particles by pressing the dry mixture into a solid mass. After it becomes a solid mass, it is then broken down again to produce particles that are larger than the original powder (granule). Dry granulation is used for active ingredients that have an effective dose that is too high to be directly compressed, active ingredients that are sensitive to heating and humidity, active ingredients that are difficult to flow (Chaerunnisa et al, 2009). Ibu profen is a derivative of propionic acid which has strong analgesic, antipyretic and not too strong anti-inflammatory properties. Ibuprofen has a dose-dependent duration of around 9-8 hours which is longer than the half-life. The recommended dose varies depending on body mass and indication. Paracetamol has poor compactibility and fluidity, which causes difficulties during compression with drugs that have poor compactibility in large doses. It is most appropriate to use the granulation method in this practicum using the dry granulation method because ibuprofen is not resistant to heat or moisture. Prepare tools and materials, Weighing 175 grams of Acetaminophen, 100 grams of Ibuprofen, 7.3 grams of Manihot Starch (F1= 10.95 g, F2= 36.5 g, F3= 73 g), 7.3 grams of PVP, and (F1= 0, 13985 g, F2= 0.08875 g, F3=0.00845 g), mix ad homogeneously (inner phase), The resulting internal phase mixture is inserted into the die on a tablet press, until slugs are formed, with each weighing more than 500 mg. Put the slugging results into the mortar then grind slowly until granules are formed, Sift the granules with a no 12 mesh sieve. In testing the water content of F1 granules, it was found that the granules met the water content requirements because they had a percent value of less than 5%, which was 2.55% in F1. Meanwhile, water content has not yet been obtained for F2, F3 and K-, because the slugging process cannot be carried out. Testing the angle of repose F1 before compression is 24°, after compression is 25°. At F2 before compression it is 25°, at F3 before compression it is 30°. The test results of all formulations met a good angle of repose range of 25 - 30°, but did not match the formula design. In flow time testing. According to the Indonesian Ministry of Health, 2018 stated that the flow speed is good if the granules flow <10 seconds. In F1, the flow time before they become granules is 50 seconds and after they become granules it is 6.39 seconds, where these results meet the literature. Meanwhile, for F2, F3, and K-, no results were obtained after becoming granules because the formulation could not go through the slugging process.

Variations in the type of abrasive material used in the formulation of body scrub preparations on the evaluation of the preparation Juvita Herdianty; Arif Wijayanto
Strada Journal of Pharmacy Vol. 3 No. 2 (2021): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v3i2.141

Cosmetics are products that are used to clean and beautify the skin. Body scrubs or what is commonly known as bath scrubs are scrubs that are used when the skin is wet. How to use it is by applying it evenly to the skin of the body and then rubbing it slowly. Body scrub components, which consist of fat components, can increase skin moisture. The water phase can increase hydration for fresh-looking skin. Surfactants in body scrubs can also replace the role of soap. One form of body scrub dosage form that is widely available on the market is the cream dosage form (Paradila et al., 2022). The caffeine content in coffee can make the skin moist so it feels smoother and firmer. Arabica coffee beans contain antioxidants which can provide benefits, one of which is preventing cell damage due to exposure to free radicals. Arabica coffee with a concentration of 2% shows a good exfoliating agent that does not irritate the skin and improves the appearance of the skin without side effects (Putri et al., 2021). This study aims to formulate and evaluate the physical quality results of coffee powder body scrub cream with emulgator concentrations of 15%, 14% and 13% stearic acid, and 1%, 2% and 3% triethanolamine. Experimental research method to determine variations in the concentration of stearic acid and triethanolamine emulsifiers. Observation of the results of evaluating the physical quality of the preparation includes organoleptic tests, homogeneity, pH, stickiness tests, spreadability tests and emulsion type. The results of this research indicate that there is an influence of differences in the concentration of stearic acid and triethanolamine in that F1 has a denser form than F2 and F3, after storage for 3 weeks F2 and F3 experienced a color change to light brown. This shows that the formulation has the best properties for body scrub cream preparations, is stable and meets the requirements based on organoleptic tests, homogeneity tests, pH tests in accordance with the standard facial skin pH in general, namely 4.5-7, while for the emulsion type test, and the stability test that was carried out on day 12 did not experience any changes or phase separation, namely F1 with a stearic acid concentration of 15% and triethanolamine 1%.

Formulation of Acetaminophen Granules with Porang Tuber Amylum (Amorphophallusoncophyllus) that Meets the Parameters of Particle Size Distribution and Destruction Time Arif Wijayanto; Juvita Herdianty
Strada Journal of Pharmacy Vol. 6 No. 1 (2024): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v6i1.168

Many farmers are interested in planting porang tubers, with many farmers planting porang tubers, the price of porang tubers will decrease during harvest . Porang tubers have several contents, namely starch, glucomannan, fiber, fat, protein, minerals and vitamins. Glucomannan content can be used as a tablet binder, thickener, gilling agent, film former, coating material emulsifier, and stabilizer. The purpose of this study was to determine the concentration of porang tuber flour as a binder in Acetaminophenum granules using the wet granulation method. Granules were made into three formulations with variations in the concentration of porang tuber flour, namely FI 5%, FII 7.5% and FIII 10%. GRANULES were tested for tablet uniformity, tablet hardness, tablet fragility , disintegration time, and granule size distribution. The data obtained were analyzed using Kruskal Wallis. The results of the analysis showed that variations in the concentration of porang tuber flour had different effects, based on the Kruskal Wallis analysis which showed a significant value of 0.10 (p> 0.05). The formulation that has a good physical quality test is formulation III, with a tablet hardness value of 6.84 kg and a disintegration time of 5.74 minutes which is almost close to the control (+) 14.27 kg and 6.38 minutes. The higher the concentration of porang tuber flour , the higher, the longer the disintegration time.

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