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All Journal Open Access Health Scientific Journal Journal of Global Research in Public Health Strada Journal of Pharmacy
Arif Wijayanto
Department of Pharmacy, Institut Ilmu Kesehatan STRADA Indonesia, Kediri, Indonesia
Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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A Physical Quality and Antioxidant Test of Strawberry Leaf Fraction Lotion DPPH Method (1,1- Diphenyl-2- Picryhydrazyl) Candra Asih Setyaningrum, Candra; Arif Wijayanto; Juvita Herdianty; Devita Riafinola Andaririt
Strada Journal of Pharmacy Vol. 7 No. 1 (2025): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i1.176

Abstract

Lotion is a cosmetic preparation that functions to moisturize and protect the skin by providing a soothing effect. This research utilizes natural ingredients in the form of strawberry leaf extract (Fragaria vesca) to create a lotion formulation with high antioxidant activity. The objective of this study is to determine the effect of varying concentrations of strawberry leaf extract on the physical quality and antioxidant activity of the lotion. This experimental study involved formulating lotions with different concentrations of strawberry leaf extract at 2%, 4%, and 6%. The antioxidant activity was evaluated using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) method to measure the extract's ability to scavenge free radicals. The main active component in strawberry leaf extract is polyphenol compounds, which act as natural antioxidants in cosmetic products. The results showed that the strawberry leaf fraction lotion had a soft texture, green color, and a characteristic strawberry leaf scent. The pH test had a significance value of 0.00. The viscosity test also had a significance value of 0.00. The adhesion test results showed a significance value of 0.00, and the spreadability test also had a significance value of 0.00. The DPPH antioxidant test showed regression values of 0.932 for the positive control, 0.854 for the negative control, 0.948 for F1, 0.985 for F2, and 0.967 for F3. This study provides strong evidence that strawberry leaf fraction is suitable as an active ingredient in antioxidant cosmetic products, with the potential to compete with conventional ingredients. The SPSS test results showed a significant effect of concentration on free radical inhibition, as well as significant differences in pH, spreadability, and adhesion tests among the formulations. However, some groups did not meet the assumptions of normality and homogeneity, indicating the need for alternative analytical methods for further validation
Formulation And Physical Quality Test Of Black Glutinous Rice (Oryza Sativa L. Var. Glutinosa) And Olive Oil Body Scrub Herdianty, Juvita; Aniqoh Meliana Putri, Luluk; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.97

Abstract

Background: The purpose of using a body scrub is to remove dead skin cells and dirt, and unclog pores, resulting in brighter, whiter skin. Many types of body scrubs are available today, each with a variety of benefits, from smoothing to whitening. Black glutinous rice is currently a popular choice for use in cosmetics. Black glutinous rice contains 109.52–256.61 mg of anthocyanin per 100 grams. The antioxidant activity of anthocyanins can be enhanced by the presence of other phytochemicals, such as flavanols, catechins, or vitamins, which are also commonly found in fruit.Methods: This research method is experimental in making body scrub preparations from black sticky rice as the active ingredient with varying concentrations of 5%, 10%, and 15%. Evaluation of the body scrub preparations by looking at the results of the physical quality of the preparations which include organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The body scrub preparations will be tested for 3 days and stored at room temperature. Data are analyzed descriptively by comparing them to the Indonesian National Standard.Results: The results of the study showed that the preparation met the physical quality requirements, the results of organoleptic quality, namely the formulation of body scrub preparations F1, F2, and F3. The results of the pH test of F1, F2, F3 were in the range of 6.03-6.48, the results of the spreadability test showed results in the range of 4.48-6.98, and the adhesion test produced a range of 0.2.30 -0.2.45.Conclusion: The conclusion of this study is that the formulations F1, F2 and F3 with the addition of olive oil have good physical quality, are stable and meet the Indonesian National Standard.
Validation of the UV-Vis Spectrophotometric Method for the Determination of Ascorbic Acid Content in Beverage Preparations Based on a Standard Vitamin C Calibration Curve Andaririt, Devita Riafinola; Purnaningtyas, Sri Rahayu Dwi; Wijayanto, Arif
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.101

Abstract

Background: Vitamin C or ascorbic acid (C₆H₈O₆) is an essential water-soluble compound, widely used in functional beverages due to its antioxidant properties. This compound plays a role in neutralizing free radicals, strengthening the immune system, and helping the absorption of iron in the body. Packaged beverages containing vitamin C can experience degradation due to storage temperature (pH), production process, and the length of product circulation on the market. This impacts degradation of ascorbic acid and decreases the levels of vitamin C in beverage preparations, so accurate and validated analytical methods are needed to ensure the conformity of ascorbic acid levels with the label.Methods: Determination of ascorbic acid levels using a UV-Vis spectrophotometer at maximum wavelength. A standard curve was prepared from a standard vitamin C solution with a concentration of 10–18 ppm, resulting in a regression equation as the basis for calculating sample levels. Method validation included linearity, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ) tests according to quantitative analysis guidelines.Results: The standard curve equation is Y = 0.020x + 0.030Y with r2 = 0.995r indicating good linearity. The vitamin C content in the sample is 1.045 mg/140 mL or 103.5% of the label (1000 mg), still within the Pharmacopoeia limits (90–110%). The LOD and LOQ values are 0.429 ppm and 1.3 ppm, respectively. The precision results show a %RSD of 0.1260% and an accuracy (% recovery) of 103.5%.Conclusion:The results showed that the UV-Vis spectrophotometry method had good linearity, accuracy, and precision. The vitamin C content in the product met standards. Validation parameters demonstrated that this method was consistent in analyzing vitamin C in beverage preparations.  
Formulation of Fibrauren tinctoria Lour. Extract Serum, As an Antioxidant with the 1,1-Diphenyl 2-Picryhydrazyl (DPPH) Method Wijayanto, Arif; Herdianty, Juvita; Putri, Luluk Aniqoh Meliana; Sumanto, Ardhi Broto
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.125

Abstract

Background: Serum is a preparation with a high concentration of active ingredients and low viscosity, which delivers a thin film of active ingredients to the skin surface. The use of Fibraurea tinctoria has been carried out since ancient times by the Dayak, Banjar, and Kutai tribes as a traditional treatment for liver disease, diabetes, and to increase the body's immunity from various causes of disease such as bacteria. Fibraurea tinctoria is believed to be able to ward off the negative effects caused by free radicals such as antioxidants.Methods: This experimental study investigated the antioxidant activity of Fibraurea tinctoria extract serum with varying concentrations of hydroxyethyl cellulose 1.0%, 1.5%, and 2.0% using the DPPH methods, which is simple, easy, fast, and sensitive, and requires a small sample. This method provides information on the reactivity of the tested compound with a stable radical. Evaluations of the Fibraurea tinctoria extract serum preparation was carried out by observing the results of physical quality tests, including organoleptic tests, homogeneity tests, pH tests, adhesion tests, and spreadability tests. The serum preparation was tested for 3 days and stored at room temperature. Data were analyzed descriptively by comparing it with the Indonesian National Standard.Results: The results showed that the serum extract preparations of Fibraurea tinctoria F1st, F2nd, and F3rd showed varying IC₅₀ values, where lower values ​​indicated stronger antioxidant potential. Formulation F3rd showed the lowest IC₅₀ value (3.11 ppm), F2nd (3.74 ppm) and F1st (4.67 ppm), all of which were stronger than the base (5.11 ppm).Conclusion: In this research, formulations F1st, F2nd, and F3rd had the highest antioxidant activity, with F3rd at a concentration of 2.0%. The identified strong antioxidant activity is the main basis for the potential of Fibraurea tinctoria extract serum as an active antioxidant ingredient.
Co-Authors Ardhi Broto Sumanto Atary Anggita Candra Asih Setyaningrum, Candra Devita Riafinola Juvita Herdianty Purnaningtyas, Sri Rahayu Dwi Putri, Luluk Aniqoh Meliana