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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Poltekita : Jurnal Ilmu Kesehatan JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah
Rizaldy, Rheza
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Effect of Phylantus ninuri leaf extract on kidney and liver histopathological features in formaldehyde-exposed rats Milla, Meidona Nurul; Istadi, Yani; Rizaldy, Rheza
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (609.431 KB) | DOI: 10.30659/sainsmed.v13i1.17515

Abstract

Formaldehyde (FA) metabolism in the body reduces glutathione levels, resulting in liver and kidney damage. Phylantus ninuri (meniran) has been demontrated to have hepatoprotective properties. However, the effect of meniran administration on the histological features of the liver and kidney in in formaldehyde-exposed rats has not been adequately studied. The study was aimed to determine the effect of meniran on the histopathological feature of liver and kidney cell. This was a posttest randomized control group design. A total of 24 male Wistar rats were divided into 4 groups of 6 rats each. Group 1 was a control group that received only oral formaldehyde. Group 2, Group 3, Group 4 was administered oral formaldehyde together with meniran extract at dose of 100 mg/kg BW, 200 mg/kg BW, and 300 mg /kg BW respectively for 14 days. The histopathological changes of the kidneys and liver were assesed using hematoxylin and eosin (HE) staining. The mean of kidney and liver damage in the meniran group at various doses was lower than that of control group. There was a significant difference in the mean of kidney damage between the control group and the meniran group at various doses (p<0.05). The mean histopathological score of liver damage showed a significant difference between the control group and various treatments (p<0.05). Ethanolic extract of meniran leaves ameliorates liver and kidney damage in formaldehyde-exposed rats.
Influence of Knowledge, Attitude, and Behavior on Hospital Workers' Vitamin D Febriarto*, Dimas; Makarim, Fadhli Rizal; Rizaldy, Rheza
JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Vol 8, No 3 (2023): Juni, socio-economics, community law, cultural history and social issues
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jimps.v8i3.26362

Abstract

This study aims to determine the role of knowledge, attitudes, and behaviors in relation to vitamin D levels among hospital workers who have limited sunlight exposure and those who are exposed to sunlight. This cross-sectional study were conducted on 54 participants randomly selected from hospital outdoor worker, clinic worker, and operating room worker.  The participants completed a validated Vitamin D knowledge, attitude, and behaviour questionnaire. Blood samples were collected to measure 25(OH)D using ELISA method. Mann-whitney test was used to assess Vitamin D level between groups, while influence of knowledge, attitude, and behaviour on vitamin D levels were assessed using Chi-square test.
Combination of Eucheuma Cottonii and Corticosteroids has a Superior Immunomodulatory Effect on Asthma Rizaldy, Rheza; Mulyani, Sri Priantini; Sumarawati, Titiek
Poltekita : Jurnal Ilmu Kesehatan Vol. 17 No. 3 (2023): November
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v17i3.3247

Abstract

Asthma prevalence has been increasing globally which is commonly treated using corticosteroid as gold standard treatment. However, corticosteroids have adverse effects and cases of corticosteroid-resistant asthma are emerging. Eucheuma cottonii (EC) has been shown to potentially attenuate inflammatory response in type I hypersensitivity. This study aimed to investigate the effect of Eucheuma cottonii extract and methylprednisolone combination on IL-4, IL-10, and histamine levels in Ovalbumin-induced asthma BALB/c mice. Thirty female BALB/c mice were randomly assigned to 6 groups : (1) Sham; (2) Ovalbumin-induced asthma mice; (3) Ovalbumin-induced asthma mice treated with methylprednisolone (MP) 0.24 mg/day; (4) Ovalbumin-induced asthma mice treated with EC extract 300 mg/kgBW/day; (5) Ovalbumin-induced asthma mice treated with combination of both. Treatments were given respectively for 7 days. Plasma IL-4, IL-10, and histamine levels were measured using ELISA method. The combination group showed both the lowest IL-4 levels (89.30 ± 1.37 pg/ml) and  the highest IL-10 levels (487.03 ± 20.57 pg/ml) compared to other asthma-like mouse groups (p = 0.001). No significant difference was observed in histamine levels among all treatments (p > 0.05). The administration of a combination of methylprednisolone and Eucheuma cottonii extract significantly affected plasma IL-4 and IL-10 levels compared to monotherapies. However, there was no significant difference in plasma histamine levels compared to monotherapies.
Co-Authors Febriarto*, Dimas Makarim, Fadhli Rizal Milla, Meidona Nurul Mulyani, Sri Priantini Titiek Sumarawati Yani Istadi