Sri Kunarti, Sri
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Effective dose of propolis extract against pain response in mice (Mus musculus) using writhing test method Salsabilla Zamrutizahra, Chonny; Widjiastuti, Ira; Kunarti, Sri
Conservative Dentistry Journal Vol. 12 No. 2 (2022): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v12i2.2022.86-89

Abstract

Background: Odontogenic pain has a high prevalence. One of the alternative materials used as medicine in dentistry is propolis. Propolis is a mixture of natural resins containing flavonoid and phenolic acids that play a role in suppressing the pain response through COX and NF-kB inhibition mechanisms. The content of active propolis compounds is influenced by the type of bee, region, geographical conditions, climate change, seasons, and botanical sources causing different effectiveness of propolis. This is supported by several studies that show a variety of effective doses that produce an optimal analgesic effect, thus a research plan was developed to discover the effective dose of propolis extract on suppressing pain response in mice using the writhing test method. Purpose: To determine the effective dose of propolis extract towards pain response in mice. Methods: This study was conducted using the writhing test method to see the analgesic effect of propolis extract. The research sample consisted of 30 mice which were divided into five treatment groups, namely the piroxicam control group, and the propolis extract group at doses of 35 mg/kgBW, 70 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW. Results: The results showed that the propolis extract dose of 70 mg/kgBW had no significant difference with the piroxicam control group, while between the doses of 35 mg/kgBW, 105 mg/kgBW, 140 mg/kgBW there was a significant difference towards the piroxicam control group. Conclusion: Propolis extract 70 mg/kgBW is the effective dose in suppressing pain response in mice
Differences of compressive strength between calcium carbonate from blood clam shells and calcium hydroxide as a candidate for pulp capping material Saraswati, Widya; Juniarti, Devi Eka; Lestari, Vita; Soetojo, Adioro; Kunarti, Sri; Cahyani, Febriastuti; Suardita, Ketut; Rahardia, Nabiela
Conservative Dentistry Journal Vol. 14 No. 1 (2024): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v14i1.2024.11-14

Abstract

Background: Pulp capping is one of the treatments for reversible pulpitis and aims to maintain pulp vitality. This treatment requires a material that can protect the pulp with good biocompatibility. The physical and mechanical properties, bio interactivity and bioactivity of pulp capping materials are very important for the formation of reparative dentin. Calcium hydroxide (Ca(OH)2) as the gold standard material in pulp capping treatment also has some disadvantages. Another alternative for pulp capping material is blood clam shell because it contains 98% calcium carbonate (CaCO3), which is a compound with a bone-like structure and can induce pulp cell differentiation. Objective: To investigate and explain the difference in compressive strength between CaCO3 from blood clam shells and Ca(OH)2 as a candidate pulp capping material. Methods: This research is a laboratory experimental study with post test only control group design method. Ca(OH)2 and CaCO3 samples were formed with a mixture of powder and aquadest with 4x6 mm sample size. The samples were dried at room temperature and the compressive strength was measured using a universal testing machine (UTM). Result: There is a significant difference in compressive strength between Ca(OH)2 and CaCO3 blood clam shells in the Mann-Whitney test results (p<0.05). Conclusion: The results of the compressive strength test between the mixture of Ca(OH)2 with aquadest in a ratio of 1:1 are greater than the mixture of CaCO3 blood clam shells with aquadest in a ratio of 3:1 so that pure CaCO3 blood clam shells with distilled water without other additives cannot be used as a candidate for capping pulp material.
Apex resection treatment on tooth 21 and 22 with suspected radicular cyst Cahyani, Febriastuti; Saraswati, Widya; Mulyadi, Reyz Pasenda; Wahab, Sofi Arnesti; Halima, Siti Noorraida; Dzulfikri, Ahzahra Indah; Zubaidah, Nanik; Kunarti, Sri; Soetojo, Adioro
Conservative Dentistry Journal Vol. 14 No. 2 (2024): July-December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v14i2.2024.87-89

Abstract

Background: Apex resection is the surgical removal of the apex or root end of a tooth. Endodontic failure is the most usual reason of treatment being performed. Retreatment may be the first option for teeth which have been treated conventionally and exhibit a persistent apical lesion. In particular, failures during conventional therapy could hinder results by leading infections to spread to inaccessible apical regions, necessitating surgery. Purpose: This case report aims to describe the management of radicular cyst on previously treated tooth. Case: A 51-year-old male patient came to Soewandhie General Hospital with a complaint of swelling on his hard palate from one year before. The left maxillary incisor has undergone root canal treatment about 1 year ago, but had not been permanently filled. Case Management: The treatments given were retreatment for 21 and root canal treatment for 22, then followed by cyst enucleation and apex resection on both teeth. Conclusion: Apex resection shows a satisfying result for treating previously treated tooth with persistent apical lesion.
Effect of nano calcium carbonate from Anadara granosa shell induced odontoblast-like cells as a pulp capping material candidate Saraswati, Widya; Ismiyatin, Kun; Goenharto, Setyabudi; Kunarti, Sri; Zubaidah, Nanik; Halima, Siti Noorraida; Daradjat, Kinanti Naianuha; Gusniarti, Haninda Dhipta
Conservative Dentistry Journal Vol. 15 No. 1 (2025): January-June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cdj.v15i1.2025.43-45

Abstract

Background: Vital pulp therapy is a treatment to repair and maintain pulp vitality. Calcium hydroxide is the gold standard in pulp capping materials. Calcium hydroxide has advantage antibacterial. However, calcium hydroxide has some disadvantages such form a layer liquefaction necrosis. Blood clam shells contain 98.7% calcium carbonate. Calcium carbonate (CaCO3) content becomes a good source of calcium can be used as a bone repair material. Purpose: To review effect nano CaCO3 from Anadara granosa shell induced odontoblast-like cells as a pulp capping candidate. Nanoparticles CaCO3 has advantages such as high surface area, low toxicity, biocompatibility, biodegradability, pH-sensitivity, and osteoconductivity. Reviews: Nano CaCO3 from Anadara granosa are promising to promote odontoblast-like cells formation. Conclusion: Nano CaCO3 its potential to influence odontoblast-like cells, which play a crucial role in dentin regeneration and repair.