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All Journal E-Prodenta Journal of Dentistry Journal of Case Reports in Dental Medicine Interdental Jurnal Kedokteran Gigi (IJKG) Science Midwifery
Priyo Hadi, Priyo
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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PENGARUH PEMBERIAN ZnSO4 1 % TOPIKAL TERHADAP EKSPRESI MMP-9 DAN JUMLAH FIBROBLAS PADA PENYEMBUHAN ULKUS TRAUMATIKUS TIKUS WISTAR DIABETES MELITUS Hidayat, Lukman Hakim; Hadi, Priyo; Radithia, Desiana
E-Prodenta Journal of Dentistry Vol 2, No 2 (2018)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.718 KB) | DOI: 10.21776/ub.eprodenta.2018.002.02.4

Abstract

Diabetes mellitus adalah penyakit yang berdampak pada proses penyembuhan luka di dalam mulut. Pada penderita diabetes melitus, aktifitas prolifrasi fibroblast menurun dan aktifitas enzim kolagenese serta MMP-9 meningkat, sehingga penyembuhan ulserasi pada rongga mulut akan menjadi lebih lama. Zinc sulfat merupakan mineral yang dapat meningkatkan sinyal antar sel, proliferasi komponen penyembuhan, serta migrasi komponen pada tahapan penyembuhan.  Tujuan: untuk menganalisis pengaruh pemberian zinc sulfat 1% secara topikal pada ekspresi MMP-9 dan jumlah sel fibroblas jaringan mukosa mulut hewan coba pada kondisi diabetes mellitus, yang mengalami ulkus traumatikus. Metode: Pada penelitian ini hewan coba (48 ekor tikus wistar) berusia 2-3 bulan dan berat badan 150-200 gram, dibagi menjadi empat grup. Untuk mendapatkan tikus diabetes, maka subjek diinduksi dengan streptozotocin (30mg) yang dilarutkan dalam 1,33 ml buffer (asam sitrate). Untuk membuat ulser pada jaringan mukosa mulut, maka dilakukan dengan menempelkan burniser panas selama 10 detik pada mukosa bibir subjek. Pada setiap periode ekperimen (hari ke-5 dan ke-7) dilakukan pengambilan jaringan mukosa, dan dilanjutkan dengan pembuatan preparat histologi. Pada preparat histologi digunakan pengecatan HE untuk mengidentifikasi dan menghitung jumlah fibroblast, sedangakan IHS untuk mengidentifikasi dan menghitung ekspresi MMP-9. Metoda statistik one-way Anova digunakan untuk analisis perbandingan antara grup perlakuan dan grup kontrol. Signifikansi didasarkan pada nilai p<0.05. Hasil: Pemberian zinc sulfat 1% secara topikal pada ulkus traumtikus pada tikus diabetes mengakibatkan terjadi peningkatkan jumlah fibroblas (p<0,05) dan menurunkan ekspresi MMP-9 (p<0,05) yang diamati pada setiap periode eksperimen yang ditetapkan dalam penelitian ini. Kesimpulan: Zinc sulfat 1% dapat mempercepat proses penyembuhan ulkus traumatikus pada hewan coba dengan kondisi diabetes mellitus. Kata kunci : diabetes melitus, ulkus traumatikus, zinc sulfat , MMP-9, fibroblas.
TATALAKSANA RECURRENT INTRA ORAL HERPES DISERTAI CANDIDIASIS YANG DIRUJUK OLEH DERMATOLOGIST Ganesha, Raziv; Setyaningtyas, Dwi; Savitri E, Diah; Hadi, Priyo; Israyani
Interdental: Jurnal Kedokteran Gigi Vol 16 No 1 (2020): Interdental Jurnal Kedokteran Gigi (IJKG)
Publisher : Faculty of Dentistry, Mahasaraswati Denpasar University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46862/interdental.v16i1.794

Abstract

Introduction : Herpes simplex virus (HSV) is one variant of the herpes virus that infects humans, has two main types of HSV-1 that manifests more found in the mucosa of the mouth, pharynx, and skin (upper waist), and the type HSV-2 manifests in the genital area (lower waist). Case: 16-year-old female patient were referred from dermatologis RSAL Dr Ramelan Surabaya with complaints of many ulcers, whitish area of the tongue, palatum, vestibulum and genitals. Case Treatment: patients treated with systemic drugs of acyclovir, fluconazole, folic acid, vitamin B, vitamin C, methyl prednisolone, aloe vera extract topical. Patients were tested for blood, HSV-1 & HSV-2 (+), HIV (-), ANA (-). Discussion: Herpes simplex infection is a disease caused by the herpes simplex virus (HSV) which is a DNA virus (Deoxyribonucleic acid). In humans, the herpes virus can be latent and reactivate Reactivation can occur because of a trigger in the form of decreased immunity due to weather changes, fever, sun exposure, emotional stress, trauma, pregnancy, hormonal, systemic diseases, allergies, and immunosuppression. In this case the cause is thought to be due to hormonal. The diagnosis of primary HSV infection and recurrent infection is usually obtained from clinical features and laboratory tests are used establish the diagnosis. Conclucion: Recurrence of HSV infection can be reduced if avoid trigger factors. HSV infection management aimed at the control of pain, supportive treatment and definitive treatment. In this case, multidisciplinary collaboration is required in the treatment because it involves two sites, oral and genital. Keyword : HSV, Recurrent Herpes Oral, Oral Candidiasis
Management of aphthous-like ulcer induce by trauma in patient with thalassemia beta intermedia: a case report Riyanto, Dahlia; Soebadi, Bagoes; Hadi, Priyo; Radithia, Desiana
Journal of Case Reports in Dental Medicine Vol 2, No 1 (2020)
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jcrdm.v2i1.110

Abstract

Objective: Thalasemia is an inherited blood diseases cause which abnormalities systemically and intraorally. This case report to discuss management of Aphthous-Like Ulcer in 24 year old man with Thalasemia β Intermedia and need blood transfusion every month. Ulcer occured 2 days before transfusion.Methods: Based on history, clinical examination, hematologi and ferritin tests.Results: The diagnosis was Aphthous Like ulcer induce by trauma. Patient was treated using anti-inflammatory mouthwash and recovery was achieved within 3 weeks follow-up. Conclusion: Management of oral manifestation in Thalasemia patient need multidiciplinary approach to obtain successful therapy.
Management of acute pseudomembranous candidiasis with angular cheilitis in diabetic patient Winias, Saka; Hadi, Priyo; Prasetya, Shakira Garini; Sinaga, Angelica Joyce Yokhebeth
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1980

Abstract

Diabetes mellitus (DM) is being increasingly documented even in developing countries. C. albicans infection is frequently found in diabetic patients. Diabetics and the ‘poorly controlled patients are considered as immunocompromised, though it is not easy to characterise the immunologic deficiencies clearly. Since infection is mostly preceded by colonization. The risk factors that increased the risk of Candida carriage in diabetic patients with DM were a higher age and a higher HbA1c level (poor regulation of DM). The purpose of this study is to report the management of Acute Pseudomembranous Candidiasis with Angular Cheilitis in diabetic patients. A 51-year-old lady complained of dryness and pain in the corner of the mouth, recurrence within 2 years after she had been diagnosed diabetic, which had worsened in the last two weeks. The corner of the mouth showed a fissure with reddish area. Oral mucosa showed multiple yellow-white pseudomembranous. The patient was prescribed antiseptic mouthwash and an antifungal oral suspension, which should be applied to the lesion 3-4 times daily. Ketoconazole, as a systemic antifungal, was given 200 mg/day. The laboratory test showed an increase in leucocytes cells count, monocytes, and ESR. A direct mycological examination and culture observation Candida albicans was performed. Referral to an internist to manage her systemic condition. This study concludes that immune dysfunctions in diabetics is contribute to the pathogenesis of Oral Candidiasis and Angular Cheilitis, which may lead to optimum treatment.
Co-Authors Desiana Radithia, Desiana Dwi Setyaningtyas, Dwi Hidayat, Lukman Hakim Israyani Prasetya, Shakira Garini Raziv Ganesha Riyanto, Dahlia Saka Winias Savitri E, Diah Sinaga, Angelica Joyce Yokhebeth Soebadi, Bagoes