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All Journal MKGK (Majalah Kedokteran Gigi Klinik) (Clinical Dental Journal) UGM ODONTO Dental Journal Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran E-Prodenta Journal of Dentistry Journal of Case Reports in Dental Medicine Interdental Jurnal Kedokteran Gigi (IJKG) Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal Odonto dental journal
Desiana Radithia, Desiana
Department Of Oral Medicine, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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PENGARUH PEMBERIAN ZnSO4 1 % TOPIKAL TERHADAP EKSPRESI MMP-9 DAN JUMLAH FIBROBLAS PADA PENYEMBUHAN ULKUS TRAUMATIKUS TIKUS WISTAR DIABETES MELITUS Hidayat, Lukman Hakim; Hadi, Priyo; Radithia, Desiana
E-Prodenta Journal of Dentistry Vol 2, No 2 (2018)
Publisher : Fakultas Kedokteran Gigi UB

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (224.718 KB) | DOI: 10.21776/ub.eprodenta.2018.002.02.4

Abstract

Diabetes mellitus adalah penyakit yang berdampak pada proses penyembuhan luka di dalam mulut. Pada penderita diabetes melitus, aktifitas prolifrasi fibroblast menurun dan aktifitas enzim kolagenese serta MMP-9 meningkat, sehingga penyembuhan ulserasi pada rongga mulut akan menjadi lebih lama. Zinc sulfat merupakan mineral yang dapat meningkatkan sinyal antar sel, proliferasi komponen penyembuhan, serta migrasi komponen pada tahapan penyembuhan.  Tujuan: untuk menganalisis pengaruh pemberian zinc sulfat 1% secara topikal pada ekspresi MMP-9 dan jumlah sel fibroblas jaringan mukosa mulut hewan coba pada kondisi diabetes mellitus, yang mengalami ulkus traumatikus. Metode: Pada penelitian ini hewan coba (48 ekor tikus wistar) berusia 2-3 bulan dan berat badan 150-200 gram, dibagi menjadi empat grup. Untuk mendapatkan tikus diabetes, maka subjek diinduksi dengan streptozotocin (30mg) yang dilarutkan dalam 1,33 ml buffer (asam sitrate). Untuk membuat ulser pada jaringan mukosa mulut, maka dilakukan dengan menempelkan burniser panas selama 10 detik pada mukosa bibir subjek. Pada setiap periode ekperimen (hari ke-5 dan ke-7) dilakukan pengambilan jaringan mukosa, dan dilanjutkan dengan pembuatan preparat histologi. Pada preparat histologi digunakan pengecatan HE untuk mengidentifikasi dan menghitung jumlah fibroblast, sedangakan IHS untuk mengidentifikasi dan menghitung ekspresi MMP-9. Metoda statistik one-way Anova digunakan untuk analisis perbandingan antara grup perlakuan dan grup kontrol. Signifikansi didasarkan pada nilai p<0.05. Hasil: Pemberian zinc sulfat 1% secara topikal pada ulkus traumtikus pada tikus diabetes mengakibatkan terjadi peningkatkan jumlah fibroblas (p<0,05) dan menurunkan ekspresi MMP-9 (p<0,05) yang diamati pada setiap periode eksperimen yang ditetapkan dalam penelitian ini. Kesimpulan: Zinc sulfat 1% dapat mempercepat proses penyembuhan ulkus traumatikus pada hewan coba dengan kondisi diabetes mellitus. Kata kunci : diabetes melitus, ulkus traumatikus, zinc sulfat , MMP-9, fibroblas.
CORRELATION OF Ki67 EXPRESSION TO DEGREE OF DYSPLASIA IN LINGUAL EPITHELIAL DYSPLASIA IN Rattus norvegicus EXPOSURED BY CIGARETTE SMOKE (Hubungan Ekspresi Ki67 Terhadap Derajat Displasia Pada Epitel Mukosa Lidah Rattus norvegicus yang Dipapar Asap Rokok) Rina Kartika Sari; Hening Tuti Hendarti; Bagus Soebadi; Priyo Hadi; Desiana Radithia; Adiastuti Endah P
ODONTO : Dental Journal Vol 6, No 2 (2019): December 2019
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.6.2.76-87

Abstract

Background: Dysplasia is malignant transformation of stratified squamous epithelium characterized by cellular atypia and loss of stratification and maturation. It can caused by cigarette smoke. Measuring the activity of cell proliferation as the beginning of dysplasia is very useful to know the development of malignancy. One of proliferation marker is Ki67 that expressed in all cell cycle phase except G0.Methods: 30 male wistar rats divided into: control grup (n=10), exposed to cigarette smoke for 4 weeks (n=10), 8 weeks (n=10) as much as 20 cigarettes/group/day/exposure used smoking pump. Specimen were stained HE to see dysplasia and Ki67 expression seen immunohistochemically. Statistical analyzed by Spearman correlation.Result: There was an increase in mean of Ki67 expression and significant differences between groups (p=0,000) and also significant difference of degree of dysplasia between groups (p=0,000). There was a strong correlation between Ki67 score to degree of dysplasia (p=0.001).Conclusion: Increased of Ki67 expression proportional to the Increase in degrees of dysplasia
MANAGEMENT OF HSV-1 AND HSV-2 PRIMARY INFECTION IN ADULT PATIENT: A CASE REPORT Bima Ewando Kaban; Dahlia Riyanto; Adiastuti Parmadiati; Desiana Radithia; Bagus Soebadi
Dentino : Jurnal Kedokteran Gigi Vol 6, No 1 (2021)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v6i1.10647

Abstract

ABSTRACT Infection of Herpes Simplex Virus (HSV) type 1 and 2 causes medical problems throughout the world. HSV-1 infection often affects the oral regions and HSV-2 infection is the most prevalent cause of genital ulcerations.  It is possible for HSV-2 to cause oro-labial herpes and HSV-1 to cause genital herpes. Primary HSV infection usually affects children or adolescent, whereas adults usually experience infection more frequently due to viral reactivation. Objective:  To discuss the management of Primary HSV-1 and HSV-2 Infection which appears simultaneously in adults. Case report: a 33yearold female patient came to hospital with multiple painful ulcers in her tongue, buccal and labial mucosa, preceded by prodrome, followed with eruption and outbreak of vesicles on her skin. The first laboratory examination confirmed a high titer of reactive Immunoglobulin M (IgM) of anti-HSV-1 and Immunoglobulin M (IgM) anti-HSV-2. She was diagnosed to have Primary HSV-1 and HSV-2 Infection and treated with oral Acyclovir and Chlorine dioxide mouthwash with good healing. The clinical presentation, differential diagnosis and management of primary herpetic stomatitis are discussed. Conclusion: Correct diagnosis and treatment can restore well-being, avoid secondary problems for patients, and prevent the use of inappropriate drugs.Keywords : Herpes Simplex Virus, HSV-1, HSV-2, Management, Primary Herpes Infection
ORAL CANDIDIASIS IN HIV PATIENT SUFFERING PNEUMOCYSTIC CARINII PNEUMONIA Dahlia Riyanto; Rindang Tanjungsari; Tri Pudy Asmarawati; Desiana Radithia
Dentino : Jurnal Kedokteran Gigi Vol 5, No 1 (2020)
Publisher : FKG Unlam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v5i1.8126

Abstract

Background: HIV/AIDS infection provoked opportunistic infection systhemically and intraorally. Pneumocystic carinii pneumonia (PCP) and Oral candidiasis (OC) is the most prevalent opportunistic infection among HIV/AIDS patient and may serve as indicator of low CD4 count in HIV infection. Objective: This paper reports management of oral candidiasis in pneumocystic carinii pneumonia that affects a patient with HIV. Case: A 39 year-old man was hospitalized for pneumocystic carinii pneumonia with weakness of gait and emaciated posture. He was also diagnosed of HIV/AIDS infection through CD4 count and HIV rapid test. Intraoral white patches was reported occured within 2 days being hospitalized. Several tests were ordered resulting, metabolic acidosis, CD4 count were 10 cells/μL, HIV rapid test (ICT) was reactive for 3 methods, and microbiologic examination was positif to C.albicans from the smear of white plaque. The patient also diagnosed with OC pseudomembranous type. Case Management: Patient was treated using intravenous fluconazole 100 mg/day for five days and antiseptic mouthwash. Recovery was achieved within 3 weeks follow-up along with given anti retroviral (ARV) treatment by the internist. Conclusion: Management of OC in HIV/AIDS patient with PCP infection in this case were used systemic antifungal and antiseptic mouthwash. The multidiciplinary approach in managing this case obtained successful therapy.
Oral rinse as a potential method to culture Candida isolate from AIDS patients Desiana Radithia; Hening T. Hendarti; Bagus Soebadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 44 No. 4 (2011): December 2011
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (411.327 KB) | DOI: 10.20473/j.djmkg.v44.i4.p177-180

Abstract

Background: Candida isolate is easily sampled from oral cavity by swabbing directly on the candidiasis lesion, to be smeared onto slides for direct examination or cultured in a growth medium. This method is by far the gold standard for defining candidiasis diagnosis. However it is difficult to apply on sensitive patients and almost impossible on patients showing no clinical appearance of oral candidiasis. AIDS patients are very prone to candida infection and have a tendency of repetitive infection involving mixed species. As many candida species show different susceptibility to anti-fungal agents, it is necessary to identify the species causing the infection in the management of oral candidiasis. Oral rinse is a suggested method to obtain candida isolate to be cultured for further analysis such as species identification. This method is simple and less risky on infection transmission as less tools are required in the procedure. Purpose: This study aimed to assess the application of oral rinse as an alternative method to culture Candida isolate from AIDS patients. Methods: A cross-sectional observative study was conducted in HIV/AIDS in-Patient Facility of Intermediate Care Unit for Infection Disease, Dr. Soetomo Hospital Surabaya. Fourteen stadium 4 AIDS patients matching criteria were swabbed on 1/3-posterior of the tongue, and then given 10 ml phosphate buffer saline to rinse vigorously for 15 seconds. Both specimens were cultured on Sabouraud’s dextrose agar and colony growth was observed. Results: Candida colonies were able to grow from all 14 isolates (100%) by both methods. Qualitatively, cultures from oral rinse specimens were more populated than cultures from swab specimens. Conclusion: Oral rinse is an applicable technique to obtain Candida species isolate. This technique is safe, easy, non-invasive, and needs less tools therefore less risky for HIV transmission.Latar belakang: Isolat Candida mudah diambil dengan cara mengusap lesi candidiasis, baik untuk dioleskan pada kaca preparat untuk pemeriksaan langsung maupun dikultur. Hingga kini, metode tersebut dinyatakan sebagai “standar emas” untuk menentukan diagnosis. Namun kekurangan metode ini yaitu berisiko merangsang muntah pada pasien sensitif, dan hanya bisa dilakukan bila tampak jelas ada lesi. Candidiasis adalah penyakit nosokomial yang sering terjadi. Pasien AIDS sangat rentan terhadap infeksi oportunis ini secara rekuren dan persisten. Identifikasi spesies penyebab harus dilakukan karena berbagai spesies Candida memiliki kerentanan yang berbeda terhadap berbagai jenis antifungal. Oral rinse adalah metode pengambilan isolat Candida yang non-invasif. Isolat yang didapat bisa dikultur dan diidentifikasi, selain itu bisa dilakukan pada pasien yang belum menunjukkan adanya lesi candidiasis untuk menentukan besar risiko pasien terkena candidiasis, sehingga dapat ditentukan perlu tidaknya pemberian profilaksis antifungal. Tujuan: Penelitian ini bertujuan mengamati efektivitas metode oral rinse untuk mengisolasi Candida dari rongga mulut pasien AIDS. Metode: Penelitian observasional dilakukan di bagian Rawat Inap Unit Perawatan Intermediate Penyakit Infeksi RSUD Dr. Soetomo. Swab pada 1/3 posterior lidah dilakukan pada 14 pasien yang memenuhi kriteria, kemudia pasien diberi 10 ml phosphate buffer saline untuk berkumur kuat-kuat selama 15 detik. Spesimen yang didapat melalui kedua metode dikultur pada medium Sabouraud untuk diamati. Hasil: Koloni Candida berhasil dikultur dari 14 spesimen (100 %) melalui kedua metode isolasi. Secara kualitiatif tampak bahwa hasil kultur dari oral rinse tampak lebih subur. Kesimpulan: Oral rinse adalah metode yang dapat diaplikasikan untuk mengisolasi Candida dari rongga mulut pasien. Tekniknya mudah, aman, non-onvasif, dan tidak memerlukan peralatan dan ketrampilan khusus, sehingga mengurangi risiko transmisi HIV.
Human-leukocyte antigen typing in Javanese patients with recurrent aphthous stomatitis Diah Savitri Ernawati; Bagus Soebadi; Desiana Radithia
Dental Journal (Majalah Kedokteran Gigi) Vol. 43 No. 1 (2010): March 2010
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.658 KB) | DOI: 10.20473/j.djmkg.v43.i1.p26-30

Abstract

Background: Recurrent aphthous stomatitis (RAS) is a common oral disorder that despite extensive researches, the etiology of this phenomenon is still unknown. Because this phenomenon has been observed more often in families than in individual cases, genetic influence has been investigated in most researches. Purpose: The aim of study was to evaluate the association between human leukocyte antigen (HLA) and RAS in Javanese more precisely. Method: The analysis of HLA-A, and HLA-B in 85 Javanese RAS patients and 71 healthy control subjects, were performed by using the standard NIH microlymhocytotoxicity technique. Immunohistochemistry was performed for identification of HLA-DR and HLA- DQ antigen using monoclonal antibodies anti HLA-DR and DQ. Result: Our result revealed a close association between HLA-A9 and HLA-B35 RAS subject. A significant increase in the frequency of some antigens such as HLA-A9 (72,94%, p < 0,05;RR = 2,21), HLA-A24 (65,82%; RR = 1,24) and HLA-B35 in subjects with RAS was observed. Analysis with Immunohistochemistry HLA-DR, HLA-DQ is expressed on the surface of epithelial cells membrane of oral mucosa and macrophages in both major and minor RAS patients. Conclusion: HLA antigens are involved in susceptibility to RAS and the phenotypes were difference with other previous studies. HLA- linked genetic factors may play a role in the development of RAS.Latar belakang: Stomatitis aftosa rekuren (SAR) merupakan salah satu gangguan di rongga mulut yang paling sering terjadi. Fenomenapenyakit ini masih belum jelas dan masih membutuhkanpenelitian yang lebih lanjut. Faktor keturunan lebih sering daripada kasus individual. Pengaruh faktor genetik telah diteliti oleh beberapapeneliti. Tujuan: Tujuan penelitian ini untuk mengetahui adanya kaitan HLA dengan SARpada suku jawa secara lebih tepat. Metode: Analisis HLA-A, HLA-Bpada 85penderita RAS dan 71 penderita kontrol yang berasal dari suku Jawa dihitung dengan menggunakan teknik NIH Micro Lymphocytotoxicity. Teknik Imunohistokimia dilakukan untuk mengidentifikasi antigen HLA-DR, HLA DQ dengan menggunakan antibodi monoklonal HLA-DR & DQ. Hasil: Menununjukkan hubungan yang kuat antara HLA-A9 dan HLA-B-35 pada pasien SAR. Terdapat peningkatan yang signifikan dari beberapa antigen seperti HLA-A9 (72,94%, p < 0,05, RR = 2,21), HLA-A24 (65,82%, RR = 1,24) dan HLA-B35 pada pasien SAR yang di observasi. Analisis dengan Imunohistokimia tampak HLA-DR, DQ diekspresikan pada permukaan membran sel dan makrofag pada pasien SAR mayor maupun minor. Kesimpulan: Antigen HLA terlibat dengan kepekaan terjadinya RAS, dan fenotipnya berbeda dengan hasil penelitian sebelumnya HLA dan faktor genetik berperan penting pada terjadinya SAR.
Allergic contact cheilitis due to lipstick Yatty Ravitasari; Desiana Radithia; Priyo Hadi
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 4 (2015): December 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (392.075 KB) | DOI: 10.20473/j.djmkg.v48.i4.p173-176

Abstract

Background: Cheilitis is a common problem of unknown etiology. A possible cause of cheilitis is contact allergy. Drugs, lipsticks, sunblock and toothpaste are the most common implicated allergens. Allergic contact cheilitis is a chronic superficial inflammatory disorder of the vermilion borders characterized by desquamation due to delayed-type hypersensitivity reaction. Purpose: We report a management of Allergic contact cheilitis due to lipsticks. Case: A 21-year-old woman had a history of atopic allergy to eggs, milk, and chicken presented with sore, dry, fissured, scaled and sometimes bleeding lip, over a 3-month period after application of a lipstick. Her symptoms persisted despite treatments with hydrocortisone cream. The patient provided a detailed history and underwent physical examination and patch tests to cosmetic components and patch test to her own lipstick. The patient had strongly-positive result to the tested lipstick. A diagnosis of allergic contact cheilitis was made based on the history and clinical findings. Case management: Patient was advised to avoid wearing lipstick. To relieve symptoms, treatment was initiated with combined topical corticosteroid, antibiotic, and moisturizer. Conclusion: Contact allergy patients should be tested for both cosmetic component series and their own lipsticks to exclude exfolliative cheilitis, infection, or light actinic cheilitis as causal agents.
Fungal inhibitory effect of Citrus Limon peel essential oil on Candida albicans Iwan Hernawan; Desiana Radithia; Priyo Hadi; Diah Savitri Ernawati
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 2 (2015): June 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.332 KB) | DOI: 10.20473/j.djmkg.v48.i2.p84-88

Abstract

Background: Oral candidiasis is an opportunistic infections due to Candida albicans that often found in people with HIV/AIDS. Anti-fungi, polyne and azole, are used in the treatment of oral candidiasis, but often cause persistence and recurrence. Citrus Limon peel contains terpenoids capable of inhibiting the synthesis of ergosterol, a component of the fungal cell wall that helps to maintain cell membrane permeability. Essential oil derived from citrus limon peel, thus, is expected to inhibit the growth of Candida albicans. Purpose: This research was aimed to know how essential oil derived from citrus Limon peel can inhibit the growth of Candida albicans. Method: This research was a laboratory experimental research carried out in three phases. First, essential oil was made with cold pressing method, and then the concentration of 100% was diluted to 50%, 12.5%, 6.25%, 3.125%, 1.56% and 0.78%. A test was conducted on the culture of Candida albicans in Sabouraud broth, accompanied by control (+) and (-). Second, the dilution of essential oil was conducted to alter the concentration with inhibitory power, from the strongest one to the weakest one, and then it was tested on the culture of Candida albicans. Third, spreading was carried out from liquid culture to agar media in order to measure the number of colonies. Result: Candida albicans did not grow on media with 100% essential oil treatment, but it grew on media with 50% essential oil treatment. In the second phase, dilution of 100%, 90%, 80%, 70%, 60% and 50% was conducted. The growth of Candida albicans was found on the treatment media of 60% and 50%. On the agar media, the growth occurred in the cultured medium treated with 70%. Conclusion: The minimum inhibitory power of essential oil derived from citrus Limon peel against Candida albicans was in the concentration of 80%. Essential oil derived from citrus Limon peel has antifungal effect and potential as a therapeutic agent for oral candidiasis.
The effect of ethyl acetate fraction of Citrus limon peel on mesenchymal cell proliferation and polybacterial growth Astrid Marinna; Priyo Hadi; Desiana Radithia
Dental Journal (Majalah Kedokteran Gigi) Vol. 48 No. 3 (2015): September 2015
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.407 KB) | DOI: 10.20473/j.djmkg.v48.i3.p144-149

Abstract

Background: Oral diseases remain to be global health problem. The common therapy involved the use of modern medicines with their various side effects. Citrus limon are potentials as anti-inflammatory, anti-fungal, anti-oxidant, anti-viral and anti-bacterial. Purpose: The purpose of this study was to determine the effect of ethyl acetate fraction of citrus limon peel extract on human gingival mesenchymal cell proliferation and palm commensal polybacterial growth. Method: This study was experimental study with post test only control group design. Citrus limon peel extracted and partitioned in order to obtain ethyl acetate fraction of 3.125%, 2.75%, 2.375%, 2%, and 1.5625%. Toxicity test was performed after 24 hours using the MTT Assays. Cell viability was measured by optical density formazonand read by ELISA reader 620 nm. Results: All treatment groups showed less than 60% cell viability. The highest cell was 19.36 (1.5625% concentration) and the lowest was 12.65 (3.125% concentration). The highest anti-bacterial inhibition value was 8.9125 mm (3.125% concentration) and the lowest was 6.0625 mm (1.5625% concentration). Conclusion: The higher concentration of ethyl acetate fraction Citrus limon peel extract, the higher toxicity and inhibitory properties against commensal palm polybacteria.
The correlation between exposure to cigarette smoke and the degree of mucosal epithelium-based dysplasia in Rattus norvegicus tongues Dorisna Prijaryanti; Diah Savitri Ernawati; Desiana Radithia; Hening Tuti Hendarti; Rosnah Binti Zain
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p187-191

Abstract

Background: Cigarette smoke contains various carcinogenic substances such as polycyclic aromatic hydrocarbons and nitrosamines. These chemicals not only have the potential to damage DNA, but can also induce genetic mutations and activate genes that function during apoptosis. Thus, if the gene is dysregulated, it will cause cells to survive, proliferate and subsequently lead to the development of cancerous ones. Histologically, the carcinogenic process affecting the oral cavity starts with hyperplasia and dysplasia, followed by severe dysplasia then leading to invasive cancer and metastatic processes in other bodies. Purpose: This study aims to reveal the correlation between exposure to cigarette smoke and the degree of epithelial dysplasia evident in research subjects. Methods: This study used 27 samples of Rattus norvegicus tongue, divided into three groups, namely; a control group, a treatment group subjected to four weeks’ exposure to cigarette smoke, and a treatment group subjected to exposure lasting eight weeks. Each rat was placed in an individual chamber and exposed to smoke from 20 cigarettes introduced by a pump via a pipe for 7.5 minutes. The degree of epithelial dysplasia in each case was subsequently observed microscopically using HE staining technique. Results: Mild epithelial dysplasia increased by 0.82%, during the fourth week of exposure to cigarette smoke and by 2.99% during the eighth week. Similarly, moderate epithelial dysplasia rose by 5.29% during the fourth week of exposure and 5.99% during the eighth week. Severe epithelial dysplasia also increased by 2.2% during the fourth week of exposure and by 2.66% during the eighth week. Conclusion: The longer the exposure to cigarette smoke, the higher the degree of ensuing dysplasia.
Co-Authors Adiastuti Endah P Adiastuti Endah Parmadiati Adiastuti Parmadiati Asmarawati, Tri Pudy Astrid Marinna Aulya Setyo Pratiwi Ayu Fresno Argadianti Ayuningtyas, Nurina F. Bagus Soebadi Bagus Soebadi Bagus Soebadi Bagus Soebadi Bagus Soebadi, Bagus Bima Ewando Kaban Bima Ewando Kaban Dahlia Riyanto Dewi, Gremita Kusuma Diah Savitri Ernawati Dorisna Prijaryanti Endah, Adiastuti Ernawati, Diah S. Fatma Yasmin Mahdani Hening T. Hendarti Hening Tuti Hendarti Hidayat, Lukman Hakim Intan Noha Brilyanti Iwan Hernawan Kuntardjo, Yuhanna Lani Berlina Talahatu Maharani, Annissaqiella Nafi’ah, Nafi’ah Novitasari Novitasari Nurina Febriyanti Ayuningtyas Pasaribu, Togu Andrie Simon Perwiradinata, Ronden Pradnyani , I Gusti Agung Sri Pramitha, Selviana Rizky Pratiwi, Aulya Setyo Prijaryanti, Dorisna Priyo Hadi Priyo Hadi Priyo Hadi Priyo Hadi, Priyo Puspasari, Karlina Puspitasari, Yeni Rajah, Karthiyayinee Alagir Ratna Fitri, Adinda Reiska Kumala Bakti Retno Pudji Rahayu Rina Kartika Sari Rindang Tanjungsari Riskayanti, Ni Putu Riyanto, Dahlia Rosnah Binti Zain Sismiyanti, Rossy Soebadi, Bagoes Subarnbhesaj, Ajiravudh Sukmawati, Natasya Fauzia Surboyo, Meircurius Dwi Condro Yatty Ravitasari Yuliana Yuliana Yuskhaidir, Yuskhaidir