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All Journal The Indonesian Biomedical Journal Universa Medicina Majalah Kedokteran Nusantara The Journal Of Medical School Buletin Farmatera Sumatera Medical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik) The Journal of Society Medicine (JSOCMED)
Dairion Gatot, Dairion
Division Of Hematology Oncology Medic, Department Of Internal Medicine, Faculty Of Medicine, University Of Sumatera Utara Medan
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PROFIL ANEMIA DAN TROMBOSITOPENIA PADA PASIEN SIROSIS HEPATIS NON HEPATITIS: PROFILE OF ANEMIA AND THROMBOCYTOPENIA IN PATIENTS WITH NON-HEPATITIS LIVER CIRRHOSIS Ray, Vahira Nissha Matovani; Olmen, Lider; Gatot, Dairion
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 9 No. 1 (2026): Issue in Progress
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v9i1.1022

Abstract

Anemia is a common hematological complication in liver cirrhosis, caused by gastrointestinal bleeding, hypersplenism, and bone marrow dysfunction. This study aimed to analyze the relationship between hematological parameters and the severity of non-hepatitis liver cirrhosis. A cross-sectional observational study was conducted on 30 patients with non-hepatitis liver cirrhosis at Dr. Ferdinand Lumbantobing General Hospital, Sibolga, from December 2023 to August 2024. Laboratory parameters included hemoglobin, MCV, MCHC, and platelet count, analyzed using the Spearman correlation test (p<0.05). Among 30 patients, 21 (70%) were male and 9 (30%) female. Macrocytic anemia was predominant (53.3%), followed by microcytic (26.7%) and normocytic (20%). Most patients (50%) were in Child-Pugh B class, and thrombocytopenia occurred in 70% of cases. Significant correlations were found between hemoglobin, MCV, MCHC, and platelet count with cirrhosis severity (p=0.00). These findings indicate that anemia, particularly macrocytic type, is closely linked to chronic liver disease progression. Hematological parameters may serve as simple and valuable clinical indicators for assessing disease severity. A significant relationship exists between anemia and the severity of non-hepatitis liver cirrhosis. AbstrakAnemia merupakan komplikasi hematologis yang sering dijumpai pada pasien sirosis hepatis, disebabkan oleh perdarahan saluran cerna, hipersplenisme, serta gangguan fungsi sumsum tulang. Penelitian ini bertujuan menganalisis hubungan antara parameter hematologi dan derajat keparahan sirosis hepatis non-hepatitis. Penelitian observasional dengan desain potong lintang ini melibatkan 30 pasien sirosis hepatis non-hepatitis di RSU Dr. Ferdinand Lumbantobing, Sibolga, periode Desember 2023-Agustus 2024. Data laboratorium meliputi kadar hemoglobin, MCV, MCHC, dan jumlah trombosit. Analisis menggunakan uji korelasi Spearman dengan tingkat signifikansi p<0,05. Dari total 30 pasien, 21 (70%) berjenis kelamin laki-laki dan 9 (30%) perempuan. Jenis anemia yang dominan adalah makrositik (53,3%), diikuti mikrositik (26,7%) dan normositik (20%). Sebagian besar pasien (50%) berada pada kategori sirosis sedang (Child-Pugh B), dan 70% mengalami trombositopenia. Terdapat hubungan signifikan antara hemoglobin, MCV, MCHC, dan trombosit dengan derajat keparahan sirosis hepatis (p=0,00).b Hasil ini menunjukkan bahwa anemia, khususnya makrositik, sering berkaitan dengan progresivitas penyakit hati kronis. Parameter hematologi berpotensi menjadi indikator klinis sederhana dalam menilai keparahan sirosis. Terdapat hubungan bermakna antara anemia dan derajat keparahan sirosis hepatis non-hepatitis. Parameter hematologi dapat digunakan sebagai indikator progresivitas penyakit hati kronis.
Co-Authors Ahsan Tanio Daulay Alfajri, Muhammad Jailani Alfajri dharma Lindarto, dharma Dika Iyona Sinulingga Handayani, Savina Lubis, Heny Syahrini Mardia, Andri Iskandar Mardia, Andri Iskandar Mardiya Sari Olmen, Lider Ray, Vahira Nissha Matovani Rusli Dhanu Santi Syafril Santi Syafril, Santi Savita Handayani Savita Handayani Sholat, Alfi Dewi Syafrizal Nasution Syahrini Lubis, Henni tantri, Anita Vally Ramayanda Zainal Abdi