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All Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of Biomedicine and Translational Research Majalah Kedokteran
Forman Erwin Siagian
Departemen Parasitologi, Fakultas Kedokteran Universitas Kristen Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Public Health

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Anisakiasis Pada Ikan Laut Di Indonesia: Prevalensi, Sebaran Dan Potensi Patogenitasnya Pada Manusia Forman Erwin Siagian; Esy Maryanti
Jurnal Ilmu Kedokteran Vol 14, No 1 (2020): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v14i1.2020.11-23

Abstract

Nematode worm Anisakis sp is the causative agent of anisakiasis, a zoonosis which continues to be a health problem in humans, globally. Its clinical spectum varies from mild to very severe and always connected with sea fishes, one important source of nutrition for the community that cannot be ignored. In addition, consumer’s behavior and lifestyle in processing and consuming sea fishes also have has the potency as the predisposing factor for its transmission and clinical manifestations. This review article aimed to describes recent global data on anisakiasis and its occurrence in marine fishes of Indonesian waters and the risk of transmission in the community.
Kelainan yang Berhubungan dengan Larva Anisakis sp. Forman Erwin Siagian; Gandhy Todo Yansen Siagian; Aryan Obrien Siagian
Majalah Kedokteran UKI Vol. 27 No. 3 (2010): JULI-SEPTEMBER
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Meningkatnya konsumsi ikan laut dimasyarakat dapat membawa dampak negatif di bidang kesehatan. Berbagai kelainan dapat disebabkan oleh parasit yang menginfeksi ikan, misalnya cacing Anisakis sp yang menyebabkan anisakiasis. Infestasi larva dapat menyebabkan gangguan berupa alergi, apendisitis bahkan obstruksi saluran cerna. Tanda patologis dan gejala klinisnya seringkali tidak khas, akibatnya diagnosisnya sering sulit ditegakkan sehingga terapi yang sesuai tidak dapat diberikan. Pentingnya pemahaman mengenai anisakiasis dan mekanismenya dalam menyebabkan penyakit akan membantu meningkatkan kewaspadaan terhadap potensi infeksi. Kata kunci: hipersensitivitas, ikan laut, larva, cacing, Anisakiasis, Anisakidae Abstract The increase of fish consumption, especially that originated from the deep sea, gives negative impact on health. Fish parasite like Anisakis sp can caused several health derangement such as allergy, appendicitis and even intestinal obstruction. The pathology and clinical signs are not always pathognomonic. Therefore, it is often difficult to diagnose correctly entailing in the delay of proper treatment. It is important to pay attention and better understanding about anisakiasis and the pathogenesis mechanism. Hence, it would increase awareness of the infection. Keyword: hypersensitivity, marine fish, larvae, worm, anisakiasis, Anisakidae
Faktor Virulen Drofilaria immitis Pada Jaringan Tubuh Manusia Forman Erwin Siagian
Majalah Kedokteran UKI Vol. 25 No. 1 (2007): JANUARI-MARET
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mkvol34iss2pp60

Abstract

Abstrak Dirofilaria immitis merupakan cacing golongan nematoda dengan tempat predileksi pada jantung dan arteria pulmonalis anjing maupun kucing, serta banyak jenis hewan lain. Pada manusia, cacing itu menyebabkan infeksi zoonosis yang disebut dirofilariasis dan bisa berakibat fatal. Infeksi terjadi melalui gigtan nyamuk zooantropofilik yang mengandung stadium mikrofilaria. Teoritis D. Immitis tidak dapat berkembang menjadi cacing dewasa diluar hospes definitifnya. Namun dilaporkan beberapa kasus sumbatan pembuluh darah paru dan jantung oleh cacing dewasa. Kemampuan untuk bertahan hidup dan menimbulkan gangguan organ dalam hospes non alamiahnya menunjukan adanya sejumlah faktor virulen yang menyebabkan sistem kekebalan kesulitan untuk menghancurkan cacing ini. Faktor virulen cacing adalah stadium mikrofilaria dengan produk-produk sekresi, eksresi, dan enzimatik. Kata Kunci : D. Immitis, zoonosis, dirofilariasis, faktor virulensi Abstract Dirofilaria immitis is a filarial nematode of dogs, cats, and many kind of animals with its predilection site heart and lung vessels. In human, this worm can cause zoonotic infection that can be fatal named dirofilariasis. Infection occur though the bit of zooantrophohilic mosquito that contain infective microfilaria. Theoretically, D. Immitis will not be able develop and become adult worm outside its definite host, but several cases of heart and pulmonal vessels obstruction caused by adult stage have been reported. The ability to survive and destroy the inner organ of the non-natural hosts showed that there are several virulence factor that made the host immune system failed. This paper aimed to discuss about virulence factor of D.immitis. Keywords : D. Immitis, zoonosis, dirofilariasis, viruence factors.
Aktivitas Antijamur Ekstrak Biji Pepaya (Carica Papaya L.) Varietas Bangkok Forman Erwin Siagian; Dena Carolina Sabono; Muhammad Alfarabi
Majalah Kedokteran UKI Vol. 36 No. 1 (2020): JANUARI-APRIL
Publisher : Fakultas Kedokteran Universitas Kristen Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/mk.v36i1.2987

Abstract

Abstrak Candida sp. dan Cryptococcus sp. merupakan jamur oportunistik yang dapat menyebabkan penyakit pada manusia dan dapat berakibat fatal jika tidak ditangani dengan cepat dan tepat. Saat ini terdapat permasalahan yaitu resistensi antijamur dan jenis terapi terhadap jamur yang terbatas. Terdapatnya bahan alam yang melimpah di Indonesia menjadi suatu potensi untuk mengembangkan obat anti jamur baru yang memiliki efektivitas tinggi, efek samping yang minimal, dan murah. Salah satu bahan alam yang belum tereksplorasi untuk antijamur adalah biji pepaya varietas bangkok. Biji pepaya selama ini lebih banyak menjadi limbah organik. Oleh karena hal tersebut, tujuan dari penelitian ini adalah untuk menguji aktivitas antijamur dari ekstrak biji pepaya bangkok (Carica papaya L.). Jamur yang digunakan pada penelitian ini adalah Candida albicans dan Cryptococcus neoformans. Metode yang digunakan adalah perhitungan zona hambat pada sumur di cawan petri. Hasil penelitian menunjukkan bahwa tidak terdapat zona hambat pada media yang terdapat C. albicans dan C. neoformans. Dapat disimpulkan, ekstrak biji papaya tidak memiliki aktivitas antijamur terhadap kedua jamur tersebut. Kata kunci: Pepaya bangkok, Antijamur, Bahan alam Abstract Candida sp. and Cryptococcus sp. are opportunistic fungi that can be fatal disease in humans if not treated properly. However, resistance of antifungal drugs have been emerged, therefore limit their benefit for therapy. Many natural products in Indonesia have potential to be established for new antifungal drugs that have high effectiveness, minimal side effects, and inexpensive. Papaya bangkok seed has not been explored for its antifungal activity. This seed become more organic waste. The aim of this study was to test antifungal activity of various papaya bangkok seed extract concentrations. We measured the inhibiton zone of papaya extract to Candida albicans and Cryptococcus neoformans. Result showed no inhibition zone for each seed extract concentrations. Papaya bangkok seed extract has not antifungal activity. Keywords: Papaya bangkok, antifungal, natural product
Detection of Blastocystis Hominis by Method of Cultivation in The Feces of Orphanage Children in Pekanbaru, Riau Province, Indonesia Esy Maryanti; Suri Dwi Lesmana; Wira Firja; Muhammad Devlin; Mislindawati Mislindawati; Forman Erwin Siagian
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.16470

Abstract

Background: Blastocystis hominis is an intestinal protozoan that can infect humans and animals. The distribution coverage is very wide and is transmitted through the fecal-oral route. The incidence of blastocystosis due to Blastocystis hominis is higher in developing countries because it is associated with poor hygiene practice, inadequate sanitation, close contact with pets domesticated animals and or contaminated food. Blastocystis hominis infection can cause clinical manifestations, from asymptomatic to chronic diarrhea, depending on the Blastocystis subtype and the patient's immune system. brief background of the topic and significance of the study.Objective: The aim of this study was to detect and determine the incidence of Blastocystis hominis infection in the feces of children at the Pekanbaru Orphanage using the culture method.Methods: The sample is the feces of children from nine orphanages in Pekanbaru. Detection of Blastocystis by the modified Jone's Medium culture method but using sheep's serumResults: A total of 95 children's stool samples were examined from 9 orphanages in Pekanbaru, it was found that 63 children (66.3%) were positive for Blastocystis hominis using the culture method, positive Blastocystis hominis was found more in boys (58.7%%) than girls, and based on age group, 6-12 years were found to be the age group with the most infection (84.1%). Generally, the source of drinking water in orphanages is refilled drinking water and all orphanages have cats as pets, and a few have chickens, birds, and goats as petsConclusion: High incidence of Blastocystis hominis can be detected in the feces of Pekanbaru orphanage children using the culture method. 
Co-Authors Aryan Obrien Siagian Dena Carolina Sabono Esy Maryanti Gandhy Todo Yansen Siagian Mislindawati Mislindawati Muhammad Alfarabi Muhammad Devlin Suri Dwi Lesmana Wira Firja