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All Journal Paediatrica Indonesiana Indonesian Journal of Obstetrics & Gynecology Science
Aditiawati Aditiawati, Aditiawati
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Health Professions Medicine & Pharmacology Public Health

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Cognitive function in Indonesian children with type 1 diabetes mellitus Ulfa, Marselya; Aditiawati, Aditiawati; Hasanah, Yulisnawati; Dhaini, Shafri; Bakrie, Achirul; Indra, Raden Muhammad
Paediatrica Indonesiana Vol. 64 No. 1 (2024): January 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.1.2024.44-50

Abstract

Background Children with type 1 diabetes mellitus (T1DM) are at risk of cognitive impairment. While the pathophysiology is still unclear, cognitive impairment in children with T1DM can result in significant negative effects on quality of life. Objective to evaluate the cognitive function of Indonesian children with T1DM and its association with glycemic control and to identify factors affecting cognitive function in children with T1DM. Methods The cognitive function of children aged 6 years or older with T1DM was measured using the Wechsler Intelligence Scale for Children-Revised (WISC-R). We analyzed for potential associations between cognitive function and glycemic control based on mean HbA1c levels and other factors, such as the age of onset, duration of illness, and maternal educational attainment. We also identified failure to achieve age-appropriate results on any of the WISC-R subtests (cognitive impairment) and associated factors. Results A total of 46 subjects were included in this study, with a mean age of 12.8 (SD 3.4) years. There were 27 (58.7%) girls and 19 (41.3%) boys. Subjects’ mean full-scale IQ (FSIQ) was 91.35 (SD 11.43). A moderate negative correlation was found between FSIQ and mean HbA1c levels (r=-0.43; P<0.01). Children with mothers who had university degrees had significantly higher IQs (mean difference 7.39; 95%CI 3.10 to 13.66; P=0.02) than those with mothers without degrees. Failure of any WISC-R subtest was noted in 34 subjects, consisting of 17 verbal, 1 performance, and 34 verbal and performance subtests. A higher proportion of those with cognitive impairment had mean HbA1c >10%. However, compared to those with mean HbA1c ?10, the difference did not reach a statistical significance (OR 5.0; 95%CI 0.95 to 26.31; P=0.50) Conclusion Glycemic control and maternal educational attainment are associated with cognitive function in Indonesian children with T1DM. Poor glycemic control is also associated with a higher risk of cognitive impairment.
Penanganan Kasus Kehamilan 32 Minggu dengan Hipertiroid Janin-Fetal Goiter Albernande, Anggy; Sutrisno, Muhammad Al Farisi; Lestari, Peby Maulina; Mafiana, Rose; Kusnadi, Yulianto; Indrayadi, Indrayadi; Aditiawati, Aditiawati
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 1 Maret 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i1.609

Abstract

Hipertiroid pada kehamilan didefinisikan sebagai peningkatan kadar free T4. Hipertiroid terjadi pada 2/1000 kehamilan yaitu hipertiroid yang tidak terkontrol selama kehamilan meningkatkan risiko krisis tiroid, kelahiran prematur, dan kematian janin. Pasien Ny. DK 21 tahun datang dengan keluhan benjolan di leher kanan sebesar telur puyuh, hamil 21 minggu, dengan hasil USG fetal goiter. Pemeriksaan fisik didapatkan keadaan umum baik, suhu 36,60C; tekanan darah: 120/80 mmHg; frek. nadi: 92x/menit; frek. nafas: 20 x/menit. Pada pemeriksaan Leopold I didapatkan tinggi fundus uteri 21 cm, teraba bagian lunak. Leopold II teraba tahanan memanjang di sisi kiri kesan punggung. Leopold III teraba bagian terbawah bulat, melenting dan keras U 5/5, kesan kepala. DJJ 159x/mnt, TBJ 1240 gram. Pada pasien dilakukan observasi dan kontrol dengan rentang 2 minggu setelah pemeriksaan. Tata laksana pada pasien ini adalah asam folat, kalsium karbonat, vitamin D, propylthiouracil, folamil, dan ferrous sulfat.Management of Cases 32 Weeks Gestational Pregnancy with Fetal Hyperthyroidism-Fetal GoiterAbstractHyperthyroidism in pregnancy is defined as an increase in free T4 levels. Hyperthyroidism occurs in 2/1000 pregnancies where uncontrolled hyperthyroidism during pregnancy increases the risk of thyroid crisis, premature birth and fetal death. Patient Mrs. 21 year old DK came with complaints of a lump in her right neck the size of a quail egg, 21 weeks pregnant, with ultrasound results of fetal goiter. Physical examination revealed good general condition, temperature 36.60C; blood pressure: 120/80 mmHg; Strange. pulse: 92x/minute; Strange. breath: 20 x/minute. On examination by Leopold I, the height of the uterine fundus was 21 cm, and the soft part was palpable. Leopold II has a longitudinal resistance on the left side of the dorsal impression. Leopold III palpable lower part round, melted and hard U 5/5, head impression. DJJ 159x/minute, TBJ 1240 grams. Patients were observed and monitored at intervals of 2 weeks after the examination. Treatment for this patient is folic acid, calcium carbonate, vitamin D, propylthiouracil, folamyl and ferrous sulfate.Key words: Hyperthyroidism, fetal goiter, propylthiouracil
Stress levels and menstrual cycles in high school adolescents Saldinar, Alena Briliantyas; Athiah, Medina; Hasanah, Yulisnawati; Nurwanny, Raissa; Aditiawati, Aditiawati
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.325-30

Abstract

Background Around 15.5 million (34.9%) adolescents in Indonesia experience stress. Most of the stress in adolescents comes from internal and external academic demands. One of the negative impacts of stress is the disruption of hormonal mechanisms in the female reproductive system, which can affect the menstrual cycle. Objective To analyze the relationship between stress level and menstrual cycle in adolescent girls aged 15 - 17 years who have menses  ≥ 2 years. Methods This study used primary data from instruments such as the Depression Anxiety Stress Scale (DASS 42) questionnaire modified by Damanik and the menstrual cycle questionnaire by Aldiba filled on Google forms by 1,565 adolescents from four high schools in Palembang City. We also excluded adolescents with conditions that could potentially bias the study, such as endocrine diseases (pituitary tumors and Cushing's syndrome), athletes with intensive physical activity, use of hormonal drugs, and abnormalities in nutritional status. Results A total of 281 of 961 respondents who met the inclusion criteria were randomly selected through a stratified proportional random sampling method. Of those who reported experiencing stress, 27% experienced moderate stress. The majority of subjects experienced menstrual cycle disorders (55.5%). Adolescents with moderate stress level and above had a greater percentage of menstrual cycle disorders compared to adolescents who did not experience stress (P=0.039). Severe levels of stress were significantly associated with menstrual cycle irregularities (P=0.025) Conclusion Stress levels are significantly associated with menstrual cycle irregularities among high school adolescents in Palembang City.
Co-Authors Achirul Bakrie, Achirul Albernande, Anggy Athiah, Medina Dhaini, Shafri Indra, Raden Muhammad Indrayadi, Indrayadi Nurwanny, Raissa Peby Maulina Lestari, Peby Maulina Rose Mafiana Saldinar, Alena Briliantyas Sutrisno, Muhammad Al Farisi Ulfa, Marselya Yulianto kusnadi Yulisnawati Hasanah