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All Journal Jurnal Kedokteran Diponegoro Medica Hospitalia
Hexanto Muhartomo, Hexanto
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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THE RELATIONSHIP BETWEEN ESR, HEMATOCRIT, PLATELETS COUNT AND OUTCOME OF CNS TUMOR PATIENTS WHO RECEIVED CHEMOTHERAPY AT RSUP DR. KARIADI SEMARANG Budi, Hyasinta Paramita; Rahmawati, Maria Belladona; Budisulistyo, Trianggoro; Muhartomo, Hexanto
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.555 KB) | DOI: 10.14710/dmj.v9i2.27097

Abstract

Background : Central nervous system tumors, both primary and secondary tumor, are malignancies which result in mental disorder, and neurological deficit. Therefore, the patients can end up being social burden for their environment. Hematological laboratory test including ESR, hematocrit, and platelets count are very practical. However, they are functional for predicting outcome. Aim: The current study aimed to determine the relationship between ESR, hematocrit, platelets count, and outcome of CNS tumor patients who received chemotherapy at RSUP dr. Kariadi Semarang. Method : This recent study was conducted at Medical Record Installation by collecting data from patient’s medical record. Data taken by researcher were hematologic profile (ESR, hematocrit, and platelets count), demographic data (age, gender, type of tumor, symptomatic treatment, and comorbidity), and outcome. Data were analyzed using univariate analytical method to show data distribution, bivariate analytical method to determine the relationship with outcome, and multivariate analytical method to determine which variable had the most significant relation. Result : Bivariate analytical method using chi-square test showed insignificant p value for hematocrit (p=0,541 total data, p=0,960 case, p=0,518 control). Platelets count analysis didn’t give significant p value either (p=0,541 total, p=0,790 case, p=0,292 control). There were no data could be obtained about ESR. Conclusion : The current study showed no relationship between hematocrit and outcome, neither the relationship between platelets count and outcome.Keywords : ESR, hematocrit, platelets count, outcome
The Relationship Between Serum Folic Acid Levels With The Cognitive Function of The Elderly Hermanto, Hermanto; Muhartomo, Hexanto; Husni, Amin; Widiastuty, Maria Immaculata; Suryawati, Herlina; Wati, Arinta Puspita
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.891

Abstract

Background: Cognitive decline is a common condition that occurs in the elderly. One of the early indicators of senility is a decrease in cognitive function. Folic acid is thought to protect the arteries from damage because of homocysteine by converting homocysteine into cysteine and then excreted in the urine. Increased levels of homocysteine can interfere with vascular function and cause toxic effects on neurons thereby increasing the risk of cognitive decline. Objective: To determine the relationship between serum folic acid levels and cognitive function of the elderly. Method: Analytical descriptive research with a cross-sectional approach. The research subjects were the elderly who met the inclusion criteria and did not have exclusion criteria. The research was conducted from May to July 2022 at the Pucang Gading Nursing Home, Semarang. Serum folic acid levels were examined using the ELISA (Enzyme-linked immunosorbent assay) method. Cognitive function was assessed using the Indonesian version of the Montreal Cognitive Assessment (MoCA) simultaneously on the subject. Cognitive function is normal if the MoCA-INA value is ≥ 26 and it is said to be cognitive dysfunction if the MoCA-INA value is < 26. Data were analyzed using the Spearman test. Results are considered significant if the value of p <0.05.  Result: There is a strong positive correlation between serum folic acid levels and cognitive function in the elderly (r=0.914, p<0.001). There is a relationship between educational level and cognitive function (r=0.922, p<0.001) where higher education correlates with increased cognitive function in the elderly. Conclusion: There is a significant positive correlation between serum folic acid levels and cognitive function in the elderly
RELATIONSHIP BETWEEN LOCATION AND NUMBER OF LESIONS BASED ON HEAD CT SCAN WITH BEHAVIORAL PSYCHOLOGICAL SYMPTOMS OF DEMENTIA: A Study on Post-Ischemic Stroke Patients with Vascular Cognitive Impairment at Kariadi Hospital Semarang Novalya, Fadhilla Eka; Puspita Wati, Arinta; Kustiowati, Endang; Tugasworo, Dodik; Muhartomo, Hexanto
Medica Hospitalia : Journal of Clinical Medicine Vol. 13 No. 2 (2026): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v13i2.1389

Abstract

Background: Behavioral Psychological Symptoms of Dementia (BPSD) characterized by disturbances in perception, thought content, mood, or behavior, frequently occur alongside Vascular Cognitive Impairment (VCI), significantly affecting the functional and cognitive status of post-stroke patients. Previous studies have identified certain stroke characteristics — such as multiple lesions, infarct volume and lesion location (e.g. left hemisphere) — as risk factors for post-stroke dementia. Epidemiological data on BPSD and research on the relationship between the location and number of stroke lesions and BPSD remain limited. Aim: To determine the relationship between the location and number of stroke lesions based on head CT scan with BPSD Methods: Cross-sectional study involving post-ischemic stroke patients at the Outpatient Installation of Kariadi Hospital Semarang. An evaluation was conducted on the location and number of stroke lesions in relation to the occurrence of Behavioral Psychological Symptoms of Dementia, based on Abe’s Behavioral Psychological Symptoms of Dementia Score. The confounding variables of the study were age, occupation, education level, nutritional status, and caregiver. Analysis was conducted using the Independent T test, Mann Whitney U and Kruskal-wallis. Significant results p<0.05 Results: The mean ABE BPSD score was 7.17 with a median of 4. The most common symptoms were depression/low mood, irritability, and sleep disturbance (33.3% each), followed by excitement and agitation (28.6%). Of the total subjects, 31% had stroke in the non-dominant hemisphere, 26.2% in the dominant hemisphere, and 42.9% in both hemisphere. A total of 64.3% had frontal lesions, while 35.7% had non-frontal lesions. Based on the number of lesions, 54.8% had single lesions and 45.2% had multiple lesions. The location of the lesions in the frontal region (p<0.001), the number of multiple lesions (p<0.001) and younger age (p=0.042) were significantly associated with a more severe ABE BPSD score. Conclusion: Location of frontal lesions, number of multiple lesions based on head CT scan and younger age have significant association with BPSD in post-ischemic stroke patients with VCI.
Co-Authors Amin Husni Arinta Puspita Wati, Arinta Puspita Budi, Hyasinta Paramita Budisulistyo, Trianggoro Dodik Tugasworo Endang Kustiowati Hermanto Hermanto Novalya, Fadhilla Eka Puspita Wati, Arinta Rahmawati, Maria Belladona Suryawati, Herlina Widiastuty, Maria Immaculata