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THE RELATIONSHIP BETWEEN ESR, HEMATOCRIT, PLATELETS COUNT AND OUTCOME OF CNS TUMOR PATIENTS WHO RECEIVED CHEMOTHERAPY AT RSUP DR. KARIADI SEMARANG Budi, Hyasinta Paramita; Rahmawati, Maria Belladona; Budisulistyo, Trianggoro; Muhartomo, Hexanto
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 2 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background : Central nervous system tumors, both primary and secondary tumor, are malignancies which result in mental disorder, and neurological deficit. Therefore, the patients can end up being social burden for their environment. Hematological laboratory test including ESR, hematocrit, and platelets count are very practical. However, they are functional for predicting outcome. Aim: The current study aimed to determine the relationship between ESR, hematocrit, platelets count, and outcome of CNS tumor patients who received chemotherapy at RSUP dr. Kariadi Semarang. Method : This recent study was conducted at Medical Record Installation by collecting data from patient’s medical record. Data taken by researcher were hematologic profile (ESR, hematocrit, and platelets count), demographic data (age, gender, type of tumor, symptomatic treatment, and comorbidity), and outcome. Data were analyzed using univariate analytical method to show data distribution, bivariate analytical method to determine the relationship with outcome, and multivariate analytical method to determine which variable had the most significant relation. Result : Bivariate analytical method using chi-square test showed insignificant p value for hematocrit (p=0,541 total data, p=0,960 case, p=0,518 control). Platelets count analysis didn’t give significant p value either (p=0,541 total, p=0,790 case, p=0,292 control). There were no data could be obtained about ESR. Conclusion : The current study showed no relationship between hematocrit and outcome, neither the relationship between platelets count and outcome.Keywords : ESR, hematocrit, platelets count, outcome

Pain Improvement Among Chronic Lumbar Disc Herniation Patients Underwent Epidural Triamcinolone With Or Without Hyaluronidase Injection Within 3 Months Of Follow-Up: A Prospective Study Budisulistyo, Trianggoro; Husni, Amin; Tugasworo, Dodik; Pudjonarko, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.850

Background Chronic lumbar disc herniation (CLDH) will accompany by chronic inflammation, so the fibrosis tissues formed in the epidural space and adjacent nerve roots, and lead to mixed pain syndrome. Objectives To compare between triamcinolone only and hyaluronidase 1500 international unit (IU) administration epidural injection for treating bulged or protrusion CLDH. Methods This prospective study involved CLDH patients visiting the outpatient department of Neurology at Dr. Kariadi Hospital Semarang Indonesia from November 2021 until August 2022. They divided: triamcinolone (Group 1) and hyaluronidase 1500 IU and triamcinolone epidural injection (Group 2) with 3 days of hospitalization. Neurotrophic was prescribed during 3 months of follow-up and ordered for personal physical treatment. They analyzed pain improvements (NRS and Pain DETECT), and the Oswestry Disability Index (ODI) scores. Results The 37 subjects were recruited but 1 female dropped out cause of re-injection, so 13 males and 23 females aged between 24 to 72 years old (mean 48+2) were followed. They significantly improved (Wilcoxon test p=.000), as the NRS score was 47.9% (Group 1) and 55.4% (Group 2). ODI scores without significance (Mann-Whitney p> .005), such at 2 weeks (group 1= 20.4%, group 2= 23.6%) and 3 months (group 1= 58.1%, group 2= 53.7%). They observed nociceptive and neuropathic improvement even though needed more time for the healing process. Conclussions This study proved hyaluronidase administration before triamcinolone epidural injection with better improvements for treating bulged or protrusion CLDH patients.

Association Of Neuropathic Pain Improvement And hs-CRP Changes Among Trigeminal Neuralgia Patients Experienced Radiofrequency Ablation 60o and 65o Celcius: 6 months follow up Arlina, Yani; Budisulistyo, Trianggoro; Pudjonarko, Dwi; Tugasworo, Dodik; Suryawati, Herlina; Diah Pasmanasari, Elta
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.876

INTRODUCTION: Trigeminal neuralgia (NT) is a neuropathic pain that involves the trigeminal nerve in the face. The first-line medical management of patients with NT is Carbamazepine (CBZ). Radiofrequency ablation (RFA) procedure is a minimally invasive procedure using a high-frequency current-generating device that produced heat ablate of C-fibers with effectiveness around 76% for 10 yeas follow-up. Inflammed trigeminal nerve (TG) or the branch(es) might be one of the underlying mechanisms unless vascular compression is a common etiology. The heat effects might be according to the temperature set up varies recently from 60°C to 95°C. METHOD: This observational study enrolled 75 severe NT subjects without satisfactory improvement of treatments, divided into 3 groups: analgesics prescription (Control), RFA 60, and RFA 65 Groups. The LANSS scores and hs-CRP levels were followed-up before (baseline), 2 weeks, 3, and 6 months experienced the treatments. Subjects ages in the range of 48.32 + 12.73 to 50.88 + 14.59 years old, and the duration of illness from 4.48 to 10.32 months. RESULT: The LANSS score >12 before treatments showed significance improvements (p<0.001), as in the Control (64% with neuropathic pain), RFA 60 (100% with neuropathic pain), and RFA 65 group (92% with nociceptive pain) at 2 weeks followed-up. At 3 and 6 months observed 100% subjects with nociceptive pain but without significancies. Even though the hs-CRP levels observed reduced for all groups, especially RFA 60 and RFA 65, but have no significances. CONCLUSION: The LANSS scores changes observed significant improvement in all groups, which mentioned if the neuropathic pain syndromes might be better under each treatment. The Hs-CRP levels improvement is better in the neuro ablation groups than analgesic drugs treatment. Even though the Hs-CRP are following of systemic nonspecific inflammation, NT is a focal inflammation.

The Wistar Rat Parietal Lobe Cell And Pain Perception Changes After Frequent Of Mobile Phone Electromagnetic Wave Expose Tamad, Fatiha Sri Utami; Budisulistyo, Trianggoro; Husni, Amin; Retnaningsih, Retnaningsih; Suryawati, Herlina; Suryadi, Suryadi
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.884

Background: The increasing number of mobile phone users raises concerns about the effects. Mobile phone electromagnetic wave radiation harms pain perception due to granular cell changes in the cerebral parietal cortex. Objective: To determine the effect of exposure to electromagnetic waves mobile phone on pain perception due to changes in the granular cells of the cerebral parietal cortex Wistar rats. Methods: Experimental research using randomized posttest with control group design. Samples were 28 rats divided into 4 groups. The control group was not exposed, the treatment group was exposed to 2100 MHz electromagnetic waves for 2 hours/day with a distance of 3 cm for 15 days in treatment group 1, for 30 days in treatment group 2, and 45 days in treatment group 3. Measurement of pain onset using the hot method. Changes in pain threshold were taken from the difference in pain onset after exposure to before exposure. Granular cell changes in the cerebral parietal cortex were assessed from the total score with the provisions of normal cells (sumx0), hydropic degenerated cells (sumx1), and necrotic cells (sumx2). Results: The longer the exposure to mobile phones, the higher the pain threshold and the cerebral parietal cortex granular cell damage score. There was a significant difference in pain threshold and changes in cerebral parietal cortex granular cells between groups (p=0.000). There was a significant relationship between changes in the parietal cerebral cortex granular cells and pain threshold in Wistar rats exposed to electromagnetic waves (p=0.000). Conclusion: Exposure to mobile phone electromagnetic waves affects pain perception due to changes in the granular cells of the cerebral parietal cortex in wistar rats.

Effect Of Triamcinolone Trigger Point Injection On Changes In TNF-α Levels And Oswestry Disability Index (ODI) Scores Non-Specific Low Back Pain (LBP) Patients Fakih, Mohamad; Suryadi; Tugasworo, Dodik; Pudjanarko, Dwi; Husni, Amin; Budisulistyo, Trianggoro; Puspitawati, Arinta
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 1 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i1.976

Background: Low back pain (LBP) is the most common musculoskeletal problem and a major cause of worldwide disability causing increased health costs and indirect costs associated with reduced or lost productivity. One of the therapeutic management of LBP is Triamcinolone trigger point injection. Until now, research on the effect of Triamcinolone trigger point injection on changes in TNF-α levels and Oswestry Disability Index (ODI) scores in Non-Specific LBP patients is still limited. Objective: To analyze the effect of Triamcinolone trigger point injection on changes in TNF-α levels and ODI scores before and after Triamcinolone trigger point injection in Non-Specific LBP patients. Methods: This is a quasi-experimental analytic observational study with a pre and post-test group design approach. Subjects were diagnosed with Non-Specific LBP who had met the inclusion criteria (acute pain less than 3 months, patient age 30-55 years, moderate-severe pain intensity, had never received a Triamcinolone trigger point injection) with the exclusion criteria patients experiencing severe pain. not only caused by NPB. The study subjects were checked for TNF-α levels and ODI scores before and after the Triamcinolone trigger point injection. Then a paired T-test was carried out. Results: During the study period September - November 2022 at the Neurology Outpatient Polyclinic, RSUP Dr. Kariadi Semarang obtained 32 subjects. There was a significant difference between changes in TNF-α levels before and after Triamcinolone trigger point injection (p=0.000). There was a significant difference in ODI scores before and after the Triamcinolone trigger point injection (p=0.000). There was no significant relationship between the risk factors for gender, occupation, BMI, physiotherapy, and changes in TNF-α levels with changes in the ODI score. Conclusion: There is a significant difference in changes in TNF-α levels and ODI scores before and after Triamcinolone trigger point injection.

The Effect of Moringa Leaves Extract on Sperm Motility in Male Mice Exposed to Electromagnetic Radiation of Mobile Phone Sabrina, Hasnaa Alyasi; Budisulistyo, Trianggoro; Juniarto, Achmad Zulfa; Sareharto, Tun Paksi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 3 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i3.43904

Background: Electromagnetic radiation can induce an increase in oxidative stress. The presence of oxidative stress can impact the structure of the plasma membrane of sperm cells, damage the structure of Deoxyribonucleic Acid (DNA), and accelerate the process of apoptosis, ultimately leading to a decline in sperm quality. This increase in oxidative stress can be prevented by substances that serve as antioxidants. Moringa plants, particularly the leaves, contain various substances that can act as antioxidants for the body. These include flavonoids, alkaloids, saponins, tannins, and terpenoids. The antioxidant content in Moringa leaves is believed to safeguard the process of spermatogenesisAim: To determine the impact of Moringa (Moringa oleifera) leaf extract on the motility of spermatozoa in BALB/C mice subjected to exposure to electromagnetic waves.Methods: This study utilized design featuring a post-test-only control group design, dividing participants into four randomly assigned groups, namely a negative control group, a positive control group (exposure to electromagnetic waves), and 2 treatment groups (moringa leaf extract at dose of 100 mg/kg BW and 400mg/kg BW). Each group compromised 5 experimental animals, and the treatments were administered for duration of 30 days. Spermatozoa preparations were made for each group and observed under a microscope (400x). Data were analyzed by initially testing for normality using the Shapiro-Wilk test. If the data distribution was normal, the hypothesis examination involved conducting a One Way ANOVA followed by subsequent Post Hoc testing.Results: The results of the one-way ANOVA test indicated differences between groups of mice (p<0.05). The post hoc test results further demonstrated that a dose of 400 mg/kg BW was the most effective in preventing a decrease in spermatozoa motility. This effect is believed to be atttributed to the presence of vitamin C, beta carotene, beta-sitosterol, flavonoids, and polyphenols.Conclusion: There is an improvement in spermatozoa motility in BALB/C mice exposed to electromagnetic waves after the administration of Moringa leaf extract.

The Effect of Moringa Leaves Extracts on MDA Level in Male Mice Exposed to Electromagnetic Radiation of Mobile Phones Amalia, Nadia Ilmi; Budisulistyo, Trianggoro; Wibowo, Dhega Anindita; Sareharto, Tun Paksi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 4 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i4.43905

Background: The use of cell phones causes anxiety about the effects of electromagnetic wave radiation emitted because of the production of free radicals in the body is increased by cell phone electromagnetic wave radiation. This escalation results in an elevated production of Reactive Oxygen Species (ROS), resulting in elevated Malondialdehyde (MDA) levels due to lipid peroxidation, which is toxic to the body. One way to reduce MDA levels is to introduce antioxidants into the body. Previous studies have found that Moringa leaf extract can be used as a good source of antioxidants.Objective: The aim of this research was to assess the impact of Moringa leaf extract administration on the MDA levels in BALB/C mice subjected to electromagnetic waves emitted by cell phones.Methods: This study employed an experimental study with a post-test only control group design. The research involved 23 male BALB/c mice, divided into four groups. The healthy control group received no treatment, while the negative control group was exposed to cell phone electromagnetic waves for 2 hours/day. Groups P1 and P2 received Moringa leaf extract at doses of 100 mg/kgBW and 400 mg/kgBW, respectively, in addition to being exposed to cellular phone electromagnetic waves for 2 hours/day. The treatment was administered for 30 days following a 7-dayadaptation period. On the 31st day, blood plasma samples were takenfrom all mice and examined for MDA levels. The data underwent analysis through non-parametric One-Way ANOVA and subsequent Pos Hoc LSD tests. Significance is acknowledged for p-values less than 0.05.Results: The highest MDA levels were found in the K (-) group, namely 0.43 ± 0.18 ppm, and the lowest MDA levels were observed in the P1 group, with values of 0.19 ± 0.08 ppm. A significant difference was noted between the K (-) group and the P1 group (p = 0.05), while no significant difference were observed in the other groups.Conclusion: Administering Moringa leaf extract at a dose of 100 mg/kgBW/day can reduce MDA levels in mice exposed to electromagnetic waves from cell phones.

Differences in the Degree of Spasticity in Post-Haemorrhagic and Non-Haemorrhagic Stroke Patients Based on the Modified Ashworth Scale Abhista, Ifandias Gian; Sugianto, Maria Belladonna Rahmawati; Kesoema, Tanti Ajoe; Budisulistyo, Trianggoro
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 3 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i3.1137

Background : Stroke is a brain function disorder caused by vascular disturbances with manifestations ranging from paralysis to death. Stroke is a health issue with high incidence and mortality rates. Furthermore, post-stroke patients can experience various residual symptoms such as spasticity, which can lead to decreased productivity and socio- economic impacts. Spasticity is a common symptom in stroke survivors, with a prevalence ranging from 30% to 80%. This symptom typically appears several weeks after a stroke and can persist for up to 12 months, causing reduced productivity and socio-economic challenges. Hemorrhagic strokes result from blood vessel rupture, while non- hemorrhagic strokes are caused by ischemia. Both types can damage motor pathways, leading to spasticity. Understanding the differences in spasticity severity between stroke types may guide targeted rehabilitation strategies. The aimsof ths study was to determine the difference in the degree of spasticity in post-stroke patients between hemorrhagic and non-hemorrhagic strokes based on the Modified Ashworth Scale. Methods : An analytical observational study with a cross-sectional design was conducted. The study included 33 post-hemorrhagic stroke patients and 33 post-non- hemorrhagic stroke patients. The degree of spasticity was measured using the Modified Ashworth Scale. Statistical analysis was performed using the Chi-Square test. Results : The Chi-Square test for the variable "stroke type" and "degree of spasticity" yielded a p-value of 0.428 (p > 0.05). The Chi-Square test is considered significant when the p-value is < 0.05. Conclusion : There is no difference in the degree of spasticity

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